Organometallic Ligands

<p>Recombinant protein against VEGF(A); binds placental growth factor (PIGF)</p>

<p>Inhibitor of protein kinases; induces apoptosis; anti-cancer</p>

<p>Nociceptin/orphanin FQ peptide receptor antagonist</p>

<p>5-HT6 serotonin receptor antagonist; anti-convulsant</p>

<p>Active metabolite of ifosfamide; alkylates and cross-links DNA; antineoplastic</p>

<p>Serine protease inhibitor</p>

<p>Inhibitor of DNA replication; inhibitor of theophylline and caffeine metabolism</p>

<p>FP receptor ligand; activator of PGF2αR</p>

<p>Inhibits Akt translocation by targeting the pleckstrin homology (PH) domain. Inhibits hepatitis C virus NS5B RNA-dependent RNA polymerase (IC50 = 79 µM). Attenuates cannabinoid agonist-mediated proliferation of neural stem/precursor cells.</p>

<p>Inhibitor of phosphodiesterase 7</p>

<p>Analogue of GABA; GABA receptor agonist used in epilepsy</p>

<p>Vismodegib is a Hedgehog (Hh) pathway inhibitor belonging to the 2-arylpyridine class. It acts as a competitive antagonist of the smoothened receptor (SMO) localized in the cell membrane. SMO activates an intracellular cascade that results in activation and nuclear translocation of Gli family transcription factor. Vismodegib has been used in clinical trials for treatment of advanced cancers.</p>

<p>1-NM-PP1, also known as 1NM-PP1, is an inhibitor of the Src kinase. Studies have shown that 1-NM-PP1 inhibits analog-sensitive kinases (as-kinases) characterised by a small amino acid as gatekeeper of the ATP binding site. Tested to prevent parasitic infections, 1-NM-PP1 inhibited the Toxoplasma gondii life cycle when used at a higher concentration than 500 nM.</p>

<p>Inhibitor of acetylcholinesterase</p>

<p>Inhibitor of NPM-ALK kinase</p>

<p>Sumoylation inhibitor; reported to inhibit histone acetylation transferase</p>

<p>Vasopressin acetate is a synthetic analog of the natural hormone vasopressin, which is derived from peptide synthesis. This product acts as an antidiuretic hormone, primarily targeting kidney receptors to promote water reabsorption and constrict blood vessels. Its mode of action involves binding to V1 and V2 receptors, leading to increased water retention and vasoconstriction.</p>

<p>Multi-kinase inhibitor; inhibits epoxide hydrolase; antineoplastic</p>

<p>Cyclosporin B is an antifungal and immunosuppressive cyclic peptide, which is derived from the fungus *Tolypocladium inflatum*. The compound is a member of the cyclosporin family, characterized by cyclic polypeptides with a unique arrangement of amino acids that enable its biological activity. Though its precise mode of action is not completely delineated, it is observed to influence cell growth and viability by potentially disrupting cellular communication or signal transduction pathways.</p>

<p>Pam3Csk4 (Pam3) is a TLR1/2 agonist which when combined with the TLR3 agonist polyinosinic:polycytidylic acid (polyI:C), forms the adjuvant system known as L-pampo. L-pampo has demonstrated the ability to produce stronger antibody generation against Hepatis B Virus compared to Alum and takes part in cell-mediated immune responses for example leading to elevated multifunctional CD4+ T cells. It has also shown its potential in producing strong humoral and cellular immune responses as an adjuvant against SARS-CoV-2.</p>