Sigma receptor
Sigma receptors are unique binding sites that, unlike traditional GPCRs, do not fit into the classical categories of receptor proteins. They are involved in modulating neurotransmitter systems and have been implicated in various neurological and psychiatric disorders. Sigma receptors are also associated with cell survival, and their ligands are being explored for therapeutic applications in neuroprotection, cancer, and pain management. At CymitQuimica, we offer a selection of high-quality sigma receptor modulators to support your research in neuroscience, oncology, and receptor biology.
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Glycerol phenylbutyrate
CAS:611168-24-2
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is …
Formula:
C33H38O6
Purity:
99.00% - 99.74%
Color and Shape:
Solid
Molecular weight:
530.65
Ref: TM-T15393
| 10mg | 47.00 € | ||
| 25mg | 65.00 € | ||
| 50mg | 88.00 € | ||
| 100mg | 144.00 € | ||
| 200mg | 207.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
Blonanserin
CAS:132810-10-7
Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like …
Formula:
C23H30FN3
Purity:
99.85%
Color and Shape:
Solid
Molecular weight:
367.5
Ref: TM-T1180
| 5mg | 37.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 93.00 € | ||
| 50mg | 124.00 € | ||
| 100mg | 172.00 € | ||
| 200mg | 299.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
Roluperidone
CAS:359625-79-9
Roluperidone (CYR-101) is a novel cyclic amide derivative.
Formula:
C22H23FN2O2
Purity:
96.46% - 97.77%
Color and Shape:
Solid
Molecular weight:
366.43
Ref: TM-T15034
| 1mg | 35.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 163.00 € | ||
| 50mg | 259.00 € | ||
| 100mg | 375.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
S1R agonist 2
CAS:150085-21-5
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for …
Formula:
C21H27NO
Purity:
99.04%
Color and Shape:
Solid
Molecular weight:
309.45
Ref: TM-T72059
| 2mg | 40.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 169.00 € | ||
| 50mg | 248.00 € | ||
| 100mg | 366.00 € | ||
| 200mg | 517.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
UKH-1114
CAS:2113664-14-3
UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating …
Formula:
C22H24F3NO
Color and Shape:
Solid
Molecular weight:
375.43
Ref: TM-T203242
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
AD353
AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced …
Formula:
C23H30N2O2
Color and Shape:
Solid
Molecular weight:
366.5
Ref: TM-T203662
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for …
Formula:
C22H28N2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
320.47
Ref: TM-T78915
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
BMY-14802
CAS:105565-56-8
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of …
Formula:
C18H22F2N4O
Purity:
98.93%
Color and Shape:
Soild
Molecular weight:
348.39
Ref: TM-T67739
| 1mg | 40.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 264.00 € | ||
| 50mg | 432.00 € | ||
| 100mg | 638.00 € | ||
| 500mg | 1,359.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's …
Formula:
C22H26N2O
Color and Shape:
Solid
Molecular weight:
334.45
Ref: TM-T74813
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value …
Formula:
C22H28N2O2
Color and Shape:
Solid
Molecular weight:
352.47
Ref: TM-T201225
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
KSK67
CAS:2566715-93-1
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects …
Formula:
C22H27N3O2
Purity:
99.11%
Color and Shape:
Soild
Molecular weight:
365.47
Ref: TM-T77593
| 1mg | 48.00 € | ||
| 5mg | 97.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 279.00 € | ||
| 50mg | 482.00 € | ||
| 100mg | 832.00 € | ||
| 200mg | 1,121.00 € | ||
| 500mg | 2,783.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic …
Formula:
C26H27N3O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
397.51
Ref: TM-T78734
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 …
Formula:
C21H28ClNO
Purity:
98%
Color and Shape:
Solid
Molecular weight:
345.91
Ref: TM-T78087
| 2mg | 96.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
AB21 HCl
AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces …
Formula:
C23H29ClN2O
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
384.2
Ref: TM-T77340L
| 1mg | 115.00 € | ||
| 5mg | 245.00 € | ||
| 10mg | 363.00 € | ||
| 25mg | 562.00 € | ||
| 50mg | 775.00 € | ||
| 100mg | 1,035.00 € | ||
| 200mg | 1,406.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
PD 144418 oxalate
CAS:1794760-28-3
PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; …
Formula:
C20H24N2O5
Purity:
99.08%
Color and Shape:
Solid
Molecular weight:
372.42
Ref: TM-T39211
| 1mg | 59.00 € | ||
| 5mg | 133.00 € | ||
| 10mg | 187.00 € | ||
| 25mg | 321.00 € | ||
| 50mg | 467.00 € | ||
| 100mg | 683.00 € | ||
| 200mg | 938.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8
Formula:
C24H32N2O8
Purity:
98.54%
Color and Shape:
Solid
Molecular weight:
476.52
Ref: TM-T62396L
| 5mg | 62.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 188.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Wednesday 28 May 2025
AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM …
Formula:
C25H30N2O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
438.52
Ref: TM-T78916
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 28 May 2025
AF-710B
CAS:1235733-73-9
AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors …
Formula:
C20H27N3OS
Purity:
98.62% - 99.89%
Color and Shape:
Solid
Molecular weight:
357.51
Ref: TM-T23649
| 1mg | 316.00 € | ||
| 2mg | 470.00 € | ||
| 5mg | 750.00 € | ||
| 10mg | 1,064.00 € | ||
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € |
Estimated delivery in United States, on Friday 30 May 2025
Opipramol
CAS:315-72-0
Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic …
Formula:
C23H29N3O
Purity:
99.84% - 99.98%
Color and Shape:
Solid
Molecular weight:
363.5
Ref: TM-T61376
| 1mg | 73.00 € | ||
| 5mg | 155.00 € | ||
| 10mg | 216.00 € | ||
| 25mg | 368.00 € | ||
| 50mg | 547.00 € | ||
| 100mg | 782.00 € | ||
| 200mg | 1,074.00 € |
Estimated delivery in United States, on Friday 30 May 2025
S1RA
CAS:878141-96-9
S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating …
Formula:
C20H23N3O2
Purity:
99.45%
Color and Shape:
Solid
Molecular weight:
337.42
Ref: TM-T1865
| 1mg | 38.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 133.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 319.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Friday 30 May 2025
