gsk-3
GSK-3 inhibitors are compounds that target Glycogen Synthase Kinase 3 (GSK-3), an enzyme involved in numerous cellular processes, including glycogen metabolism, gene transcription, and cell proliferation. GSK-3 is implicated in various diseases, such as diabetes, neurodegenerative disorders, and cancer. Inhibitors of GSK-3 are important tools for exploring these pathways and developing potential therapies. At CymitQuimica, we provide GSK-3 inhibitors to support your research in metabolic diseases, neurobiology, and oncology.
Found 109 products of "gsk-3"
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GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36Ref: TM-T8605
1mg84.00€5mg166.00€10mg245.00€25mg404.00€50mg567.00€100mg767.00€200mg1,018.00€1mL*10mM (DMSO)170.00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formula:C19H18N4O2Purity:97.72% - 99.75%Color and Shape:SolidMolecular weight:334.37Ref: TM-T1741
1mg40.00€2mg52.00€5mg80.00€10mg117.00€25mg207.00€50mg333.00€100mg406.00€1mL*10mM (DMSO)59.00€BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.Formula:C18H12BrN3O3Purity:97.15%Color and Shape:SolidMolecular weight:398.21Ref: TM-T6787
1mg34.00€2mg46.00€5mg66.00€10mg99.00€25mg177.00€50mg281.00€100mg439.00€1mL*10mM (DMSO)73.00€Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.
Formula:C9H9BrN2O3Purity:99.86% - >99.99%Color and Shape:SolidMolecular weight:273.08SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Formula:C16H10ClN3O5Purity:99.55%Color and Shape:SolidMolecular weight:359.72GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Formula:C12H12N2O3SPurity:98.06%Color and Shape:SolidMolecular weight:264.3RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Formula:C25H27FN6O4Purity:98.68% - 99.40%Color and Shape:SolidMolecular weight:494.52(E/Z)-GSK-3β inhibitor 1
CAS:(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.Formula:C14H10N2OPurity:98.60%Color and Shape:SolidMolecular weight:222.24Ref: TM-T9178
2mg35.00€5mg56.00€10mg94.00€25mg154.00€50mg222.00€100mg318.00€200mg432.00€1mL*10mM (DMSO)63.00€7BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.174-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Formula:C8H6BrClOPurity:98.34% - 99.41%Color and Shape:White To Beige SolidMolecular weight:233.49KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Formula:C16H11BrN2OPurity:97.14% - 98.99%Color and Shape:Tan SolidMolecular weight:327.18Ref: TM-T2247
1mg35.00€2mg50.00€5mg66.00€10mg89.00€25mg178.00€50mg303.00€100mg449.00€500mg1,018.00€1mL*10mM (DMSO)71.00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formula:C20H24Br2N4OSPurity:99.67% - ≥95%Color and Shape:SolidMolecular weight:528.3CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Formula:C20H17Cl2N9O2Purity:97.25% - 99.59%Color and Shape:SolidMolecular weight:486.31Ref: TM-T2608
5mg71.00€10mg102.00€25mg205.00€50mg334.00€100mg537.00€500mg1,134.00€1mL*10mM (DMSO)To inquireALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFormula:C16H11N3O3Purity:99.8%Color and Shape:SolidMolecular weight:293.28Ref: TM-T7426
1mg55.00€5mg110.00€10mg173.00€25mg296.00€50mg424.00€100mg587.00€200mg792.00€1mL*10mM (DMSO)105.00€CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Formula:C20H17Cl2N9O2Purity:99.45%Color and Shape:SolidMolecular weight:486.31Ref: TM-T3074
1mg44.00€2mg55.00€5mg96.00€10mg153.00€25mg298.00€50mg487.00€100mg705.00€1mL*10mM (DMSO)97.00€1-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Formula:C15H10BrN3OPurity:99.73%Color and Shape:Tan SolidMolecular weight:328.16Ref: TM-T6358
1mg74.00€5mg152.00€10mg236.00€25mg439.00€50mg620.00€100mg888.00€200mg1,198.00€1mL*10mM (DMSO)177.00€Dihydronarwedine
CAS:Dihydronarwedine is a metabolite of Galanthamine, an inhibitor of glycogen synthase kinase 3β (GSK3β)Formula:C17H21NO3Color and Shape:SolidMolecular weight:287.35TC-G 24
CAS:GSK-3β inhibitorFormula:C15H11ClN4O3Purity:98%Color and Shape:SolidMolecular weight:330.73Cazpaullone
CAS:Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.Formula:C16H10N4OColor and Shape:SolidMolecular weight:274.28VP3.15
CAS:VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Formula:C20H20F3N3OPurity:98%Color and Shape:SolidMolecular weight:375.39TWS-119
CAS:TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.Formula:C22H16F6N4O6Color and Shape:SolidMolecular weight:546.38PfGSK3/PfPK6-IN-2
CAS:PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.Formula:C24H25Cl2N5OSColor and Shape:SolidMolecular weight:502.46PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFormula:C21H19N5OPurity:98%Color and Shape:SolidMolecular weight:357.413F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFormula:C15H14N2O4Purity:98.14% - 98.25%Color and Shape:SolidMolecular weight:286.28ZDWX-25
CAS:ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.Formula:C17H15N3O3Color and Shape:SolidMolecular weight:309.32TCS 2002
CAS:GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.Formula:C18H14N2O3SColor and Shape:SolidMolecular weight:338.38GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFormula:C14H13N3OSPurity:98.58%Color and Shape:SolidMolecular weight:271.34MRT80
CAS:MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.Formula:C15H15N5OPurity:98%Color and Shape:SolidMolecular weight:281.31BRD3731
CAS:BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.Formula:C24H31N3OColor and Shape:SolidMolecular weight:377.52GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Formula:C17H19N3OSPurity:99.51%Color and Shape:SolidMolecular weight:313.42BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.
Formula:C22H25N3OPurity:99.92%Color and Shape:SolidMolecular weight:347.4518BIOder
CAS:18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Formula:C9H7ClN2O2Purity:98%Color and Shape:SolidMolecular weight:210.62ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Formula:C18H14N4OSPurity:98.92%Color and Shape:SolidMolecular weight:334.39GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Formula:C20H15N3O4SPurity:97.33%Color and Shape:SolidMolecular weight:393.42GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formula:C18H15N5Purity:99.85% - 99.86%Color and Shape:SolidMolecular weight:301.35Ref: TM-T78578
1mg101.00€5mg230.00€10mg414.00€25mg884.00€50mg1,215.00€100mg1,639.00€200mg2,215.00€1mL*10mM (DMSO)239.00€GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Formula:C14H14N4O3SPurity:99.08%Color and Shape:SolidMolecular weight:318.35BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formula:C21H13BrN2O3Purity:99.93%Color and Shape:SolidMolecular weight:421.24Ref: TM-T14613
1mg33.00€5mg75.00€10mg110.00€25mg210.00€50mg313.00€100mg447.00€200mg617.00€1mL*10mM (DMSO)81.00€BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formula:C20H23N3OPurity:99.89%Color and Shape:SolidMolecular weight:321.42PT-65
CAS:PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].Formula:C51H63N13O12SColor and Shape:SolidMolecular weight:1082.19Antitrypanosomal agent 14
CAS:Antitrypanosomal agent 14 (Compound 1), a potent T.Formula:C14H23N3OSPurity:98%Color and Shape:SolidMolecular weight:281.42SAR502250
CAS:SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.Formula:C19H18FN5O2Color and Shape:SolidMolecular weight:367.38GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFormula:C20H20ClN5OSPurity:98.46%Color and Shape:SolidMolecular weight:413.92(Rac)-BRD0705
CAS:(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.Formula:C20H23N3OPurity:99.7%Color and Shape:SolidMolecular weight:321.42Ref: TM-T12664
1mg92.00€5mg200.00€10mg299.00€25mg484.00€50mg658.00€100mg892.00€1mL*10mM (DMSO)146.00€A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Formula:C17H13F3N4O2Purity:99.9%Color and Shape:SolidMolecular weight:362.31TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:99.39% - ≥98%Color and Shape:SolidMolecular weight:526.515-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormula:C16H10IN3O2Color and Shape:SolidMolecular weight:403.17GSK-3 inhibitor 1
CAS:GSK-3 inhibitor 1 is a GSK-3 inhibitor.Formula:C22H17ClFN5O2Purity:98.42%Color and Shape:SolidMolecular weight:437.85GSK3β-IN-1
CAS:GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.Formula:C17H13FN2O4SColor and Shape:SolidMolecular weight:360.36
