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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1037 products of "PI3K/Akt/mTOR Signaling"

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  • EGFR mutant-IN-2
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    EGFR mutant-IN-2

    CAS:
    <p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>
    Formula:C27H27F3N6O2S
    Color and Shape:Solid
    Molecular weight:556.6

    Ref: TM-T86344

  • P-2281
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    P-2281

    CAS:
    <p>P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell</p>
    Formula:C9H8ClN3O
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:209.63

    Ref: TM-T28285

  • PI3Ka-IN-5
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    PI3Ka-IN-5

    CAS:
    <p>PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .</p>
    Formula:C30H35N9O5
    Color and Shape:Solid
    Molecular weight:601.66

    Ref: TM-T73110

  • PI3K/mTOR Inhibitor-13
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    PI3K/mTOR Inhibitor-13

    CAS:
    <p>PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.</p>
    Formula:C20H13F2N5O3S
    Color and Shape:Solid
    Molecular weight:441.41

    Ref: TM-T72380

  • PI3Kα/mTOR-IN-1
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    PI3Kα/mTOR-IN-1

    CAS:
    <p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>
    Formula:C16H18N6O
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:310.35

    Ref: TM-T12589

  • EGFR-IN-2
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    EGFR-IN-2

    CAS:
    <p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>
    Formula:C26H33N9O3S
    Purity:98.52% - 99.79%
    Color and Shape:Solid
    Molecular weight:551.66

    Ref: TM-T11159

  • Mutated EGFR-IN-2
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    Mutated EGFR-IN-2

    CAS:
    <p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>
    Formula:C29H35FN8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:562.64

    Ref: TM-T12130

  • PI3K-IN-38
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    PI3K-IN-38

    CAS:
    <p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>
    Formula:C20H24N6O2
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:380.44

    Ref: TM-T61618

  • PI3K/mTOR Inhibitor-8
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    PI3K/mTOR Inhibitor-8

    CAS:
    <p>PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) &amp; mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase &amp; induces apoptosis in HCT-116 cells.</p>
    Formula:C23H22N8O4S
    Color and Shape:Solid
    Molecular weight:506.54

    Ref: TM-T63470

  • AMPK activator 4
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    AMPK activator 4

    CAS:
    <p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>
    Formula:C24H21ClN2O3
    Purity:99.46% - 99.65%
    Color and Shape:Solid
    Molecular weight:420.89

    Ref: TM-T62238

  • Tyrphostin AG 112
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    Tyrphostin AG 112

    CAS:
    <p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>
    Formula:C13H8N4O
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:236.23

    Ref: TM-T8534

  • PI3K-IN-9
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    PI3K-IN-9

    CAS:
    <p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>
    Formula:C19H23N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:365.43

    Ref: TM-T12458

  • PI3Kγ inhibitor 1
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    PI3Kγ inhibitor 1

    CAS:
    <p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>
    Formula:C32H26N8O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:586.67

    Ref: TM-T12464

  • PI3K-IN-10
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    PI3K-IN-10

    CAS:
    <p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>
    Formula:C23H19ClN6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.89

    Ref: TM-T12456

  • EGFR-IN-53
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    EGFR-IN-53

    CAS:
    <p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>
    Formula:C14H13N3O2S
    Color and Shape:Solid
    Molecular weight:287.34

    Ref: TM-T60574

  • EGFR/C797S-IN-1
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    EGFR/C797S-IN-1

    CAS:
    <p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>
    Formula:C28H30N4O3
    Color and Shape:Solid
    Molecular weight:470.56

    Ref: TM-T72788

  • PI3-Kinase α Inhibitor 2
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    PI3-Kinase α Inhibitor 2

    CAS:
    <p>Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and</p>
    Formula:C16H15N3O2S
    Color and Shape:Solid
    Molecular weight:313.37

    Ref: TM-T35525

  • EGFR-IN-5
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    EGFR-IN-5

    CAS:
    <p>EGFR-IN-5 inhibits EGFR &amp; mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>
    Formula:C31H38FN9O
    Purity:98.17%
    Color and Shape:Solid
    Molecular weight:571.69

    Ref: TM-T11160

  • PI3Kδ/γ-IN-1
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    PI3Kδ/γ-IN-1

    CAS:
    <p>PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.</p>
    Formula:C25H28N6O4S
    Color and Shape:Solid
    Molecular weight:508.59

    Ref: TM-T63497

  • YLF-466D
    Targetmol
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    YLF-466D

    CAS:
    <p>YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.</p>
    Formula:C29H20ClNO3
    Purity:97.74%
    Color and Shape:Solid
    Molecular weight:465.93

    Ref: TM-T13368