Deuterated Compounds

<p>Applications D-Galacturonic Acid-13C6 is labelled D-Galacturonic Acid (G186500, Monohydrate) which is used in the synthesis of N-(D-galacturonoyl) amino acids and dipeptides.<br>References Klaus, U., et al.: Environ. Sci. Technol., 34, 3514 (2000),<br></p>

<p>Applications A labelled metabolite of Colchicine (C640000). Has shown anti-tumor activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martinez, M. et al.: J. Appl. Toxicol., 15, 49 (1995); De Vincenzo, R. et al.: Oncol. Res., 11, 145(1999); Das, D. et al.: Biochim. Biophys. Acta., 1502, 351 (2000); Wagner, B. et al.: J. Biol. Chem., 275, 22461(2000);<br></p>

<p>Applications Formamide-1-d1 (CAS# 35692-88-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Proline-2-d1 (CAS# 282729-06-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Butane-d8-diamine 2HCl (CAS# 284665-22-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl-1,1,1,3,3,3-d6 Alcohol (CAS# 53853-65-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Hydroxyethyl Nortadalafil-d4 is the isotope labelled analog of 2-Hydroxyethyl Nortadalafil (H942245); a derivative of Tadalafil (T004500) which is a compound used for the treatment of erectile dysfunction. Also a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003); Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005); Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>

<p>Applications 4,4-Bis(4-aminophenylsulfonyl)-azobenzene-d16 is the isotope labelled analog of 4,4-Bis(4-aminophenylsulfonyl)-azobenzene. 4,4-Bis(4-aminophenylsulfonyl)-azobenzene is synthesized from dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>

<p>Applications 4-(Phenyl-d5)-3-buten-2-one (cas# 56187-93-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N-tert-Boc-2-(4-formyl-2-methoxyphenoxy)ethylamine-d3 (cas# 1189481-50-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Bromopropane-1,1,3,3,3-d5 (CAS# 163400-20-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Potassium Dodecanoate-2,2-d2 (CAS# 82867-25-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Erythromycin Ethyl Succinate-13C,d3 is the deuterated form of Erythromycin Ethyl Succinate (E649985), which is a derivative of Erythromycin (E649950), an antibiotic.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979); Serisier, D. et al.: J. Am. Med. Assoc., 309, 1206 (2013);<br></p>

<p>Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Applications Monobutyl sulfate-D9 is a labelled analogue of Monobutyl sulfate (M525130). Monobutyl sulfate is used as a wetting agent in the mercerization (a treatment that gives cotton its shiny appearance and also functions to increase its strength) of cotton. Monobutyl sulfate is also used in the polymerization of tetrahydrofuran.<br>References Pruckmayr, G. &amp; Wu, T.: Macromolecules, 11, 662 (1978); Shenai, V., Int. Dyer Text. Print. Bleach. Finish., 158, 246 (1977)<br></p>

<p>Applications Tetrahydro-2-(2-methoxyethoxy)-2H-pyran-d7 is an intermediate used in the synthesis of Roxithromycin-d7 (R700852), which is a semisynthetic labeled Erythromycin derivative. Antibacterial.<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Applications 1,3-Dimethoxybenzene-d10 (CAS# 340257-57-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyryl-d7 Chloride is an isotope labelled compound of Butyryl Chloride (B810510). Butyryl Chloride is used in the synthesis of chromones which are involved in the relaxing of smooth muscle. Also used in the synthesis of antiproliferative agents based on anilines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rodriguez-Ramos, F. et al.: Bioorg. Chem., 50, 17 (2013); Cazares-Marinero, J. et al.: J. Org. Chem., 744, 92 (2013);<br></p>

<p>Applications Tuberculostearic Acid Ethyl-d5 Ester is labelled Tuberculostearic Acid Ethyl Ester (T897095), the ethyl ester of Tuberculostearic Acid (T897090) which is a saturated fatty acid produced by Actinomycetales bacteria.<br>References Frencha, G., et al.: The Lancet, 330, 117 (1987)<br></p>

<p>Applications Bis(6-methylheptyl) Phthalate-3,4,5,6-d4 (CAS# 2209087-06-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Ethyl-d5-naphthalene (CAS# 1219805-14-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Used in the preparation of cosmetic and pharamceutical products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Testosterone Laurate-d23 is the isotopic analog of Testosterone Laurate. Testosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.<br>References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)<br></p>

<p>Applications 2,6-Dimethyl-d6-nitrobenzene (CAS# 285138-83-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2S,2'S)-Ethambutol-d10 (1,1,1',1',2,2'-d6; ethylene-d4) (CAS# 1129526-24-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Decyltrimethylammonium-d9 Iodide is an intermediate used in the synthesis of n-Decyltrimethylammonium-d9 Chloride (D525512), which is an isotope labelled quaternary ammonium salt used to study ionic interactions of detergents with lipid membranes.<br>References Beck, A., et al.: J. Phy. Chem., 48, 15862 (2010);<br></p>

<p>Applications Benzene-1,2,4-d3 (CAS# 14941-53-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Homocystine-3,3,3’,3’,4,4,4’,4’-d8 is the labeled form of L-Homocysteine (H591360), an increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications (2-Bromoethyl-1,1,2,2-d4)-benzene is an intermediate used in the synthesis of Phenelzine-d4 Sulfate (P295902), which is a labeled hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidepressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.<br>References MacKenzie, E.M. et al.: Neurochem. Res., 33, 430 (2008);Chiche, F. et al.: Mol. Pharmacol., 75, 1052 (2009); McKenna, K.F, et al.: J. Neural Trans., 41, 115 (1994);<br></p>

<p>Applications Isotope labelled Indene is an organic building block that has been used in the synthesis of isatins as selective inhibitors of carboxylesterases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hyatt, J.L., et. al.: J. Med. Chem., 50, 1876 (2007)<br></p>

<p>Applications Labelled Malic Acid. The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.<br>References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),<br></p>

<p>Applications: An intermediate in the preparation of labelled thymidine derivatives<br>References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),<br></p>

<p>Applications Diphenyl Phthalate-3,4,5,6-d4 (CAS# 1398065-61-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chlorophenol is an intermediate used in the synthesis of Diclofenamide-13C6 (D436532), which is a labeled Diclofenamide, a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).<br>References Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);<br></p>

<p>Applications 1-Dodecan-d25-ol, is the labeleld isptope of Dodecanol, that can be used to make surfactants, lubricating oils,and pharmaceuticals, such as Brij L23-d25 (P688277).<br>References Richard Stephenson and James Stuart, "Mutual Binary Solubilities: Water-Alcohols and Water-Esters", J. Chem. Eng. Data, 1986, 31, 56-70<br></p>

<p>Applications Isotope labelled D-Fructose (F792500), a monosaccharide that naturally occurs in large number of fruits and plants.<br>References Shum, M., et al.: Am. J. Physiol., 304, 197 (2013); Zeng, S.S., et al.: J. Pharma. Biomed. Anal., 76, 87 (2013);<br></p>

<p>Applications Isotope labelled 1,3,5-Xylenol, is a versatile building block used in the synthesis of a more complex compounds. It is the precursor in the preparation of 3,5-Xylenol Phosphate (3:1) (X749550).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Makarenko, I. M., et al.: Deposited Doc.,7 (1975);<br></p>

<p>Applications N-Decane-d22 was useful for neutron imaging of liquid swelling and surface phenomena during methane absorption in ethanol and n-​decane under high pressure.<br>References Vopicka, O., et al.: PLoS One, 15, 0238470 (2020)<br></p>

<p>Applications Cyclopentanone-d8 (CAS# 4477-17-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Propineb-d3 is the labeled analog of Propineb (P771450), which is used as a fungicide.<br>References Sharma, I.M., et. al.: J. Mycology Plant Pathology, 44, 92 (2014); Gupta, R.C., et. al.: Pestology, 37, 43 (2013)<br></p>

<p>Applications n-Dodecyl-d25-amine (CAS# 1219802-72-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Acetate (2-13c, 99%) (cas# 13291-89-9) is a useful research chemical.<br></p>

<p>Applications N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide-d7 is deuterium labeled N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide (F489575).N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide is an impurity of Furanylfentanyl (F864085), which is an opiod analgesic agent and an analog of Fentanyl (F275000). In addition, N-(4-Fluorophenyl)-2-methyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide may be a useful compound for developing fentanyl-conjugated vaccines by utilizing a protein–drug conjugate that generates an in vivo immunoantagonist, which can minimize the concentration of a specific drug at the sites of action.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bremer, P. T., et al.: Angew. Chem. Int. Ed. 55, 3772 (2016); Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998)<br></p>

<p>Applications MCPA Ethyl Ester-D3 is the deuterated form of MCPA Ethyl Ester (M199705), which is a derivative of MCPA, an herbicide.<br>References Elliott, B., et al.: Mutagenesis, 20, 3 (2005), Pfleeger, T., et al.; Environmental Toxicology and Chemistry 30, 455 (2010)<br></p>

<p>Applications Tri-n-butyl-d27-amine (CAS# 1219805-78-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-​1-​Adamantyl-​d15-acetamide is an intermediate in the synthesis of 1-Adamantan-d15-amine (A575823), which is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian.<br>References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983)<br></p>

<p>Applications 1-Bromoheptane-1-d1 (CAS# 38007-40-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Nitrofluorobenzene-13C6 is an intermediate for the synthesis of Flufenacet-13C6 (F599422), labelled Flufenacet (F599420) which is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.<br>References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012)<br></p>

<p>Applications 1-Bromooctane-8,8,8-d3 (CAS# 69373-25-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled analog of a metabolite of Cetirizine and Hydroxyzine.<br></p>

<p>Applications Propargyl Alcohol-13C3 is labelled Propargyl Alcohol (P762550) which is used as a corrosion inhibitor, a metal complex solution, a solvent stabilizer and an electroplating brightener additive. It is also used as an intermediate in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, T., et al.: Res. Chem. Interm. (2013); Choudhary, Y., et al.: SPE Product. Operat., 28, 268 (2013); Hed, Y., et al.: J. Mater. Chem. Mater. Bio. Med., 1, 6015 (2013)<br></p>

<p>Applications Trandolaprilat-d3 Monohydrate, is the labeled analogue of Trandolaprilat Monohydrate (T713520), a metabolite of Trandolapril, an antihypertensive.<br>References Blankley, C.J., et al.: J. Med. Chem., 30, 992 (1987)<br></p>

<p>Applications α-Methylglyceric Acid-d4 is derived from Acetone-d6 (A163802), which is an isotope labeled Acetone, a common organic building block in organic chemistry. Also, it is the deuterated form of α-Methylglyceric Acid (M311505), which is a biogenic secondary organic aerosol used in air quality diagnosis.<br>References Neubert, L., et al.: J. Am. Chem. Soc., 134, 12239 (2012); Zhai, J.J., et al.: J. Am. Soc. Mass. Spec., 20, 1366 (2009); Ru, P., et. al.: Environ. Sci. Technol., 48, 8491 (2014); Napelenok, S.L., et. al.: Environ. Sci. Technol., 48, 464 (2014); Stone, E.A., et. al.: Environ. Chem., 9, 263 (2012)<br></p>

<p>Applications Heptanoic-2,2,3,3-d4 Acid (CAS# 1219803-28-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Reagent used in the addition of labelled cyclopropane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006),<br></p>

<p>Applications Diethyl L-(+)-Tartrate-13C4 is the isotope labelled analog of Diethyl L-(+)-Tartrate. Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.<br>References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);<br></p>

<p>Applications 4-Chlorotoluene-2,3,5,6-d4 (CAS# 85577-24-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Anthraquinonesulfonic Acid Sodium Salt-d7, is the labeled analogue of Anthraquinone-2-sulfonic Acid Sodium Salt (A679280), which is used as a dopant to enhance membrane integration with electrocatalysis.<br>References Zhao,F., Liu, L., Yang, F., Ren, N.: Chem. Eng. J., 230, 491 (2013);<br></p>

<p>Applications Used in the preparation of antiviral agents.<br></p>

<p>Applications Tetramethyl-d12-urea (CAS# 51219-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>

<p>Applications 3-Bromotoluene-2,4,6-d3 (CAS# 1219805-60-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethylamine-d11 (CAS# 1173019-51-6) is a useful isotopically labeled research compound.<br></p>