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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1030 products of "PI3K/Akt/mTOR Signaling"

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  • PI3K/mTOR Inhibitor-13
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    PI3K/mTOR Inhibitor-13

    CAS:
    <p>PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.</p>
    Formula:C20H13F2N5O3S
    Color and Shape:Solid
    Molecular weight:441.41

    Ref: TM-T72380

  • EGFR-IN-16
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    EGFR-IN-16

    CAS:
    <p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>
    Formula:C16H11NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:265.26

    Ref: TM-T8525

  • mTOR inhibitor-2
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    mTOR inhibitor-2

    CAS:
    <p>mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).</p>
    Formula:C23H21N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:411.46

    Ref: TM-T12124

  • Mutated EGFR-IN-2
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    Mutated EGFR-IN-2

    CAS:
    Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.
    Formula:C29H35FN8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:562.64

    Ref: TM-T12130

  • SDZ281-977
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    SDZ281-977

    CAS:
    <p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>
    Formula:C18H20O5
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:316.35

    Ref: TM-T16866

  • 3,5-dimethyl PIT-1
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    3,5-dimethyl PIT-1

    CAS:
    <p>PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as</p>
    Formula:C16H15N3O4S
    Color and Shape:Solid
    Molecular weight:345.37

    Ref: TM-T35491

  • (E/Z)-CP-724714
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    (E/Z)-CP-724714

    CAS:
    <p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>
    Formula:C27H27N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.54

    Ref: TM-T6046

  • PI3Kδ/γ-IN-1
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    PI3Kδ/γ-IN-1

    CAS:
    <p>PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.</p>
    Formula:C25H28N6O4S
    Color and Shape:Solid
    Molecular weight:508.59

    Ref: TM-T63497

  • NU-7163
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    NU-7163

    CAS:
    <p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>
    Formula:C18H17NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:295.33

    Ref: TM-T24559

  • EGFR-IN-2
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    EGFR-IN-2

    CAS:
    <p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>
    Formula:C26H33N9O3S
    Purity:98.52% - 99.79%
    Color and Shape:Solid
    Molecular weight:551.66

    Ref: TM-T11159

  • MRT80
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    MRT80

    CAS:
    <p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>
    Formula:C15H15N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.31

    Ref: TM-T28108

  • PI3Kα/mTOR-IN-1
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    PI3Kα/mTOR-IN-1

    CAS:
    <p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>
    Formula:C16H18N6O
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T12589

  • PI3Ka-IN-5
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    PI3Ka-IN-5

    CAS:
    <p>PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .</p>
    Formula:C30H35N9O5
    Color and Shape:Solid
    Molecular weight:601.66

    Ref: TM-T73110

  • PI3Kα-IN-13
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    PI3Kα-IN-13

    CAS:
    <p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>
    Formula:C21H19N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.41

    Ref: TM-T79685

  • EGFR-IN-68
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    EGFR-IN-68

    CAS:
    <p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>
    Formula:C24H22N2O
    Color and Shape:Solid
    Molecular weight:354.44

    Ref: TM-T61267

  • EGFR-IN-53
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    EGFR-IN-53

    CAS:
    <p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>
    Formula:C14H13N3O2S
    Color and Shape:Solid
    Molecular weight:287.34

    Ref: TM-T60574

  • EGA
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    EGA

    CAS:
    EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.
    Formula:C16H16BrN3O
    Purity:98% - 99.6%
    Color and Shape:Solid
    Molecular weight:346.22

    Ref: TM-T25365

  • EGFR-IN-21
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    EGFR-IN-21

    CAS:
    <p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>
    Formula:C36H44BrN10O2P
    Color and Shape:Solid
    Molecular weight:759.68

    Ref: TM-T73103

  • Nemiralisib
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    Nemiralisib

    CAS:
    <p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>
    Formula:C26H28N6O
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:440.54

    Ref: TM-T15431

  • PI4KIII β inhibitor 3
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    PI4KIII β inhibitor 3

    CAS:
    PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
    Formula:C22H22N8OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.53

    Ref: TM-T12467