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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1025 products of "PI3K/Akt/mTOR Signaling"

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  • (S)-Sunvozertinib
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    (S)-Sunvozertinib

    CAS:
    <p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>
    Formula:C29H35ClFN7O3
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:584.08

    Ref: TM-T9304

  • GS87
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    GS87

    CAS:
    <p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>
    Formula:C16H11N5O2S
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:337.36

    Ref: TM-T8605

  • WS6
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    WS6

    CAS:
    <p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>
    Formula:C29H31F3N6O3
    Purity:97.65% - 99.95%
    Color and Shape:Solid
    Molecular weight:568.59

    Ref: TM-T2106

  • PD158780
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    PD158780

    CAS:
    <p>PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.</p>
    Formula:C14H12BrN5
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:330.18

    Ref: TM-T5410

  • Autophinib
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    Autophinib

    CAS:
    <p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>
    Formula:C14H11ClN6O3
    Purity:99.25% - 99.41%
    Color and Shape:Solid
    Molecular weight:346.73

    Ref: TM-T4219

  • Selective PI3Kδ Inhibitor 1
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    Selective PI3Kδ Inhibitor 1

    CAS:
    <p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>
    Formula:C23H20FN7O
    Purity:97.96%
    Color and Shape:Solid
    Molecular weight:429.45

    Ref: TM-T5831

  • PKI-166 hydrochloride
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    PKI-166 hydrochloride

    CAS:
    <p>EGFR-kinase inhibitor, IC50 0.7 nM, &gt;3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>
    Formula:C20H19ClN4O
    Color and Shape:Solid
    Molecular weight:366.85

    Ref: TM-T36643

  • NRC-2694
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    NRC-2694

    CAS:
    <p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>
    Formula:C24H26N4O3
    Purity:99.90%
    Color and Shape:Solid
    Molecular weight:418.49

    Ref: TM-T16343

  • AZ-5104
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    AZ-5104

    CAS:
    AZ5104 is a potent EGFR inhibitor.
    Formula:C27H31N7O2
    Purity:98.40% - 99.59%
    Color and Shape:Solid Powder
    Molecular weight:485.58

    Ref: TM-T2491

  • Mutant EGFR inhibitor
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    Mutant EGFR inhibitor

    CAS:
    <p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>
    Formula:C27H30ClN7O2
    Purity:98% - 99.75%
    Color and Shape:Solid
    Molecular weight:520.03

    Ref: TM-T2705

  • YKL-06-061
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    YKL-06-061

    CAS:
    <p>YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.</p>
    Formula:C30H37N7O2
    Purity:99.52% - 99.79%
    Color and Shape:Solid
    Molecular weight:527.66

    Ref: TM-T5576

  • ETP-46321
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    ETP-46321

    CAS:
    <p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>
    Formula:C20H27N9O3S
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:473.55

    Ref: TM-TQ0229

  • CL-387785
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    CL-387785

    CAS:
    <p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>
    Formula:C18H13BrN4O
    Purity:99.56% - 99.62%
    Color and Shape:Solid
    Molecular weight:381.23

    Ref: TM-T2245

  • CP-380736
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    CP-380736

    CAS:
    CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.
    Formula:C14H18N2O5
    Purity:99.68%
    Color and Shape:White To Off-White Solid
    Molecular weight:294.3

    Ref: TM-T19814

  • WS3
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    WS3

    CAS:
    WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
    Formula:C28H30F3N7O3
    Purity:97.93% - 99.94%
    Color and Shape:Solid
    Molecular weight:569.58

    Ref: TM-T2055

  • JCN037
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    JCN037

    CAS:
    <p>JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).</p>
    Formula:C16H11BrFN3O2
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:376.18

    Ref: TM-T8431

  • KI8751
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    KI8751

    CAS:
    <p>KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.</p>
    Formula:C24H18F3N3O4
    Purity:99.22% - 99.9%
    Color and Shape:Solid
    Molecular weight:469.41

    Ref: TM-T2446

  • KY19382
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    KY19382

    CAS:
    <p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>
    Formula:C17H11Cl2N3O2
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:360.19

    Ref: TM-T9025

  • TAS0728
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    TAS0728

    CAS:
    <p>TAS0728 is a HER2 inhibitor, with antitumor activity</p>
    Formula:C26H32N8O3
    Purity:97.78%
    Color and Shape:Solid
    Molecular weight:504.58

    Ref: TM-T7819

  • Bisindolylmaleimide I
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    Bisindolylmaleimide I

    CAS:
    <p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>
    Formula:C25H24N4O2
    Purity:98.19% - 98.75%
    Color and Shape:Orange Solid
    Molecular weight:412.48

    Ref: TM-T6513