Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1537 products for "Cytoskeletal Signaling".
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HA15-Biotin
CAS:HA15-Biotin, a synthetic HA15-biotin conjugate, shows similar activity and may aid in proteomics.Formula:C37H45N7O5S3Color and Shape:SolidMolecular weight:763.993-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formula:C13H11N5O2Purity:99.88%Color and Shape:SolidMolecular weight:269.26Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formula:C38H52O10Purity:98%Color and Shape:SolidMolecular weight:668.81SNIPER(ABL)-050
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.Formula:C68H84N12O9Purity:98%Color and Shape:SolidMolecular weight:1213.47MS21
CAS:MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.Formula:C58H79ClN12O6SColor and Shape:SolidMolecular weight:1107.86G-5555 hydrochloride (1648863-90-4 free base)
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.Formula:C25H26Cl2N6O3Purity:98%Color and Shape:SolidMolecular weight:529.42BGC0222
BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.Formula:C1241H2276N64O552Color and Shape:SolidMolecular weight:26927.36Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formula:C12H15N5O5Purity:99.85%Color and Shape:SolidMolecular weight:309.28Ref: TM-T9605
1mg119.00€5mg260.00€1mL*10mM (DMSO)341.00€10mg394.00€25mg640.00€50mg893.00€100mg1,198.00€7-Epi-docetaxel
CAS:7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.Formula:C43H53NO14Purity:98%Color and Shape:SolidMolecular weight:807.88RA-PR058
RA-PR058 is an orally active Ramalin derivative capable of penetrating the blood-brain barrier, with multi-target regulatory functions. By reducing BACE1 expression, decreasing excessive tau protein phosphorylation, and mitigating anxiety-like behaviors, along with displaying favorable pharmacokinetic properties, RA-PR058 shows promise as a multi-target modulator for Alzheimer's disease.Formula:C11H15ClF3N3OColor and Shape:SolidMolecular weight:297.7Fibronectin CS1 Peptide
CAS:Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Formula:C38H64N8O15Purity:98%Color and Shape:SolidMolecular weight:872.96SQLE-IN-1
CAS:SQLE-IN-1 is a SQLE inhibitor with antitumor activity that inhibits the proliferation of Huh7 and the protein expression of PI3K and AKT.Formula:C24H21F2N5O2SPurity:99.89%Color and Shape:SolidMolecular weight:481.52Ref: TM-T83658
1mL*10mM (DMSO)44.00€1mg96.00€5mg205.00€10mg334.00€25mg655.00€50mg1,044.00€100mg1,558.00€Combretastatin A-1 phosphate tetrasodium
CAS:OXi-4503, a prodrug of Combretastatin A-1, disrupts tubulin, inhibits Wnt/β-catenin and AKT, and has anti-tumor/vascular effects.Formula:C18H18Na4O12P2Color and Shape:SolidMolecular weight:580.24Tubulin inhibitor 38
Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cellFormula:C17H13ClN6OSColor and Shape:SolidMolecular weight:384.84hCA/Wnt/β-catenin-IN-1
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8Color and Shape:Odour SolidTubulin polymerization-IN-78
Tubulin polymerization-IN-78 (compound 10a) is an inhibitor of tubulin polymerization, with an IC50 value of 2.69 μM. It exhibits antiproliferative activity.Color and Shape:Odour SolidJD-13
CAS:JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.Formula:C25H32N4O3Purity:99.32% - 99.69%Color and Shape:White SolidMolecular weight:436.56Modified MMAF
CAS:Modified MMAF, an ADC cytotoxin, aids in ADC synthesis for targeted cancer research.Formula:C45H73N7O8Color and Shape:SolidMolecular weight:840.1Chemerin-9 (149-157)
CAS:Chemerin-9, a nonapeptide C-terminal fragment of chemerin, retains full protein's activity as a ChemR23 agonist.Formula:C54H66N10O13Purity:98%Color and Shape:SolidMolecular weight:1063.16β-catenin-IN-7
β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, andFormula:C17H13BrN2O2SColor and Shape:SolidMolecular weight:389.27Abl Cytosolic Substrate
CAS:Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ).Formula:C64H101N15O16Purity:98%Color and Shape:SolidMolecular weight:1336.58SNIPER(ABL)-039
CAS:SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 ofFormula:C54H68ClN11O9S2Purity:98%Color and Shape:SolidMolecular weight:1114.77MS170
CAS:MS170, specific PROTAC AKT degrader, potent with DC 50 of 32 nM, binds AKT1/2/3 with Kd 1.3, 77, 6.5 nM respectively.Formula:C45H56ClN9O7Color and Shape:SolidMolecular weight:870.45Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Formula:C63H118N18O14SPurity:98%Color and Shape:SolidMolecular weight:1383.8Gamitrinib TPP hexafluorophosphate
CAS:Gamitrinib TPP hexafluorophosphate is a mitochondrial-targeted HSP90 inhibitor with anticancer activity that can be used to study cancer and viral infection.Formula:C52H65F6N3O8P2Purity:98.52% - 98.52%Color and Shape:SolidMolecular weight:1036.03ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Formula:C90H154N30O17Purity:98%Color and Shape:SolidMolecular weight:1928.4LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Formula:C32H43N11O15S2Color and Shape:SolidMolecular weight:885.88Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Color and Shape:SolidMolecular weight:730.34008Tubulin polymerization-IN-44
Tubulinpolymer-in-44 (compound 7w) effectively inhibits Tubulin with an IC50 value of 0.21 μM and induces apoptosis by arresting the G2/M phase, making itFormula:C19H15Cl2N3O3SColor and Shape:SolidMolecular weight:436.31ML-B01
ML-B01 is an orally active inhibitor targeting Akt and PKA, with IC50 values of 2 nM and 136 nM, respectively. It demonstrates good blood-brain barrier (BBB) permeability in mice.Formula:C24H31Cl2N5OColor and Shape:SolidMolecular weight:476.44Vinzolidine
CAS:Vinzolidine is a semi-synthetic vinca alkaloid. It exerts cytotoxic effects on tumor cells by inhibiting cell division through disruption of tubulin polymerization. Vinzolidine can be utilized in research to investigate synergy with other chemotherapy or biotherapy drugs, as well as cancer cell tolerance or resistance, and to explore strategies to overcome these challenges.Formula:C48H58ClN5O9Color and Shape:SolidMolecular weight:884.46Peptide5
CAS:Connexin43 peptide: lessens swelling, astrogliosis, inflammation, neuron death post-spinal injury; analgesic for neuropathic pain.Formula:C60H98N16O20SColor and Shape:SolidMolecular weight:1395.6Integrin Binding Peptide acetate
Integrin Binding Peptide acetate is a fibronectin-derived peptide that binds integrins, enabling PEG-hydrogel functionalization for cell adhesion.Formula:C42H63N15O16S·xC2H4O2Purity:95.03%Color and Shape:White SolidMolecular weight:1066.12 (free base)TAT-Gap19
CAS:Cx43 blocker, IC50 ~7μM; doesn't affect gap junctions/Panx1. TAT motif enhances effect; works in vivo, brain-penetrant.Formula:C119H212N46O26Purity:98%Color and Shape:SolidMolecular weight:2703.28AT-1002
CAS:AT-1002 is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.Formula:C32H53N9O7SPurity:98%Color and Shape:SolidMolecular weight:707.88INY-03-041 trihydrochloride
INY-03-041 trihydrochloride: potent, selective PROTAC AKT degrader; combines Ipatasertib and Lenalidomide; IC50s: AKT1 (2.0 nM), AKT2 (6.8 nM), AKT3 (3.5 nM).Formula:C44H59Cl4N7O5Color and Shape:SolidMolecular weight:907.8AS-605240 potassium
AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 µM and 0.550 µM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.Formula:C12H6KN3O2SColor and Shape:SolidMolecular weight:294.98178STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Purity:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.12 kDaDavunetide
CAS:Davunetide: neuroprotective 8-amino acid peptide, improves daily function in schizophrenia, boosts memory in mild cognitive impairment.Formula:C36H60N10O12Purity:98%Color and Shape:SolidMolecular weight:824.922-Methylthiophenothiazine
CAS:2-Methylthiophenothiazine, with CAS No. 7643-08-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Methylthiophenothiazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C13H11NS2Purity:99.89%Color and Shape:SolidMolecular weight:245.36NSC 357754 dihydrochloride
NSC 357754 dihydrochloride is an inhibitor of Claudin. It can enhance trans-epithelial electrical resistance and reduce the permeability of specific cations. This compound is useful for research into intestinal diseases mediated by Claudin-2 and/or Claudin-15.Color and Shape:Odour SolidTAT-Gap19 TFA
TAT-Gap19 TFA is a peptide that inhibits Cx43 hemichannels but not gap junctions and may reduce liver fibrosis.Formula:C121H213F3N46O28Color and Shape:SolidMolecular weight:2817.27β-catenin-IN-37
CAS:β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI.Formula:C13H9N9OColor and Shape:SolidMolecular weight:307.277SNIPER(ABL)-033
CAS:SNIPER(ABL)-033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL proteinFormula:C61H73F3N10O9S2Purity:98%Color and Shape:SolidMolecular weight:1211.42huATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Color and Shape:Odour LiquidDelcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Formula:C122H203N45O36S2Purity:98.92%Color and Shape:SolidMolecular weight:2940.33Ref: TM-T11740L
1mg166.00€2mg213.00€5mg313.00€10mg442.00€25mg642.00€50mg880.00€100mg1,179.00€200mg1,594.00€Gly-Arg-Gly-Asp-Ser
CAS:Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Formula:C17H30N8O9Purity:98%Color and Shape:SolidMolecular weight:490.47CYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Formula:C38H40F2N6O4Color and Shape:SolidMolecular weight:682.76FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Formula:C28H26Cl2N4O3Color and Shape:SolidMolecular weight:537.44LT25
CAS:LT25 (compound 17) acts as an agonist for the α5β1 integrin, exhibiting an EC50 value of 9.9 nM.Formula:C15H17N3O5Color and Shape:SolidMolecular weight:319.31
