Organic Halides

<p>Applications 1-(2,3-Dimethylphenyl)ethyl Chloride is an impurity of Medetomidine (M203250), an α2-Adrenergic agonist. Sedative; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987), Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987), Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988), Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996),<br></p>

<p>Impurity Lamotrigine USP Related Compound B/ Lamotrigine EP Impurity E<br>Applications 2,3-Dichlorobenzoic Acid (Lamotrigine USP Related Compound B) is the key intermediate for antiepileptic drug Lamotrigine (L173250) and other pharmaceuticals for the treatment of central nervous system (CNS) disorders and disease.<br>References Liao Q., et al.: JingXi. Huagong., 36, 18 (2006); Qadeer, G., et al.: J. Brazilian. Chem. Soc., 18, 1176 (2007); Pellon, R.F., et al.: Syn. Commun., 37, 1853 (2007); Wang, J.F., et al.: Thermochimica. Acta., 512, 118 (2011);<br></p>

<p>Applications N,N-Dimethylbenzeneethanamine is used in the synthesis of squalene synthase inhibitors.<br>References Spencer, T. et al.: J. Org. Chem., 64, 807 (1999); Shechter, I. et al.: Bioorg. Med. Chem. Lett., 6, 2585 (1996);<br></p>

<p>Stability Material darkens in storage with no loss in purity<br>Applications 3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Penning, T. et al.: J. Med. Chem., 40, 1347 (1997);<br></p>

<p>Applications Ethyl 2-Chloracetoacetate is used in the preparation of oxazoles and thiazoles as agonists for peroxisome proliferator-activated receptor δ. It is also used to synthesize dimethylimidazothiadiazolecarbohydrazides with anticancer activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sznaidman, M., et al.: Bioorg. Med. chem. Lett., 13, 1517 (2003); Terzioglu, N., et al.: Eur. J. Med. Chem., 38, 781 (2003)<br></p>

<p>Applications This compound is used in the synthesis of Diclazuril (D436200) and diclazuril derivatives.<br></p>

<p>Applications 2-(4-Octylphenyl)-1-iodoethane (cas# 162358-07-8) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Semicarbazide Hydrochloride is a metabolite of Nitrofuran (N493840), a minor antimicrobial used in veterinary medicine affecting semicarbazide-sensitive amine oxidase (SSAO) activity (1). Semicarbazide may be found in from nitrofuran residues in honey extracts (2) as well as milk from dairy cows (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.Environmental contaminants; Food contaminants; Heat processing contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliott J. et al.: J Pharm Pharmacol. 1989 Jan;41(1):37-41. 2. Tribalat L. et al.: Anal Bioanal Chem. 2006 Dec;386(7-8):2161-8. 3. Chu, P. et al.: J. Agric. Food Chem. 2007 Feb:55(6);2129-2135<br></p>

<p>Applications 2,5-Dibromophenol<br></p>

<p>Stability Temperature sensitive - closes readily. Store at -80°C<br>Applications Used for isolating bases by means of Reinecke's salt.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dudley, H., et al.: Biochem. J., 27, 157 (1933),<br></p>

<p>Applications 3,3-Difluoroazetidine Hydrochloride is used in preparation of Dihydropyrimidine compounds as antiviral agents.<br>References Song, H., et al.:U.S. Pat. Appl. Publ., (2020);<br></p>

<p>Stability Hygroscopic<br>Applications A substrate for peroxidase, and a reagent for the spectrophotometric determination of selenium.<br></p>

<p>Applications Fadrozole hydrochloride is a very potent and selective inhibitory effect of the aromatase enzyme system.<br></p>

<p>Applications 4-Chloro-2,5-dimethoxyaniline was an analyte identified in a screening study of electronic nicotine delivery systems (ENDS), which are regulated tobacco products.<br>References Hung, P. H., et al.: J. Applied Toxic., 40, 1566 (2020)<br></p>

<p>Stability Moisture Sensitive (Reactive)<br>Applications Iodotrimethylsilane is a reagent used for cleaving ethers, esters, carbamates, ketals and lactones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heck, M., et al.: Tetrahedron Lett., 35, 5445 (1994); Hiral, G., et al.: Biorg. Med. Chem. Lett., 14, 2647 (2004)<br></p>

<p>Applications 2-Bromo-1-propanol is used in the epoxide productions from Flavobacterium.<br>References Geigert, J., et al.: Appl. Environ. Microbiol. Applied<br></p>

<p>Applications Used to protect alcohols during organic synthesis.<br>References Shen, H., et al.: J. Med. Chem., 53, 2666 (2010), Qiang, L., et al.: Bioorg. Med. Chem. Lett., 20, 836 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications Iodoacetonitrile (cas# 624-75-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Bromoacetonitrile is a water disinfectant byproduct. 2-Bromoacetonitrile has been found to show mutagenic activity on Salmonella typhimurium strain TA100.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A.E., et. al.: Toxicol. Appl. Pharm., 100, 271 (1989); Le Curieux, F., et. al.: Mutat. Res-genet. Tox., 341, 289 (1995)<br></p>

<p>Applications 1-[4-(2-Chloroethoxy)phenyl]-2-phenylethanone (cas# 19561-95-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Dimethyldimyristylammonium bromide is a cationic surfactant used in the study of lipid raft domains in membranes.<br>References Uyama, M.; et al.: J. Oleo Sci., 67, 67 (2018).<br></p>

<p>Applications 4-Bromo-2,6-diisopropylaniline is used as a reactant in the preparation of hyperbranched ethylene oligomers.<br>References Wiedemann, T., et. al.: J. Am. Chem. Soc., 136, 2078 (2014)<br></p>

<p>Applications 2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.<br>References Kang, S., et al.: J. Med. Chem., 57, 5293 (2014);<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-(3-Chloropropyl)theobromine (cas# 74409-52-2) is a useful research chemical.<br></p>

<p>Applications 2-Chlorobenzyl Chloride is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)<br></p>

<p>Applications 2,6-Dibromo-4-fluorophenol<br></p>

<p>Applications Perfluorodecyl iodide is used to prepare 3,5-bis(perfluorodecyl)phenylboronic acid, "green" catalyst for the direct amide condensation reaction. It is also used to synthesize 3-(perfluorodecyl)prop-1-ene.<br>References Ishihara, K, et al.: Synlett., 9, 1371 (2001); Ryu, I., et al.: Tetrahedron Lett., 42, 947 (2001)<br></p>

<p>Applications Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Driscoll, J.S. et al.: J. Med. Chem., 34, 3280 (1991); Pan, L. et al.: J. Pharm. Biomed. Anal., 52, 589 (2010);<br></p>

<p>Applications A valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.<br>References Perham, R.N. &amp; Thomas, J.O.: J. Mol. Biol., 62, 415 (1971), Jue, R., et al: Biochemistry, 17, 5399 (1978)<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Used for preparation of substituted indazole amides as glucokinase activators.<br>References Perles, J., et al.: J. Mater. Chem., 14, 2683 (2004),<br></p>

<p>Applications 1,3,5-TRIMETHYL-1,3,5-TRIS(3,3,3-TRIFLUOROPROPYL)CYCLOTRISILOXANE (cas# 2374-14-3) is a useful research chemical.<br></p>

<p>Stability Form Trimer in solution<br>Applications 2-Fluoro-6-hydroxyphenylboronic Acid is a synthetic reagent used in the preparation of alkylene-bridged [(3,4-dihydro-2H-benzo[b][1,4]oxazinyl) or (piperidinyl)(biphenyl-3-yl)pyrazolo[1,5-a]pyrimidinyl](tert-butoxy)acetic acid derivatives as HIV integrase inhibitors for treating HIV infection.<br>References Naidu, N., et al.: PCT Int. Appl. (2014), WO 2014028384 A1 20140220;<br></p>

<p>Applications 2,4-Dichloro-3,5-dinitrobenzotrifluoride is a reagent used in the synthesis of kinesin spindle protein inhibitors. Potential use as an alternative to neurotoxic MT inhibitors.<br>References Dong, J. et al.: Eur. J. Med. Chem., 70, 427 (2013);<br></p>

<p>Applications 1-Chloro-2-nitrobenzene is a useful synthetic intermediate. It was used in the synthesis of 1-hydroxybenzotriazole derivatives. Reaction of 1-chloro-2-nitrobenzene with dinitrogen pentoxide in dichloromethane is strongly catalysed by H-Faujasite-720.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fathalla, M., et al.: J. Chem. Soc. Pak., 33, 324 (2011); Claridge, R., et al.: J. Chem. Soc. Perkin Trans. II, 9, 1815, (1999)<br></p>

<p>Applications DOTA-4AMP, is a macrocyclic ligand used for preparation of magnetic resonance imaging contrast agents.<br>References Sun, X, et al.: Huaxue Tongbao, vol. 75, :21-26 (2012);<br></p>

<p>Applications 1-fluoro-3,3-dimethyl-1$l^{3},2-benziodoxole (cas# 1391728-13-4) is a useful research chemical.<br></p>

<p>Applications Dibromoformaldoxime is a reagent that undergoes cycloaddition with alkynes to prepare substituted 3-bromo-isoxazoles in high yield.<br>References Chiarino, D., et al.: J. Heterocyclic Chem., 24, 43 (1987); De Amici, M., et al.: J. Org. Chem., 54, 2646 (1989); Castelhano, A., et al.: 16, 335 (1988).<br></p>

<p>Applications Intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol<br>References Kitagawa, M., et al.: Chem. Pharm. Bull., 39, 2681 (1991), Keller, T., et al.: Chem. Pharm. Bull., 49, 1009 (2001),<br></p>

<p>Applications 7-Bromoheptanol is a useful synthetic intermediate. It can be used to prepare N-substituted [(carboxymethyl)phenoxy]ethyl benzoxazinones as PPARγ agonists and antidiabetic (type 2) agents. It can also be used to prepare thiochroman and chroman derivatives as pure antiestrogens.<br>References Rybczynski, P., et al.: J. Med. Chem., 47, 196 (2004); Kanbe, Y., et al.: Bioorg. Med. Chem., 14, 4803 (2006)<br></p>

<p>Applications 1-Chloroethyl isopropyl carbonate (cas# 98298-66-9) is a useful research chemical.<br></p>

<p>Applications 3-Aminobenzamidine Dihydrochloride is a reactant that has been used in the synthesis of N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase.<br>References Collins, J.L., et. al.: J. Med. Chem., 41, 2858 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Used in nucleophilic substitution.<br>References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),<br></p>

<p>Applications 2-Iodoxybenzoic Acid is used in the oxidation of alcohols in organic synthesis. It is also frequently used in the preparation of Dess-Martin periodinane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Frigerio, M. et al.: J. Org. Chem., 60, 7272 (1995); Ireland, R. et al.: J. Org. Chem., 58, 2899 (1993);<br></p>

<p>Applications Reagent used in the preparation of carbonic anhydrase inhibitors.<br></p>

<p>Applications A reagent used in the preparation of hepatitis C virus NS3 protease inhibitors and PMPA prodrugs with antiretroviral activity.<br>References Sheng, X. et al.: Bioorg, Med. Chem. Lett., 169, 3453 (2009); Arimilli, M.N. et al.: Antiviral Chem. Chemother., 8, 557 (1997);<br></p>

<p>Applications 1-Chloro-6-iodohexane is used in studies to demonstrate the direct reduction of 1-Bromo-6-chlorohexane/1-Chloro-6-iodohexane at silver cathodes in Dimethylformamide.<br>References Rose, J.A., et al.: ?Electrochim. Acta, 218, 311-317 (2016)<br></p>