CymitQuimica logo
PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

Show 2 more subcategories

Found 1038 products of "PI3K/Akt/mTOR Signaling"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • PI3Kγ inhibitor 2
    Targetmol
    + Info

    PI3Kγ inhibitor 2

    CAS:
    <p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>
    Formula:C20H18F3N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:433.38

    Ref: TM-T12465

  • BX-320
    Targetmol
    + Info

    BX-320

    CAS:
    <p>BX-320, a PDK1 inhibitor (IC50=30nM), selectively blocks Akt/p70S6K1 phosphorylation, induces apoptosis, and inhibits cancer cell growth.</p>
    Formula:C23H31BrN8O3
    Color and Shape:Solid
    Molecular weight:547.45

    Ref: TM-T37561

  • BEBT-109
    Targetmol
    + Info

    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Formula:C27H32N8O3
    Purity:97.26%
    Color and Shape:Solid
    Molecular weight:516.6

    Ref: TM-T80643

  • Simotinib
    Targetmol
    + Info

    Simotinib

    CAS:
    <p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>
    Formula:C25H26ClFN4O4
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:500.95

    Ref: TM-T35916

  • EGFR-IN-61
    Targetmol
    + Info

    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Formula:C33H37ClN8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:629.15

    Ref: TM-T73128

  • EGFR-IN-85
    Targetmol
    + Info

    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Formula:C26H30N8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T78574

  • JGK-068S
    Targetmol
    + Info

    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Formula:C22H23BrFN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:488.35

    Ref: TM-T79124

  • PI3K/mTOR Inhibitor-12
    Targetmol
    + Info

    PI3K/mTOR Inhibitor-12

    CAS:
    <p>PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.</p>
    Formula:C27H27F2N9O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:611.62

    Ref: TM-T72374

  • EGFR-IN-30
    Targetmol
    + Info

    EGFR-IN-30

    CAS:
    <p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, &lt;1 nM WT/mutants) with potential in cancer research.</p>
    Formula:C28H33BrN7O2P
    Color and Shape:Solid
    Molecular weight:610.49

    Ref: TM-T73108

  • CymitQuimica logo
    Targetmol
    + Info

    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Formula:C54H54Cl2FN7O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1067.08

    Ref: TM-T73995

  • 2′-Thioadenosine
    Targetmol
    + Info

    2′-Thioadenosine

    CAS:
    <p>2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against</p>
    Formula:C10H13N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:283.31

    Ref: TM-T78634

  • DZD1516
    Targetmol
    + Info

    DZD1516

    CAS:
    <p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>
    Formula:C28H27F2N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:547.56

    Ref: TM-T79297

  • EGFR mutant-IN-1
    Targetmol
    + Info

    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Formula:C34H39ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.17

    Ref: TM-T11164

  • GSK-3β inhibitor 8
    Targetmol
    + Info

    GSK-3β inhibitor 8

    CAS:
    <p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>
    Formula:C20H20ClN5OS
    Purity:98.46%
    Color and Shape:Solid
    Molecular weight:413.92

    Ref: TM-T35556

  • EGFR-IN-36
    Targetmol
    + Info

    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Formula:C26H25ClN6O2
    Color and Shape:Solid
    Molecular weight:488.97

    Ref: TM-T63265

  • AMPK-α1β1γ1 activator 1
    Targetmol
    + Info

    AMPK-α1β1γ1 activator 1

    CAS:
    <p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>
    Formula:C25H24ClNO9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.91

    Ref: TM-T83125

  • PI3K/mTOR Inhibitor-7
    Targetmol
    + Info

    PI3K/mTOR Inhibitor-7

    CAS:
    <p>Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.</p>
    Formula:C29H33N9O4
    Color and Shape:Solid
    Molecular weight:571.63

    Ref: TM-T64041

  • Rheb inhibitor NR1
    Targetmol
    + Info

    Rheb inhibitor NR1

    CAS:
    <p>Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.</p>
    Formula:C25H19BrCl2N2O3S
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:578.3

    Ref: TM-T16741

  • PI3K-IN-54
    Targetmol
    + Info

    PI3K-IN-54

    CAS:
    <p>Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.</p>
    Formula:C20H24F2N8O3
    Purity:98.15%
    Color and Shape:Solid
    Molecular weight:462.45

    Ref: TM-T77771

  • BGB-8035
    Targetmol
    + Info

    BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Formula:C24H31N5O4
    Purity:96.74%
    Color and Shape:Solid
    Molecular weight:453.53

    Ref: TM-T73381