Deuterated Compounds

<p>Applications o-Xylene-alpha,alpha,alpha,alpha',alpha',alpha'-d6 (CAS# 25319-54-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromo-2-(ethyl-d3)pyridine is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications Indole-2,4,5,6,7-d5-3-acetic-alpha,alpha-d2 Acid (CAS# 1173020-21-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone Hexanoate-d11 is the isotopic analog of Testosterone Hexanoate. Testosterone Hexanoate is a metabolite of testosterone(T155000), which is used in analytical studies to determine the use of anabolic steroid esters and related compounds in equine hair sample though ultra high performance liquid chromatography-tandem mass spectrometry.<br>References Gray, B.P., et al.: Analtica Chemica Acta, 787, 163 (2013); McKinney, A., et al.: Bioanalysis 1, 785 (2009)<br></p>

<p>Applications Ethyl-alpha,alpha-d2-benzene-d5 (CAS# 84272-90-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, the novel raw material for deodorants application and is widely used as a cosmetic emollient. 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol reliably inhibits the odor-causing bacteria, yeast and fungi on the skin.<br>References Nagao, S.: Frag. J., 34, 39 (2006); Lawan, K. et al.: J. Health Sci., 23, 1 (2009); Leschke, M.: SOFW J., 136, 10 (2010);<br></p>

<p>Applications 2,4,6-Trimethylbenzeneamine-d11 (cas# 1126138-13-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenelzine-d5 Sulfate (phenyl-d5) (CAS# 1219798-40-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methylcycloheptane-d3 is the isotope analog of Methylcycloheptane. It is synthesized form cycloheptanone (C989555), which is a common reagent used as the precursor for the synthesis of various pharmaceuticals including NF-κB-inducing kinase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, K., et al.: Bioorg. Med. Chem. Lett., 23, 1238 (2013); Hayden, M., et al.: Cell, 132, 344 (2008); Mackay, F., et al.: Annu. Rev. Immunol., 21, 231 (2003)<br></p>

<p>Applications Carcinogenic compound commonly found in hair dyes and henna ink, also a commonly used synthetic intermediate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mulyono; T., et al.: J. Biosci. Bioeng., 103, 147 (2007), Mosley-Foreman, C., et al.: Food Chem. Toxicol., 46, 3780 (2008), Patel, A.K., et al.: J. Agric. Food Chem., 56, 9236 (2008), Akyuz, M., et al.: J. Pharm. Biomed. Anal., 47, 68 (2008),<br></p>

<p>Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications n-Tetracontane-d82 (CAS# 1219802-99-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Undecanoic-11,11,11-d3 Acid (CAS# 1219802-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope Labelled D-Altrose (A575700) is the epimer of D-glucose at C3 and have recently been discovered to possess antioxidant properties by the suppression of reactive oxygen species production in mitochondria due to competition with D-glucose at the cellular level.<br>References Ishihara, Y., et al.: J. Biosci. Bioeng., 112, 638 (2011); Fukumoto, T., et al.: Planta., 234, 1083 (2011);<br></p>

<p>Applications 1-Iodopropane-1,1-d2 (CAS# 25493-14-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Dimethyl Phthalate (D477975). It is used as insect repellent.<br>References Iselin, B., et al.: Helv. Chim. Acta., 40, 373 (1957),<br></p>

<p>Applications D-​Valine-​2,​3,​4,​4,​4,​4',​4',​4'-​d8 is one of the analytes used to validate high resolution mass spectrometry-based approach for metabolomic fingerprinting of human gut phenotype.<br>References Vanden Bussche, J., et al.: Anal. Chem., 87, 10927 (2015);<br></p>

<p>Applications Benzyl-2,3,4,5,6-d5 Acetate (CAS# 1398065-57-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5alpha-Cholestane-3,3-d2 (CAS# 122241-86-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-4-Hydroxyphenyl-d4-alanine-2,3,3-d3 (CAS# 402835-78-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine-d2 ,13C1, is the labeled analogue of (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine (C365935), used for the synthesis of Efavirenz (E425000), which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications 1-Chlorohexane-d13 (CAS# 1219798-45-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetophenone-d3 is an isotopic analog of acetophenone (A164015), a reagent used in the production of fragrances and resin polymers. This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perez, D., et al.; Bioorg. Med. Chem., 17, 6914 (2009), Giet, J., et al.: J. Agric. Food Chem., 57, 6787 (2009), Dimoula, K., et al.: Biotechnol. J., 4, 712 (2009),<br></p>

<p>Applications Styrene-alpha,beta,beta-d3 (CAS# 3814-93-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labeled 1,4-cyclohexanedione with high isotopic purity.<br>References Stibbe, W.; et al.: J. Labelled Compounds Radiopharmaceuticals, 16, 567 (1979),<br></p>

<p>Applications cis-8,11,14-Eicosatrienoic Acid Ethyl Ester-d5 is the isotope labelled analog of cis-8,11,14-Eicosatrienoic Acid Ethyl Ester (E477920); the ethyl ester derivative of cis-8,11,14-Eicosatrienoic Acid (E477930) which is a fatty acid with selective tumoricidal activity.<br>References Das, U., et al.: Cancer Lett., 56, 235 (1991); Rudra, P., et al.: Anticancer Res., 21, 29 (2001); Menendez, J., et al.: Breast Cancer Res. Treat., 72, 203 (2002)<br></p>

<p>Applications 1-Propyl-d5-amine is labelled 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,2,4-Trimethyl 13C6-benzene is a labelled aromatic standard.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Bis(2-butoxyethyl) Phthalate-d4 is labelled Bis(2-butoxyethyl) Phthalate (B415115), a plasticizer.<br>References Song, J., et al.: Suliao Keji, 41, 80 (2013); Bloom, P., et al.: J. Chromat., 72, 35 (1972)<br></p>

<p>Stability Volatile<br>Applications rac 1,2-Diaminopropane-d3 is labelled rac 1,2-Diaminopropane which was used as model precursor in the electron induced deposition of amorphous carbon nitride films. It was also used to synthesize cage peroxide, 1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wnuk, J., et al.: J. Phys. Chem., 113, 12345 (2009); Edward, J., et al.: Can. J. Chem., 77, 1057 (1999)<br></p>

<p>Applications Ethyl 2-Hydroxybutyrate-d5 is labelled Ethyl 2-Hydroxybutyrate (E918860) which is used to prepare 1,5-diarylpyrazole derivatives with herbicidal activities. It is also used in the synthesis of antagonists benzofuranylpiperidines and benzothiophenylpiperidines.<br>References Kudo, N., et al.: Chem. Pharm. Bull., 47, 857 (1999); Watanabe, Y., et al.: J. Heterocyclic Chem., 30, 445 (1993)<br></p>

<p>Applications 3-Hydroxyphenylacetic Acid-d4 is the deuterated isotope of 3-Hydroxyphenylacetic Acid (H949070).<br></p>

<p>Applications An intermediate for the synthesis of Labelled Ketoprofen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Derewenda, Z., et al.: J. Mol. Biol., 227, 818 (1992), Grochulski, P., et al.: J. Biol. Chem., 268, 12843 (1993).<br></p>

<p>Applications N-(2-(1,3-Dioxoisoindolin-2-yl)ethoxy-d4)benzamide is an intermediate in the synthesis of Fluvoxamine-d4 Maleate (F603503), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.<br>References Claassen, V., et al.: Br. J. Pharmacol., 60, 505 (1977); Koran, L.M., et al.: J. Clin. Psychopharmacol., 16, 121 (1996); Ware, M.R., et al.: J. Clin. Psychiatry, 58, Suppl. 5, 15 (1997); Inazu, M., et al.: Neurochem. Int., 39, 39 (2001)<br></p>

<p>Applications Hexadecanoic-15,15,16,16,16-d5 Acid (CAS# 285979-77-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 2,4-Diaminobutyric Acid. 2,4-Diaminobutyric Acid is a pharmacological tool and potential chiral building block. 2,4-Diaminobutyric Acid is also used as an internal standard for amino acid analysis. 2,4-Diaminobutyric Acid is also found to inhibit GABA transaminase, thus producing an elevation of GABA level, and to have an antitumor activity in vitro and in vivo against mouse fibrosarcoma cells.<br>References Riordan, J.F. et al.: Methods Enzymol., 47, 31 (1977); Beart, P.M. et al.: Neurscience Lett., 5, 193 (1977); Ronquist, G. et al.: J. Cancer Res. Clin. Oncol., 96, 259 (1980); Solladie-Cavallo, A. et al.: Tetrahedron Lett., 30, 6011 (1989);<br></p>

<p>Applications Vinylene-D2 Carbonate is deuterium labelled analogue of Vinylene Carbonate (V375010), which is used as an additive for electrolyte solutions for Lithium-ion and Sodium-ion batteries.<br>References Aurbach, D., et al.: Electrochim. Acta, 47, 1423 (2002); Hu, Y., et al.: Angew. Chem. Int. Ed., 47, 1645 (2008); Komaba, S., et al.: Adv. Funct. Mater., 21, 3859 (2011);<br></p>

<p>Applications Potassium Octadecanoate-2,2-d2 (CAS# 352438-86-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled analog of N-Nitrosobis(2-hydroxypropyl)amine (N525225), a compound that exhibits carcinogenicity in duct cells.<br>References Chang, P., et al.: Environ. Mol. Mutagen, 41, 43 (2003), Prohaska, J., et al.: Exp. Biol. Med., 228, 959 (2003), Abe, K., et al.: Biomed. Res., 26, 187 (2005), Abe, M., et al.: J. Toxicol. Pathol., 19, 129 (2006),<br></p>

<p>Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.<br></p>

<p>Applications 4-n-Octyl-d17-anisole (CAS# 1219794-56-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phosphoric Acid-D4 Trifluoroboroane Deuterium Oxide is an intermediate in the synthesis of 3-Hydroxy Benzopyrene-d11 (H829402), which is a abelled metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer.<br>References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Toluic-2,3,5,6-d4 Acid (CAS# 1219798-71-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 1-Pentene, used in the synthesis of iminosugars such as d-xylitol and l-arabinitol. Also usd in the synthesis of hydrazones of substituted salicylaldehydes.<br> E3<br>References Biela, A. et al.: Tetrahedron, 69, 3348 (2013); Ding, S. et al.: J. Coord. Chem., 66, 2023 (2013);<br></p>

<p>Applications 4-Fluoro-1,3-dioxolan-2-one-d3 is the labeled version of 4-Fluoro-1,3-dioxolan-2-one (F591523)<br></p>

<p>Applications (2,4-Dichlorophenoxy-d3)acetic-d2 Acid (CAS# 352438-69-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Methylform-d1-amide (CAS# 26103-38-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetradecanoic-14,14,14-d3 Acid (CAS# 62217-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Methacrylate-d5 (CAS# 55935-46-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Fenthoxon (Dimethylphosphate-d6) is derived from Methyl Alcohol-d4 (M265107), which is the labeled analog of methyl alcohol, a common laboratory solvent used primarily in spectroscopic techniques (UV/VIS, NMR, IR). Also, it is a major metabolite of Fenthion (FEN). It is used as organophosphorus pesticides.<br>References Dawson, D.M. et al.: Phys. Chem. Chem. Phys., 15, 919 (2013); Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),<br></p>

<p>Applications Tetra-n-propyl-d28-ammonium Bromide (CAS# 284474-84-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications (S)-3-Aminopiperidin-2-one-D6 is a labelled analogue of (S)-3-Aminopiperidin-2-one (A627940). (S)-3-Aminopiperidin-2-one, is an building block , used in the synthesis of various pharmaceutical compounds. It is an intermediate in the synthesis of calpinactam derivatives, possessing antimycobacterial activity.<br>References Kenichiro, N., et al.: Bioorg. Med. Chem. Lett., 22, 7739 (2012);<br></p>

<p>Applications N-((7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide-13C2 is an intermediate in the synthesis of Midazolam-13C2 the labeled analogue of Midazolam (M343000), an anesthetic; anticonvulsant; sedative; hypnotic.<br>References Dundee, J. W., et al.: Drugs, 28, 519 (1984); Lahat, E., et al.: Br. Med. J., 321, 83 (2000)<br></p>

<p>Applications 1-Iodo-2,3-dimethoxybenzene-d6 is the isotope labelled analog of 1-Iodo-2,3-dimethoxybenzene. 1-Iodo-2,3-dimethoxybenzene is used in the preparation of fused heterocyclic amido compounds as a potential anti hepatitis C virus agents.<br>References Aoyama, H., et al.: Bioorg. Med. chem., 19, 2675 (2011);<br></p>

<p>Applications Cardiogenol C-d4, Hydrochloride is an isotope labelled analog of Cardiogenol C, Hydrochloride. Cardiogenol C, Hydrochloride is a potent, cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.<br>References Wu, X., et al.: J. Am. Chem. Soc., 126, 1590 (2004)<br></p>

<p>Applications DL-Lysine-4,4,5,5-d4 2HCl (CAS# 284664-88-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Chlorooctane-d17 (CAS# 1219803-93-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Intermediate in the production of labelled Dutasteride<br>References Wlassoff, W., et al.: J. Pharm. Pharmacol., 59, 1549 (2007), Kumar, N., et al.: Bioorg. Med. Chem., 17, 5388 (2009),<br></p>

<p>Applications N-Desmethyl Regorafenib-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (D293270); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Applications Thymine-alpha,alpha,alpha,6-d4 Glycol (mixture of diastereomers) (CAS# 132523-94-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide-D3 is the deuterated form of (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide (C363865), which is used in the synthesis of Vildagliptin (V305000), an oral anti-diabetic drug, and its impurities (H971380) (Impurity A).<br>References Kumar, N., et al.: J. Pharmaceut. Biomed.,119, 114 (2016); Deng, Y., et al.: Lett. Org. Chem., 11, 780 (2014);<br></p>

<p>Applications Flumazenil-D3 is an intermediate in the synthesis of Flumazenil Carboxylic Acid-D3 (F500457), which is an isotope labelled form of Flumazenil Carboxylic Acid (F500455); a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. &amp; Goa, K.: Drugs, 35, 448 (1988); Klotz, U. &amp; Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>

<p>Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Butyl-1,1,2,2-d4 Alcohol (CAS# 118104-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotop labelled Ethyl 3-Hydroxybutyrate is a useful synthetic intermediate. It is a reagent used to synthesize α-azido carboxylic acids. It is also used in Palladium mediated spiroketal synthesis.<br>References Evans, D., et al.: J. Am. Chem. Soc., 112, 4011 (1990); Conway, J., et al.: Tetrahedron, 61, 11910 (2005)<br></p>

<p>Applications Ethyl-1,1-d2-methylamine (CAS# 223459-63-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetylglycine N-Methylamide-d8 is an isotopic analog of N-Acetylglycine N-Methylamide (7606-79-3).<br></p>