CaSR
The calcium-sensing receptor (CaSR) is a GPCR that plays a vital role in maintaining calcium homeostasis by regulating parathyroid hormone secretion and calcium reabsorption in the kidneys. CaSR is also involved in various other physiological processes, including bone metabolism and vascular function. Modulators of CaSR are used in the treatment of conditions such as hyperparathyroidism, osteoporosis, and cardiovascular diseases. At CymitQuimica, we provide a selection of high-quality CaSR modulators to support your research in calcium metabolism, endocrinology, and bone health.
Found 32 products of "CaSR"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
AC265347
CAS:<p>AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity for the study of neuroblastoma.</p>Formula:C17H17NOSPurity:>99.99%Color and Shape:SolidMolecular weight:283.39Strontium ranelate
CAS:<p>Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis and can slow the course of osteoarthritis of the knee.</p>Formula:C12H6N2O8S·2SrPurity:98.97%Color and Shape:Crystalline SolidMolecular weight:513.49Evocalcet
CAS:<p>Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR).</p>Formula:C24H26N2O2Purity:98.88% - 99.68%Color and Shape:SolidMolecular weight:374.48G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Formula:C10H18N2O5Color and Shape:SolidMolecular weight:246.26Upacicalcet HCl
<p>Upacicalcet HCl, a calcium mimetic, reduces blood PTH by targeting parathyroid receptors; treats secondary hyperparathyroidism.</p>Formula:C11H15Cl2N3O6SPurity:98.56%Color and Shape:SoildMolecular weight:388.22Etelcalcetide
CAS:<p>Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.</p>Formula:C38H73N21O10S2Purity:98%Color and Shape:SolidMolecular weight:1048.26Poly-D-lysine hydrobromide (MW 150000-300000)
<p>Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.</p>Color and Shape:Odour Solidγ-Glu-Abu TFA
<p>Gamma-Glu-AbuTFA is the TFA salt form of Gamma-Glu-Abu. This compound acts as an agonist for the calcium sensing receptor (CaSR), activating CaSR in HEK-293 cells with an EC50 of 0.21 μM.</p>Formula:C11H17F3N2O7Color and Shape:SolidMolecular weight:346.26Poly-D-lysine hydrobromide (MW 1000-5000)
<p>Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetically produced polymeric substrate widely used in neural cell culture. Additionally, Poly-D-lysine hydrobromide acts as a CaSR agonist peptide.</p>Color and Shape:Odour SolidCalcium-Sensing Receptor Antagonists I
CAS:<p>Calcium-Sensing Receptor Antagonists I functions as an antagonist to the parathyroid hormone receptors that sense calcium.</p>Formula:C23H24N2O2Color and Shape:SolidMolecular weight:360.45NPS-2143 hydrochloride
CAS:<p>NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.</p>Formula:C24H25ClN2O2·HClPurity:99.38% - 99.67%Color and Shape:SolidMolecular weight:445.38Etelcalcetide hydrochloride
CAS:<p>Etelcalcetide HCl, a synthetic peptide modulator of CaSR, lowers PTH in dialysis patients with secondary hyperparathyroidism.</p>Formula:C38H73N21O10S2HClPurity:>99.99%Color and Shape:SolidMolecular weight:1353.33NPS2390
CAS:<p>NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)</p>Formula:C19H21N3OPurity:97.13%Color and Shape:SolidMolecular weight:307.39Cinacalcet
CAS:<p>Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .</p>Formula:C22H22F3NPurity:99.48%Color and Shape:Yellow OilMolecular weight:357.41TNCA
CAS:<p>TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.</p>Formula:C12H12N2O2Purity:97.33% - 97.73%Color and Shape:SolidMolecular weight:216.24Cinacalcet hydrochloride
CAS:<p>Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-</p>Formula:C22H23ClF3NPurity:99.96% - >99.99%Color and Shape:Off-White To Tan SolidMolecular weight:393.87γ-L-Glutamyl-L-alanine
CAS:<p>γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).</p>Formula:C8H14N2O5Purity:99.49%Color and Shape:SolidMolecular weight:218.21Ligustroflavone
CAS:<p>Ligustroflavone (Nuezhenoside) has anti-inflammatory activity.</p>Formula:C33H40O18Purity:98% - 99.92%Color and Shape:SolidMolecular weight:724.66Gadolinium chloride
CAS:<p>Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist</p>Formula:Cl3GdPurity:98%Color and Shape:White Crystalline SolidMolecular weight:263.61Poly-D-lysine hydrobromide (MW 30000-70000)
CAS:<p>Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.</p>Formula:(C6H14N2O2)x·xHBrColor and Shape:SolidMolecular weight:227.102Calhex 231 hydrochloride
CAS:<p>Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .</p>Formula:C25H28Cl2N2OPurity:99.36%Color and Shape:SolidMolecular weight:443.41Tecalcet Hydrochloride
CAS:<p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>Formula:C18H23Cl2NOPurity:99.97%Color and Shape:SolidMolecular weight:340.29GSK3004774
CAS:<p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>Formula:C32H40N4O3Purity:98%Color and Shape:SolidMolecular weight:528.68(Rac)-Upacicalcet
CAS:<p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>Formula:C11H14ClN3O6SColor and Shape:SolidMolecular weight:351.76NPS-2143
CAS:<p>NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.</p>Formula:C24H25ClN2O2Purity:99.56%Color and Shape:SolidMolecular weight:408.92Ronacaleret HCl
CAS:<p>Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.</p>Formula:C25H32ClF2NO4Purity:99.97%Color and Shape:SolidMolecular weight:483.98Encaleret
CAS:<p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>Formula:C29H33ClFNO4Color and Shape:SolidMolecular weight:514.03CaSR antagonist-1
CAS:<p>CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation</p>Formula:C29H24FN3O2SPurity:98%Color and Shape:SolidMolecular weight:497.58Calindol hydrochloride
CAS:<p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>Formula:C21H21ClN2Purity:99.47%Color and Shape:SolidMolecular weight:336.86H-Glu-Thr-OH
CAS:<p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>Formula:C9H16N2O6Color and Shape:SolidMolecular weight:248.23TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Formula:C36H46N4O4SColor and Shape:SolidMolecular weight:630.84SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Formula:C26H32N2O4Purity:99.22%Color and Shape:SolidMolecular weight:436.54
