Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1382 products of "Cytoskeletal Signaling"
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LDV FITC
CAS:<p>fluorescent ligand that binds to the α4β1 integrin (VLA-4)</p>Formula:C69H81N11O17SPurity:98%Color and Shape:SolidMolecular weight:1368.53Certepetide
CAS:<p>Certepetide, or iRGD, is a cyclic peptide that enhances tumor penetration and researches solid cancers.</p>Formula:C37H60N14O14S2Color and Shape:SolidMolecular weight:989.09Mps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Formula:C35H39N9O3Color and Shape:SolidMolecular weight:633.74Dafsolimab
CAS:<p>Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is</p>Color and Shape:Liquid4,4'-Di-O-methylellagic acid
CAS:<p>4,4'-Di-O-methylellagic acid is a useful organic compound for research related to life sciences. The catalog number is T125016 and the CAS number is 3374-77-4.</p>Formula:C16H10O8Color and Shape:SolidMolecular weight:330.248ML 2-23
<p>ML 2-23 is a potent BCR-ABL degrader operating as a PROTAC, exhibiting selective proteasome-dependent degradation of BCR-ABL within leukemia cells [1].</p>Formula:C47H53BrCl2N10O7SPurity:98%Color and Shape:SolidMolecular weight:1052.86Zolbetuximab MMAE
<p>Zolbetuximab MMAE (IMAB362 MMAE) is a compound targeting Claudin 18.2 (CLDN18.2) with anti-cancer activity, used in the study of gastric and pancreatic cancers.</p>Purity:95% - 95%Color and Shape:LiquidMolecular weight:150 kDaProtein Kinase C (19-36)
CAS:<p>Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.</p>Formula:C93H159N35O24Purity:98%Color and Shape:SolidMolecular weight:2151.48Fradafiban hydrochloride
<p>Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.</p>Formula:C20H22ClN3O4Color and Shape:SolidMolecular weight:403.86Myosin V-IN-1
CAS:<p>Myosin V-IN-1: potent, selective Myosin V inhibitor, Ki of 6 μM; hinders actin-activated ATPase by blocking ADP release.</p>Formula:C29H26N6O3SPurity:98.64% - 98.64%Color and Shape:SolidMolecular weight:538.62G-5555 hydrochloride (1648863-90-4 free base)
<p>G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.</p>Formula:C25H26Cl2N6O3Purity:98%Color and Shape:SolidMolecular weight:529.42HA15-Biotin
CAS:<p>HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.</p>Formula:C37H45N7O5S3Color and Shape:SolidMolecular weight:763.99Integrin Binding Peptide
CAS:<p>Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.</p>Formula:C42H63N15O16SColor and Shape:SolidMolecular weight:1066.12PROTAC tubulin-Degrader-1
<p>PROTAC tubulin-Degrader-1 (Compound W13) functions as an inhibitor of PROTAC tubulin and exhibits anti-tumor activity against human lung cancer.</p>Color and Shape:Odour SolidBimosiamose
CAS:<p>Bimosiamose has anti-inflammatory effects[1].</p>Formula:C46H54O16Purity:98%Color and Shape:SolidMolecular weight:862.91TAT-Gap19 TFA
<p>TAT-Gap19 TFA is a peptide that inhibits Cx43 hemichannels but not gap junctions and may reduce liver fibrosis.</p>Formula:C121H213F3N46O28Color and Shape:SolidMolecular weight:2817.27Tubulin inhibitor 36
<p>Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells,</p>Formula:C16H13ClN6SColor and Shape:SolidMolecular weight:356.83Epothilone F
CAS:<p>Epothilone F, an active metabolite of Epothilone D with a hydroxymethyl on thiazole, disrupts cell division, shows promise over taxanes, and is water-soluble.</p>Formula:C27H41NO7SColor and Shape:SolidMolecular weight:523.68Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:<p>Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.</p>Formula:C56H110N22O14Purity:98%Color and Shape:SolidMolecular weight:1315.61KGDS
CAS:<p>KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].</p>Formula:C15H27N5O8Color and Shape:SolidMolecular weight:405.4Tubulin inhibitor 38
<p>Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell</p>Formula:C17H13ClN6OSColor and Shape:SolidMolecular weight:384.84Foxy-5
CAS:<p>Foxy-5 is a wnt5a peptide mimetic</p>Formula:C26H42N6O12S2Purity:98%Color and Shape:SolidMolecular weight:694.77Combretastatin A-1 phosphate tetrasodium
CAS:<p>OXi-4503, a prodrug of Combretastatin A-1, disrupts tubulin, inhibits Wnt/β-catenin and AKT, and has anti-tumor/vascular effects.</p>Formula:C18H18Na4O12P2Color and Shape:SolidMolecular weight:580.2411H-Benzo[a]carbazole
CAS:<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Formula:C16H11NPurity:99.14%Color and Shape:SolidMolecular weight:217.27DSPE-PEG1000-iRGD
<p>DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.</p>Color and Shape:Odour SolidSNIPER(ABL)-058
CAS:<p>SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein</p>Formula:C62H75N11O9SPurity:98%Color and Shape:SolidMolecular weight:1150.39MS21
CAS:<p>MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.</p>Formula:C58H79ClN12O6SColor and Shape:SolidMolecular weight:1107.86K34c hydrochloride
CAS:<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Formula:C26H30ClN3O4Purity:99.76% - 99.89%Color and Shape:SoildMolecular weight:483.99MAL3-101
CAS:<p>MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).</p>Formula:C54H66N4O10Color and Shape:SolidMolecular weight:931.12MS170
CAS:<p>MS170, specific PROTAC AKT degrader, potent with DC 50 of 32 nM, binds AKT1/2/3 with Kd 1.3, 77, 6.5 nM respectively.</p>Formula:C45H56ClN9O7Color and Shape:SolidMolecular weight:870.45PDS-0330
CAS:<p>PDS-0330, a claudin-1 inhibitor, hinders CRC growth and metastasis with micromolar affinity and promising pharmacokinetics.</p>Formula:C25H17N3O2SPurity:99.93%Color and Shape:SoildMolecular weight:423.49Phomopsin A
CAS:<p>Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis.</p>Formula:C36H45ClN6O12Purity:98%Color and Shape:SolidMolecular weight:789.23JG-258
CAS:<p>JG-258 is an inactive negative control for Hsp70 inhibitors [1] .</p>Formula:C20H22ClN3OS3Color and Shape:SolidMolecular weight:452.06AT-1002
CAS:<p>AT-1002 is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.</p>Formula:C32H53N9O7SPurity:98%Color and Shape:SolidMolecular weight:707.88TBL-100
<p>TBL-100 is a human monoclonal antibody (mAb) that targets Tau. It is applicable for research in Alzheimer's disease (AD) and progressive supranuclear palsy.</p>Color and Shape:Odour LiquidNDNA4
<p>NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.</p>Formula:C31H35F3N2O5SPurity:98%Color and Shape:SolidMolecular weight:604.68A20FMDV2
CAS:<p>A20FMDV2 is a highly selective αvβ6 integrin inhibitor with an IC 50 of 3 nM, demonstrating 1,000-fold greater selectivity for αvβ6 compared to other RGD-directed integrins like αvβ3, αvβ5, and α5β1. This compound can be derived from the foot-and-mouth disease virus and is suitable for radiolabeling, enabling PET imaging of αvβ6 integrin-positive tumors.</p>Formula:C93H163N31O28Color and Shape:SolidMolecular weight:2163.48LDV-FITC TFA
<p>LDV-FITC TFA is a fluorescent peptide, specifically an FITC-conjugated LDV peptide. This compound binds to the α4β1 integrin with high affinity, displaying a Kd of 0.3 nM in the presence of Mn2+ and 12 nM in its absence, when binding to U937 cells. LDV-FITC TFA is useful for assessing α4β1 integrin affinity.</p>Formula:C69H81N11O17S·xC2HF3O2SAMβA TFA
<p>SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improves</p>Formula:C50H73N17O16·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:1168.22 (free acid)cRGDfK-thioacetyl ester
CAS:<p>cRGDfK-thioacetyl ester, a bioactive polypeptide, exhibits selective affinity for integrins and can modify near-infrared (NIR) fluorescent probes for targeted</p>Formula:C31H45N9O9SPurity:98%Color and Shape:SolidMolecular weight:719.81hCA/Wnt/β-catenin-IN-1
<p>hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8</p>Color and Shape:Odour SolidKTC1101
CAS:<p>KTC1101 is a pan-PI3K inhibitor with antiproliferative and anticancer activities, reducing phosphorylation of downstream AKT and mTOR.</p>Formula:C21H26F2N8O3Purity:98.75%Color and Shape:SoildMolecular weight:476.48Sangivamycin
CAS:<p>Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.</p>Formula:C12H15N5O5Purity:99.85%Color and Shape:SolidMolecular weight:309.28Chaetominine
CAS:<p>Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.</p>Formula:C22H18N4O4Color and Shape:SolidMolecular weight:402.406BrCaQ-C10-TPP
<p>6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.</p>Formula:C45H47Br2N2O3PColor and Shape:SolidMolecular weight:854.65AT7867 dihydrochloride
CAS:<p>AT7867 dihydrochloride inhibits Akt1/2/3 and p70S6K/PKA, with IC50s: 32/17/47 nM & 85/20 nM, respectively, and hampers tumor growth.</p>Formula:C20H22Cl3N3Color and Shape:SolidMolecular weight:410.77Debio 0932
CAS:<p>Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.</p>Formula:C22H30N6O2SPurity:98.98%Color and Shape:SolidMolecular weight:442.58(±)-1,2-Diolein
CAS:<p>(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.</p>Formula:C39H72O5Color and Shape:SolidMolecular weight:620.99Kinesore
CAS:<p>Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.</p>Formula:C20H16Br2N4O4Purity:97.24%Color and Shape:SolidMolecular weight:536.17Cilengitide TFA
CAS:<p>Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.</p>Formula:C29H41F3N8O9Color and Shape:SolidMolecular weight:702.68
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