Deuterated Compounds

Applications (±)-Prasugrel-d3 (acetate-d3) (CAS# 1127253-02-4) is a useful isotopically labeled research compound. This compound can be used for treating percutaneous coronary intervention.
References Czarnik, A., U.S. Pat. Appl. Publ., 9,(2009);

Applications Diethyl 3,7-Bis(formyloxy)-25-methyl-cholestane-26,27-dioic Acid Ester-d3 is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.
References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)

Applications Labelled Dibenz[a,h]acridine (D416900). A urinary metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. A heterocyclic aromatic compound with potent mutagenic and carcinogenic properties.One of the azaarenes found in grilled meat.
References Smith, C.J., et al.: Food Chem. Toxicol., 38, 637 (2000), Koehler, D.A., et al.:; J. Ind. Ecol., 9, 143 (2005), Arnot, J.A., et al.: Environ. Toxicol. Chem., 27, 341 (2008),

Applications 4-Chlorophenylamine-13C6 (cas# 89059-39-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-Bromoheptane-7,7,7-d3 (CAS# 344253-18-5) is a useful isotopically labeled research compound.

Applications Product formed by Cyclohexan-1,3-dione Hydrolase enzyme
References Torisu, K., et al.: Eur. J. Med. Chem., 40, 505 (2005), Rosenbaum, C., et al.: J. Med. Chem., 48, 1179 (2005), Huang, C., et al.: Bioorg. Med. Chem. Lett., 16, 507 (2006),

Applications Labelled Malic Acid. The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.
References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),

Applications 2-Acetyl-3,4,5,6-tetrahydropyridine-d4 Hydrochloride, is the labeled analogue of 2-Acetyl-3,4,5,6-tetrahydropyridine Hydrochloride (A188500), the most important bread flavor component.
References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995),

Applications 1-Bromoeicosane-20,20,20-d3 (CAS# 202480-72-6) is a useful isotopically labeled research compound.

Applications (2-Bromoethyl-1,1,2,2-d4)-benzene is an intermediate used in the synthesis of Phenelzine-d4 Sulfate (P295902), which is a labeled hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidepressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.
References MacKenzie, E.M. et al.: Neurochem. Res., 33, 430 (2008);Chiche, F. et al.: Mol. Pharmacol., 75, 1052 (2009); McKenna, K.F, et al.: J. Neural Trans., 41, 115 (1994);

Applications p-Toluidine-d3 (methyl-d3) (CAS# 23346-25-0) is a useful isotopically labeled research compound.

Applications Methyl trans-Cinnamate-d7 (CAS# 2022152-96-9) is a useful isotopically labeled research compound.

Applications 4-(Oxiranylmethyl)morpholine-d5 Hydrochloride is an intermediate for the synthesis of 2-NP-AMOZ-d5 (N894952), which is a labelled derivatized of AMOZ (A634600), a metabolite of Nitrofuran.
References Vroomen, L., et al.: Toxicol. Appl. Pharmacol., 95, 53 (1988), Delatour, T., et al.: J. Agric. Food Chem., 51, 6371 (2003), Stadler, R., et al.: Analyst, 129, 276 (2004),

Applications Decyltrimethylammonium-d9 Iodide is an intermediate used in the synthesis of n-Decyltrimethylammonium-d9 Chloride (D525512), which is an isotope labelled quaternary ammonium salt used to study ionic interactions of detergents with lipid membranes.
References Beck, A., et al.: J. Phy. Chem., 48, 15862 (2010);

Applications 1-Bromohexane-1,1-d2 (CAS# 78904-38-8) is a useful isotopically labeled research compound.

Applications 1-Bromononane-6,6,7,7-d4 (CAS# 1219805-44-3) is a useful isotopically labeled research compound.

Applications Testosterone Laurate-d23 is the isotopic analog of Testosterone Laurate. Testosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.
References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)

Applications Sodium Acetate-13C2,D3 (cas# 123333-80-2) is a compound useful in organic synthesis.

Applications 2-Ethyl-d5-naphthalene (CAS# 1219805-14-7) is a useful isotopically labeled research compound.

Applications Fluorene-13C6 is a labelled polycyclic aromatic hydrocarbon.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Di Toro, D., et al.: Environ. Toxicol. Chem., 19, 1971 (2000), Vines, C., et al.: Aquat. Toxicol., 51, 225 (2000), Incardona, J., et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004), Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006),

Applications Bis(6-methylheptyl) Phthalate-3,4,5,6-d4 (CAS# 2209087-06-7) is a useful isotopically labeled research compound.

Applications 4-Chlorohippuric Acid-d4 is the isotope labelled analog of 4-Chlorohippuric Acid (C367420); a derivative of Hippuric Acid (H356700) and the major metabolite in human urine.
References Köppel, C., et al.: Arzneimittel-Forsch., 36, 1116 (1986); Oelschläger, H., et al.: Die Pharmazie, 53, 620 (1998)

Applications n-Propyl-1,1-d2 Alcohol (CAS# 40422-04-6) is a useful isotopically labeled research compound.

Applications Pramaxo impurity C-D6 labelled. (6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine-D6 can be byproduct of process for the preparation of pramipexole and salts thereof by reductive amination of (diamino)tetrahydrobenzothiazole with propanal.
References Deo, K., et al.: Indian Pat. Appl., IN 2013MU02843 A 20150703 (2015)

Applications Methyl Acetate-d3 (CAS# 21300-54-9) is a useful isotopically labeled research compound.

Applications 2-Phenyl-d5-ethyl Isothiocyanate (CAS# 912627-98-6) is a useful isotopically labeled research compound.

Applications Testosterone Hexanoate-d11 is the isotopic analog of Testosterone Hexanoate. Testosterone Hexanoate is a metabolite of testosterone(T155000), which is used in analytical studies to determine the use of anabolic steroid esters and related compounds in equine hair sample though ultra high performance liquid chromatography-tandem mass spectrometry.
References Gray, B.P., et al.: Analtica Chemica Acta, 787, 163 (2013); McKinney, A., et al.: Bioanalysis 1, 785 (2009)

Applications 2,4,6-Trimethylbenzeneamine-d11 (cas# 1126138-13-3) is a compound useful in organic synthesis.

Applications 4-Fluorobenzyl-d6 Alcohol (CAS# 1071809-48-7) is a useful isotopically labeled research compound.

Applications 5-Bromo-2,4-pyrimidinedione-13C,15N2 is the isotope labelled analogue of Bromouracil, a halogenated nitrogenous base on RNA nucleosides.
References Morinaga, H., et al.: Bioorg. Med. Chem., 21, 466 (2013);

Applications Labelled Farnesyl Pyrophosphate. Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.
References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),

Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);

Applications Undecanoic-11,11,11-d3 Acid (CAS# 1219802-11-5) is a useful isotopically labeled research compound.

Applications 1-Iodopropane-1,1-d2 (CAS# 25493-14-5) is a useful isotopically labeled research compound.

Applications 2-Iodopropane-2-d1 (CAS# 95927-03-0) is a useful isotopically labeled research compound.

Applications D-​Valine-​2,​3,​4,​4,​4,​4',​4',​4'-​d8 is one of the analytes used to validate high resolution mass spectrometry-based approach for metabolomic fingerprinting of human gut phenotype.
References Vanden Bussche, J., et al.: Anal. Chem., 87, 10927 (2015);

Applications Benzyl-2,3,4,5,6-d5 Acetate (CAS# 1398065-57-0) is a useful isotopically labeled research compound.

Applications 2,3-Dihydro-2-[3-(2-phenoxyethoxy)phenyl]-4(1H)-quinazolinone-D5is the isotopic labelled analog of 2,3-Dihydro-2-[3-(2-phenoxyethoxy)phenyl]-4(1H)-quinazolinone.

Applications Isotope labelled Trimethylsilyl Cyanide (T796750) is used as a reagent in the synthesis of optically active cyanohydrins. Used in the preparation of Reissert compounds, which represent reactive polyamides. Toxic to humans.
References Roberge, C. et al.: Tetrahedron Asymm., 18, 208 (2007); Jois, Y. et al.: Macromol., 26, 6151 (1993); Lumor, S. et al.: J. Food. Sci., 76, T16 (2011);

Applications 1-Bromooctane-3,3,4,4-d4 (CAS# 1219803-37-8) is a useful isotopically labeled research compound.

Applications 1-[5-Chloro-2-(2,4-dichlorophenoxy)phenylethanone]-d2 Major (cas# 1189477-14-2) is a compound useful in organic synthesis.

Applications 4-Chlorobenzyl-2,3,5,6-d4 Cyanide (CAS# 1219804-00-8) is a useful isotopically labeled research compound.

Applications Pentachlorothioanisole-13C6, is the labeled analogue of Pentachlorothioanisole (P238170), which can be used in the preparation of arenethiols and arenethiolates as seen in agrochemicals or fungicides.
References Dulik, D. et al.: Xenobiotica, 22, 325 (1992); Rakitin, O. et al.: Sci. Synth., 31a, 949 (2007);

Applications Lombazole-d9 is deuterium labelled form of Lombazole (L470205), which is imidazole based antimicrobial agent with some antifungal activity.
References Barug, D., De Groot, K.: Antimicrob. Agents Chemother., 28, 643 (1985); Barug, D., et al.: Antimicrob. Agents Chemother., 30, 238 (1986);

Applications 2-Ethyl 13C6-toluene is a labelled aromatic standard.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications cis-8,11,14-Eicosatrienoic Acid Ethyl Ester-d5 is the isotope labelled analog of cis-8,11,14-Eicosatrienoic Acid Ethyl Ester (E477920); the ethyl ester derivative of cis-8,11,14-Eicosatrienoic Acid (E477930) which is a fatty acid with selective tumoricidal activity.
References Das, U., et al.: Cancer Lett., 56, 235 (1991); Rudra, P., et al.: Anticancer Res., 21, 29 (2001); Menendez, J., et al.: Breast Cancer Res. Treat., 72, 203 (2002)

Applications (±)-2-Chloropropionyl-2,3,3,3-d4 Chloride (CAS# 1219794-98-5) is a useful isotopically labeled research compound.

Applications Sodium n-hexadecyl-d33 sulfate is labelled Sodium n-hexadecyl sulfate.It is an anionic surfactant.
References Nikas, Y., et al.: Langmuir, 10, 3512 (1994); Moradi, M., et al.: Talanta, 82, 1864 (2010)

Applications Methylcyclopentane-d12 (CAS# 144120-51-4) is a useful isotopically labeled research compound.

Applications 1-Heptyne-6,6,7,7,7-d5 (CAS# 83418-35-3) is a useful isotopically labeled research compound.

Applications Labelled Isopentenyl Pyrophosphate. Used for the preparation of antitumor agents phosphohalohydrins.
References Dhe-Paganon, S., et al.: Biochem., 33, 13355 (1994), Tanaka, Y., et al.: Nature, 375 155 (1995), Wesch, D., et al.: Eur. J. Immunol., 27, 952 (1997),

Applications (3,4,5-Trimethoxyphenyl)acetic-alpha,alpha-d2 Acid (CAS# 344299-45-2) is a useful isotopically labeled research compound.

Applications rac Isopropyl (±)-10-camphorsulfate-d7 is the isotope analog of rac Isopropyl (±)-10-camphorsulfate. rac Isopropyl (±)-10-camphorsulfate is an Impurity from the synthesis of Frovatriptan Succinate (F768500) and a chiral derivative of Camphor.
References Parsons, A.A., et al.: J. Cardiovasc. Pharmacol., 30, 136 (1997); Siow, C.H., et al.: Cephalalgia, 24, 1045 (2004); Poolsup, N., et al.: J. Clin. Pharm. Ther., 30, 521 (2005); Peng, R., et al.: Biochem. Pharmacol., 35, 1391 (1986), Tanaka, E., et al.: Biochem. Pharmacol., 41, 472 (1991),

Applications 4,4'-Dihydroxybiphenyl-d8 (rings-d8) (CAS# 612480-60-1) is a useful isotopically labeled research compound.

Applications Bromocyclopropane-d5 is labelled bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)

Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.

Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),

Applications 1,14-Tetradecanedioic-d24 Acid (CAS# 130348-88-8) is a useful isotopically labeled research compound.

Applications N,N-Diethylbenzamide-d5 is an intermediate in the synthesis of Benz[a]anthracene-7,12-dione-D4 (B197942), a polycyclic aromatic hydrocarbon that is present in the emission soot of biomass fuels combustion.

Applications n-Hexadecyl-2,2,16,16,16-d5 Alcohol (CAS# 1219799-18-4) is a useful isotopically labeled research compound.

Applications Dimethyl chlorothiophosphate-D6 is a labelled analog of Dimethyl chlorothiophosphate (D473292). Dimethyl chlorothiophosphate is an organophosphorus reagent that is used to synthesize phosphorus analogues of γ-aminobutyric acid, compounds that exhibit anticonvulsant properties. Dimethyl chlorothiophosphate is also used as a reagent to synthesize Parathion (P192220), a widely used pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cates, L., et al.: J. Med. Chem., 27, 654 (1984); DeBruin, K. & Boros, E.: J. Org. Chem., 55, 609 (1990); Hall, S.: J. Am. Chem. Soci., 72, 2768 (1950); Kotronarou, A. & Hoffmann, M.: Env. Sci. Tech., 26, 1460 (1992)

Applications Dexamethasone Hemisuccinate-d4 is the isotope labelled analog of Dexamethasone Hemisuccinate (D298855); a derivative of Dexamethasone (D298800) which is a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)

Applications 4-Chlorobiphenyl-2',3',4',5',6'-d5 (CAS# 51624-37-4) is a useful isotopically labeled research compound.

Applications 4-Aminobutyric-4,4-d2 Acid (CAS# 107022-06-0) is a useful isotopically labeled research compound.

Applications n-Pentyl 3-Methyl-2-pentyl Phthalate-d4, is the labeled form of n-Pentyl 3-Methyl-2-pentyl Phthalate (P283625), a phthalate ester, which are ubiquitous environmental contaminants that interact with peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors. It is used as a plasticizer to impart softness and flexibility to PVC products.
References Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);

Applications Hexachloroethane-13C1 (CAS# 93952-15-9) is a useful isotopically labeled research compound.

Applications 1-Bromododecane-12,12,12-d3 (CAS# 204259-68-7) is a useful isotopically labeled research compound.

Applications 2-Hydroxy-2-phenyl-d5-1H-indene-1,3(2H)-dione is the labeled analogue of 2-Hydroxy-2-phenyl-1H-indene-1,3(2H)-dione (H949575), an impurity of phenindione (P297250), a proton pump inhibitor and traditional nonsteroidal anti-inflammatory drug used for acute interstitial nephritis and acute kidney injury.
References Haywood, P.A., et. al.: P. Anal. Div. Chem. Soc., 15, 332 (1978); Leonard, C.E., et al.: Pharmacoepidemiol. Drug. Safety., 21, 1155 (2012); Moda, T.L., et al.: Bioorg. Med. Chem. Lett., 22, 2889 (2012); Dhareshwar, S.S., et al.: J. Pharma. Sci., 99, 2711 (2010)

Applications Monobutyl sulfate-D9 is a labelled analogue of Monobutyl sulfate (M525130). Monobutyl sulfate is used as a wetting agent in the mercerization (a treatment that gives cotton its shiny appearance and also functions to increase its strength) of cotton. Monobutyl sulfate is also used in the polymerization of tetrahydrofuran.
References Pruckmayr, G. & Wu, T.: Macromolecules, 11, 662 (1978); Shenai, V., Int. Dyer Text. Print. Bleach. Finish., 158, 246 (1977)

Applications N-(4-Aminobenzoyl-d4)-β-alanine is the labeled analogue of N-(4-Aminobenzoyl)-β-alanine (A593795), a metabolite of BX661A, a therapeutic agent used in the treatment of ulcerative colitis, chemotaxis and reactive oxygen species production in polymorphonuclear leukocyctes. Inhibits lipid peroxidation in large intestinal mucosa after mesenteric ischemia/reperfusion.
References Kimura, I. et al.: Arzneimittelforschung., 48, 1007 (1998); Kumamoto, T. et al.: Jpn. J. Pharmacol., 75, 187 (1997);

Applications Heptanoic-7,7,7-d3 Acid (CAS# 156779-04-3) is a useful isotopically labeled research compound.

Applications Potassium Dodecanoate-2,2-d2 (CAS# 82867-25-2) is a useful isotopically labeled research compound.

Applications 1-Chloropropane-d7 (CAS# 761374-88-3) is a useful isotopically labeled research compound.

Applications Hexadecanoic-3,3-d2 Acid (CAS# 83293-32-7) is a useful isotopically labeled research compound.