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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1034 products of "PI3K/Akt/mTOR Signaling"

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  • PI3K/mTOR Inhibitor-3
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    PI3K/mTOR Inhibitor-3

    CAS:
    <p>PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.</p>
    Formula:C22H23N5O
    Color and Shape:Solid
    Molecular weight:373.45

    Ref: TM-T61516

  • RV-1729
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    RV-1729

    CAS:
    <p>RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.</p>
    Formula:C39H39ClN8O5
    Color and Shape:Solid
    Molecular weight:735.23

    Ref: TM-T28627

  • PI4KIII β inhibitor 3
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    PI4KIII β inhibitor 3

    CAS:
    PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
    Formula:C22H22N8OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.53

    Ref: TM-T12467

  • FT-1518
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    FT-1518

    CAS:
    FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.
    Formula:C20H26N8O
    Purity:98.34% - 98.80%
    Color and Shape:Solid
    Molecular weight:394.47

    Ref: TM-T11328

  • TCS 2002
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    TCS 2002

    CAS:
    <p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>
    Formula:C18H14N2O3S
    Color and Shape:Solid
    Molecular weight:338.38

    Ref: TM-T22157

  • MS 154N
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    MS 154N

    CAS:
    <p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>
    Formula:C47H56ClFN8O8
    Color and Shape:Solid
    Molecular weight:915.45

    Ref: TM-T41157

  • PI3K/mTOR Inhibitor-9
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    PI3K/mTOR Inhibitor-9

    CAS:
    PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).
    Formula:C23H27N7O2
    Color and Shape:Solid
    Molecular weight:433.51

    Ref: TM-T62438

  • AZD3458
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    AZD3458

    CAS:
    <p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, &lt;4.5, and 6.5 , respectively).</p>
    Formula:C20H23N3O4S2
    Color and Shape:Solid
    Molecular weight:433.54

    Ref: TM-T12466

  • EGFR-IN-67
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    EGFR-IN-67

    CAS:
    EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].
    Formula:C18H17N3S
    Color and Shape:Solid
    Molecular weight:307.41

    Ref: TM-T60729

  • Antiproliferative agent-34
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    Antiproliferative agent-34

    CAS:
    <p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>
    Formula:C27H27N7O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.55

    Ref: TM-T79368

  • DNA-PK-IN-1
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    DNA-PK-IN-1

    CAS:
    <p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>
    Formula:C23H26N8O2
    Color and Shape:Solid
    Molecular weight:446.5

    Ref: TM-T62648

  • ZDWX-25
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    ZDWX-25

    CAS:
    <p>ZDWX-25, a strong GSK-3β &amp; DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>
    Formula:C17H15N3O3
    Color and Shape:Solid
    Molecular weight:309.32

    Ref: TM-T60748

  • BKI-1369
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    BKI-1369

    CAS:
    <p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>
    Formula:C23H27N7O
    Color and Shape:Solid
    Molecular weight:417.51

    Ref: TM-T10556

  • CAL-130 Hydrochloride
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    CAL-130 Hydrochloride

    CAS:
    <p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>
    Formula:C23H23ClN8O
    Color and Shape:Solid
    Molecular weight:462.94

    Ref: TM-T10660L

  • PIMPC
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    PIMPC

    CAS:
    PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits
    Formula:C21H19N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.41

    Ref: TM-T79693

  • EGFR-IN-16
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    EGFR-IN-16

    CAS:
    <p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>
    Formula:C16H11NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:265.26

    Ref: TM-T8525

  • PI3Kγ inhibitor 7
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    PI3Kγ inhibitor 7

    CAS:
    PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].
    Formula:C31H25N9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:555.59

    Ref: TM-T79111

  • Tyrphostin 51
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    Tyrphostin 51

    CAS:
    Tyrphostin 51 is an effective inhibitor of EGFR kinase.
    Formula:C13H8N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:268.23

    Ref: TM-T24909

  • NU-7163
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    NU-7163

    CAS:
    NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.
    Formula:C18H17NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:295.33

    Ref: TM-T24559

  • Epertinib
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    Epertinib

    CAS:
    <p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>
    Formula:C30H27ClFN5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.02

    Ref: TM-T11213L