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gsk-3

gsk-3

GSK-3 inhibitors are compounds that target Glycogen Synthase Kinase 3 (GSK-3), an enzyme involved in numerous cellular processes, including glycogen metabolism, gene transcription, and cell proliferation. GSK-3 is implicated in various diseases, such as diabetes, neurodegenerative disorders, and cancer. Inhibitors of GSK-3 are important tools for exploring these pathways and developing potential therapies. At CymitQuimica, we provide GSK-3 inhibitors to support your research in metabolic diseases, neurobiology, and oncology.

Found 112 products of "gsk-3"

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  • LY2090314
    Targetmol
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    LY2090314

    CAS:
    <p>LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.</p>
    Formula:C28H25FN6O3
    Purity:99.21% - 99.91%
    Color and Shape:Solid
    Molecular weight:512.53

    Ref: TM-T1755

  • GS87
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    GS87

    CAS:
    <p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>
    Formula:C16H11N5O2S
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:337.36

    Ref: TM-T8605

  • AZD1080
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    AZD1080

    CAS:
    <p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>
    Formula:C19H18N4O2
    Purity:97.72% - 99.75%
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T1741

  • BIO-acetoxime
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    BIO-acetoxime

    CAS:
    <p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, &gt;240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>
    Formula:C18H12BrN3O3
    Purity:97.15%
    Color and Shape:Solid
    Molecular weight:398.21

    Ref: TM-T6787

  • Bikinin
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    Bikinin

    CAS:
    <p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>
    Formula:C9H9BrN2O3
    Purity:99.86% - >99.99%
    Color and Shape:Solid
    Molecular weight:273.08

    Ref: TM-T1965

  • GSK-3β inhibitor 10
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    GSK-3β inhibitor 10

    CAS:
    <p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>
    Formula:C12H12N2O3S
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:264.3

    Ref: TM-T9725

  • RGB-286638 free base
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    RGB-286638 free base

    CAS:
    <p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>
    Formula:C29H35N7O4
    Purity:98% - 99.91%
    Color and Shape:Solid
    Molecular weight:545.63

    Ref: TM-T2378

  • GNF4877
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    GNF4877

    CAS:
    <p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>
    Formula:C25H27FN6O4
    Purity:98.68% - 99.40%
    Color and Shape:Solid
    Molecular weight:494.52

    Ref: TM-T11447

  • (E/Z)-GSK-3β inhibitor 1
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    (E/Z)-GSK-3β inhibitor 1

    CAS:
    <p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>
    Formula:C14H10N2O
    Purity:98.60%
    Color and Shape:Solid
    Molecular weight:222.24

    Ref: TM-T9178

  • 7BIO
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    7BIO

    CAS:
    <p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>
    Formula:C16H10BrN3O2
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:356.17

    Ref: TM-T22012

  • 4-Chloro-2'-bromoacetophenone
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    4-Chloro-2'-bromoacetophenone

    CAS:
    <p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>
    Formula:C8H6BrClO
    Purity:98.34% - 99.41%
    Color and Shape:White To Beige Solid
    Molecular weight:233.49

    Ref: TM-T8908

  • KenPaullone
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    KenPaullone

    CAS:
    <p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>
    Formula:C16H11BrN2O
    Purity:97.14% - 98.99%
    Color and Shape:Tan Solid
    Molecular weight:327.18

    Ref: TM-T2247

  • VP3.15 dihydrobromide
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    VP3.15 dihydrobromide

    CAS:
    <p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>
    Formula:C20H24Br2N4OS
    Purity:99.67% - ≥95%
    Color and Shape:Solid
    Molecular weight:528.3

    Ref: TM-T5956

  • CHIR-98014
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    CHIR-98014

    CAS:
    <p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>
    Formula:C20H17Cl2N9O2
    Purity:97.25% - 99.59%
    Color and Shape:Solid
    Molecular weight:486.31

    Ref: TM-T2608

  • ALSTERPAULLONE
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    ALSTERPAULLONE

    CAS:
    <p>Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec</p>
    Formula:C16H11N3O3
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:293.28

    Ref: TM-T7426

  • AR-A014418
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    AR-A014418

    CAS:
    <p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>
    Formula:C12H12N4O4S
    Purity:>99.99% - ≥95%
    Color and Shape:Solid
    Molecular weight:308.31

    Ref: TM-T1881

  • CHIR 98024
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    CHIR 98024

    CAS:
    <p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>
    Formula:C20H17Cl2N9O2
    Purity:96.74%
    Color and Shape:Solid
    Molecular weight:486.31

    Ref: TM-T3074

  • 1-Azakenpaullone
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    1-Azakenpaullone

    CAS:
    <p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, &gt;100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>
    Formula:C15H10BrN3O
    Purity:99.73%
    Color and Shape:Tan Solid
    Molecular weight:328.16

    Ref: TM-T6358

  • BRD0209
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    BRD0209

    CAS:
    <p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>
    Formula:C22H25N3O
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:347.45

    Ref: TM-T26894

  • TC-G 24
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    TC-G 24

    CAS:
    <p>GSK-3β inhibitor</p>
    Formula:C15H11ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:330.73

    Ref: TM-T23436

  • Cazpaullone
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    Cazpaullone

    CAS:
    <p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>
    Formula:C16H10N4O
    Color and Shape:Solid
    Molecular weight:274.28

    Ref: TM-T26959

  • VP3.15
    Targetmol
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    VP3.15

    CAS:
    <p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>
    Formula:C20H22N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:366.48

    Ref: TM-T13310

  • BRD1652
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    BRD1652

    CAS:
    <p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>
    Formula:C20H20F3N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:375.39

    Ref: TM-T26896

  • ZDWX-25
    Targetmol
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    ZDWX-25

    CAS:
    <p>ZDWX-25, a strong GSK-3β &amp; DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>
    Formula:C17H15N3O3
    Color and Shape:Solid
    Molecular weight:309.32

    Ref: TM-T60748

  • PfGSK3/PfPK6-IN-2
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    PfGSK3/PfPK6-IN-2

    CAS:
    <p>PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.</p>
    Formula:C24H25Cl2N5OS
    Color and Shape:Solid
    Molecular weight:502.46

    Ref: TM-T72629

  • PIMPC
    Targetmol
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    PIMPC

    CAS:
    <p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>
    Formula:C21H19N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.41

    Ref: TM-T79693

  • 3F8
    Targetmol
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    3F8

    CAS:
    <p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>
    Formula:C15H14N2O4
    Purity:98.14% - 98.25%
    Color and Shape:Solid
    Molecular weight:286.28

    Ref: TM-T22180

  • TCS 2002
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    TCS 2002

    CAS:
    <p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>
    Formula:C18H14N2O3S
    Color and Shape:Solid
    Molecular weight:338.38

    Ref: TM-T22157

  • GSK-3β inhibitor 12
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    GSK-3β inhibitor 12

    CAS:
    <p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>
    Formula:C14H13N3OS
    Purity:98.58%
    Color and Shape:Solid
    Molecular weight:271.34

    Ref: TM-T60472

  • Aloisine B
    Targetmol
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    Aloisine B

    CAS:
    <p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>
    Formula:C15H14ClN3
    Purity:95.15%
    Color and Shape:Solid
    Molecular weight:271.74

    Ref: TM-T69188

  • GSK3-IN-2
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    GSK3-IN-2

    CAS:
    <p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>
    Formula:C17H19N3OS
    Purity:98.8%
    Color and Shape:Solid
    Molecular weight:313.42

    Ref: TM-T73270

  • BRD3731
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    BRD3731

    CAS:
    <p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>
    Formula:C24H31N3O
    Color and Shape:Solid
    Molecular weight:377.52

    Ref: TM-T61578

  • 18BIOder
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    18BIOder

    CAS:
    <p>18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.</p>
    Formula:C9H7ClN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:210.62

    Ref: TM-T24969

  • MRT80
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    MRT80

    CAS:
    <p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>
    Formula:C15H15N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.31

    Ref: TM-T28108

  • DIF-3
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    DIF-3

    CAS:
    <p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>
    Formula:C13H17ClO4
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:272.72

    Ref: TM-T60485

  • EHT 1610
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    EHT 1610

    CAS:
    <p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>
    Formula:C18H14FN5O2S
    Purity:98.59%
    Color and Shape:Solid
    Molecular weight:383.4

    Ref: TM-T15204

  • ARN25068
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    ARN25068

    CAS:
    <p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>
    Formula:C19H18N6S
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:362.45

    Ref: TM-T61360

  • GSK-3β inhibitor 2
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    GSK-3β inhibitor 2

    CAS:
    <p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>
    Formula:C14H14N4O3S
    Purity:99.08%
    Color and Shape:Solid
    Molecular weight:318.35

    Ref: TM-T11471

  • BIP-135
    Targetmol
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    BIP-135

    CAS:
    <p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>
    Formula:C21H13BrN2O3
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:421.24

    Ref: TM-T14613

  • GSK-3 Inhibitor XIII
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    GSK-3 Inhibitor XIII

    CAS:
    <p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>
    Formula:C18H15N5
    Purity:99.85% - 99.86%
    Color and Shape:Solid
    Molecular weight:301.35

    Ref: TM-T78578

  • ABC1183
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    ABC1183

    CAS:
    <p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>
    Formula:C18H14N4OS
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:334.39

    Ref: TM-T23601

  • GSK-3β inhibitor 11
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    GSK-3β inhibitor 11

    CAS:
    <p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>
    Formula:C20H15N3O4S
    Purity:97.33%
    Color and Shape:Solid
    Molecular weight:393.42

    Ref: TM-T61809

  • BRD5648
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    BRD5648

    CAS:
    <p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>
    Formula:C20H23N3O
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:321.42

    Ref: TM-T10608

  • PT-65
    Targetmol
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    PT-65

    CAS:
    <p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>
    Formula:C51H63N13O12S
    Color and Shape:Solid
    Molecular weight:1082.19

    Ref: TM-T84913

  • Antitrypanosomal agent 14
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    Antitrypanosomal agent 14

    CAS:
    <p>Antitrypanosomal agent 14 (Compound 1), a potent T.</p>
    Formula:C14H23N3OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.42

    Ref: TM-T79254

  • SAR502250
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    SAR502250

    CAS:
    <p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>
    Formula:C19H18FN5O2
    Color and Shape:Solid
    Molecular weight:367.38

    Ref: TM-T35560

  • GSK-3β inhibitor 8
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    GSK-3β inhibitor 8

    CAS:
    <p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>
    Formula:C20H20ClN5OS
    Purity:98.46%
    Color and Shape:Solid
    Molecular weight:413.92

    Ref: TM-T35556

  • (Rac)-BRD0705
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    (Rac)-BRD0705

    CAS:
    <p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>
    Formula:C20H23N3O
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:321.42

    Ref: TM-T12664

  • A 1070722
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    A 1070722

    CAS:
    <p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>
    Formula:C17H13F3N4O2
    Purity:99.9%
    Color and Shape:Solid
    Molecular weight:362.31

    Ref: TM-T10202

  • TCS 21311
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    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purity:99.39% - ≥98%
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T17019