Deuterated Compounds

Applications Isotope labelled penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sharma, H., et al.: J. Mycol. Plant. Pathol., 42, 494 (2012); Sen, K., et al.: Food. Chem. Toxicol., 50, 3990 (2012); Pitt, W.M., et al.: Plant Disease., 96, 1303 (2012);

Applications 1,2,4-Trichlorobenzene-d3 (CAS# 2199-72-6) is a useful isotopically labeled research compound.

Applications Bromoacetic-2-13C Acid is the isotope labelled analog of Bromoacetic Acid (B679075); a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970)

Applications Labelled Methylparaben (M325660). It is used as preservative in foods, beverages and cosmetics.
References Goodwin, M., et al.: Science, 203, 559 (1979),

Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5

Applications 2-Naphthalenecarboxylic Acid-13C6 (cas# 1346602-42-3) is a compound useful in organic synthesis.

Applications tert-Butyl Methyl-d3 Ether (CAS# 29366-08-3) is a useful isotopically labeled research compound.

Applications T-705RTP-13C5 Sodium Salt is a labeled salt derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses.
References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010)

Stability Hygroscopic
Applications Clencyclohexerol-d10 is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.
References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);

Applications p-Benzoquinone-d4 is the labelled analogue of p-Benzoquinone (B206580) which is used as a catalyst in the preperation of allyl silyl ethers. p-Benzoquinone is a superoxide scavenger that has been used in the characterization of carnation-like SnS2 nanostructure photocatalysts for photodegredation. p-Benzoquinone is a toxic metabolite found in human blood.
References Kinoshita, H., et. al.: Org. Lett., 15, 5538 (2013); Liu, H., et. al.: J. Mol. Catal. A-Chem., 288, 19221 (2013); Du, H., et. al.: Environ Sci. Technol., 47, 2823 (2013)

Applications 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide-d3 is the isotope labelled analog of 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide (D453415); a compound that has been shown to be one of the potential novel biomarkers of peroxisome proliferation in the rat.
References Ringeissen, S., Biomarkers, 8, 240 (2003); Shibata, K., et al.: Biosci. Biotech. and Biochem., 77, 2105 (2013)

Applications Isotope labelled Triethyl Phosphate is a useful synthetic intermediate. It was used in the synthesis of mesoporous spheres of metal oxides and phosphates. It was also used to prepare α,β-unsatd. tricyclic enones via an intramolecular Horner-Wadsworth-Emmons cyclization. Phosphorus Flame Retardant.
References Dong, A., et al.: J. Am. Chem. Soc., 125, 4976 (2003); Pace, V., et al.: Tetrahedron Lett., 50, 3050 (2009)

Applications Oxalic Acid, Disodium Salt (1,2-13c2, 99%) (cas# 260429-91-2) is a useful research chemical.

Applications Labelled Dimethomorph (D460530). Agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),

Applications Acetophenone-13C6 is an intermediate in synthesizing Ibuprofen-13C6 (I140003), a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)

Applications Labelled Diflufenican (D445640). (Pre and post emergence foliar absorbed herbicide for winter weed control in cereal crops; carotenoid biosynthesis inhibitor.
References Conte, E., et al.: J. Agric. Food Chem., 46, 4766 (1998),

Applications N-Methyldiethanolamine-13C,d3 Hydrochloride is isotopically labelled salt form of N-Methyldiethanolamine (M301625), which is used as a reagent in the synthesis of broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. It is also used as a reagent in the synthesis of dihydroxy quaternary ammonium salts with long chain alkyl bromides that can exhibit antibacterial and antifungal activity.
References Pascual, A., et al.: Biomacromolecules, 16, 1169 (2015); Liu, W., et al.: Chem. Biol. Drug Des., 85, 91 (2015);

Applications 17beta-Estradiol-2,4-d2 (CAS# 53866-33-4) is a useful isotopically labeled research compound.

Applications Sodium Acetate-d3, is the labeled analogue of Sodium Acetate, the sodium salt of acetic acid, with a wide range of uses. Sodium Acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. Sodium Acetate may be added to foods as a seasoning.
References Clayden, j., et al.: Org. Chem., 1st ed. (2001);

Stability Hygroscopic
Applications N-Ethyl Benzamid-3-carboxylate-d5 is the isotope labelled analog of N-Ethyl Benzamid-3-carboxylate. N-Ethyl Benzamid-3-carboxylate is an impurity of Deet (D228500) which is an insect repellent.
References Gilbert, I.H., et al.: J. Econ. Entomol., 48, 741 (1955), Ambrose, A.M., et al.: Toxicol. Appl. Pharmacol., 1, 97 (1959), Blomquist, L., Acta Pharmacol. Toxicol., 41, 235 (1977), Yeung, J.M., et al.: Drug Metab. Dispos., 16, 600 (1988),

Applications Bis(2,3-dibromopropyl) Phosphate-d10 is the isotope labelled analog of Bis(2,3-dibromopropyl) Phosphate. Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles.
References Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);

Applications Labelled Iprodione. Fungicide.
References Lacroix, L., et al.: Phytiatr.-Phytopharm., 23, 165 (1974), Brenneman, T.B., et al.: Plant Dis., 71, 546 (1987),

Applications Labelled Morpholine. Morpholines compounds used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Salicylate as analgesic; antipyretic; anti-inflammatory.
E0
References Paladini, D., et al.: Biochem., 48, 5760 (2009), Bard, B., et al.: J. Med. Chem., 52, 3416 (2009),

Applications Isotope labelled herbicide
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),

Applications Labelled 1,2-Bis(2,4,6-tribromophenoxy)ethane (B585425). One of the major "novel" brominated flame retardants (NBFRs) from varous polymer materials. An environmental pollutant.
References Zhu, L., et al.: Environ. Sci. Technol., 40, 3711 (2006), Qui, X., et al.: Environ. Sci. Technol., 42, 31 (2008), Stone, R., et al.: Science, 325, 1055 (2009),

Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3 is labelled (R)-10-Monohydroxy-10,11-dihydro Carbamazepine which is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs.
References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),

Applications Azoniaspironortropanol-d8 Chloride is the labeled analogue of Azoniaspironortropanol Chloride (A965125), an intermediate used for the synthesis of Trospium Chloride (T892800), an Antispasmodic, used in treatment of urinary incontinence.
References Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966); Lux, G., et al.: Fortschr. Med., 96, 2113 (1978); Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995); Zinner, N.R., et al.: Expert Opin. Pharmacother., 6, 1409 (2005)

Applications A labelled metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);

Applications Benzoic Acid-d5 is a compound useful in organic synthesis. A pentadeuterated form of benzoic acid for proteomics research.
References Kurogochi, M., et al.: Molecules, 19, 9944 (2014); Liang, X., et al.: Asian J. Org. Chem., 6, 1063 (2017)

Applications Labelled Trimethylamine. Trimethylamine is a versatile building block used in the synthesis of various compounds ranging from cholines, plant growth regulators, strongly basic anion exchange resins, dye leveling agents as well as a number of basic dyes.
References Miroshnichenko, E.A. et al.: Zhur. Obshch. Khim., 63, 2375 (1993); Liu, X. et al.: Jiang. HUag., 33, 173 (2005); Xu, J. et al.: Color. Technol., 120, 316 (2004);

Applications Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.
References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)

Applications Simazine-d10 is the isotope labelled analog of Simazine (S465900); a selective pre-emergence herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bailey, G.W., et al.: Residue Rev., 10, 97 (1965); Chun, O., et al.: Food Chem. Toxicol., 41, 1063 (2003); Berrada, H., et al.: Food Control., 21, 36 (2010)

Applications Labelled Monobutyl Phosphate (M525050). Mono and dibasic phosphate esters are anionic surfactants which have the main feature of the stability in alkaline conditions over other surfactants. They have a wide range of properties including outstanding wetting, emulsification, lubrication, coupling activity and detergency.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ramirez, F., et al.: Tetrahedron, 35, 1581 (1979);

Applications Isotope labelled 2-Toluidine (T536205) is a carcinogenic and toxic aromatic amine and is a potential bladder cancer risk, surmised from urine assessment and analysis (1). It is contained in hair dye, henna and dyed hair samples (2,3). Possible mutagen (4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. El-Bayoumy, K. et al.: Cancer Res. 1986 Dec;46(12 Pt 1):6064-7.2. Turesky R. et al.: Chem. Res. Toxicol. 2003 Sep;16(9):1162-73.3. Andrew, A. et al.: Int. J. Cancer. 2004 Apr 20;109(4):581-6.4. Kirkland, D. et al.: Mutat. Res. 2005 Dec 30;588(2):88-105.

Applications Labelled N-Nitrosopiperidine (N545370). A carcinogenic nitrosocompound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bos, J., et al.: Cancer Res., 49, 4682 (1989), Wong, H., et al.: Carcinogenesis, 24, 291 (2003), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 601 (2005),

Applications A labelled metabolite of Malachite Green in seafood products. A labelled triphenylmethane dye with fungicidal and limited antiseptic activity. The term Malachine green applies to the oxalate as well as the chloride. Harmful if swallowed. Avoid release to the environment.
References Carter, S.G., et al.: J. Biochem. Biophys. Methods, 7, 7 (1982), Saikan, S., et al.: J. Chem. Phys., 79, 4154 (1983), Clemmensen, S., et al.: Arch. Toxicol., 56, 43 (1984),

Applications Benzoic Acid-13C6 (cas# 125945-98-4) is a compound useful in organic synthesis.

Applications Adipic Acid-13C6 is labelled Adipic Acid (A291590) which is primarily used in the synthesis of nylon. It has been used as a reagent in the solid-state polymerization of nylon analogs.
References Kim, Y. et al.: Ind. Eng. Chem. Res., 51, 15801 (2012)

Applications 4-Hydroxybenzhydrazide-d4 Major is labelled 4-Hydroxybenzhydrazide which works as an indicator in the determination of carbohydrates. Tissue (liver) bounded 4-Hydroxybenzhydrazide, the acid-hydrolyzable side chain of Nifuroxazide (N458500) can be used as a marker to monitor it’s use as an antibiotic in chicken.
References Lever, M., et al.: Anal. Biochem., 139, 205 (1984); Rocco, M., et al.: Anal. Biochem., 377, 251 (2008); Gao, F., et al.: J. Sci. Food Agr., 93, 2172 (2013)

Applications Sodium Formate (13c, 99%; D, 98%) (cas# 1215684-17-5) is a useful research chemical.

Applications Dimethyl phthalate-3,4,5,6-d4

Applications S-Methyl-d3-thioacetaminophen is deuterium labeled S-Methyl-3-thioacetaminophen (M330610), a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).
References (1) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)(2) Fairbrother, J.E., et al.: Anal. Profiles Drug Subs., 3, 1 (1974) (3) Hinson, J.A., et al.: Rev. Biochem. Toxicol., 2, 103 (1980)

Applications Labelled methomyl, a carbamate insecticide. Also used in Cannabis testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Armes, N., et al.: Bull. Entomol. Res., 86, 499 (1996); Shono, T., et al.: Pest. Biochem. Physiol., 75, 1 (2003)

Applications 1,4-Butane-1,1,2,2,3,3,4,4-d8-diamine (D416027) is a labelled isotope of 1,4-Diaminobutane (D416025). It is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);

Applications N-Hexadecanol (2,2,3,3...16,16,16-D31, 98%) (cas# 203633-15-2) is a useful research chemical.

Applications L-(+)-Lactic Acid-13C3 Sodium Salt is the isotope labelled analog of L-(+)-Lactic Acid Sodium Salt. Sodium Salt of Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.
References Borsook, et al.: J. Biol. Chem., 102, 449 (1933); Brin, M., et al.: Ann. N.Y. Acad. Sci., 119, 851 (1965);

Applications Ethane-d5-thiol (CAS# 61260-03-5) is a useful isotopically labeled research compound.

Applications Pinoxaden-d3 is a deuterized labeled form of Pinoxaden (P469505), which is derived from Diethylene Glycol Dimethanesulfonate (D444275), an intermediate in the production of alkylating agents.
References Wong, I., et al.: J. Med. Chem., 52, 5311 (2009); Muehlebach, M., et al.: Bioorg. Med. Chem., 17, 4241 (2009)