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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1037 products of "PI3K/Akt/mTOR Signaling"

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  • TG100-115
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    TG100-115

    CAS:
    <p>TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.</p>
    Formula:C18H14N6O2
    Purity:99.22% - 99.26%
    Color and Shape:Solid
    Molecular weight:346.34

    Ref: TM-T2672

  • NS309
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    NS309

    CAS:
    <p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>
    Formula:C8H4Cl2N2O2
    Purity:97.55%
    Color and Shape:Solid
    Molecular weight:231.04

    Ref: TM-T4612

  • Cetuximab
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    Cetuximab

    CAS:
    <p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>
    Formula:C107H179N35O36S7
    Purity:95 - 98.60%
    Color and Shape:Liquid
    Molecular weight:152 kDa

    Ref: TM-T9905

  • ONO-7475
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    ONO-7475

    CAS:
    <p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>
    Formula:C32H26N4O6
    Purity:98.74%
    Color and Shape:Solid
    Molecular weight:562.57

    Ref: TM-T8327

  • WH-4-025
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    WH-4-025

    CAS:
    <p>WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.</p>
    Formula:C39H38F3N7O5
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:741.76

    Ref: TM-T9219

  • Methyl 2,5-dihydroxycinnamate
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    Methyl 2,5-dihydroxycinnamate

    CAS:
    <p>Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.</p>
    Formula:C10H10O4
    Purity:99.60%
    Color and Shape:Crystalline
    Molecular weight:194.18

    Ref: TM-T22974

  • PS47
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    PS47

    CAS:
    <p>PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.</p>
    Formula:C17H15ClO2
    Purity:99.09%
    Color and Shape:Solid
    Molecular weight:286.75

    Ref: TM-T24677

  • PIK-293
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    PIK-293

    CAS:
    <p>PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.</p>
    Formula:C22H19N7O
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:397.43

    Ref: TM-T3348

  • ALK-IN-1
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    ALK-IN-1

    CAS:
    <p>ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.</p>
    Formula:C26H34ClN6O2P
    Purity:99.74% - 99.80%
    Color and Shape:Solid
    Molecular weight:529.01

    Ref: TM-T3059

  • ETP-45658
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    ETP-45658

    CAS:
    <p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>
    Formula:C16H17N5O2
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:311.34

    Ref: TM-T25399

  • Zorifertinib
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    Zorifertinib

    CAS:
    <p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>
    Formula:C22H23ClFN5O3
    Purity:98.20% - 99.36%
    Color and Shape:White To Off-White Solid
    Molecular weight:459.9

    Ref: TM-T3659

  • MTX-211
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    MTX-211

    CAS:
    <p>MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.</p>
    Formula:C20H14Cl2FN5O2S
    Purity:97.6% - >99.99%
    Color and Shape:Solid
    Molecular weight:478.33

    Ref: TM-T4296

  • Desmethyl Erlotinib hydrochloride
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    Desmethyl Erlotinib hydrochloride

    CAS:
    <p>Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.</p>
    Formula:C21H21N3O4·HCl
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:415.87

    Ref: TM-T6619

  • PF-06409577
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    PF-06409577

    CAS:
    <p>PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).</p>
    Formula:C19H16ClNO3
    Purity:95.17% - 98.21%
    Color and Shape:Solid
    Molecular weight:341.79

    Ref: TM-T4427

  • R547
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    R547

    CAS:
    <p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>
    Formula:C18H21F2N5O4S
    Purity:90% - 99.64%
    Color and Shape:Solid
    Molecular weight:441.45

    Ref: TM-T6312

  • 5-Bromoindole
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    5-Bromoindole

    CAS:
    <p>5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate</p>
    Formula:C8H6BrN
    Purity:99.99%
    Color and Shape:White To Beige Crystalline Powder
    Molecular weight:196.04

    Ref: TM-T7473

  • AG-1478
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    AG-1478

    CAS:
    <p>AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.</p>
    Formula:C16H14ClN3O2
    Purity:99.03% - 99.71%
    Color and Shape:Solid
    Molecular weight:315.75

    Ref: TM-T2047

  • AG 555
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    AG 555

    CAS:
    <p>AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.</p>
    Formula:C19H18N2O3
    Purity:98.02% - 99.94%
    Color and Shape:Solid
    Molecular weight:322.36

    Ref: TM-T4326

  • PF-04802367
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    PF-04802367

    CAS:
    <p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>
    Formula:C16H16ClN5O3
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:361.78

    Ref: TM-T9611

  • DMH-25
    Targetmol
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    DMH-25

    CAS:
    <p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>
    Formula:C15H8Br3NO3
    Purity:99.26%
    Color and Shape:Solid
    Molecular weight:489.94

    Ref: TM-T8569