Deuterated Compounds

<p>Applications Benzoic Acid-d5 is a compound useful in organic synthesis. A pentadeuterated form of benzoic acid for proteomics research.<br>References Kurogochi, M., et al.: Molecules, 19, 9944 (2014); Liang, X., et al.: Asian J. Org. Chem., 6, 1063 (2017)<br></p>

<p>Applications Labelled Formic Acid is used to improve NMR profiling of amino metabolites in biofluids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ye, T. et al.: Anal. Chem., 82, 2303 (2010); Gowda, G.A., Anal. Chem., 82, 8983 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications (±)-Albuterol-d3 (3-hydroxymethyl-d2; alpha-d1) (CAS# 1219798-60-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Chrysene (C428000). Chrysene occurs in coal tar. Is formed during distillation of coal, in very small amount during distillation or pyrolysis of many fats and oils. Chrysene is one of the basic polycyclic aromatic hydrocarbon (PAH) which is toxic environmental pollutant and consistently exposed to sunlight. However, little information is available on its photogenotoxicity.  The objective of the present study was to analyze the effects of Chrysene, under environmental intensity of UVB (0.6 mW/cm2) in human skin epidermal cell line (HaCaT).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anderson, D., et al.: Mutat. Res., 307, 261 (1994), Diamond, S., et al.: Environ. Toxicol. Chem., 25, 3015 (2006), Fotakis, G., et al.: Toxicol. Lett., 160, 171 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.<br>References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Lauroyl-L-carnitine-d3 Hydrochloride is labelled Lauroyl-L-carnitine (L178680) which is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analog of aminomethanephosphonic acid (A617340), a degradation product of glyphosate (G765000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goupe, R.H., et al.: Pest. Manag. Sci., 68, 16 (2012); Saxton, M.A., et al.: J. Great. Lakes. Res., 37, 683 (2011);<br></p>

<p>Applications Labelled Physcion. A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.<br>References Thiericke, R., et al.: Nat. Prod. Rep.,10, 265 (1993), Lin, C., et al.: J. Nat. Prod., 58, 1934 (1995), Julia, S., et al.: J. Biotechnol., 124, 690 (2006), Wang, W., et al.: J. Antibiot., 60, 603 (2007),<br></p>

<p>Applications n-Nonane-d20 (CAS# 121578-11-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 17beta-Estradiol-2,4-d2 (CAS# 53866-33-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methacrylic Acid-d6 (CAS# 92140-95-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Methylnaphthalene-D10 is a labelled analogue of 2-Methylnaphthalene (M323130). 2-​Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been used as an indicator of smoke exposure in food and packaging materials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Johnston, J.J., et. al.: J. Agr. Food Chem., 42, 1954 (1994)<br></p>

<p>Applications Indole-3-Acetic-d2 Acid (cas# 24420-86-8) is a useful research chemical.<br></p>

<p>Applications Labelled Dimethomorph (D460530). Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)<br></p>

<p>Applications Isotope labelled Triethyl Phosphate is a useful synthetic intermediate. It was used in the synthesis of mesoporous spheres of metal oxides and phosphates. It was also used to prepare α,β-unsatd. tricyclic enones via an intramolecular Horner-Wadsworth-Emmons cyclization. Phosphorus Flame Retardant.<br>References Dong, A., et al.: J. Am. Chem. Soc., 125, 4976 (2003); Pace, V., et al.: Tetrahedron Lett., 50, 3050 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications 3,4-Dihydroxybenzaldehyde-d3 is an intermediate in synthesizing DL-threo-Droxidopa-d3 (D689953). It is an isotope labelled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994),<br></p>

<p>Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211<br></p>

<p>Applications A labelled metabolite of Catecholamines.<br>References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)<br></p>

<p>Stability Light Sensitive<br>Applications Isotope labelled N-Nitrosodiethylamine (N525465) (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens (1) primarily inducing tumors of liver (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Farber, E. et al.: Cancer Res. 1984 Oct;44(10):4217-23.2. el-Demerdash, E. et al.: Anticancer Res. 2002 Mar-Apr;22(2A):977-84.3. Kweon, S. et al.: Life Sci. 2003 Sep 26;73(19):2515-26.<br></p>

<p>Applications Glyburide-d3 (methoxy-d3) (CAS# 1219803-02-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanolamine-13C2 is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);<br></p>

<p>Applications Spiroxamine-d4, is the labeled analogue of Spiroxamine (S683500), which is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: J. Agric. Food Chem., 53, 1857 (2005), Abrahim, A., et al.: J. Pharm. Biomed. Anal., 51, 131 (2010), Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010),<br></p>

<p>Applications Dibutyldiethyltin is an organotin compound that is an environmental pollutant that is present in sediment and sewage sludge.<br>References Mueller, M.D. et al.: Anal. Chem., 59, 617 (1987);<br></p>

<p>Applications The active labelled component of the antifertility agent nicarbazin, in chicken, duck, and goose plasma.<br>References Polin, D., et al.: Poultry Sci., 35, 1367 (1956), Primus, T.M., et al.: J. Agric. Food Chem., 49, 3589 (2001),<br></p>

<p>Applications Labelled Bromoacetic Acid. Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);<br></p>

<p>Applications Labelled Methylparaben (M325660). It is used as preservative in foods, beverages and cosmetics.<br>References Goodwin, M., et al.: Science, 203, 559 (1979),<br></p>

<p>Stability Volatile<br>Applications Isotope labelled Acetonitrile is used as a polar aprotic solvent in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, H.H., et al.: Phy. Chem. Phys., 15, 7666 (2013); Kim, J.Y., et al.: J. Mater. Chem. A., et al.: 1, 5982 (2013);<br></p>

<p>Applications Diphenyl Methyl Phosphate-d3 is the deuterated form of Diphenyl Methyl Phosphate (D492423), which is a phosphorus flame retardant additive.<br>References Stapleton, H. M., et al.: Environ. Sci. Technol., 46, 13432(2012)<br></p>

<p>Applications Isotope Labelled 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);<br></p>

<p>Applications (±)-1-Amino-2-propanol-1,1,2,3,3,3-d6 (CAS# 1219795-13-7) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications Labelled Styrene (S687790). Used in the manufacturing plastics; synthetic rubber; resins; insulator.<br>References Meyer. H.J., et al.: Arzneim.-Forsch., 19, 617 (1969), Pahwa, R., et al.: Vet. Hum. Toxicol., 35, 516 (1993),<br></p>

<p>Applications β-Cyclodextrin Deuterated is an isotope analog of β-Cyclodextrin (C987830), which is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation.<br>References Motoyama, A. et al.: J. Pharmac. Biomed. Anal., 28, 97 (2002); Nakamura, N. et al. Biotechnol. Bioeng., 19, 87 (1977); Riddle, L. A. et al.: J. Chrom. Sci., 45, 330 (2007);<br></p>

<p>Applications 4-Hydroxybenzophenone-d4 is an isotopic analog of 4-Hydroxybenzophenone (H829305), a metabolite of benzophenone (B204980).<br>References Stocklinski, A. et al. Life Sciences 26, 365(1980)<br></p>

<p>Applications Tetraphenylstannane-d20 is an isotope labelled organometallic compound and an intermediate in the synthesis of isotope labelled Chlorotriphenylstannane (C4222525), a compound used in the synthesis of nano particles that bears triamide ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Nitrobenzoic Acid-d4 is labelled 4-Nitrobenzoic Acid (N493550) which is used in the synthesis of anti-Trypanosoma cruzi agents in the treatment of chagas disease.<br>References Palace-Berl, F. et al.: Bioorg, Med. Chem. Lett., 21, 5395 (2013); Zhou, L. et al.: J. Med. Chem., 56, 796 (2013);<br></p>

<p>Applications A labelled form of Pirimicarb (P508768) which is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuchiyama, T.; et al.: Journal of Chromatography A, 1524, 233 (2017).<br></p>

<p>Applications 1-Butan-1,1-d2-ol is the deuterium labeled version of 1-Butanol (B690045). It can be used in the synthesis of more complex isotope labeled compounds.<br>References Sharma, Shikha, et al.: J. of Radioanaly. and Nuc. Chem., 302(1), 583-591 (2014);Hirsekorn, Kurt F., et al.: J. of the Ame. Chem. Soc., 127(13), 4809-4830 (2005)<br></p>

<p>Stability Volatile<br>Applications Isopropyl-d7-amine may act as a potential protease inhibitor but also takes part in numerous organic chemical reactions such as amide synthesis.<br> E0<br>References Dam, J.H. et al.: Chem. A. Eur. J., 16, 6820 (2010); Latli, B. et al.: J Labelled. Compd. Radiopharm., 48, 447 (2005);<br></p>

<p>Applications One of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). It has a role in transporting protein Bsu1, contributes to thiamine uptake; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.<br>References Williams, R., et al.: J. Biol. Chem., 87, 581 (1930), Rodionov, D., et al.: J. Biol. Chem., 277, 48949 (2002),Nosaka, K., et al.: Mol. Microbiol., 58, 467 (2005),<br></p>

<p>Applications 2-Butanol-d3 has been used to examine the loss of water form metastable 2-butanol/Mn+ cations using mass spectrometry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schroder, D., Schwarz, H.: Int. J. Mass Spec., 231, 139 (2004)<br></p>

<p>Applications Methyl 2-Hydroxybenzoate-3,4,5,6-d4 (CAS# 1219802-12-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetaminophen-13C2, 15N1 is doubly labeled Acetaminophen (A161220), an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).<br>References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)<br></p>

<p>Applications Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neuburger, M., et al.: Eur. J. Biochem., 267, 2882 (2000), Krijt, J., et al.: Clin. Chem., 47, 1821 (2001), Yen, T.-Y., et al.: J. Mass Spectrom., 37, 15 (2002),<br></p>

<p>Applications A bactericide detected in rivers and lakes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lindstrom, A., et al.: Environ. Sci. Technol., 36, 2322 (2002)<br></p>

<p>Applications Labelled analogue of Phosphorylethanolamine (P360900). Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Myller, A.T. et al.: Appl. Surf. Sci., 257, 1616 (2010);<br></p>

<p>Applications 1-Naphthoic Acid-d7 (cas# 634179-80-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Glycidol. Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981), Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984),<br></p>

<p>Applications N-Ethyl-2-hydroxysuccinimide-d5 is the isotope labelled analog of N-Ethyl-2-hydroxysuccinimide (E919180); a metabolite of N-ethyl-2-pyrollidone (NEP) which is a frequently used industrial solvent shown to be embryotoxic in animal experiments.<br>References Schindler, B.K., et al.: Anal. Chem., 84, 3787 (2012)<br></p>

<p>Applications Isotope labelled 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA. 5,6-Dihydrothymine is a radiolysis product of DNA.<br>References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);<br></p>