Sigma receptor
Sigma receptors are unique binding sites that, unlike traditional GPCRs, do not fit into the classical categories of receptor proteins. They are involved in modulating neurotransmitter systems and have been implicated in various neurological and psychiatric disorders. Sigma receptors are also associated with cell survival, and their ligands are being explored for therapeutic applications in neuroprotection, cancer, and pain management. At CymitQuimica, we offer a selection of high-quality sigma receptor modulators to support your research in neuroscience, oncology, and receptor biology.
Found 48 products for "Sigma receptor".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Roluperidone
CAS:Roluperidone (CYR-101) is a novel cyclic amide derivative.Formula:C22H23FN2O2Purity:96.08% - 97.77%Color and Shape:SolidMolecular weight:366.43Glycerol phenylbutyrate
CAS:Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Formula:C33H38O6Purity:98.54% - 99.74%Color and Shape:Transparent LiquidMolecular weight:530.65Blonanserin
CAS:Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.Formula:C23H30FN3Purity:99.85% - 99.99%Color and Shape:SolidMolecular weight:367.50S1R agonist 1
CAS:S1R agonist 1 is a selective S1R agonist; modulates calcium signaling; neuroprotective; used for Alzheimer's research.Formula:C20H25NOPurity:99.12%Color and Shape:Transparent LiquidMolecular weight:295.42σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Formula:C22H28N2O2Color and Shape:SolidMolecular weight:352.47σ1R-IN-1
σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.Formula:C15H22N2Color and Shape:SolidMolecular weight:230.35Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-inducedFormula:C22H26N2OColor and Shape:SolidMolecular weight:334.45AD353
AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.Formula:C23H30N2O2Color and Shape:SolidMolecular weight:366.5AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.Formula:C22H28N2Purity:98%Color and Shape:SolidMolecular weight:320.47AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.Formula:C25H30N2O5Purity:98%Color and Shape:SolidMolecular weight:438.52SKF 34874
CAS:SKF 34874 is an active sigma receptor ligand that can be used in biochemical experiments and drug synthesis research.Formula:C11H11Cl2N3OPurity:99.95%Molecular weight:272.13AB21 HCl
AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.Formula:C23H29ClN2OPurity:99.91%Color and Shape:SolidMolecular weight:384.2PD 144418 oxalate
CAS:PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.Formula:C20H24N2O5Purity:98.76%Color and Shape:SolidMolecular weight:372.42S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.Formula:C21H28ClNOPurity:98%Color and Shape:SolidMolecular weight:345.91UKH-1114
CAS:UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.Formula:C22H24F3NOColor and Shape:SolidMolecular weight:375.43KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Formula:C24H32N2O8Purity:98.12%Color and Shape:SolidMolecular weight:476.52Cutamesine dihydrochloride
CAS:Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.Formula:C23H32N2O2·2HClPurity:99.96%Color and Shape:SolidMolecular weight:441.43Ref: TM-T3597
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg86.00€25mg167.00€50mg260.00€100mg401.00€200mg580.00€σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Formula:C21H23NOSPurity:99.8%Color and Shape:SolidMolecular weight:337.48S1RA hydrochloride
CAS:S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki >Formula:C20H24ClN3O2Purity:98% - 99.84%Color and Shape:SolidMolecular weight:373.87Ref: TM-T4229
1mg35.00€5mg75.00€1mL*10mM (DMSO)84.00€10mg105.00€25mg205.00€50mg334.00€100mg492.00€500mg973.00€4-IBP
CAS:4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .Formula:C19H21IN2OPurity:98.99%Color and Shape:SolidMolecular weight:420.29
