ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Found 71 products of "ATM/ATR"
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Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Formula:C20H22ClN7OPurity:98.8% - 99.03%Color and Shape:SolidMolecular weight:411.89Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Formula:C23H26O7Purity:99.13% - 99.92%Color and Shape:SolidMolecular weight:414.45FEN1-IN-1
CAS:<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Formula:C15H12N2O5SPurity:99.65% - 99.80%Color and Shape:SolidMolecular weight:332.33GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formula:C20H29N3O7SPurity:99.97%Color and Shape:SolidMolecular weight:455.53Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C24H25N5O3SPurity:97.34% - >99.99%Color and Shape:SolidMolecular weight:463.55Hexapeptide-11
CAS:<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Formula:C36H48N6O7Purity:98%Color and Shape:SolidMolecular weight:676.8ATM Inhibitor-8
<p>ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of</p>Formula:C26H34N6O2Purity:98%Color and Shape:SolidMolecular weight:462.59ATM Inhibitor-9
<p>ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].</p>Formula:C25H32N6O2Purity:98%Color and Shape:SolidMolecular weight:448.56CA-M11
<p>CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.</p>Formula:C34H46N2O6SColor and Shape:SolidMolecular weight:610.80Abd110
CAS:<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formula:C25H32N6O4SColor and Shape:SolidMolecular weight:512.63GJ103 sodium salt
CAS:<p>GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.</p>Formula:C16H13N4NaO3SPurity:99.70% - 99.91%Color and Shape:SolidMolecular weight:364.36Ceralasertib
CAS:<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Formula:C20H24N6O2SPurity:98% - 99.99%Color and Shape:SolidMolecular weight:412.51AZD0156
CAS:<p>AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.</p>Formula:C26H31N5O3Purity:99.13% - 99.87%Color and Shape:SolidMolecular weight:461.56CP-466722
CAS:<p>CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.</p>Formula:C17H15N7O2Purity:99.1% - 99.14%Color and Shape:SolidMolecular weight:349.35KU-55933
CAS:<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Formula:C21H17NO3S2Purity:97.21% - >99.99%Color and Shape:SolidMolecular weight:395.49AZ20
CAS:<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Formula:C21H24N4O3SPurity:98% - 99.69%Color and Shape:SolidMolecular weight:412.51NU6027
CAS:<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29PIK-93
CAS:<p>PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.</p>Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4CGK733
CAS:<p>CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.</p>Formula:C23H18Cl3FN4O3SPurity:98% - 99.67%Color and Shape:SolidMolecular weight:555.84Adefovir dipivoxil
CAS:<p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>Formula:C20H32N5O8PPurity:98% - 99.80%Color and Shape:It Has Broad-Spectrum Antiviral ActivityMolecular weight:501.47KU60019
CAS:<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Formula:C30H33N3O5SPurity:95.9% - 99.36%Color and Shape:SolidMolecular weight:547.67VE-821
CAS:<p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>Formula:C18H16N4O3SPurity:97.19% - 99.97%Color and Shape:SolidMolecular weight:368.41AZ32
CAS:<p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>Formula:C20H16N4OPurity:98.68% - 99.68%Color and Shape:SolidMolecular weight:328.37Elimusertib
CAS:<p>Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in</p>Formula:C20H21N7OPurity:98.72% - 99.84%Color and Shape:SolidMolecular weight:375.43Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Formula:C27H32FN5O2Purity:97.41% - 99.72%Color and Shape:SolidMolecular weight:477.57ETP-46464
CAS:<p>ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).</p>Formula:C30H22N4O2Purity:97.76%Color and Shape:SolidMolecular weight:470.52Mirin
CAS:<p>Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.</p>Formula:C10H8N2O2SPurity:99.24%Color and Shape:SolidMolecular weight:220.25ART0380
CAS:<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>Formula:C18H24N6O2SPurity:99.06% - >99.99%Color and Shape:SolidMolecular weight:388.49SKLB-197
CAS:<p>SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.</p>Formula:C25H24N6OColor and Shape:SolidMolecular weight:424.5ATR-IN-10
CAS:<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Formula:C27H24N4OColor and Shape:SolidMolecular weight:420.51Ceralasertib formate
CAS:<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Formula:C21H26N6O4SColor and Shape:SolidMolecular weight:458.54ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Formula:C19H22N8OColor and Shape:SolidMolecular weight:378.43Gartisertib
CAS:<p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>Formula:C25H29F2N9O3Purity:99.52%Color and Shape:SolidMolecular weight:541.55ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Formula:C19H25N7OColor and Shape:SolidMolecular weight:367.45ATR-IN-23
CAS:<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Formula:C20H22N6O3S2Purity:98%Color and Shape:SolidMolecular weight:458.56ATR-IN-6
CAS:<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Formula:C28H28FN7O2Color and Shape:SolidMolecular weight:513.57ATR-IN-18
CAS:<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Formula:C19H22F3N7O5SColor and Shape:SolidMolecular weight:517.48ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Formula:C19H22N8OPurity:98%Color and Shape:SolidMolecular weight:378.43ATR-IN-13
CAS:<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Formula:C24H24FN9OColor and Shape:SolidMolecular weight:473.51AZ 5704
CAS:<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Formula:C23H23FN6O2Color and Shape:SolidMolecular weight:434.47ATR-IN-8
CAS:<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Formula:C20H22N6O2SColor and Shape:SolidMolecular weight:410.49ATR-IN-22
CAS:<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Formula:C25H31N7OPurity:98%Color and Shape:SolidMolecular weight:445.56ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Formula:C29H31N5O4SColor and Shape:SolidMolecular weight:545.65ATR-IN-5
CAS:<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Formula:C27H32F3N9OColor and Shape:SolidMolecular weight:555.6(S)-Ceralasertib
CAS:<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Formula:C20H24N6O2SColor and Shape:SolidMolecular weight:412.51ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Formula:C23H27N7OPurity:98%Color and Shape:SolidMolecular weight:417.51ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Formula:C30H36N6O3Color and Shape:SolidMolecular weight:528.65
