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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • BPI-15086
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    BPI-15086

    CAS:
    <p>BPI-15086 is an orally active, effective, irreversible inhibitor selective for mutations, targeting both EGFR and the T790M resistance mutation tyrosine kinase. It can be utilized in the study of non-small cell lung cancer.</p>
    Formula:C29H33ClN8O4
    Color and Shape:Solid
    Molecular weight:593.08

    Ref: TM-T200004

  • BML-265
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    BML-265

    CAS:
    <p>BML-265 is a potent inhibitor of EGFR tyrosine kinase (EGFR tyrosine kinase). It disrupts Golgi apparatus integrity in human cells and hinders the transport of secretory proteins across various substances. In contrast, BML-265 does not affect the integrity and transport of the Golgi apparatus in rodent cells.</p>
    Formula:C18H15N3O2
    Color and Shape:Solid
    Molecular weight:305.331

    Ref: TM-T204769

  • GSK3β-IN-2
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    GSK3β-IN-2

    CAS:
    <p>GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.</p>
    Formula:C25H18N4O
    Color and Shape:Solid
    Molecular weight:390.437

    Ref: TM-T205461

  • PI3K-IN-37
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    PI3K-IN-37

    CAS:
    <p>PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).</p>
    Formula:C25H26N6O2
    Color and Shape:Solid
    Molecular weight:442.51

    Ref: TM-T62580

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    DNA-PK-IN-9

    <p>DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.</p>
    Formula:C21H21N5O2
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T61533

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    EGFR/HER2-IN-5

    <p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>
    Color and Shape:Solid

    Ref: TM-T64254

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    EGFR-IN-24

    <p>EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).</p>
    Formula:C30H35FN6O3
    Color and Shape:Solid
    Molecular weight:546.64

    Ref: TM-T63857

  • NU5455
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    NU5455

    CAS:
    <p>NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.</p>
    Formula:C34H33N3O5S
    Color and Shape:Solid
    Molecular weight:595.71

    Ref: TM-T64204

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    EGFR/HER2-IN-8

    <p>EGFR/HER2-IN-8 inhibits EGFR, HER2, DHFR (IC50: 0.45, 0.244, 5.669 μM); useful in cancer research, safe and selective.</p>
    Formula:C16H16N4O2S
    Color and Shape:Solid
    Molecular weight:328.39

    Ref: TM-T60938

  • D-69491 hydrochloride
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    D-69491 hydrochloride

    CAS:
    <p>D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.</p>
    Formula:C25H26Cl2FN7O3
    Color and Shape:Solid
    Molecular weight:562.42

    Ref: TM-T201568

  • GSK3β-IN-1
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    GSK3β-IN-1

    CAS:
    <p>GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.</p>
    Formula:C17H13FN2O4S
    Color and Shape:Solid
    Molecular weight:360.36

    Ref: TM-T204474

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    GSK-3β inhibitor 7

    <p>GSK-3β inhibitor 7 is a GSK-3β inhibitor (IC50: 5.25 μM).</p>
    Formula:C27H23BrN4O2S
    Color and Shape:Solid
    Molecular weight:547.47

    Ref: TM-T63866

  • EGFR-IN-35
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    EGFR-IN-35

    CAS:
    <p>EGFR-IN-35, an acrylamide-based EGFR inhibitor, shows promise for EGFR mutation-related cancers like NSCLC.</p>
    Formula:C25H24ClN7O2
    Color and Shape:Solid
    Molecular weight:489.96

    Ref: TM-T63282

  • GSK-3β inhibitor 26
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    GSK-3β inhibitor 26

    CAS:
    <p>GSK-3β inhibitor26 (Compound D14) is a GSK-3β inhibitor with an IC50 of 18.23 μM. This compound is applicable in research related to cancer, inflammation, and neurodegenerative diseases.</p>
    Formula:C15H11N3O3
    Color and Shape:Solid
    Molecular weight:281.266

    Ref: TM-T205441

  • Pred17
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    Pred17

    <p>Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.</p>
    Formula:C27H22BN3O
    Color and Shape:Solid
    Molecular weight:415.29

    Ref: TM-T201786

  • EGFR-IN-126
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    EGFR-IN-126

    CAS:
    <p>EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.</p>
    Formula:C28H28BrFN4O3
    Color and Shape:Solid
    Molecular weight:567.45

    Ref: TM-T200496

  • SIK2-IN-3
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    SIK2-IN-3

    CAS:
    <p>SIK2-IN-3 is an orally active selective inhibitor of SIK1/2 with IC50 values of 0.128/0.084 μM. It hinders the phosphorylation of CRTC3 and suppresses the production of pro-inflammatory factors in myeloid cells. Additionally, SIK2-IN-3 alleviates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model.</p>
    Formula:C23H24N6O2
    Color and Shape:Solid
    Molecular weight:416.48

    Ref: TM-T207716

  • HER2-IN-21
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    HER2-IN-21

    CAS:
    <p>HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.</p>
    Formula:C20H18N4O3S
    Color and Shape:Solid
    Molecular weight:394.447

    Ref: TM-T205331

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    GSK-3β inhibitor 6

    <p>GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM.</p>
    Formula:C20H17BrN4
    Color and Shape:Solid
    Molecular weight:393.28

    Ref: TM-T61804

  • GSK-3β inhibitor 20
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    GSK-3β inhibitor 20

    CAS:
    <p>GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.</p>
    Formula:C22H21N5O2S
    Color and Shape:Solid
    Molecular weight:419.50

    Ref: TM-T200457