Organic Halides

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications 5-Fluorobenzofuran-3-one<br></p>

<p>Applications 2,3,5-Trichloroaniline (cas# 18487-39-3) is a useful research chemical.<br></p>

<p>Applications (3E)-1,6-Dibromo-3-hexene (cas# 59533-63-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-AMINOETHANOL HYDROCHLORIDE (cas# 2002-24-6) is a useful research chemical.<br></p>

<p>Applications Trimethylsilylethynyl(phenyl)iodonium Tetrafluoroborate is used in synthesis of 1-Alkynyl(triphenyl)arsonium Tetrafluoroborates by onium transfer reaction of 1-Alkynyl(phenyl)iodonium Tetrafluoroborates with Triphenylarsine. Also, used in preparation of Furan- and Thiophene-substituted alkynes and alkynyl ketones by Copper Iodide-catalyzed coupling and carbonylation of Heterocyclic Boronic Acids with Alkynyliodonium salts.<br>References Nagaoka, T., et al.: Tetrah. Lett., 36, 261-4 (1995); Yu, Chan-Mo, et al.: Synlett, 2631-2634 (2005);<br></p>

<p>Stability Moisture Sensitive<br>Applications 3,3,3-Trifluoro-2-(trifluoromethyl)propionyl chloride (cas# 382-19-4) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-N-(3-chloropropyl)benzenesulfonamide<br></p>

<p>Applications Used for preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.<br>References Whitehead, C., et al.: J. Org. Chem., 27 (1962), Phillips, D., et al.: Bioorg. Med. Chem., 10 (2002),<br></p>

<p>Applications Hexachloroethane is a highly efficient chlorinating agent in the preparation of chlorosilanes from hydrosilanes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pongkittiphan, V., et al.: Tetrahedron Lett., 50, 5080 (2009)<br></p>

<p>Applications (2,3-Dichloro-4-oxyphenyl)-2-thienylmethanone (cas# 40180-03-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-Bromopropiophenone is an electron-deficient aryl bromide that has the ability to self-polymerize using binary palladium catalyst. 4'-Bromopropiophenone is also used as a reagent in the synthesis of substituted 2-aminothiazoles (e.g. 2-Aminobenzothiazole [A593500]), compounds that are inhibitors of neuronal degeneration in patients with Alzheimer’s disease.<br>References Bensaid, S., et al.: Tetrahedron Lett., 52, 1383 (2011); Lagoja, I., et al.: Eur. J. Pharm. Sci., 43, 386 (2011); Matsubara, K., et al.: J. Organom. Chem., 691, 3693 (2006)<br></p>

<p>Applications 2,3,5,6-Tetrachloro-p-xylene is a derivative of 2,3,5,6-Tetrachloro-4-methyl benzonitrile used as intermediates of pesticide with fluorine.<br>References Oliver, B.G., et al.: Environ. Sci. Technol., 19, 842 (1985), Boden, N., et al.: Tetrahedron Lett., 47, 8685 (1995),<br></p>

<p>Applications 6-Chloro-2,1,3-benzoselenadiazole (cas# 6343-86-8) is a compound useful in organic synthesis.<br></p>

<p>Applications p-Trifluoroacetyltoluene is used as a reagent in the synthesis of 5-methylene-2-(trifluoromethyl)morpholin-3-one derivatives which have fungicidal activity.<br>References Tian, L., et al.: RSC Adv., 5, 100418 (2015)<br></p>

<p>Applications Oxydiethylene Bis(chloroformate) is a useful research intermediate for organic synthesis.<br>References Qian, W., et al.: Zhejiang Yike Daxue Xuebao, 25, 252 (1996); Alekseev, N. N., et al.: Kinetika i Kataliz, 29, 471 (1988); Alekseev, N. N., et al.: Plast. Massy, 5, 52 (1984)<br></p>

<p>Applications A metabolite of halogenated aniline.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cnubben, N.H.P., et al.: Biochem. Pharmacol., 49, 1235 (1995),<br></p>

<p>Applications 2-[[[(9H-Fluoren-9-ylmethoxy)Carbonyl]Amino]Methoxy]-Acetic acid is a useful reagent in organic synthesis.<br></p>

<p>Applications 4-Chloro-2-fluorophenylacetic acid (cas# 194240-75-0) is a useful research chemical.<br></p>

<p>Applications 3,3,3-trifluoro-2-oxopropanoic acid (cas# 431-72-1) is a useful reagent in the biotransformation of pentafluoropropane in rat and humans.<br>References Bayer, T., et al.: Chem. Res. Toxicol., 15, 723 (2002)<br></p>

<p>Applications Bis(Dichloromethyl) Ether an important reagent used in chemical research.<br>References Hsu, F. L., et al.: ACS Med. Chem. Lett., 10, 761-766 (2019)<br></p>

<p>Applications 2-Chloro-1-(2-((3-chloropropyl)amino)-2-oxido-1,3,2-oxazaphosphinan-3-yl)ethanone is an intermediate used in the synthesis of Ifosfamide Impurity A (I265005), which is an impurity of Ifosfamide (I265000), a cytostatic agent related structurally to cyclophosphamide.<br>References Creaven, P. J., et al.: Cancer Treat. Rep., 60, 445(1976), Schoenike, S. E., Clin. Pharm., 9, 179(1990), Skinner, R., et al.: J. Clin. Oncol., 11, 173 (1993).<br></p>

<p>Applications A 3-aryl substituted Azetidine (A813000).<br></p>

<p>Stability Very unstable to water and protic solvents.<br>Applications N,N-Dimethylmethyleneiminium chloride (cas# 30354-18-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-[(5-Bromo-2-fluorophenyl)amino]propanamide (cas# 1218082-92-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications Ethyltriphenylphosphonium Bromide is used as a wittig reagent. Ethyltriphenylphosphonium Bromide and other phosphonium salts show antiviral activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romanov, G.V. et al.: Khim.-Farm. Zhur., 24, 28 (1990);<br></p>

<p>Applications 1-Bromo-3-iodobenzene is a useful compound for preparing an organic light-emitting device.<br>References Park, S. U., et al.: Repub. Korea (2020), KR 2176164 B1<br></p>

<p>Applications 2-Chloro-4,6-dimethoxyaniline Hydrochloride (cas# 82485-84-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1,2-bis(Chloromethoxy)ethane is a carcinogenic compound.<br>References Kar, S., Roy, K.: Chemoshpere, 87, 339 (2012)<br></p>

<p>Applications 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride is used in the preparation of multifunctional cationized cotton fabric based on TiO2 nanomaterials.<br>References Farouk, A., et la.: Int. J. Biol. Macromolecules, 61, 230 (2013);<br></p>

<p>Applications 4-(4-Fluorophenyl)benzoic acid<br></p>

<p>Applications 1-Iododecane (cas# 2050-77-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Used for production of peptide thioester. This compound often contains some of the analogous alkyl bromide.<br></p>

<p>Applications 2,4-Dinitrobenzenesulfenyl Chloride is used in the modification of chlorea toxins and it’s promoters.<br>References De Wolf M. J., et al. : J. Biol. Chem., 256, 5481 (1981)<br></p>

<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,​3-​Bis(bromomethyl)​-​5-​methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>

<p>Applications 2-Amino-5-cyanobenzotrifluoride is used in the design and synthesis of 4-phenylpyrrole derivatives as androgen receptor antagonists which show efficacy against prostate cancer cells.<br>References Yamamoto, S. et al.: Bioorg. Med. Chem. Lett., 20, 422 (2012), Chen, J. et al.: Synth. Met., 160, 1953 (2010);<br></p>

<p>Applications o-Tolylhydrazine Hydrochloride is a reagent used in the organic syntheses such as opioid receptor antagonists as well as adenosine receptor antagonists as well as adenosine receptor antagonists.<br>References Colotta, V. et al.: J. Med. Chem., 43, 3118 (2000); Portoghese, P. et al.: J. Med. Chem., 33, 1714 (1990);<br></p>

<p>Applications Carbonochloridic Acid 1,2,2,2-Tetrachloroethyl Ester is used in the synthesis of Doxorubicin (D558000), is used as an antineoplastic. Also used in the synthesis of metabolites of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.<br>References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications 4-Chlorobutyl Acetate is a reagent used in the synthesis of novel cyclic ADP ribose derivatives. Also used in the synthesis of a transient receptor potential melastatin 2 antagonist involved in insulin secretion.<br>References Galeone, A. et al.: Tetra., 58, 363 (2002); Moreau, C. et al.: J. Med. Chem., 56, 10079 (2013); Togashi K, et al.: EMBO J., 25, 1804 (2006);<br></p>

<p>Applications Tigoloyl Chloride is used in the polymerization of propylene as well as through a Freidel-Crafts reaction for the preparation of permethylindenyl complexes of transition metals. As well, it is primarily used as a reagent in the enantioselective synthesis of dihydropyrans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References O'Hare, D. et al.: Organometallics, 11, 48 (1992); Kaminsky, W. et al.: J. Organomet. Chem., 487, 181 (1995); Evans, D. A. et al.: J. Am. Chem. Soc., 122, 1635 (2000);<br></p>

<p>Applications Nonafluoropentanoic Anhydride is a useful compound in silicon-based energy storage devices.<br>References Ji, L., &amp; Benjamin, Y.: U.S. Pat. Appl. Publ. (2020), US 20200203711 A1<br></p>

<p>Applications Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Applications Isobutyryl chloride is a useful intermediate commonly used in synthetic chemistry. Isobutyryl chloride is also a potential inducer of pulmonary adenomas in strain A mice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Theiss, J., et al.: Cancer Res., 39, 391 (1979)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.<br>References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);<br></p>

<p>Applications 2-(2,2,2-Trifluoroethoxy)ethanol (cas# 2358-54-5) is a useful research chemical.<br></p>

<p>Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Applications 1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Czopek, A., et al.: Bioorg. Med. Chem., 23, 3436 (2015)<br></p>

<p>Stability Moisture Sensitive<br>Applications PERFLUOROHEXANE SULPHONYL FLUORIDE (cas# 423-50-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (S)-(-)-2-Chloropropionic Acid (cas# 29617-66-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3,6-Dibromo-9H-fluoren-9-one is a reagent in the preparation of diphenylamine-fluorenone derivatives as potential fluorescent probes for neuroblastoma cell staining.<br>References Capodilupo, A., et al.: Tetrahedron, 72, 2920 (2016)<br></p>

<p>Applications Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.<br>References Crooks, S. et al.: Int. J. Biochem. Cell. Biol., 30, 173 (1998); Wenkert, E. et al.: J. Org. Chem., 55, 6203 (1990);<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications Bromoform is a brominated organic solvent, sedative and flame retardant, in the past. Now it is mainly used as a laboratory reagent, for example as an extraction solvent.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haag, W., et al.: Environ. Sci. Technol., 26, 1005 (1992); Giesen, D., et al.: Theoretical Chem. Accounts, 98, 85 (1997); Shvakumar, D., et al.: J. Chem. Theory Compt., 5, 919 (2009)<br></p>

<p>Applications Bromodifluoromethyl Phenyl Sulfone can be used to prepare difluoromethyl ethers via difluoromethylation of alcohols.<br>References Xie, Q., et.al.:Angew. Chem. Int., 56, 3206-3210, (2017);<br></p>

<p>Applications 2,2,2-Trifluoroethyl Formate acts as a reagent for the preparation of HCV NS5B inhibitor MK-3281, an inhibitor of hepatitis C virus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colarusso, S., et al.: Synlett, 11, 1527 (2011)<br></p>

<p>Applications 2-(Methylsulfinyl)ethylamine Hydrochloride is used as a reagent in the synthesis of the lapatinib analog L-2 (selatinib) which is a potent dual EGFR/HER-2 inhibitor for the treatment of cancer.<br>References Zhang, L., et al.: Eur. J. Med. Chem., 69, 833 (2013)<br></p>

<p>Applications Ethyl 4-Chloroacetoacetate (cas# 638-07-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(methylamino)ethane-1-thiol hydrochloride (cas# 33744-33-1) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-bromoethanesulfonate is a useful reagent for the esterification of sulfonic acids.<br>References Etienne, A., et al.: Comptes Rendus Acad. Sci., 275, 633 (1972)<br></p>

<p>Applications 5-Aminopentanenitrile Hydrochloride is a useful research chemical.<br></p>

<p>Applications Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.<br>References Qi, J.L., et al.: Euro. J. Medn. Chem., 46, 934 (2011); Schirlin, D., et al.: J. Enzymes. Inhibition., 1, 243 (1987);<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications 2-​Bromo-4-​thiazolesulfonyl chloride is a useful chemical for research.<br></p>

<p>Applications 1-Bromo-2-fluorobenzene is used as a reagent in the synthesis of organic compounds inlcuding that of brominated N-arylated carbazoles which are widely useful in organic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., Synthesis, pages ahead of print, (2015);<br></p>

<p>Applications 1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride is a derivative of 1,1,1-Trichloromethanesulfonic Acid a very strong acid used in protonation reactions, and as a catalyst in esterifications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. et al.: Chem. Rev., 77, 69 (2006);<br></p>