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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • PQR514
    Targetmol
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    PQR514

    CAS:
    <p>PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.</p>
    Formula:C16H20F2N8O2
    Purity:98.77% - 99.19%
    Color and Shape:Solid
    Molecular weight:394.38

    Ref: TM-T70058

  • CGP77675
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    CGP77675

    CAS:
    <p>CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and</p>
    Formula:C26H29N5O2
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:443.54

    Ref: TM-T30855

  • Larotinib
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    Larotinib

    CAS:
    <p>Larotinib is an orally active, potent, and broad-spectrum tyrosine kinase inhibitor (TKI) with an IC50 of 0.6 nM for EGFR.</p>
    Formula:C24H26ClFN4O4
    Purity:98.45%
    Color and Shape:Solid
    Molecular weight:488.94

    Ref: TM-T73334

  • PKI-166
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    PKI-166

    CAS:
    <p>PKI-166: oral EGF-R tyrosine kinase inhibitor (IC50: 0.7 nM), halts growth &amp; spread of many human cancers, including pancreatic.</p>
    Formula:C20H18N4O
    Purity:99.2%
    Color and Shape:Solid
    Molecular weight:330.38

    Ref: TM-T16549

  • MELK-8a hydrochloride
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    MELK-8a hydrochloride

    CAS:
    <p>MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). </p>
    Formula:C25H33ClN6O
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:469.02

    Ref: TM-T11996

  • RS1-PDK1 inhibitor
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    RS1-PDK1 inhibitor

    CAS:
    <p>RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.</p>
    Formula:C15H9ClN2O2S3
    Purity:98.12%
    Color and Shape:Solid
    Molecular weight:380.89

    Ref: TM-T24741

  • TGX-115
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    TGX-115

    CAS:
    <p>TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) &amp; p110δ (IC50=0.63μM), treats various cardiovascular diseases.</p>
    Formula:C20H20N2O3
    Purity:99.48%
    Color and Shape:Solid
    Molecular weight:336.38

    Ref: TM-T24873

  • Rezivertinib
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    Rezivertinib

    CAS:
    <p>Rezivertinib (BPI-7711) is an EGFR inhibitor with antitumor activity and can be used to study central nervous system diseases.</p>
    Formula:C27H30N6O3
    Purity:99.26% - 99.89%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T36644

  • NVP-BAG956
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    NVP-BAG956

    CAS:
    <p>NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).</p>
    Formula:C28H21N5
    Purity:99.25% - 99.80%
    Color and Shape:Solid
    Molecular weight:427.5

    Ref: TM-TQ0313

  • EGFR-IN-9
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    EGFR-IN-9

    CAS:
    <p>EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).</p>
    Formula:C29H24N4O3
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:476.53

    Ref: TM-T11163

  • ABC1183
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    ABC1183

    CAS:
    <p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>
    Formula:C18H14N4OS
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:334.39

    Ref: TM-T23601

  • GSK-3β inhibitor 2
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    GSK-3β inhibitor 2

    CAS:
    <p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>
    Formula:C14H14N4O3S
    Purity:99.08%
    Color and Shape:Solid
    Molecular weight:318.35

    Ref: TM-T11471

  • (R)-(-)-Rolipram
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    (R)-(-)-Rolipram

    CAS:
    <p>(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.</p>
    Formula:C16H21NO3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:275.34

    Ref: TM-T13448

  • PF-249
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    PF-249

    CAS:
    <p>PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.</p>
    Formula:C17H16ClN3O3
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:345.78

    Ref: TM-T24626

  • LY 456236 hydrochloride
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    LY 456236 hydrochloride

    CAS:
    <p>LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM.</p>
    Formula:C16H16ClN3O2
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:317.77

    Ref: TM-T22954

  • SRX3207
    Targetmol
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    SRX3207

    CAS:
    <p>SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.</p>
    Formula:C29H29N7O3S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:555.65

    Ref: TM-T22430

  • EGFR-IN-30
    Targetmol
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    EGFR-IN-30

    CAS:
    <p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, &lt;1 nM WT/mutants) with potential in cancer research.</p>
    Formula:C28H33BrN7O2P
    Color and Shape:Solid
    Molecular weight:610.49

    Ref: TM-T73108

  • EGFR-IN-32
    Targetmol
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    EGFR-IN-32

    CAS:
    <p>EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)</p>
    Formula:C31H34N6O3
    Color and Shape:Solid
    Molecular weight:538.64

    Ref: TM-T63798

  • PI3K/mTOR Inhibitor-14
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    PI3K/mTOR Inhibitor-14

    CAS:
    <p>PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and</p>
    Formula:C28H30N8O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:558.66

    Ref: TM-T81470

  • MTI-31
    Targetmol
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    MTI-31

    CAS:
    <p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, &gt;5,000-fold selectivity, and an IC50 of 39 nM.</p>
    Formula:C26H30N6O3
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:474.55

    Ref: TM-T35343