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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1030 products of "PI3K/Akt/mTOR Signaling"

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  • GSK3β Inhibitor XI
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    GSK3β Inhibitor XI

    CAS:
    <p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>
    Formula:C18H15N5O3
    Color and Shape:Solid
    Molecular weight:349.35

    Ref: TM-T36088

  • (R)-VX-984
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    (R)-VX-984

    CAS:
    <p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>
    Formula:C23H21D2N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.49

    Ref: TM-T12648

  • 2B-(SP)
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    2B-(SP)

    CAS:
    <p>Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)</p>
    Formula:C71H123N26O29P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1835.87

    Ref: TM-TP2211

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    Etevritamab

    CAS:
    <p>Etevritamab is a monoclonal antibody that targets CD3E/EGFR.</p>
    Color and Shape:Liquid

    Ref: TM-T9901A-101

  • AZ14240475
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    AZ14240475

    <p>AZ14240475 is a potent, selective, brain-penetrant inhibitor of EGFREx20Ins mutants (EGFREx20Ins mutants) with a pIC50 of 7.6, playing a significant role in cancer research.</p>
    Formula:C23H15ClF2N6O2
    Color and Shape:Solid
    Molecular weight:480.854

    Ref: TM-T204475

  • AG-1478 hydrochloride
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    AG-1478 hydrochloride

    CAS:
    <p>AG1478 HCl is an epidermal growth factor receptor protein inhibitor.</p>
    Formula:C16H15Cl2N3O2
    Color and Shape:Solid
    Molecular weight:352.21

    Ref: TM-T20199

  • CHIR-98023
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    CHIR-98023

    CAS:
    <p>CHIR-98023 is a bio-active chemical.</p>
    Formula:C20H16Cl2N8O2
    Color and Shape:Solid
    Molecular weight:471.30

    Ref: TM-T30884

  • mTOR inhibitor 13
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    mTOR inhibitor 13

    CAS:
    <p>Urea derivative; selective mTOR blocker; IC50: 0.29nM (mTOR), 119nM (PI3Kα).</p>
    Formula:C24H22N6O2S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:458.54

    Ref: TM-T9310

  • GSK2292767 FA
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    GSK2292767 FA

    <p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>
    Formula:C25H30N6O7S
    Purity:99.52%
    Color and Shape:Soild
    Molecular weight:558.61

    Ref: TM-T6850L

  • ARUK2001607
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    ARUK2001607

    CAS:
    ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.
    Formula:C14H13N3O2S2
    Purity:99.75%
    Color and Shape:Soild
    Molecular weight:319.40

    Ref: TM-T67845

  • PROTAC EGFR degrader 10
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    PROTAC EGFR degrader 10

    CAS:
    <p>PROTAC EGF Rdegrader 10 (Compound B56) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR) with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 37 nM and degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibiting the proliferation of BaF3 wild-type and EGFR mutants with an IC50 of less than 150 nM.</p>
    Formula:C49H65ClN10O7S
    Color and Shape:Solid
    Molecular weight:973.62

    Ref: TM-T88273

  • CYH33
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    CYH33

    CAS:
    <p>CYH33: Oral PI3Kα inhibitor, IC50=5.9 nMα/598 nMβ/78.7 nMδ/225 nMγ; blocks Akt, ERK; causes G1 arrest in breast/lung cancer; effective on solid tumors.</p>
    Formula:C24H29F3N8O5S
    Color and Shape:Solid
    Molecular weight:598.6

    Ref: TM-T38978

  • Dacomitinib metabolite M2
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    Dacomitinib metabolite M2

    CAS:
    <p>Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.</p>
    Formula:C27H32ClFN6O4S
    Color and Shape:Solid
    Molecular weight:591.1

    Ref: TM-T23950

  • BMS-599626
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    BMS-599626

    CAS:
    <p>BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.</p>
    Formula:C27H27FN8O3
    Purity:98.73%
    Color and Shape:Solid
    Molecular weight:530.55

    Ref: TM-T2610

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    AMPK activator 13

    <p>AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen</p>
    Purity:98%
    Color and Shape:Odour Solid

    Ref: TM-T83127

  • HDS 029
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    HDS 029

    CAS:
    <p>HDS 029 has a wide range of applications in life science related research.</p>
    Formula:C17H11ClFN5O
    Color and Shape:Solid
    Molecular weight:355.76

    Ref: TM-T37080

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    IHMT-PI3K-455

    <p>IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for</p>
    Formula:C26H21F2N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.49

    Ref: TM-T78836

  • PROTAC PI3K/110β degrader-1
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    PROTAC PI3K/110β degrader-1

    CAS:
    <p>PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.</p>
    Formula:C51H65N9O9S
    Color and Shape:Solid
    Molecular weight:980.18

    Ref: TM-T207401

  • STX-478
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    STX-478

    CAS:
    <p>STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumor</p>
    Formula:C16H12F5N5O2
    Purity:98.31% - 99.78%
    Color and Shape:Solid
    Molecular weight:401.29

    Ref: TM-T78211

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    Cinrebafusp alfa

    CAS:
    <p>Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM to</p>
    Purity:98%
    Color and Shape:Liquid

    Ref: TM-T80590