Toxicology

<p>Applications 4-Benzyloxyacetophenone is used in preparation of inhibitors of various proteins such as hepatitis C virus polymerase, glucosylceramide synthase and protein tyrosine phosphatase 1B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, Y., et al.: Bioorg. Med. Chem. Lett., 19, 5363 (2009); Lee, L., et al.: J. Biol. Chem., 274, 14662 (2009); Liu, Z., et al.: Bioorg. Med. Chem. Lett., 21, 3755 (2011)<br></p>

<p>Applications Terbinafine is used to treat infections caused by a fungus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Impurity Itraconazole Impurity 16<br>Applications cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-4-yl-methyl)-1,3-dioxolan-4-yl]methyl Methanesulfonate (Itraconazole Impurity 16) is an impurity in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989);<br></p>

<p>Applications Labelled Tiludronic Acid (T441250). A biphosphonate bone resorption inhibitor.<br>References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),<br></p>

<p>Applications A glucuronide metabolite of Chlorpyrifos (C425300).<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications An impurity of Trimethoprim (T795615) with inhibitory effects on the enzyme dihydrofolate reductase.<br>References Kompis, I. et al.: Enzyme Inhib. Proc. Meet., 177 (1980); Hess, S. et al.: J. Pharmac. Biomed. Anal., 25, 531 (2001);<br></p>

<p>Applications Labelled Tazarotene (T010050). An acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Antiacne; antipsoriatic. Used in treatment of photodamaged skin.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004),<br></p>

<p>Applications Isoxaflutole is an pesticide used to selectively control both grass and broad-leaved weeds in maize and sugar cane. Isoxaflutole is known to work by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD) which results in the disruption of pigment biosynthesis.<br>References Fillosls, E.F., et al.: Int. Sugar. J., 115, 135 (2013); Laini, A., et al.: Sci. Total. Environ., 438, 312 (2012);<br></p>

<p>Applications PhIP (A617000) derivative. Carcinogen.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Cyromazine (C989300). Insect growth regulator. Insecticide.<br>References Hall, R.D., et al.: J. Econ. Entomol., 73, 564 (1980), Hart, R.J., et al.: Aust. Vet. J., 59, 104 (1982),<br></p>

<p>Applications A labelled antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>

<p>Stability Not stable in solution<br>Applications Flazasulfuron, is a Trifluoro-pyridine derivative acting as a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, H., et al.: Zhejiang Huagong, 42, 1 (2011);<br></p>

<p>Applications Spinetoram belongs to spinosyn family of insecticides and shows potential of natural products research.<br>References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)<br></p>

<p>Applications 5β-Androsterone β-D-Glucuronide is a glucuronide metabolite of Testosterone (T155000).<br>References Weusten, J., et al.: J. Steroid Biochem., 32, 689 (1989), Antignac, J., et al.: Steroids, 70, 205 (2005),<br></p>

<p>Applications Butyrophenone derivative having neuroleptic activity, used as an antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shimoda, K., et al.: Pharmacol. Toxicol., 83, 164 (1998), Sekine, Y., et al.: Eur. J. Clin. Pharmacol., 55, 583 (1999), Oka, T., et al.: Life Sci., 76, 225 (2004), Fujikawa, M., et al.: Prog. Neuro-Psychopharmacol. Biol. Psych., 32, 755 (2008),<br></p>

<p>Applications Methylparaoxon is used in esterase detoxication of acetylcholinesterase inhibitor pesticides using human liver samples in vitro.<br>References Moser, V. C., et al.: Toxicology, 353, 11 (2016)<br></p>

<p>Applications Oxamyl is a carbamate pesticide used to control nematode in protected crops and potato cultivation (1). Oxamyl metabolites are useful compounds to characterize omxamyl-degrading microbes and to investigate metabolic pathway of Oxamyl. Oximino Oxamyl is a metabolite of Oxamyl (O845140) in apple, orange, and tomato (2,3).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Rousidou, K., et al.: Front Microbiol. 29, 7 (2016)(2) Salama, A. K.: J Environ Sci Health B 33, 569 (1998)(3) Baines, R. C., and Small, R. H.: J Nematol. 8, 122 (1976)<br></p>

<p>Applications A protected metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.<br></p>

<p>Stability Hygroscopic<br>Applications A sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)<br></p>

<p>Applications An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999), Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>

<p>Applications Propafenone-d5 Hydrochloride is labelled Propafenone which is a sodium channel blocker.<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983), Bryson, H. M., et al.:Drugs, 45, 85 (1993), Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998),<br></p>

<p>Impurity Fluconazole EP Impurity D<br>Applications 2-Desfluoro Fluconazole (Fluconazole EP Impurity D) is an impurity of the antifungal agent Fluconazole (F421000).<br>References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);<br></p>

<p>Applications Isocarbofos D7 (isopropyl D7) is the labelled analogue of Isocarbophos(I789303). Isocarbophos is an organophosphorus pesticide residue found in spicy foods and nuts.<br>References Gao, Y., et al.: Huaxue Shiji, 39, 1083 (2017); Dong, Y., et al.: Fenxi Huaxue, 45, 1397 (2017)<br></p>

<p>Applications A deuterated tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Applications: N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic Acid Monohydrochloride Hydrate is a component for treating or preventing obesity and insulin resistance and mitrochondrial-associated disorders.N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic Acid Monohydrochloride Hydrate is also the monohydrochloride hydrate of HBED (H107503), which is an iron chelator useful in treating iron overload.<br>References Milburn, Michael, WO 2007008548, (2007)Bergeron, Raymond J., WO 9939706, (1999)<br></p>

<p>Applications Antipruritic. Antibacterial, antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966), Abdel-Moety, E., et al.: Eur. J. Pharm. Sci., 5, 1 (1997), Basavaiah, K., et al.: Chem. Pharm. Bull., 47, 1351 (1999),<br></p>

<p>Applications Nebivolol is a cardioselective beta-1 receptor blocking agent.<br>References Montoya, A., et al.: Oncotarget, 8, 6446-6460 (2017);<br></p>

<p>Applications Suxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone. It is a drug used for joint and muscular pain.<br>References Monreal, L., et al.: res. Vet. Sci., 76, 145 (2004); Mizushima, Y., et al.: Pharm., 25, 39 (1982); Yasuda, Y., et al.: J. Pharm. Sci., 71, 565 (1982)<br></p>

<p>Applications Thiram is an ectoparasiticide. Thiram is used in agriculture to prevent fungal diseases in seed and crops. Thiram has other applications ranging from use as a topical bactericide to animal repellent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sahni, M.L. et al.: Ind. Phytopathol., 20, 71 (1967); Vir, D.: Pesticide, 11, 39 (1977); Welch, J.F. et al.: Plant. Dis. Rep., 35, 57 (1952);<br></p>

<p>Applications Chlorphenesin-D5 is an isotopic labeled form of Chlorphenesin (C424250). Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. Chlorphenesin is also used as an antimycotic agent.<br>References Whang, H.Y. et al.: Infect. Immun., 2, 60 (1970); Lichtenstein, L.M. et al.: J. Immunol., 103, 866 (1969); Thoma, K. et al.: Pharmazie, 52, 362 (1997);<br></p>

<p>Stability Light Sensitive<br>Applications N-Desmethyl (E)-α-Hydroxy Tamoxifen is a N-demethylated, α-Hydroxyated metabolite of Tamoxifen (T006000).<br>References Poon, G.K. et al.: Drug Metab.Dispos. 23,377 (1995); Teunissen, S.F. et al.: J. Pharmac. Biomed. Anal., 55, 518 (2011); Muerdter, T.E. et al.: Clin. Pharmacol. Therap., 89, 708 (2011);<br></p>

<p>Applications Triclabendazole Sulfoxide-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.<br>References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)<br></p>

<p>Applications Labelled Androgen. It has been used as an androgenic agent. Controlled substance (anabolic steroid).<br>References Bichet, N., et al.: Toxicol. Appl. Pharmacol., 106, 509 (1990), Gustafson, D., et al.: Toxicol. Sci., 53, 245 (2000), Copple, B., et al.: Toxicol. Sci., 77, 172 (2004), Takashima, K., et al.: Life Sci., 78, 2787 (2006),<br></p>

<p>Applications Tyrosol-d4 is the isotope labelled analog of Tyrosol (T947800); a phenolic antioxidant.<br>References Perez-Trujillo, M., et al.: J. Agric. Food Chem., 58, 9129 (2010); Gregus, P., et al.: J. Pharm. Biomed. Anal., 53, 674 (2010)<br></p>

<p>Applications A labelled chloroacetanilide herbicide used on vegetable crops.<br>References Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009), Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010), Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010),<br></p>

<p>Applications Tebuconazole is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Grimalt S. et al.: Anal Bioanal Chem. 2015 Apr;407(11):3083-912. Gent, D. et al.: Plant Dis. 2003 May:87(5) p591-5973. Wang, C. et al.: Pest. Biochem. Physiol. 2007 Jan:87(1) p1-8<br></p>

<p>Impurity Azithromycin EP Impurity G<br>Applications 3’-N-Desmethyl-3’-N-tosyl Azithromycin (Azithromycin EP Impurity G) is an Azithromycin (A927000) impurity.<br>References Kirst, H., et al.: Antimicrob. Agents Chemother., 33, 1419 (1989), Gandhi, R., et al.: J. Pharm. Biomed. Anal., 23, 1073 (2000),<br></p>

<p>Applications Ibudilast-d7 is the labeled analogue of Ibudilast (I125000), a leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983); Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986); Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988)<br></p>

<p>Applications 4-Hydroxy Coumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase.<br>References Foti, M. et al.: J. Agric. F., 44, 497 (1996); J. Med. Chem., 40, 242 (1997);<br></p>

<p>Applications Labelled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications A potentially related compound in cephalosporin antibacterial compounds. An isomer of Cefuroxime (C248050).<br>References Chavette, R., et al.: J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),<br></p>

<p>Applications Quinmerac-3,8-dicarboxylic Acid is a impurity of Quinmerac (Q696500(P)) which is a Auxin-type herbicide.<br>References Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001),<br></p>

<p>Stability Not stable in Solution<br>Applications Amidosulfuron, is used as pesticide and herbicides.<br>References Fan, Zh., et al.: Xiandai Nongyao, 10, 34 (2011); Coors, A., et al.: Environ. Scie. Euro.,23 (2011);<br></p>

<p>Applications An oxidative product of the drug Norethindrone (N676000). Norethindrone impurity.<br>References Reif, V., et al.: Pharmaceutical Res., 4, 54 (1987), Rao, P., et al.: Steroids, 59, 621 (1994),<br></p>

<p>Applications Quinethazone is a thiazide diuretic used to treat hypertension.<br>References DeLuca, F.M.: Sett. Med., 54, 747 (1966); Dettli, L. et al.: Ann. N.Y. Acad. Sci., 139, 471 (1966);<br></p>

<p>Applications 2,6-Dichlorobenzamide is the persistent metabolite of herbicide 2,6-Dichlorobenzonitrile (D431945).<br>References Li, H., et al.: Soil Sci. Soc. Am. J., 67, 122 (2003); Shedletzky, E., et al.: Plant Physiol., 94, 980 (1990)<br></p>

<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications Diquat Dipyridone is an metabolite of Diquat (D492900) a contact herbicide used also to produce desiccation and defoliation.<br>References Fuke, C., et al.: Legal. Med., 4, 156 (2002); Ameno, K., et al.: J. Liq. Chorma., 18, 2115 (1995); Brian, et al.: Nature, 181, 446 (1958); Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986),<br></p>

<p>Stability Very Hygroscopic<br>Applications 3-Methylglutarylcarnitine Chloride is the chloride salt of M226345, which is derived from DL-Carnitine Benzyl Ester Chloride (C184135), which is an intermediate in the synthesis of 3-Hydroxybutyrylcarnitine Hydrochloride (H830900), a reagent used to study acylcarnitine profile in thyroid disease.<br>References Hintze, U., et al.: Lipids., 10, 20 (1975)<br></p>

<p>Applications 4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.<br>References Cheng, C., et al.: ACS Med. Chem. Lett., 1, 466 (2010); Yonetoku, Y., et al.: Bioorg. Med. Chem., 16, 9457 (2008)<br></p>

<p>Applications Labelled Glycochenodeoxycholic Acid 3-Sulfate (G641270). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),<br></p>

<p>Applications Labelled Tazarotenic Acid (T010060). Tazarotenic acid is the major active metabolite of Tazarotene (T010050).<br>References Nagpal, S., et al.: J. Biol. Chem., 270, 923 (1995), Madhu, C., et al.: J. Pharm. Sci., 86, 972 (1997), Attar, M., et al.: Drug Metab. Dispos., 31, 476 (2003),<br></p>

<p>Applications A metabolite of Eplerenone. Used in combination therapy for treatment of cardiovascular disorders.<br>References Staessen, J., et al.: J. Endocrinol., 91, 457 (1981), de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), MacFadyen, R., et al.: Cardiovasc. Res., 35, 30 (1997),<br></p>

<p>Applications Pentachlorothioanisole is used in the preparation of arenethiols and arenethiolates as seen in agrochemicals or fungicides.<br>References Dulik, D. et al.: Xenobiotica, 22, 325 (1992); Rakitin, O. et al.: Sci. Synth., 31a, 949 (2007);<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References IARC Monographs, 4, 97 (1974),<br></p>

<p>Impurity Rosuvastatin EP Impurity G<br>Stability Hygroscopic<br>Applications ent-Rosuvastatin is an enantiomer of Rosuvastatin (R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor (1). Antilipemic (2,3).<br>References 1. Watanabe, M. et al.: Bioorg. Med. Chem. 1997 Feb;5(2):437-44.2. Lee, E. et al.: Clin. Pharmacol. Ther. 2005 Oct;78(4):330-41.3. Ferdinand, C. et al.: Am. J. Cardiol. 2006 Jan 15;97(2):229-35.<br></p>

<p>Stability Store in freezer<br>Applications A caffeine metabolite.<br>References Regal, K.A., et al.: J. of Chromatography B, 708, 75 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications A partially reversible gastric proton pump inhibitor.<br>References Moda, T., et al.: Lett. Drug Des. Discov., 4, 502 (2007), Belaz, K., et al.: J. Pharm. Biomed. Anal., 47, 81 (2008),<br></p>

<p>Applications S-Benzyl di-sec-Butylthiocarbamate is an herbicide used in fruits and vegetables.<br>References Wang, Z. et al.: Anal. Meth., 7, 6358 (2015);<br></p>

<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>

<p>Applications 4,4'-Dichlorodiphenyltrichloroethane is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989);<br></p>

<p>Applications Bispyribac is used as a herbicide for the prevention and control of weeds.<br>References Alister, C., et al.: Crop Prot., 25, 202 (2006), Chandi, G., et al.: J. Food Eng., 79, 592 (2007), Wilkowska, A., et al.: Food Chem., 125, 803 (2011),<br></p>

<p>Impurity Azithromycin EP Impurity M<br>Applications Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Applications Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.<br>References Park, W., et al.: Clin. Ther., 38, 2277 (2016); Kosaka, T., et al.: Cancer Sci., 104, 1017 (2013); Lonsdale, D., et al.: Med. Sci. Monit., 10, 199 (2004)<br></p>

<p>Applications A new Sildenafil (S435000) analogue.<br>References Balayssac, S., et al.: J. Pharm. Biomed. Anal., 50, 602 (2009),<br></p>

<p>Applications Labelled Diltiazem (D460620). A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).<br>References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),<br></p>

<p>Applications Pyrimethanil is a broad spectrum anilino-pyrimidine foliar fungicide. Pyrimethanil functions by inhibiting the biosynthesis of methionine in Botrytis cinerea.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neumann, G.L. et al.: Brigh. Crop Prot. Conf. Pests Dis., 1, 385 (1992); Fritz, R. et al.: Pest. Sci., 49, 40 (1997);<br></p>

<p>Applications A metabolite of Camostat. It is a pollen protease inhibitor for prevention and control of allergy.<br>References Senochuki, K., et al.: J. Med. Chem., 38, 2521 (1995)<br></p>

<p>Applications Nonselective opioid receptor antagonist; congener of Naloxone.<br>References Maickel, R.P., et al.: Ann. N.Y. Acad. Sci., 281, 321 (1976), Gritz, E.R., et al.: Clin. Pharmacol. Ther. 19, 773 (1976), Gonzales, J.P., et al.: Drugs, 35, 192 (1988), Berg, B.J., et al.: Drug Saf., 15, 274 (1996),<br></p>

<p>Applications Isotope labelled Ethyl Butyrate is used in the preparation of novel 2-cyanopyrimidines as cathespin K inhibitors. Also used in the synthesis of pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References By Rankovic, Z. et al.: Bioorg. Med. Chem. Lett.,, 20, 1524 (2010); Takeshita, H. et al.: Bioorg. Med. Chem. Lett., 20, 3893 (2010);<br></p>

<p>Applications Herbicide safener.<br>References Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005), Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007), Brazier-Hicks, M., et al.: J. Biol. Chem., 283, 21102 (2008), Vinggaard, A., et al.: Chem. Res. Toxicol., 21, 813 (2008),<br></p>

<p>Applications A metabolite of Desoxymetasone (D296970).<br>References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),<br></p>

<p>Applications The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product.<br>References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),<br></p>

<p>Applications Picolinafen-d4 is deuterium labelled Picolinafen (P436800), a pesticide. It is a molecule for selective post emergence weed control in wheat and barley.<br>References Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010); Sinclair, C., et al.: Environ. Sci. Technol., 40, 7283 (2006); Magnani, D., et al.: Atti, Giornate fitopatologiche, Perugia, 2, 405 (2000)<br></p>

<p>Impurity Fluocinolone Acetonide EP Impurity B<br>Applications (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching.<br>References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),<br></p>

<p>Applications Auxin-type herbicide.<br>References Ecker, J., et al.: Science, 268, 667 (1995), Grossmann, K., et al.: Pestic. Sci., 52, 111 (1998), Martin, P., et al.: Environ. Toxicol. Chem. 19, 2987 (2000), Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001), van Eerd, L., et al.: Weed Res., 44, 355 (2004),<br></p>

<p>Stability: Hygroscopic<br>Applications: Labelled Oseltamivir (O701000). Orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>