Antibacterial

<p>Clostomycin B2 is a bioactive chemical.</p>

<p>TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks</p>

<p>Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.</p>

<p>Azidocillin, a semi-synthetic oral β-lactam antibiotic, treats various bacterial infections including osteitis and septicemia.</p>

<p>Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with</p>

<p>Amoxycillin arginine salt is a bioactive chemical.</p>

<p>Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1].</p>

<p>6-Deoxy-8-O-methylrabelomycin is a useful organic compound for research related to life sciences.</p>

<p>ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.</p>

<p>Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).</p>

<p>Omadacycline: an aminomethylcycline antibiotic, cidal against four Streptococcus pneumoniae strains.</p>

<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>

<p>Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with</p>

<p>Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.</p>

<p>CjGlmU, a sugar nucleotidyltransferase, uses UTP and GlcNAc-1-P to make UDP-GlcNAc, and has antimicrobial research potential.</p>

<p>SC 28538, a 5-nitroimidazole, matches metronidazole in potency against multiple pathogens in vitro.</p>

<p>Antibacterial agent 49 (example 12) is a antibacterial agent.</p>

<p>Carbomycin is a bioactive chemical against Borrelia burgdorferi persisters (lyme disease).</p>

<p>Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.</p>

<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>

<p>N-3-oxo-hexadecanoyl-L-homoserine lactone, a C16 AHL, aids bacterial quorum sensing and primes plant systemic resistance.</p>

<p>Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.</p>

<p>Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.</p>

<p>Aerocyanidin is an antibiotic (antibiotic) that contains an isonitrile group and is primarily effective against Gram-positive bacteria.</p>

<p>Capoamycin is an insotatracine antibiotic investigated for anti tumor properties.</p>

<p>Aurein 2.2, a principal constituent of L.aurea skin secretions, exhibits broad-spectrum antibacterial properties, particularly effective against Gram-positive</p>

<p>Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.</p>

<p>3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>Quorum sensing involves bacteria using AHLs to coordinate gene expression for biofilm formation and virulence, via LuxR regulators.</p>

<p>ONX-0914 (PR-957) TFA is a selective LMP7 inhibitor, blocking cytokines and arthritis progression, and reactivates HIV-1.</p>

<p>Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.</p>

<p>Paldimycin B is a semi-synthetic antibiotic.</p>

<p>Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.</p>

<p>Compound IA-8, an aryl isoxazoline derivative, exhibits insecticidal efficacy against M. separate [1].</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>3α-Akebonoic acid is a natural product isolated from Holboellia coriacea Diels with antitumor activity.</p>

<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>

<p>Trans-β-terpineol, a monoterpenoid compound extracted from Schinus terebinthifolius leaves, exhibits antioxidant and antibacterial properties.</p>

<p>Gramicidin S (Gramicidin Soviet), a cationic cyclic peptide antibiotic, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria and</p>

<p>Mafenide, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.</p>

<p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>

<p>Albofungin is a xanthone isolated from A. tumemacerans.</p>

<p>AM-8191, a bacterial topoisomerase inhibitors, has broad-spectrum antibacterial activity.</p>

<p>Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.</p>

<p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>

<p>Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.</p>

<p>Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting</p>

<p>Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.</p>

<p>Spirolaxine from Sporotrichum laxum shows anti-Helicobacter pylori activity.</p>

<p>BABX inhibits FAS-II, affecting fatty acid production in S. aureus/E. coli, and blocks LXRα agonist binding. IC50: 11.4/35.3 μg/ml. MIC: 0.2-0.4 μg/ml.</p>

<p>Myristoyl glutamic acid sodium, a surfactant in amino acid cleansers, has mild antibacterial properties and cleanses the skin surface of excess oil and dirt.</p>

<p>Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.</p>

<p>Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.</p>

<p>Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].</p>

<p>Daunosamnyl-daunorubicin is used as an antibody conjugate.</p>

<p>DS86760016 inhibits LeuRS; potent against MDR Gram-negative bacteria; IC50: E. coli 0.38μM, P. aeruginosa 0.62μM, A. baumannii 0.16μM.</p>

<p>Terephthalonitrile exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and can be used in related research in the field of life sciences.</p>

<p>Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A &amp; B.</p>

<p>Desferriferribactin is a biogenetic precursor of pyoverdin.</p>

<p>Tibezonium iodide, an oropharyngeal disinfectant, possesses antibacterial properties that aid in preventing mouth infections [1].</p>

<p>Teixobactin is a recently described antibiotic .</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>Pentalysine is a peptide.</p>

<p>MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 µM and is utilized in the study of bacterial infections [1].</p>

<p>Neoaureothin, a Streptomyces metabolite, is an AR antagonist with anti-androgen and cytotoxic effects, also active against B. xylophilus.</p>

<p>Natural stilbene Longistyline A from Cajanus cajan leaves; antimicrobial against MRSA, MIC 1.56 μg/mL; neuroprotective.</p>

<p>Almurtide: Muramyl dipeptide derivative with anti-inflammatory, anti-tumor properties, protects mice from Pseudomonas and Candida infections.</p>

<p>Samandarone is a major alkaloid from the European fire salamander (Salamandra salamandra terrestris).</p>

<p>FR-295389 is a cephalosporin. FR-295389 shows effective antibacterial activity against metallo-beta-lactamase (MBL)-producers in vitro.</p>

<p>Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.</p>

<p>2-Phenoxyphenol has antibacterial against Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, Burkholderia pseudomallei, etc.</p>

<p>Lysolipin I is a bioactive chemical.</p>

<p>Thiotropocin is an antibiotic.</p>

<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>

<p>Desotamide: an antibiotic cyclic hexapeptide targeting S. aureus, S. pneumoniae, and MRSE with MICs 16, 12.5, 32 μg/ml.</p>

<p>SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.</p>

<p>Defensin HNP-3 human, a cytotoxic antibiotic peptide referred to as "defensin," exhibits inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa,</p>

<p>Reveromycin B: a spiroketal from Streptomyces, blocks EGF in Balb/MK (IC50=6 μg/ml), antifungal vs. C. albicans, pH-sensitive, not active on KB, K562 cells.</p>

<p>Maximin 1, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Racemomycin B is a beta-lysine-rich streptothricin antibiotic.</p>

<p>Calpinactam, from M. alpina, fights M. smegmatis (MIC 0.78 μg/ml), boosts silkworm survival, but ineffective against 13 other species.</p>

<p>pBD-1 TFA: an innate AMP from pigs, prevalent in mucosa, with systemic defensive properties.</p>

<p>Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).</p>

<p>Rifasutenizol (TNP-2198) is a powerful, oral dual-target antibacterial effective against microaerophilic and anaerobic bacteria.</p>

<p>Urechistachykinin II (Uru-TK II) is an invertebrate rapid kinin-related peptide (TRPs) isolated from carotenoid worms.</p>

<p>Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.</p>

<p>Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.</p>

<p>FtsZ-IN-6: strong FtsZ polymerization promoter, GTPase inhibitor, kills bacteria, low resistance and toxicity.</p>

<p>Cephabacin M4 is a new cephem antibiotic isolated from bacterial.</p>

<p>Amythiamicin A is an antibiotic effective against gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and exhibits activity against Plasmodium falciparum.</p>

<p>LL-37 peptide: acetylated at N-terminus, amidated at C-terminus; crucial in initial infection defense.</p>

<p>Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-</p>

<p>Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.</p>

<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>

<p>MtbHU-IN-1 is a Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU)inhibitor(binding to WT MtbHU with a Kd of 98 nM).</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>T3SS-IN-1 (compound B9) is a potent type III secretion system (T3SS) inhibitor that also suppresses hpa1 promoter activity and harpin protein expression,</p>

<p>Lipid X is a monosaccharide precursor of E coli lipid A.</p>

<p>Antimicrobial OV-1 peptide, derived from SMAP29, inhibits antibiotic-resistant Pseudomonas aeruginosa strains.</p>

<p>Olaquindox can be used in relevant research in the life sciences. Its product number is T2779 and CAS number is 23696-28-8.</p>

<p>Cephalonium (Cefalonium) is a first-generation cephalosporin antibiotic.</p>

<p>LL D05139(beta) is an novel antitumor antibiotic agent.</p>