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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • MS 154
    Targetmol
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    MS 154

    CAS:
    <p>MS 154 is a potent PROTAC® targeting mutant EGFR in lung cancer, sparing WT-EGFR; effective in mice, with DC50 of 11-25 nM.</p>
    Formula:C46H54ClFN8O8
    Color and Shape:Solid
    Molecular weight:901.42

    Ref: TM-T41155

  • TCS 21311
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    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purity:99.39% - ≥98%
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T17019

  • 17β-Hydroxywortmannin
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    17β-Hydroxywortmannin

    CAS:
    <p>17β-Hydroxywortmannin is an orally active phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor, exhibiting an IC50 of 0.5 nM and notably suppresses osteoclast resorption at an IC50 of 10 nM. Additionally, it demonstrates antitumor activity.</p>
    Formula:C23H26O8
    Color and Shape:Solid
    Molecular weight:430.45

    Ref: TM-T84510

  • LDHA/PDKs-IN-1
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    LDHA/PDKs-IN-1

    CAS:
    <p>Compound 20e inhibits PDKs (IC50: 0.8 μM) &amp; LDHA (IC50: 0.15 μM), halts A549 cell growth, lowers lactate, boosts oxygen use.</p>
    Formula:C19H21FN2O4
    Color and Shape:Solid
    Molecular weight:360.38

    Ref: TM-T61339

  • T-00127_HEV1
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    T-00127_HEV1

    CAS:
    <p>T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).</p>
    Formula:C22H29N5O3
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:411.5

    Ref: TM-T16967

  • mTOR inhibitor 9d
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    mTOR inhibitor 9d

    CAS:
    <p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>
    Formula:C21H23N5O3S
    Purity:99.08%
    Color and Shape:Soild
    Molecular weight:425.5

    Ref: TM-T67702

  • WYE-23
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    WYE-23

    CAS:
    <p>WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).</p>
    Formula:C26H32N8O4
    Color and Shape:Solid
    Molecular weight:520.58

    Ref: TM-T71514

  • (Rac)-BRD0705
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    (Rac)-BRD0705

    CAS:
    <p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>
    Formula:C20H23N3O
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:321.42

    Ref: TM-T12664

  • EGFR-IN-74
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    EGFR-IN-74

    <p>EGFR-IN-74 is a potent inhibitor targeting EGFR, specifically effective against the L858R/T790M mutations, exhibiting an IC50 value of 138 nM.</p>
    Formula:C32H28BrF3N6O4S
    Color and Shape:Solid
    Molecular weight:729.57

    Ref: TM-T73170

  • mTOR inhibitor 9b
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    mTOR inhibitor 9b

    CAS:
    <p>mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR</p>
    Formula:C21H23N5O2S
    Purity:99.52%
    Color and Shape:Soild
    Molecular weight:409.5

    Ref: TM-T67703

  • Labuxtinib
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    Labuxtinib

    CAS:
    <p>Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].</p>
    Formula:C20H16FN5O2
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:377.37

    Ref: TM-T79851

  • Dezapelisib
    Targetmol
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    Dezapelisib

    CAS:
    <p>Dezapelisib, an oral delta PI3K inhibitor, blocks PIP3 production and PI3K/AKT pathway, hindering tumor cell growth and survival.</p>
    Formula:C20H16FN7OS
    Color and Shape:Solid
    Molecular weight:421.45

    Ref: TM-T27157

  • SU-11752
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    SU-11752

    CAS:
    <p>SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.</p>
    Formula:C26H27N3O5S
    Color and Shape:Solid
    Molecular weight:493.57

    Ref: TM-T68870

  • HKI-357
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    HKI-357

    CAS:
    <p>HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.</p>
    Formula:C31H29ClFN5O3
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:574.05

    Ref: TM-T11569

  • PAT-505
    Targetmol
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    PAT-505

    CAS:
    <p>PAT-505 is an autologous epidermal growth factor inhibitor.</p>
    Formula:C23H18ClF2N3O2S
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:473.92

    Ref: TM-T12372

  • BMS-599626 Hydrochloride
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    BMS-599626 Hydrochloride

    CAS:
    <p>BMS-599626 HCl (AC480 HCl) is an oral inhibitor of HER1, HER2, HER4 kinases, potentially blocking tumor growth. IC50: 22/32/190 nM.</p>
    Formula:C27H28ClFN8O3
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:567.01

    Ref: TM-T5390

  • PI3K/mTOR Inhibitor-1
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    PI3K/mTOR Inhibitor-1

    CAS:
    <p>PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)</p>
    Formula:C18H22FN5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.46

    Ref: TM-T12460

  • PF-06459988
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    PF-06459988

    CAS:
    <p>PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor.</p>
    Formula:C19H22ClN7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.88

    Ref: TM-T16492

  • PI3K/mTOR Inhibitor-6
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    PI3K/mTOR Inhibitor-6

    CAS:
    <p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>
    Formula:C30H34N10O4
    Color and Shape:Solid
    Molecular weight:598.66

    Ref: TM-T64219

  • mTOR inhibitor-3
    Targetmol
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    mTOR inhibitor-3

    CAS:
    <p>mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.</p>
    Formula:C25H30N8O2
    Purity:99% - 99.64%
    Color and Shape:Solid
    Molecular weight:474.56

    Ref: TM-T12123