OX Receptor
Orexin receptors (OX1 and OX2) are GPCRs that bind to orexins, neuropeptides involved in regulating wakefulness, appetite, and energy homeostasis. Dysregulation of orexin signaling is linked to sleep disorders such as narcolepsy, as well as metabolic conditions like obesity. Orexin receptor modulators are being investigated for their therapeutic potential in treating sleep disorders, anxiety, and addiction. At CymitQuimica, we offer a range of high-quality orexin receptor modulators to support your research in sleep biology, metabolism, and neuropharmacology.
Found 54 products for "OX Receptor".
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YNT-185
CAS:YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,Formula:C33H37N5O5SPurity:99.67%Color and Shape:SolidMolecular weight:615.74EMPA
CAS:EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nMFormula:C23H26N4O4SPurity:99.11%Color and Shape:SolidMolecular weight:454.54Ref: TM-T11186
1mg49.00€2mg69.00€5mg92.00€1mL*10mM (DMSO)104.00€10mg142.00€25mg250.00€50mg375.00€100mg563.00€200mg795.00€Seltorexant
CAS:Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.Formula:C21H22FN7OPurity:99.79% - >99.99%Color and Shape:White SolidMolecular weight:407.44Ref: TM-T12877L
1mg34.00€2mg49.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg98.00€25mg144.00€50mg260.00€100mg358.00€500mg822.00€Filorexant
CAS:Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).Formula:C24H25FN4O2Purity:98.88%Color and Shape:SolidMolecular weight:420.48SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Formula:C19H18F2N4OPurity:99.75% - 99.81%Color and Shape:SolidMolecular weight:356.37Suntinorexton
CAS:Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Formula:C23H28F2N2O4SPurity:99.9%Color and Shape:White SolidMolecular weight:466.54Ref: TM-T39807
1mg158.00€5mg385.00€1mL*10mM (DMSO)395.00€10mg625.00€25mg954.00€50mg1,288.00€100mg1,738.00€200mg2,332.00€Orexin 2 Receptor Agonist 3
Orexin 2 Receptor Agonist 3 is an orally active and brain-penetrant agonist of the orexin receptor 2 (OX2) with an EC50 value of 2.5 nM. This compound increases wakefulness in both orexin/ataxin-3 NT1 mouse models and healthy Beagle dogs. It is applicable for research related to narcolepsy.Formula:C27H29F2N7O3Molecular weight:537.56OXA(17-33) TFA
OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).Formula:C81H126F3N23O24Color and Shape:SolidMolecular weight:1863OXA(17-33)
CAS:Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Formula:C79H125N23O22Purity:98%Color and Shape:SolidMolecular weight:1749Orexin B, rat, mouse
CAS:Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Formula:C126H215N45O34SPurity:98%Color and Shape:SolidMolecular weight:2936.45Orexin A (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1 (human, rat, mouse) acetate) is an excitatory neuropeptide with analgesic properties.Formula:C154H247N47O46S4Purity:99.79%Color and Shape:White SolidMolecular weight:3621.15Orexin B, human
CAS:Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.Formula:C123H212N44O35SPurity:98%Color and Shape:SolidMolecular weight:2899.34[Ala11,D-Leu15]-Orexin B(human)
CAS:OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).Formula:C120H206N44O35SPurity:98%Color and Shape:SolidMolecular weight:2857.28Orexin A (human, rat, mouse) (TFA)
Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.Formula:C154H244N47F3O46S4Purity:98%Color and Shape:SolidMolecular weight:3675.12Xenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Formula:C130H219N45O40S2Color and Shape:SolidMolecular weight:3116.54[Ala11,D-Leu15]-Orexin B acetate
[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).Formula:C122H210N44O37SPurity:98.18%Color and Shape:SolidMolecular weight:2917.31Orexin A (human, rat, mouse)
CAS:Orexin A, a 33 AA neuropeptide in humans, rats, mice, influences various processes, studied in pancreatic function and as an OX1R antagonist.Formula:C152H243N47O44S4Purity:98%Color and Shape:SolidMolecular weight:3561.1Orexin B, rat, mouse TFA
Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.Formula:C128H216F3N45O36SColor and Shape:SolidMolecular weight:3050.42[Ala11,D-Leu15]-Orexin B(human) TFA
"[Ala11,D-Leu15]-Orexin B(human) TFA is an OX2 receptor agonist with 400x selectivity over OX1 (EC50: 0.13 nM vs. 52 nM)."Formula:C122H207F3N44O37SMolecular weight:2971.28Orexin B, human-13C6,15N TFA
Orexin B, human-13C6,15N (Human orexin B-13C6,15N) TFA is a variant of Orexin B, human, labeled with 13C and 15N isotopes. This compound acts as an agonist of the orexin receptors (Orexin Receptor, OX Receptor), with Ki values of 420 nM for OXR1 and 36 nM for OXR2. Orexin B, human plays a role in the regulation of appetite, wakefulness, cardiovascular function, and neuroendocrine activity.
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