Deuterated Compounds

<p>Applications p-Xylene-d4 (ring-d4) (CAS# 16034-43-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Di(methyl-d3)-naphthalene is the labeled analogue of 1,3-Dimethylnaphthalene (D476385), a polycyclic aromatic hydrocarbon (PAH) that has been shown to have cytochrome P 450 2A6 and 2A5 inhibitory activities.<br>References Wammer, K.H., Peters, C.A.: Environ. Sci. Technol., 39, 2571 (2005); Roy, K., Roy, P.P.: Eur. J. Med. Chem., 44, 1941 (2009)<br></p>

<p>Applications Benzo[b]thien-2-yl ketone-D10 is a labelled analogue of Benzo[b]thien-2-yl ketone (B207710). Benzo[b]thien-2-yl ketone is an impurity of Zileuton (Z420000), an inhibitor of 5-lipoxygenase that is used to treat patients with asthma. Benzo[b]thien-2-yl ketone is used as a reagent to synthesize Bis(1H-2-indolyl)methanone, compounds that inhibit the activity of growth factor receptor kinase. Benzo[b]thien-2-yl ketone is also used as a reagent to prepare annulated oligothiophenes, compounds that are used in organic light-emitting devides (OLEDs).<br>References Israel, E., et al.: JAMA, 275, 931 (1996); Mahboobi, S., et al.: J. Med. Chem., 45, 1002 (2002); Mitschke, U. &amp; Bäuerle, P.: J. Chem. Soc. Perk. Trans., 1, 740 (2001); Nenajdenko, V., et al.: Russ. Chem. Bull., 61, 1456 (2012)<br></p>

<p>Applications 3-Aminodihydro-​d2-2(3H)​-​thiophenone-​4,​5-​d2 is an intermediate in the synthesis of Erdosteine-d4 (E596052), which is the isotope labelled analog of Erdosteine (E596050); a mucolytic developed for the treatment of chronic obstructive bronchitis.<br>References Kuvandik, G., et al.: Toxicol. Pathol., 36, 714 (2008); Koyu, A., et al.: Mol. Cell. Biochem., 331, 43 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010)<br></p>

<p>Applications 2-Furamide-3,4,5-d3 (CAS# 1219799-31-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications Cholesterol-3-d1 (CAS# 51467-57-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Bromopropane-1,1,1,2-d4 (CAS# 1219799-22-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dibutyl Phenyl Phosphate-d5 is the deuterated form of Dibutyl Phenyl Phosphate (D429478), which is a phosphorus flame retardant additive.<br>References Sundkvist, A. M., et al.: Environ Monit Assess., 12, 943 (2010),<br></p>

<p>Applications 4-[(Tetrahydro-2H-pyran-2-yl)oxy]-2-butyn-1-ol-1,2,3,4-13C4 is an intermediate in the synthesis of N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 (A173713). N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine-13C4 is labelled N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (A173710), which is a metabolite of butadiene.<br>References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006); Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009)<br></p>

<p>Applications 1-Decane-d21-thiol (CAS# 239090-36-9) is a useful isotopically labeled research compound. This compound has been used in experiments to directly measure water permeation using neutron reflectometry.<br>References Fies, W., et.al., Langmuir, 35, 5647-5662,(2019);<br></p>

<p>Applications Isotope labelled 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Ranu, B. et al.: J. Org. Chem. 65, 6270 (2000); Lu, J. et al.: Tetrahedron Lett., 41, 9075 (2000); Lu, J. et al.: Synlett., 1, 63 (2000);<br></p>

<p>Applications n-Pentyl-5,5,5-d3 Alcohol (CAS# 64118-19-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Pyridylacetic-alpha,alpha-d2 Acid-OD DCl (CAS# 1219802-37-5) is a useful isotopically labeled research compound.<br>Chemical Name: 3-Pyridylacetic-alpha,alpha-d2 Acid-OD DCl (CAS# 1219802-37-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled N-Acetyl-4-aminobiphenyl (A168170). N-Acetyl-4-aminobiphenyl is a metabolite of 4-Aminobiphenyl, a procarcinogenic agent.<br>References Airoldi, L., et al.: Carcinogenesis, 23, 861 (2002), Fretland, A., et al.: Toxicol. Sci., 74, 253 (2003), Gonzalez, F., et al.: Drug Metab. Rev., 35, 319 (2003), Chen, T., et al.: Int. J. Cancer, 117, 182 (2005),<br></p>

<p>Applications 2,4,5-Triamino-6-hydroxypyrimidine-13C2 Sulfate Salt is an intermediate used in the preparation of labelled 2-Amino-6,8-dihydroxypurine Hydrochloride (A604920). A labelled substituted 5-aminopyrimidines with antioxidative activity.<br>References Prochazkova, E. et al.: Free Radical Res., 46, 61 (2011); Lin, S. et al.: J. Med. Chem., 22, 741 (1979)<br></p>

<p>Applications 8-Bromo-3,7-dihydro-3-methyl-7-(1-methylethyl)-1H-purine-2,6-dione-d7, is the labeled analogue of (B683490), which is a substituted derivative of Xanthine (X499950).<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>

<p>Applications 2-[(Tetrahydro-2H-pyran-2-yl)oxy]ethanol-d4 is an intermediate used in the synthesis of Roxithromycin-d7 (R700852), which is a semisynthetic labelled Erythromycin derivative. Antibacterial.<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Applications DL-Tryptophan-d8 (CAS# 1233395-85-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Naphthalene-2,3,4,5,6,7,8-d7 (CAS# 887-68-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Isopropyl-d7-piperazine (CAS# 2089679-76-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>

<p>Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.<br>References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)<br></p>

<p>Applications 4-Cyano-4'-n-pentyl-d11-biphenyl (CAS# 57078-20-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.<br>References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)<br></p>

<p>Applications 2-Bromoaniline-d4 is the labeled analogue of 2-Bromoaniline (B679950), a reagent used in the synthesis of substituted 2-carboxanilides as herbicides and antibacterials. Also used in the synthesis of benzisothiazol-3-one derivatives as caspase-3 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kos, J. et al.: Molecules, 18, 7977 (2013); Liu, D. et al.: Bioorg. Med. Chem., 21, 2960 (2013)<br></p>

<p>Applications 1-Bromopropane-1,1-d2 (CAS# 40422-05-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl-d9-phosphine is the labeled analogue of tert-Butylphosphine (B809330), a reactant in the synthesis of phosphine ligands in metal complexes.<br>References Wiedner, E.S., et. al.: Organometallics, 29, 5390 (2010)<br></p>

<p>Applications N-Ethylaniline-d5 is labelled N-Ethylaniline (E899362) which is a versatile organic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of benzenesulfonamides as inhibitors of microsomal prostaglandin E2 synthase 1 (mPGES-1) in mice and in humans as potential anti-inflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hanke, Th., et al.: Biorg. Med. Chem., 21 (24), 7874 (2013)<br></p>

<p>Applications Hexanedioyl-d8 Chloride (CAS# 284487-62-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(2-isopropylphenyl) Phenyl Phosphate-d5 is the deuterated form of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.<br>References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);<br></p>

<p>Applications Furfuryl-d5 Alcohol (CAS# 1398065-62-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Methylboronic Acid is an methylated derivative of boronic acid, an building block towards various intermediates in suzuki coupling.<br>References Baker, J. O., et al.: Biochem.. 22, 2098 (1983); Garner, C.W., et al.: J. Biol. Chem., 255, 5064 (1980);<br></p>

<p>Applications Pentanedioic-d6 Anhydride (CAS# 1219794-53-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.<br>References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);<br></p>

<p>Applications Ethyl-alpha,alpha-d2-benzene (CAS# 1861-01-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N,4-dimethyl-1-naphthalenemethanamine-d3 is an isotope labelled impurity of Terbinafine (T107500), an orally active, antimycotic allylamine and a specific inhibitor of squalene epoxidase.<br>References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999);<br></p>

<p>Applications Isotope Labelled Bitolterol is a is a β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD.<br>References Friedel, H., et al.: Drugs., 35, 22 (1988); Cronin, M.T.D., et al.: J. Chem. Info. Comp. Sci., 42, 869 (2002); Shargel, L., et al.: Drug. Meta. Disp., 4, 72 (1976);<br></p>

<p>Applications 4-Aminophenol-13C6 is carbon-13 labeled 4-Aminophenol (A618920), a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1). 4-Aminophenol is also used as a N-formylating agent for solvent-and catalyst-free N-formylations of amines at ambient condition (2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)<br></p>

<p>Applications N,N'-Dibenzylethylene-d4-diamine (CAS# 1219795-20-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Iodotoluene-d7 (CAS# 1039678-66-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Chlorobenzene-4-d1 (CAS# 13122-34-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Cyclohexanedione-1,2,3-13C3 (cas# 1184998-71-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dimethylphenol-13C4 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)<br></p>

<p>Applications Bis(2-Chloroethyl)Ether (D8, 98%) (cas# 93952-02-4) is a useful research chemical.<br></p>

<p>Applications Isotope labelled Diethyl Oxalate is used in the synthesis of novel indole β-diketo acid derivatives as HIV-1 integrase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sechi, M., et al.: J. Med. Chem., 47, 5298 (2004);<br></p>

<p>Applications 2-Chlorotoluene-d7 (CAS# 84344-05-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanolamine is used in the preparation of various pharmaceutical compounds and inhibitors. Substituted carboxamides are synthesized using Ethanolamine that show potent antitumor activity. Also used in the synthesis of aminoquinolones which display anti-plasmodial activity.<br>References Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000)<br></p>

<p>Applications 5-Bromo Pentane-1,1,1,2,2,3,3,4,4-d9 is a isotope labeled building block.<br></p>

<p>Stability Easily Oxidized<br>Applications 1-Bromo-4-nitrobenzene-d4 (cas# 350820-19-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,4-Dibromobenzene (D4, 98%) (cas# 4165-56-4) is a useful research chemical.<br></p>

<p>Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.<br>References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.<br></p>

<p>Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.<br>References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);<br></p>

<p>Applications Tryptamine-d5 is an isotope labelled form of Tryptamine (T894600). Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.<br>References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1 (2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)<br></p>

<p>Applications Isotope labelled analogue of a protected amino acid<br>References Villiers, B., et al.: ChemBioChem. 10, 671 (2009), Fransson, R., et al.: J. Med. Chem., 53, 2383 (2010), Watts, R., et al.: Biochem., 49, 2177 (2010),<br></p>

<p>Applications 4'-Chloroacetophenone-2',3',5',6'-d4 (CAS# 284474-50-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-4-Hydroxyphenyl-2,6-d2-alanine (CAS# 57746-15-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Cyclopropylmethyl Bromide is a reagent used in the synthesis of human dihydroorotate dehydrogensase inhibitors which are based on azole scaffolds. In addition it is used in the preparation of ([11C]CMDC) for PET imaging of mGlur2 which has been a proposed target in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainas, S. et al.: Eur. J. Med. Chem., 129, 287 (2017); Ma, Y. et al.: Bioorg. Med. Chem., 25, 1014 (2017);<br></p>

<p>Applications Ammonium hydrogen phosphate-15N is the labelled analogue of Ammonium hydrogen phosphate (CAS:7722-76-1), a reagent that is useful for organic synthesis.<br></p>

<p>Applications 2-Propane-d7-thiol (CAS# 1219803-56-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Butyl-4,4,4-d3-benzene (CAS# 109232-94-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled major adduct from alkylation of DNA by the genotoxic carcinogen, propylene oxide. Molecular dosimetry studies are used to find the amount present in tissues of F344 rats after inhalation exposure to propylene oxide<br>References Rios-Blanco, M.N. et al.: Carcinogen., 24, 1233 (2003); Segerback, D. et al.: Chem.-Biol. Inter., 115, 229 (1998);<br></p>

<p>Applications 4-n-Butyl-d9-aniline (CAS# 1219794-78-1) is a useful isotopically labeled research compound.<br></p>