GPCR19
GPCR19, also known as GPR19, is a member of the G protein-coupled receptor family with roles that are still being elucidated in various physiological processes. Although less characterized than other GPCRs, GPCR19 is of interest in research focused on discovering new therapeutic targets for metabolic diseases, cancer, and neurological disorders. At CymitQuimica, we offer a selection of research tools and reagents to support your investigations into the functions and potential therapeutic applications of GPCR19.
Found 31 products of "GPCR19"
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Hyodeoxycholic acid
CAS:<p>Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.</p>Formula:C24H40O4Purity:97.29% - 98.82%Color and Shape:SolidMolecular weight:392.57Deoxycholic acid
CAS:<p>Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.</p>Formula:C24H40O4Purity:99.91% - 99.91%Color and Shape:Crystals From Alc SolidMolecular weight:392.57Ursodeoxycholic acid
CAS:<p>Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!</p>Formula:C24H40O4Purity:99.74% - ≥95%Color and Shape:White - Almost White Solid PowderMolecular weight:392.57PEN (rat)
CAS:<p>PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>Formula:C102H169N27O33Purity:98%Color and Shape:SolidMolecular weight:2301.62TGR5 agonist 1
<p>Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].</p>Formula:C28H48NNaO6SColor and Shape:SolidMolecular weight:549.74TGR5 agonist 4
<p>TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].</p>Formula:C24H38F2O5Color and Shape:SolidMolecular weight:444.555-HT7R antagonist 1 free base
CAS:<p>5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.</p>Formula:C14H17ClN4Color and Shape:SolidMolecular weight:276.77PEN (human)
CAS:<p>PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>Formula:C97H159N27O32Purity:98%Color and Shape:SolidMolecular weight:2215.49Cholic Acid 7-sulfate
CAS:<p>Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.</p>Formula:C24H40O8SColor and Shape:SolidMolecular weight:488.64TGR5 agonist 2
<p>TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].</p>Formula:C29H50NNaO6SColor and Shape:SolidMolecular weight:563.77TGR5 agonist 6
CAS:<p>Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.</p>Formula:C42H48Cl2N6O6Color and Shape:SolidMolecular weight:803.77TGR5 agonist 7
<p>TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.</p>Formula:C37H59N2NaO9SColor and Shape:SolidMolecular weight:730.93Triamterene
CAS:<p>Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.</p>Formula:C12H11N7Purity:99.77%Color and Shape:Yellow Yellow SolidMolecular weight:253.26BAR502
CAS:<p>BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).</p>Formula:C25H44O3Purity:99.95%Color and Shape:SolidMolecular weight:392.62BAR501
CAS:<p>BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。</p>Formula:C26H46O3Purity:99.29% - 99.68%Color and Shape:SolidMolecular weight:406.64TC-G 1005
CAS:<p>TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5).</p>Formula:C25H25N3O2Purity:98.60% - 99.78%Color and Shape:SolidMolecular weight:399.48Deoxycholic acid sodium salt
CAS:<p>Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates BAT thermogenic activity.</p>Formula:C24H39NaO4Purity:97.88% - 99.75%Color and Shape:Cream Crystalline PowderMolecular weight:414.56SBI-115
CAS:<p>SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5</p>Formula:C14H13ClN2O4SPurity:99.53% - 99.78%Color and Shape:SolidMolecular weight:340.78TGR5 Receptor Agonist
CAS:<p>TGR5 is a potent TGR5(GPCR19) agonist.</p>Formula:C18H14Cl2N2O2Purity:99.77% - ≥95%Color and Shape:SolidMolecular weight:361.22PEN (human) aceate
<p>PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.</p>Formula:C99H163N27O34Purity:99.25%Color and Shape:SolidMolecular weight:2275.51SB756050
CAS:<p>SB756050 is a specific TGR5 agonist.</p>Formula:C21H28N2O8S2Purity:98.78% - >99.99%Color and Shape:SolidMolecular weight:500.59Ursodeoxycholic acid sodium
CAS:<p>Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.</p>Formula:C24H40NaO4Purity:99.66% - 99.96%Color and Shape:SolidMolecular weight:415.56CAY10789
CAS:<p>CAY10789: potent CysLT1R antagonist (IC50 2.8 µM), GPBAR1 agonist (EC50 3 µM), reduces U937 cell adhesion, TNF-α, stable with promising pharmacokinetics.</p>Formula:C17H15NO2Color and Shape:SolidMolecular weight:265.31WB403
CAS:<p>WB403 activates TGR5, lowers fasting/postprandial glucose and HbA1c, enhances glucose tolerance, and normalizes pancreatic α/β-cells in diabetic mice.</p>Formula:C19H19BrN2OSPurity:98%Color and Shape:SolidMolecular weight:403.34TGR5 agonist 3
CAS:<p>Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].</p>Formula:C28H48O5Color and Shape:SolidMolecular weight:464.68INT-777 R-enantiomer
CAS:<p>INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.</p>Formula:C27H46O5Purity:98%Color and Shape:SolidMolecular weight:450.65RO5527239
CAS:<p>RO5527239 is a potent, orally available GPBAR1 agonist agent.</p>Formula:C28H31N3O3Purity:98%Color and Shape:SolidMolecular weight:457.56INT-777
CAS:<p>INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.</p>Formula:C27H46O5Purity:99.89%Color and Shape:SolidMolecular weight:450.655-HT7R antagonist 1
<p>5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.</p>Formula:C14H18Cl2N4Color and Shape:SolidMolecular weight:313.23TGR5 Receptor Agonist 3
CAS:<p>TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.</p>Formula:C29H27N3O6Color and Shape:SolidMolecular weight:513.54GPBAR1-IN-3
CAS:<p>GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].</p>Formula:C21H23NO2Color and Shape:SolidMolecular weight:321.41
