Toxicology

Applications Dibenzyloxy Tenofovir is an intermediate in the synthesis of Tenofovir Dibenzyloxy Isopropyl Carbamate (T018545); Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Applications BCX 4430 is an antiviral drug, an adenosine analog). It is developed by BioCryst Pharmaceuticals with funding from NIAID, originally intended as a treatment for Hepatitis C, but subsequently developed as a potential treatment for deadly filovirus infections such as Ebola virus disease and Marburg virus disease.
References Warren, T., et al.: Nature, 508, 7496 (2014); Kamat, S., et al.: Biochem., 52, 7366 (2013)

Applications Levamisole Phosphate is a compound used to study anthelmintic resistance status in Brazilian cattle.
References Soultello, R., et al.: Vet. Parasitol., 148, 360 (2007);

Applications Rilpivirine Amadori rearrangement Product II is an impurity of Rilpivirine(R509800) which is a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648

Applications o-Carbomethoxybenzyl Sulfonamide is a useful reactant in organic synthesis.
References Jiang, Lin, et al.: Youji Huaxue, 26(2), 203-206 (2006)

Applications Fenticonazole nitrate (F279250) impurity, with antimycotic and antibacterial activity.
References Nardi, D., et al.: Arzneim.-Forsch., 31, 2123 (1981),

Applications 1-Isocyanato-4-nitrobenzene is a useful synthetic intermediate. It can be used as a reactant in the synthesis of potent human NK1 tachykinin receptor antagonist. It can also be used to prepare N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas with antiprotozoal and antimycobacterial activities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Walpole, C., et al.: J. Med. Chem., 41, 3159 (1998); Nava-Zuazo, C., et al.: Bioorg. Med. Chem., 18, 6398 (2010)

Applications 4-Amino-1-(10-phthalimidodecyl)quinaldinium Iodide is an intermediate for the synthesis of 4-Amino-1-[10-[(2-methyl-4-quinolyl)amino]decyl]quinaldinium Iodide Hydriodide (M493250), which is an impurity of Dequalinium (D288335); the active ingredient in various medications including antiseptic and anti-malarial agents.
References Kunisada, Y., et al.: J. Biomolec. Screen., 17, 140 (2012); Zeder-Lutz., G., et al.: Anal. Biochem., 421, 417 (2012)

Applications Amoxycilloic Acid Trimer is an impurity of Amoxycilloic Acid (A634265); a degradation product/impurity of Amoxicillin (A634235, 3H2O) which is a semi-synthetic antibiotic related to Penicillin and an antibacterial.
References Connor, S., et al.: J. Pharm. Pharmacol., 46, 128 (1994); Van G., et al.: J. Vet. Pharmacol. Ther., 26, 139 (2003); Brogden, R.N., et al.: Drugs, 18, 169 (1979); Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994)

Applications 4-Benzyloxyacetophenone is used in preparation of inhibitors of various proteins such as hepatitis C virus polymerase, glucosylceramide synthase and protein tyrosine phosphatase 1B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Deng, Y., et al.: Bioorg. Med. Chem. Lett., 19, 5363 (2009); Lee, L., et al.: J. Biol. Chem., 274, 14662 (2009); Liu, Z., et al.: Bioorg. Med. Chem. Lett., 21, 3755 (2011)

Applications 5-epi Emtricitabine Carboxylic Acid is an impurity of 5-epi Emtricitabine (E524980); an epimer of Emtricitabine (E525000) which is a nucleoside reverse transcriptase inhibitor approved for treatment of HIV-1. Emtricitabine also has antagonistic activity against the hepatitis B virus.
References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993); Lim, S. et al.: Arch. Intern. Med., 166, 49 (2006); Smith, K., et al.: AIDS, 23, 1547 (2009)

Applications β-Amyrin is used as a protein tyrosine phosphatase 1B inhibitor with potential treatment towards diabetes. Also used in the synthesis of HIV-1 integrase inhibitory compounds based upon plant extracts.
References Zhang, Y. et al.: Bioorg, Med. Chem., 16, 8697 (2008); Tewtrakul, S. et al.: Phytother. Res., 17, 232 (2003);

Applications Sulfamonomethoxine-N1-glucosiduronic Acid, is a metabolite of Sulfamonomethoxine (S699145), found in human urine, after its administration. Sulfamonomethoxine is used as an antibacterial agent.
References Ueda, M.m et al.: Yakugaku Zasshi, 87, 455 (1967); Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995);

Applications Ethyl 3-(4-bromo-2-chlorophenyl)-3-oxopropionate (CAS# 131994-22-4) is a useful research chemical compound.

Applications Artemether Succinate Dimer is a derivative compound of Artemisinin (A777500), an antimalarial.
References Klayman, D.L., et al.: Science, 228, 1049 (1985); Price, R.N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000); Meshnick, S.R., et al.: Int. J., Parasitol., 32, 1655 (2002);

Applications [2R-[2α(S*),4β]]-4-[[(2,2-Dimethyl-1-oxopropoxy)methoxy]carbonyl]-α-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-5,5-dimethyl-2-thiazolidineacetic Acid is an impurity of Pivmecillinam (P550700), an orally active prodrug of Amdinocillin (A576300), an broad spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2.
References Ejim, L., et al.: Nature. Chem. Biol., 7, 348 (2011); Lees, G.M., et al.: Brit. J. Pharmacol., 73, 535 (1981);

Applications Desmethylene seco-Benzoxadiazine Marbofloxacin is an impurity of Marbofloxacin (M197000); a fluorinated quinolone antibacterial.
References Gruet, P., et al.: Vet. Rec., 140, 199 (1977); Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998)

Applications (rac)AIB-Precursor is used as a reagent in the preparation of cyclized sulfamoylarylamide derivatives for treatment of hepatitis B.
References Vendeville, S. M. H., et al.: PCT Int. Appl. 244pp. (2017)

Applications (2E)-3-[4-(Acetyloxy)-3-methoxyphenyl]-2-propenoyl Chloride is used in the synthesis of target compound of Feruloyl Arabinofuranoside; Also, it is an intermediate used in the synthesis of 3-O-(E)-Feruloylquinic Acid (F308980), which is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.
References Miyake, Y., et al.: Kenkyu Hokoku Wakaya Ken Kogyo Gijutsu Senta, 2009, 6 (2010); Dzamic, A. et al.: Ind. Crop. Prod., 51, 407 (2013); Stalmach, A. et al.: Food. Func., 5, 1727 (2014); Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013);

Applications N-Boc Gatifloxacin is an intermediate used in the synthesis of Gatifloxacin N-Oxide (G250005), which is an impurity of Gatifloxacin (G250000), an antibacterial agent.
References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),

Applications Lomefloxacin is a fluorinated quinolone antibacterial. Lomefloxacin is a DNA gyrase antagonist.
References Hirose, T., et al.: Antimicrob. Agents Chemother., 31, 854 (1987), Sanzgiri, Y.D.. et al.: Anal. Profiles Drug Subs. Excip. 23, 321 (1994),