PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(159 products)
- ATM/ATR(71 products)
- DNA-PK(50 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(241 products)
- S6 Kinase(9 products)
- gsk-3(111 products)
- mTOR(145 products)
Show 2 more subcategories
Found 1025 products of "PI3K/Akt/mTOR Signaling"
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PIK-75 hydrochloride
CAS:<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74Sulforaphene
CAS:<p>Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.</p>Formula:C6H9NOS2Purity:97.55% - 99.19%Color and Shape:Slightly Yellowish LiquidMolecular weight:175.27TX1-85-1
CAS:<p>TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.</p>Formula:C32H36N8O3Purity:98.12% - 98.12%Color and Shape:SolidMolecular weight:580.68Tyrphostin B44, (+) enantiomer
CAS:Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33GSK2334470
CAS:<p>GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.</p>Formula:C25H34N8OPurity:99.57% - 99.87%Color and Shape:SolidMolecular weight:462.59RSVA405
CAS:<p>RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor</p>Formula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Formula:C19H22N6O3SPurity:98.42% - 99.54%Color and Shape:SolidMolecular weight:414.48Trastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Purity:97.1% (SDS-PAGE); 99.2% (SEC-HPLC) - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Color and Shape:LiquidMolecular weight:Approximately 145.53 kDaTGX-221
CAS:<p>TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.</p>Formula:C21H24N4O2Purity:99.68% - >99.99%Color and Shape:SolidMolecular weight:364.44Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Formula:C23H27N5O5SPurity:97.69% - 99.25%Color and Shape:SolidMolecular weight:485.56ETP-46321
CAS:<p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>Formula:C20H27N9O3SPurity:99.8%Color and Shape:SolidMolecular weight:473.55AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Formula:C16H15ClIN3O2Purity:98.64%Color and Shape:SolidMolecular weight:443.66AEE788
CAS:<p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>Formula:C27H32N6Purity:98% - >99.99%Color and Shape:SolidMolecular weight:440.58IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formula:C22H20FN3O2Purity:99.42% - >99.99%Color and Shape:SolidMolecular weight:377.41(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formula:C14H10N2OPurity:98.60%Color and Shape:SolidMolecular weight:222.24AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Formula:C22H24N4O4Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:408.45KU-0063794
CAS:<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Formula:C25H31N5O4Purity:98.21% - >99.99%Color and Shape:SolidMolecular weight:465.54BI-4020
CAS:<p>BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.</p>Formula:C30H38N8O2Purity:97.21% - >99.99%Color and Shape:SolidMolecular weight:542.68Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurity:98.21% - 99.69%Color and Shape:SolidMolecular weight:270.29MOTS-c(Human) Acetate(1627580-64-6 free)
<p>MOTS-c(Human) Acetate is a mitochondrial-derived peptide.</p>Formula:C103H156N28O24S2Purity:100%Color and Shape:SolidMolecular weight:2234.64
