Organic Halides

<p>Applications 2-Bromo-1-bromomethyl-5-chlorobenzene (cas# 66192-24-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Chloroborane Methyl Sulfide Complex is a reagent in the synthesis of 3,4-Dimethyl-5-pentyl-2-furanundecanoic Acid (D477535); a furan fatty acid known to exhibit radical-scavenging ability and having anti-inflammatory properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Grahl, N., et al.: Marine. Biol., 157, 1567 (2010); Spiteller, G., et al.: Lipids., 40, 75 (2005); Wakimoto, T., et al.: PNSA., 108, 17533 (2011)<br></p>

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications Reagent used in the preparation of Levofloxacin.<br>References Sidique, S., et al.: Bioorg. Med. Chem. Lett., 19, 5773 (2009),<br></p>

<p>Applications 1-Bromo-4-nitrobenzene is part of a group of compounds that have the ability to stimulate the microbial degradation of polychlorinated biphenyls (PCBs), rendering them less harmful to the environment, animals and humans. 1-Bromo-4-nitrobenzene is also an electron-poor arene that has genotoxic effects on humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DeWeerd, K. &amp; Bedard, D.: Env. Sci. Tech., 33, 2057 (1999); Huang, Q., et al.: J. Env. Sci., 8, 103 (1995); Imperato. G., et al.: Adv. Synth. Cat. 348, 2243 (2006)<br></p>

<p>Applications 2,2-Difluoro-2-phenylacetic acid<br></p>

<p>Applications Methyl 8-Chloro-8-oxooctanoate is used as a reagent in the synthesis of β-cyclodextrin-6-deoxy-6-NHC(O)(CH2)6C(O)NHOH which is a β-cyclodextrin-capped histone deacetylase inhibitor that may have potential for use in treatment of cancers and inflammatory diseases. It is also used in one synthetic route for tubacin which is a known anticancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amin, J., et al.: Bioorg. Med. Chem. Lett., 23, 3346 (2013); Hong, J., et al.: Lett. Org. Chem., 7, 50 (2010);<br></p>

<p>Applications 3-Chlorobiphenyl is a polychlorinated biphenyl (PCB) congeners.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballschmiter, K., et al.: Fresenius J Anal Chem., 302, 20 (1980); Hawker, Darryl W., et al.: Environ Sci Technol., 22, 382 (1988)<br></p>

<p>Stability Light Sensitive<br>Applications (2E)-1,4-Dibromo-2-butene, is used as a reagent in the preparation of diaminoalkenes though copper-mediated diamination reaction.<br>References Martinez, C., et al.: Eur. J. Org Chem., 2014, 2017 (2014)<br></p>

<p>Applications (4-Fluorophenyl)methanesulfonyl chloride<br></p>

<p>Applications 2-Acetamido-4-(trifluoromethyl)phenylboronic acid, pinacol ester<br></p>

<p>Applications 2-Amino-4-trifluoromethoxyphenylboronic acid pinacol ester<br></p>

<p>Stability Very Very Moisture sensitive<br>Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);<br></p>

<p>Applications 4-Bromo-3-thiophenesulfonyl Chloride, Technical grade (cas# 111283-90-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications 1-Bromo-3,3-dimethyl-1-butene is used as a reagent in the preparation of bromo(dimethyl)butenes via elimination of dibromo(dimethyl)butane in the preparation of alkynes.<br>References Sydnes, L. K., et al.: Monatsh. Chem., 136, 1737 (2005)<br></p>

<p>Applications 5-Chloropent-1-yne is an intermediate in the synthesis of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications O-Cyclopropylmethyl-hydroxylamine, Hydrochloride (cas# 74124-04-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2,3-dichlorophenyl)ethanone (cas# 56041-57-7) is a useful research chemical.<br></p>

<p>Applications 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionyl chloride, rech grade<br></p>

<p>Applications 4-Cyano-3,5-difluorophenylboronic acid<br></p>

<p>Applications GAMMA-CHLOROCROTONIC ACID (cas# 26340-58-9) is a useful research chemical.<br></p>

<p>Applications pentan-2-amine hydrochloride (cas# 76716-21-7) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-3,4-dimethoxy-β-nitrostyrene is an intermediate in the synthesis of high affinity D1 dopamine receptor ligand.<br>References Tarantino, P. A., et al.: Toxicol. App. Pharmacol., 27, 507 (1974);<br></p>

<p>Applications N-(Trifluoroacetyl)hexanolamine (cas# 40248-34-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Chlorotriethylsilane is used in the preparation of potent silylating agent and lewis acid catalyst. Chlorotriethylsilane derivatived ethers have been shown to be more stable towards hydrolysis than are trimethyl ethers.<br> E0<br>References Alvisi, C. et al.: J. Org. Chem., 63, 1330 (1998): Higashiya, S. et al.: J. Org. Chem., 69, 6326 (2004); Hicks, J.D. et al.: Org. Lett., 9, 5621 (2007);<br></p>

<p>Applications Chlormefos<br></p>

<p>Applications 1-Iodo-4-nitrobenzene (cas# 636-98-6) is a useful research chemical.<br></p>

<p>Applications 2-Fluorobenzeneacetic Acid is used as a geothermal tracers to track fluid movements and chemical changes in reinjected brines.<br>References Adams, M.C., et. al.: T. Geotherm. Res. Council, 10, 415 (1986)<br></p>

<p>Applications 2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, R., et al.: Zhongguo Yiyao Gongye Zazhi, 46, 806 (2015); Zhang, X., et al.: Zhongguo Yaowu Huaxue Zazhi, 20, 25 (2010)<br></p>

<p>Applications 6-BROMOHEXANAL (cas# 57978-00-4) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-2-phenoxyethane (cas# 589-10-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 6-(4-chlorophenoxy)hexanoate is used as an intermediate in the preparation of (aryl)-N-(oxooxazolidinyl)-amides as potent quorum-sensing inhibitors of Pseudomonas aeruginosa.<br>References Jiang, K., et al.: Eur. J. Med. Chem., 194, 112252 (2020);<br></p>

<p>Applications 3-(Bromomethyl)benzonitrile is an intermediate used in the synthesis of 3-(bromomethyl)benzaldehyde. It also undergoes Suzuki cross-coupling reaction with bis(pinacolato)diboron.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilday, L., et al.: Dalton Transactions, 41, 7092 (2012); Giroux, A.: Tetrahedron Lett., 44, 233 (2003)<br></p>

<p>Applications 4-Benzyloxy-1-bromobenzene (cas# 6793-92-6 ) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromophenylethylamine is an intermediate used to prepare potent antagonists of antiapoptotic protein XIAP for treatment of cancer. It is also used in the synthesis of aryl aminosulfonamide derivatives as potent 5-HT6 receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oost, T., et al.: J. Med. Chem., 47, 4417 (2004); Nirogi, R., et al.: Bioorg. Med. Chem. Lett., 20, 4440 (2010)<br></p>

<p>Applications 4-Bromo-1-cyclopentene is an intermediate used in the synthesis of Cyclopentobarbital (C992020), which is a barbiturate derivative that has sedative and anticonvulsant properties, and was used primarily as an anaesthetic in veterinary medicine.<br>References Martin, J.R., et al.: Psychopharmacological Agents. Kirk-Othmer Encyclopedia of Chemical Technology (2000); Vander Brook, M.J., et al.: Journal of Pharmacology And Experimental Therapeutics, 80, 119-125 (1944);<br></p>

<p>Applications 2,6-Dibromo-4-chlorophenol<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,2,3,4-tetrachlorocyclopenta-1,3-diene (cas# 695-77-2) is a useful research chemical.<br></p>

<p>Applications TFAN reacts with reducing oligosaccharides in the presence of sodium cyanoborohydride to give aminoalditol derivatives, useful for linking to proteins or solid matrices. Treated this way, reducing oligosaccharides were easily separated by HPLC.<br>References Wong, H., et al.: J. Med. Chem., 17, 785 (1974), Kallin, E., et al.: Glycoconjugate Journal, 3, 311 (1986)<br></p>

<p>Applications 4-​Bromo-​3-​methyl-2-buten-1-ol is an intermediate in the synthesis of 2-[(4-Bromo-3-methyl-2-buten-1-yl)oxy]tetrahydro-2H-pyran (B681855), which is a tetrahydropyran protected intermediate used in the synthesis of L-Cysteine derivatives.<br></p>

<p>Applications 4-Bromo-3,6-dihydro-2H-pyran is a useful reagent for organic synthesis and other chemical processes.<br>References Xue, F., et al.: Heterocycles, 91, 1654 (2015); Baird, M. S., et al.: J. Chem. Soc. C. Org., 8, 1173 (1969)<br></p>

<p>Applications 3-[(Trifluoromethyl)thio]phenol is a reactant used in the preparation of 2-azolyl-4-phenoxypyrimidines as highly active herbicides that inhibit carotenoid biosynthesis.<br>References Selby, T.P., et. al.: ACS Symposium Series, 800, 74 (2002)<br></p>

<p>Applications Chlorocyclohexane, is a building block used in various chemical synthesis.<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);<br></p>

<p>Applications 5-Fluoronicotinamide<br></p>

<p>Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications 4-Fluoro-2-(trifluoromethl)benzonitrile is a reagent used in the synthesis of 5-substituted-1H-tetrazoles as antibacterials.<br>References Sivaguru, P. et al.: Tetrahedron Lett., 56, 2203 (2015); Shi, G et al.: Org. Lett., 17, 38 (2015);<br></p>

<p>Applications Methyl 3-(bromomethyl)cyclobutanecarboxylate (cas# 89892-95-5) is a useful research chemical.<br></p>

<p>Applications 2-Chloroethyl Formate is a chemical reagent used in the hydrolysis of esters.<br>References Stefanidis, D. et al.: J. Am. Chem. Soc., 115, 6045 (1993);<br></p>

<p>Applications A styrene derivative used in the preparation of bisphosphane ligand and phenanthroline-based functionalized macrocycles and catenanes.<br>References Goek, Y. et al.: Tetrahedron: Asymmetr., 21, 2768 (2010); Megiatto, J. &amp; Schuster, D.: New J. Chem., 34, 276 (2010); Megiatto, J. &amp; Schuster, D.: J. Am. Chem. Soc., 130, 12872 (2008)<br></p>

<p>Applications 1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Czopek, A., et al.: Bioorg. Med. Chem., 23, 3436 (2015)<br></p>

<p>Applications [1-(3-Fluorophenyl)-1-tosyl]methyl isocyanide (cas# 321345-36-2) is a useful research chemical.<br></p>

<p>Applications Nickel(II) Bromide, is used as a source of bromide ion. It is also an important raw material used in various chemical synthesis and also as a catalyst in cross-coupling reactions.<br>References Pramanik, M. et al.: RSC Adv. 2015, 5 (53), 42762-42767.<br></p>

<p>Applications Chlorpropham is particularly useful in agricultural settings. It is used in pesticide products for treatment of plants and soil.<br>References Wozniak, E., et al.: PCT Int. Appl. (2020), WO 2020118278 A1<br></p>

<p>Applications 4-Fluoro-2-iodobenzoic Acid is a reagent used in organic synthesis including amixile-based inhibitors of the pyruvate-ferredoxin oxidoreductases of anaerobic bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kennedy, A. et al.: Antimicrob. Agents. Chemother., 60, 3980 (2016);<br></p>

<p>Applications 3-Chlorobenzotrifluoride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (3-Fluorophenyl)methanesulfonyl chloride<br></p>

<p>Applications 2,4-Dichloro-6-nitroaniline<br></p>

<p>Applications 4-Chlorostyrene is a reagent primarily used in epoxidation reactions of olefins. Also used in the synthesis of 9-deazaxanthine derivatives as dual A2A antagonists/MAO-B inhibitors.<br>References Srinivasan, K. et al.: J. Am. Chem. Soc., 108, 2309 (1986); Samsel, E. et al.: J. Am. Chem. Soc., 107, 7606 (1985); Rivara, S. et al.: J. Med. Chem., 56, 1247 (2013);<br></p>

<p>Applications 2-Bromo-4-nitrotoluene<br></p>

<p>Applications 2,2,5,5-Tetramethylthiazolidine-4-carbonyl Chloride Hydrochloride is an intermediate in the synthesis of D,L-Penicillamine O-Lactose Adduct (P223020), which is an impurity of D-Penicillamine (P223000), a Penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010);<br></p>

<p>Applications 1,2-Diamino-4,5-dimethoxybenzene Hydrochloride is the salt form of 1,2-Diamino-4,5-dimethoxybenzene (D416425), which reacts with aldehydes to produce highly fluorescent benzimidazole derivatives. It can be used for the detection of aldehydes as well as DTAN.<br>References Iwata, T., et al.: Chem. Pharm. Bull., 33, 3499 (1985); Hara, S., et al.: J. Chromatography, 377, 111 (1986); Masui, H., et al: Inorg. Chem., 32, 258 (1993)<br></p>

<p>Applications 3,4,5-Tribromotoluene (cas# 73557-59-2) is a useful research chemical.<br></p>

<p>Applications (2-Bromoethyl)trimethylsilane has been used as a reactant in the synthesis of strychnine, norfluorocurarine, dehydrodesacetylretuline and valparicine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martin, D.B., et. al.: J. Org. Chem., 77, 17 (2012)<br></p>