OX Receptor
Orexin receptors (OX1 and OX2) are GPCRs that bind to orexins, neuropeptides involved in regulating wakefulness, appetite, and energy homeostasis. Dysregulation of orexin signaling is linked to sleep disorders such as narcolepsy, as well as metabolic conditions like obesity. Orexin receptor modulators are being investigated for their therapeutic potential in treating sleep disorders, anxiety, and addiction. At CymitQuimica, we offer a range of high-quality orexin receptor modulators to support your research in sleep biology, metabolism, and neuropharmacology.
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EMPA
CAS:680590-49-2
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 …
Formula:
C23H26N4O4S
Purity:
99.91%
Color and Shape:
Solid
Molecular weight:
454.54
Ref: TM-T11186
| 1mg | 51.00 € | ||
| 5mg | 110.00 € | ||
| 10mg | 172.00 € | ||
| 25mg | 327.00 € | ||
| 50mg | 482.00 € | ||
| 100mg | 688.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Filorexant
CAS:1088991-73-4
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 …
Formula:
C24H25FN4O2
Purity:
99.33%
Color and Shape:
Solid
Molecular weight:
420.48
Ref: TM-T16096
| 1mg | 35.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 113.00 € | ||
| 25mg | 183.00 € | ||
| 50mg | 276.00 € | ||
| 100mg | 404.00 € | ||
| 1mL*10mM (DMSO) | 81.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Seltorexant
CAS:1293281-49-8
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat …
Formula:
C21H22FN7O
Purity:
100% - 99.86%
Color and Shape:
Solid
Molecular weight:
407.44
Ref: TM-T12877L
| 1mg | 37.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 101.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 269.00 € | ||
| 100mg | 369.00 € | ||
| 500mg | 853.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
SB-408124
CAS:288150-92-5
SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x …
Formula:
C19H18F2N4O
Purity:
98.14%
Color and Shape:
Solid
Molecular weight:
356.37
Ref: TM-T6658
| 5mg | 47.00 € | ||
| 10mg | 69.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 201.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
YNT-185
CAS:1804978-81-1
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values …
Formula:
C33H37N5O5S
Purity:
98.6%
Color and Shape:
Solid
Molecular weight:
615.74
Ref: TM-T39229
| 1mg | 65.00 € | ||
| 5mg | 142.00 € | ||
| 10mg | 222.00 € | ||
| 25mg | 446.00 € | ||
| 50mg | 717.00 € | ||
| 100mg | 975.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
SB-674042
CAS:483313-22-0
SB-674042 is a nonpeptide dual antagonist of the appetite peptides OX1 and OX2 receptors.SB-674042 is …
Formula:
C24H21FN4O2S
Purity:
99.9%
Color and Shape:
Solid
Molecular weight:
448.51
Ref: TM-T16854
| 1mg | 49.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
ACT-462206
CAS:1361321-96-1
ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used …
Formula:
C20H24N2O4S
Purity:
99.45%
Color and Shape:
Solid
Molecular weight:
388.48
Ref: TM-T26559
| 1mg | 44.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 135.00 € | ||
| 25mg | 274.00 € | ||
| 50mg | 439.00 € | ||
| 100mg | 697.00 € | ||
| 500mg | 1,393.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
L-368,899 hydrochloride
CAS:160312-62-9
L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may …
Formula:
C26H43ClN4O5S2
Purity:
99.59%
Color and Shape:
Solid
Molecular weight:
591.23
Ref: TM-T11794
| 2mg | 111.00 € | ||
| 5mg | 155.00 € | ||
| 10mg | 241.00 € | ||
| 25mg | 460.00 € | ||
| 50mg | 720.00 € | ||
| 100mg | 1,010.00 € | ||
| 1mL*10mM (DMSO) | 211.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
IPSU
CAS:1373765-19-5
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus …
Formula:
C23H27N5O2
Purity:
97.05%
Color and Shape:
Solid
Molecular weight:
405.49
Ref: TM-T5503
| 2mg | 51.00 € | ||
| 5mg | 84.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 196.00 € | ||
| 50mg | 293.00 € | ||
| 100mg | 423.00 € | ||
| 200mg | 653.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
DORA-22
CAS:1088991-95-0
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on …
Formula:
C23H22F2N4O2
Purity:
97.67%
Color and Shape:
Solid
Molecular weight:
424.44
Ref: TM-T5500
| 1mg | 129.00 € | ||
| 2mg | 184.00 € | ||
| 5mg | 277.00 € | ||
| 10mg | 421.00 € | ||
| 25mg | 697.00 € | ||
| 50mg | 976.00 € | ||
| 100mg | 1,319.00 € | ||
| 1mL*10mM (DMSO) | 330.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MK-1064
CAS:1207253-08-4
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).
Formula:
C24H20ClN5O3
Purity:
99.19% - 99.88%
Color and Shape:
Solid
Molecular weight:
461.9
Ref: TM-T3722
| 1mg | 52.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 157.00 € | ||
| 25mg | 272.00 € | ||
| 50mg | 453.00 € | ||
| 100mg | 730.00 € | ||
| 1mL*10mM (DMSO) | 109.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TCS 1102
CAS:916141-36-1
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
Formula:
C27H26N4O2S
Purity:
99.35% - 99.52%
Color and Shape:
Solid
Molecular weight:
470.59
Ref: TM-T2710
| 5mg | 40.00 € | ||
| 10mg | 58.00 € | ||
| 25mg | 102.00 € | ||
| 50mg | 178.00 € | ||
| 100mg | 251.00 € | ||
| 200mg | 367.00 € | ||
| 1mL*10mM (DMSO) | 43.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SB-649868
CAS:380899-24-1
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 …
Formula:
C26H24FN3O3S
Purity:
99.53%
Color and Shape:
Solid
Molecular weight:
477.55
Ref: TM-T5498
| 1mg | 37.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 390.00 € | ||
| 50mg | 632.00 € | ||
| 100mg | 1,014.00 € | ||
| 200mg | 1,368.00 € | ||
| 1mL*10mM (DMSO) | 135.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Orexin 2 Receptor Agonist
CAS:1796565-52-0
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 …
Formula:
C32H34N4O5S
Purity:
98.26% - 99.43%
Color and Shape:
Solid
Molecular weight:
586.7
Ref: TM-T3177
| 2mg | 41.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 132.00 € | ||
| 50mg | 225.00 € | ||
| 100mg | 328.00 € | ||
| 200mg | 455.00 € | ||
| 1mL*10mM (DMSO) | 79.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PF3274167
CAS:900510-03-4
PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
Formula:
C19H19ClFN5O3
Purity:
99.67% - 99.88%
Color and Shape:
Solid
Molecular weight:
419.84
Ref: TM-T3347
| 5mg | 35.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 91.00 € | ||
| 50mg | 147.00 € | ||
| 100mg | 229.00 € | ||
| 1mL*10mM (DMSO) | 36.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MK-3697
CAS:1224846-01-8
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist …
Formula:
C23H21N5O3S
Purity:
98.15% - 98.4%
Color and Shape:
Solid
Molecular weight:
447.51
Ref: TM-T1913
| 1mg | 52.00 € | ||
| 2mg | 69.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 120.00 € | ||
| 25mg | 211.00 € | ||
| 50mg | 350.00 € | ||
| 100mg | 504.00 € | ||
| 1mL*10mM (DMSO) | 105.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TCS-OX2-29
CAS:372523-75-6
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold …
Formula:
C23H31N3O3
Purity:
99.08%
Color and Shape:
Solid
Molecular weight:
397.51
Ref: TM-T4965
| 2mg | 46.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 178.00 € | ||
| 50mg | 261.00 € | ||
| 100mg | 467.00 € | ||
| 1mL*10mM (DMSO) | 76.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Almorexant
CAS:871224-64-5
Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for …
Formula:
C29H31F3N2O3
Purity:
97.75% - 98.02%
Color and Shape:
Solid
Molecular weight:
512.56
Ref: TM-T2613
| 1mg | 46.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 141.00 € | ||
| 25mg | 310.00 € | ||
| 50mg | 510.00 € | ||
| 100mg | 742.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SB-334867 free base
CAS:792173-99-0
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
Formula:
C17H13N5O2
Purity:
100% - 99.91%
Color and Shape:
Solid
Molecular weight:
319.32
Ref: TM-T6140
| 2mg | 42.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 159.00 € | ||
| 50mg | 224.00 € | ||
| 100mg | 333.00 € | ||
| 200mg | 496.00 € | ||
| 1mL*10mM (DMSO) | 77.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Daridorexant hydrochloride
CAS:1792993-84-0
Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be …
Formula:
C23H24Cl2N6O2
Purity:
98%
Color and Shape:
Soild
Molecular weight:
487.38
Ref: TM-T67782
| 1mg | Discontinued | Request information | |
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information | |
| 500mg | Discontinued | Request information | |
| 1ml*10 (DMSO) | Discontinued | Request information |
