Deuterated Compounds

<p>Benzidine D8 is a benzidine compound that has been shown to be carcinogenic. It is used in the production of dyes and colorants, and it is found in wastewater from dyeing factories. Benzidine D8 has been detected in human urine, which may be due to occupational exposure. This chemical can also be found in the environment as a result of industrial discharge. The carcinogenicity of benzidine D8 is mediated by its ability to produce reactive metabolites that bind to DNA, forming adducts. These adducts inhibit DNA replication and transcription, leading to cell death through inhibition of protein synthesis. Benzidine D8 undergoes metabolism via oxidative reactions with amines or hydrolysis with hydrophilic compounds such as alcohols or phenols, which are present at high levels in the bladder tissue. The risk of bladder cancer increases when benzidine D8 binds to these amines or hydrophilic compounds, resulting in the formation of reactive metabolites that can bind to DNA</p>

<p>Please enquire for more information about Semicarbazide-13C,15N2 Hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4’-Hydroxy diclofenac-13C6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-MCPD-d5 is a deuterated fatty acid ester that is used to measure the level of 3-monochloropropane-1,2-diol (3-MCPD) in food products.</p>

<p>Progesterone-d9 is a compound that is used in the diagnosis of adrenocortical carcinoma. It can be extracted from the serum of patients with this cancer using an acetate extraction technique. Progesterone-d9 has been shown to be a useful biomarker for short-term exposure to water contaminated with nomegestrol acetate, and it has also been shown to be a useful tool for wastewater treatment. The use of Progesterone-d9 as a biomarker is limited by its instability in human serum and its susceptibility to matrix effects. This compound can be analyzed by liquid chromatography mass spectrometry (LC-MS/MS) methods, which are sensitive and specific. A drawback of this analytical method is that it requires extensive sample preparation.<br>The LC-MS/MS method can also be used to measure prosteroid levels, which have been found to correlate with levels of camp in humans.</p>

<p>Please enquire for more information about Chloroacetic Acid-13C2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Amino-2,4-imidazolidinedione-13C3 is an antibiotic that belongs to the group of nitrofurans. It is used for the treatment of infections caused by bacteria that are resistant to other antibiotics. The LC-MS/MS analysis showed that 1-aminohydantoin was formed as a degradation product of chloramphenicol and that this metabolite had been detected in urine samples from patients treated with chloramphenicol. Nitrofuran is also a possible degradation product. A reaction monitoring experiment using ionization monitoring and monitoring on the precursor ion at m/z 287 confirmed the presence of 1-aminohydantoin in a sample containing both chloramphenicol and nitrofuran. Quantification was performed using calibration curves obtained from pure standards.</p>

<p>Deoxycholic acid-D4 is a bile acid that is produced by the liver. It has been shown to be an indicator of insulin resistance in women with breast cancer. Deoxycholic acid-D4 has also been found to have significant interactions with other drugs, such as phenytoin, carbamazepine, and penicillin. The concentration of deoxycholic acid-D4 in the serum may be reduced by taking these drugs. This drug has a detection time of 3 hours and can be detected by liquid chromatography. Deoxycholic acid-D4 is metabolized through the human metabolism pathway, which includes dietary and logistic regression models.</p>

<p>Vitamin D2-D6 is a dietary supplement that comes in the form of an oil. It is an ionizable vitamin and is structurally similar to Vitamin D3. The most common form of this vitamin is cholecalciferol, which is found in fish oils and dairy products. Vitamin D2-D6 has been shown to be efficacious at increasing mineralization in skin cells, as well as preventing symptoms of rickets. This nutrient also assists with calcium metabolism and the absorption of dietary calcium. It can be taken by infants or adults who may have low levels of Vitamin D due to a lack of exposure to sunlight or ingestion of a poor diet.</p>

<p>Dimethyl sulfoxide-d6, commonly called deuterated DMSO or DMSO-d6, differs isotopically from dimethyl sulfoxide (DMSO), in that the hydrogen atoms have been substituted by deuterium isotopes (2D). Dimethylsulfoxide-d6 is extensively used as an NMR solvent, which shows a characteristic shift observed at 2.50 ppm in 1H-NMR.</p>

<p>4-Aminobiphenyl is a chemical compound that belongs to the group of aromatic amines. It is a human carcinogen and has been shown to cause cancer in animals. 4-Aminobiphenyl has been detected in the environment as an environmental pollutant and can be found in small quantities at low levels in food, air, and water. 4-Aminobiphenyl can be hydrolyzed by acid or alkaline hydrolysis to form its hydrolysate, which contains nitroarenes that are not present in the original compound. The DNA modification caused by 4-aminophenol may be due to its ability to modify DNA bases through reactive metabolites such as nitroarenes.</p>

<p>Allopurinol-d2 is an inhibitor of xanthine oxidase, which is an enzyme that catalyzes the conversion of hypoxanthine to xanthine and then to uric acid. Allopurinol-d2 is used for the treatment of gout and hyperuricemia. The compound was expressed in Escherichia coli and purified by electrospray ionization mass spectrometry. It has been shown to inhibit methyltransferase activity, thereby decreasing the production of urate. Allopurinol-d2 has also been shown to decrease disease activity in animal models of colitis and ulcerative colitis.</p>

<p>A labelled form of the oxalacetic acid (FO12113).</p>

<p>Please enquire for more information about Codeine-D3 solution including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-Hydroxy-4-cholesten-3-one-D7 (7OHCD7) is a metabolite of the bile acid, cholic acid. It is generated by the action of cholesterol 7α hydroxylase on cholesterol in the liver. It is excreted in bile, which is then absorbed back into the body from the gut and used for energy metabolism. 7OHCD7 has been shown to be an inhibitor of histone deacetylases, which are enzymes that regulate gene transcription. This inhibition leads to increased transcriptional regulation and reduced inflammatory responses in bowel disease models. 7OHCD7 has also been shown to increase cholesterol levels and reduce inflammation in humans with metabolic syndrome.</p>

<p>Trideuteriomethylbenzene is a chemical compound that contains three deuterium atoms. It is a member of the class of compounds called alkyl-deuteriomethylbenzenes, which are used as proton donors in chemical reactions. It has been shown to be an effective supercritical solvent for the separation of long-chain alcohols from hydrocarbons. Trideuteriomethylbenzene may also be used as a photoelectron donor for the determination of time constants and depression constants by electron diffraction.</p>

<p>1a,25-Dihydroxy vitamin D2 is a compound that exhibits various characteristics and applications. It is known for its bioavailability and water-soluble properties, making it easily absorbed by the body. This compound has been extensively studied in the field of research chemicals. One of the notable features of 1a,25-Dihydroxy vitamin D2 is its potential therapeutic effects on ganglioside GM2-related disorders. It has been shown to interact with GM2 activator proteins and fatty acids, which are involved in the metabolism of GM2 gangliosides. This interaction may have implications for the treatment of certain neurological conditions. Additionally, 1a,25-Dihydroxy vitamin D2 has been investigated for its role in modulating immune responses and inflammatory processes. Studies have suggested that this compound can inhibit the production of pro-inflammatory substances like prostaglandins, offering potential anti-inflammatory benefits. Moreover, 1a,25-Dihydroxy vitamin D</p>

<p>24,25-Dihydroxy vitamin D2 is a form of vitamin D that has been shown to be effective in the treatment of biliary cirrhosis and neonatal cirrhosis. It is synthesized from 25-hydroxyvitamin D3 by the enzyme 24-hydroxylase. The assay sensitivity for this compound is 10 ng/mL. This form of vitamin D has been shown to have an effect on serum bilirubin levels in patients with biliary cirrhosis. 24,25-Dihydroxy vitamin D2 can also be used to treat patients with chronic renal failure who are deficient in vitamin D3. The plasma concentration of 24,25-dihydroxyvitamin D2 is lower than that of 25-hydroxyvitamin D2 and 1,25-dihydroxyvitamin D2 because it is more rapidly metabolized by the liver.</p>

<p>Vitamin D3-d6 is a vitamin that has ionizable properties. It is available in the form of an oil and can be used as a dietary supplement for infants, as well as adults. Vitamin D3-d6 has been validated by various assays, including those based on chemical ionization, high-performance liquid chromatography, and gas chromatography. Sample preparation procedures include saponification and extraction with isooctane. The analytical method involves detection by UV light at 254 nm or fluorescence at 365 nm. The efficiency of this vitamin is low because it easily degrades when exposed to light or air.</p>

<p>2-MCPD-d5 is a deuterated fatty acid that can be used to calibrate gas chromatography for the determination of 2-MCPD in infant formula. The compound is processable and can be used as an internal standard. It has been validated by regression analysis and shown to have a good correlation with the sulfate solution method. 2-MCPD-d5 has been shown to produce reaction products that are similar to those produced by the methylation of 2-MCPD. This compound has also been shown to be useful as a model system for studying the formation of MCFA esters, including those containing sulfur, nitrogen, or oxygen.</p>