AMPK
AMPK inhibitors are compounds that target and inhibit AMP-Activated Protein Kinase (AMPK), an enzyme that plays a critical role in cellular energy homeostasis. AMPK is activated in response to low energy levels in cells and helps regulate processes such as glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Inhibiting AMPK is important for studying its role in metabolic diseases, cancer, and aging. At CymitQuimica, we offer a range of AMPK inhibitors to support your research in metabolism, oncology, and age-related diseases.
Found 168 products of "AMPK"
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MARK-IN-1
CAS:<p>MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).</p>Formula:C22H23F2N7OSPurity:98%Color and Shape:SolidMolecular weight:471.53AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formula:C25H24ClNO9Purity:98%Color and Shape:SolidMolecular weight:517.91Demethyleneberberine chloride
CAS:Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formula:C19H18ClNO4Purity:98%Color and Shape:SolidMolecular weight:359.8Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Formula:C31H23NO6Purity:98%Color and Shape:SolidMolecular weight:505.52MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Formula:C18H18ClF2N5OSPurity:98%Color and Shape:SolidMolecular weight:425.88PF-06679142
CAS:PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Formula:C20H17F2NO3Purity:98%Color and Shape:SolidMolecular weight:357.35AMPK-IN-1
CAS:AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Formula:C24H18ClN3O3Color and Shape:SolidMolecular weight:431.8710Z-Hymenialdisine
CAS:Pan kinase inhibitorFormula:C11H10BrN5O2Purity:98%Color and Shape:Light Yellow SolidMolecular weight:324.13MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Formula:C22H24F2N6O2Purity:99.47% - >99.99%Color and Shape:SolidMolecular weight:442.46AMPK activator 7
CAS:<p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>Formula:C23H22F3N3O5Color and Shape:SolidMolecular weight:477.43EGFR-IN-146
CAS:EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.Formula:C20H16N4Color and Shape:SolidMolecular weight:312.368HDAC11-IN-2
CAS:HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Formula:C25H35N3O3Color and Shape:SolidMolecular weight:425.564Galegine hemisulfate
CAS:Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Formula:C6H15N3O4SColor and Shape:SolidMolecular weight:225.27Equisetin
CAS:Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.Formula:C22H31NO4Purity:98%Color and Shape:SolidMolecular weight:373.49NPC26
CAS:<p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>Formula:C19H23N3O5S2Color and Shape:SolidMolecular weight:437.533Aldometanib
CAS:<p>Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.</p>Formula:C27H43Cl2IN2Purity:99.32% - 99.55%Color and Shape:SolidMolecular weight:593.46XMD-17-51 Trifluoroacetate
CAS:<p>XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.</p>Formula:C23H25F3N8O3Purity:99.65%Color and Shape:SolidMolecular weight:518.49AMPK activator C2
CAS:AMPK activator C2 is an AMPK allosteric activator.Formula:C7H6NO6PPurity:98%Color and Shape:SolidMolecular weight:231.1
