PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 242 products of "PI3K"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
PI3K-IN-6
CAS:<p>PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).</p>Formula:C17H14Cl2FN9OPurity:98%Color and Shape:SolidMolecular weight:450.26PI3Kα-IN-13
CAS:<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Formula:C21H19N5O3Purity:98%Color and Shape:SolidMolecular weight:389.41PI4KIII β inhibitor 3
CAS:<p>PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).</p>Formula:C22H22N8OSPurity:98%Color and Shape:SolidMolecular weight:446.53CAL-130 Hydrochloride
CAS:<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H23ClN8OColor and Shape:SolidMolecular weight:462.94AZD3458
CAS:<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Formula:C20H23N3O4S2Color and Shape:SolidMolecular weight:433.54PI3K-IN-10
CAS:<p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>Formula:C23H19ClN6OPurity:98%Color and Shape:SolidMolecular weight:430.89PI3Kα/mTOR-IN-1
CAS:<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Formula:C16H18N6OPurity:99.89%Color and Shape:SolidMolecular weight:310.35PI3Kγ inhibitor 1
CAS:<p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>Formula:C32H26N8O2SPurity:98%Color and Shape:SolidMolecular weight:586.67ON 146040
CAS:<p>ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.</p>Formula:C24H23N7O3SPurity:97.39%Color and Shape:SolidMolecular weight:489.55PI3K-IN-38
CAS:<p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>Formula:C20H24N6O2Purity:99.89%Color and Shape:SolidMolecular weight:380.44CHMFL-PI3KD-317
CAS:<p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.</p>Formula:C21H24ClN5O3S2Purity:99.16%Color and Shape:SolidMolecular weight:494.03AZ044
CAS:<p>AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).</p>Formula:C24H27N3O3SPurity:99.5%Color and Shape:SolidMolecular weight:437.55TGX-115
CAS:<p>TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) & p110δ (IC50=0.63μM), treats various cardiovascular diseases.</p>Formula:C20H20N2O3Purity:99.48%Color and Shape:SolidMolecular weight:336.38SRX3207
CAS:<p>SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.</p>Formula:C29H29N7O3SPurity:99.85%Color and Shape:SolidMolecular weight:555.65PQR514
CAS:<p>PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.</p>Formula:C16H20F2N8O2Purity:98.77% - 99.19%Color and Shape:SolidMolecular weight:394.38GS-9901
CAS:<p>GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.</p>Formula:C22H17ClFN9OPurity:98.60% - 99.92%Color and Shape:SolidMolecular weight:477.88NVP-BAG956
CAS:<p>NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).</p>Formula:C28H21N5Purity:99.25% - 99.80%Color and Shape:SolidMolecular weight:427.5PI3Kγ inhibitor 2
CAS:<p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>Formula:C20H18F3N5O3Purity:98%Color and Shape:SolidMolecular weight:433.38LAS191954
CAS:<p>LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).</p>Formula:C20H15N9OPurity:98%Color and Shape:SolidMolecular weight:397.39Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767GNE-490
CAS:<p>GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.</p>Formula:C18H22N6O2SPurity:99.77%Color and Shape:SolidMolecular weight:386.47CAL-130 Racemate
CAS:<p>CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47PIK-inhibitors
CAS:<p>PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.</p>Formula:C19H17N5O2Purity:96.98%Color and Shape:SolidMolecular weight:347.37MSC2360844
CAS:<p>MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).</p>Formula:C26H27FN4O5SPurity:99.54% - 99.9%Color and Shape:SolidMolecular weight:526.58NVP-QAV-572
CAS:<p>NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).</p>Formula:C17H19F2N7O3S2Purity:98%Color and Shape:SolidMolecular weight:471.5Zandelisib
CAS:<p>Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.</p>Formula:C31H38F2N8OPurity:99.88%Color and Shape:SolidMolecular weight:576.68PI3Kδ-IN-17
CAS:<p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>Formula:C23H24F3N7O2Purity:98%Color and Shape:SolidMolecular weight:487.48SAR-260301
CAS:<p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>Formula:C19H22N4O3Purity:99.74%Color and Shape:SolidMolecular weight:354.4PI3Kδ-IN-1
CAS:<p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>Formula:C22H20F3N7O2Purity:99.85%Color and Shape:SolidMolecular weight:471.44mTOR inhibitor 9d
CAS:<p>mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,</p>Formula:C21H23N5O3SPurity:99.08%Color and Shape:SoildMolecular weight:425.5MIPS-21335
CAS:<p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>Formula:C24H21N7O5Purity:98%Color and Shape:SolidMolecular weight:487.47PKI-402
CAS:<p>PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.</p>Formula:C29H34N10O3Purity:99.94%Color and Shape:SolidMolecular weight:570.65GSK-F1
CAS:<p>GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.</p>Formula:C27H18F5N5O4SPurity:97.03%Color and Shape:SolidMolecular weight:603.52GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formula:C24H32N6O3Purity:96.00% - 98.17%Color and Shape:SolidMolecular weight:452.55PF-04979064
CAS:<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Formula:C24H26N6O3Purity:98.20% - ≥98%Color and Shape:SolidMolecular weight:446.5VVD-699
CAS:<p>VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.</p>Formula:C25H30ClFN2O6S2Color and Shape:SolidMolecular weight:573.097PI3Kδ-IN-23
CAS:<p>PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.</p>Formula:C30H30N6O5Color and Shape:SolidMolecular weight:554.596UNI418
CAS:<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Formula:C22H16N6Color and Shape:SolidMolecular weight:364.40PI3kδ inhibitor 1
CAS:<p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>Formula:C28H33FN6O2Purity:98%Color and Shape:SolidMolecular weight:504.60Sonolisib
CAS:<p>Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).</p>Formula:C29H35NO8Purity:98%Color and Shape:SolidMolecular weight:525.59PI3Kδ-IN-13
CAS:<p>PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including</p>Formula:C27H39N7O4S2Color and Shape:SolidMolecular weight:589.77Duvelisib (R enantiomer)
CAS:<p>Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.</p>Formula:C22H17ClN6OPurity:98%Color and Shape:SolidMolecular weight:416.86
