Toxicology

<p>Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyloctan-1-ol Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications Labelled Octopamine (O239750). A biogenic amine that is the phenol analog of Noradrenaline. It is a neurosecretory product found in several vertebrates and invertebrates. Adrenergic.<br>References Pisano, et al.: Biochim. Biophys. Acta., 43, 566 (1960), Breen, C.A., et al.: Nature, 303, 716 (1983)<br></p>

<p>Applications Pyribambenz-Propyl is used in methods and formulations for preventing downward migration of agricultural materials.<br>References Essig, Kenneth J., et al.:PCT Int. Appl., (2020);<br></p>

<p>Applications Coumatetralyl is used as an anticoagulant rodenticide. Coumatetralyl is widely used to control rodent populations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, A., et al.: Bull Environ. Contain Toxicol., 56, 8 (1996), Brakes, C., et al.: J. Appl. Ecol., 42, 118 (2005), Giraudoux, P., et al.: Environ. Res., 102, 291 (2006),<br></p>

<p>Applications Diclosulam is used as a broadleaf herbicide that is used to control weeds in soybean and peanut crops. Diclosulam is applied either preplant or preemergence in order to maintain maximum control of weed growth.<br>References Grichar, W., et al.: Crop Protect., 23, 1145 (2004); Lancaster, S., et al.: Proc. Am. Peanut Res. Ed. Soc., No vol. given, No pp. given, (2006); Sheppard, B., et al.: Proc. South. Weed Sci. Soc., 50, 161 (1997)<br></p>

<p>Applications Tianeptine Sodium Salt is a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant.<br>References Malen, C., et al.: Experientia, 28, 811 (1972),<br></p>

<p>Applications Broflanilide is a pesticide for controlling animals and microbial pests such as unwanted insects. Broflanilide is a prominent insecticide because of it’s effective against pests with resistance to cyclodienes and fipronil. Broflanilide is metabolized to desmethyl-broflanilide that acts as a noncompetitive resistant-to-dieldrin (RDL) γ-aminobutyric acid (GABA) receptor antagonist.<br>References An, X., et al.: J. Sep. Sci., 41, 4515 (2018); Zhao, P., et al.: Nongyao Kexue Yu Guanli, 36, 23 (2015); Jeanmart, S., et al.: Bioorg. Med. Chem., 24, 317 (2016); Nakao, T., et al.: Bioorg. Med. Chem., 24, 372 (2016)<br></p>

<p>Applications A new antitumor derivative of Vinblastine; a dimeric Vinca alkaloid for cancer therapy.<br>References Chakravarty, et al.: J. Med. Chem., 26(5), 638 (1983), Christensson., et al.: Eu.r J. Biochem., 194, 755 (1990), Mayer, et al.: J. Med. Chem., 34, 3029 (1991), Yu, H., et al.: Clin. Biochem., 27, 75 (1994)<br></p>

<p>Applications An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>

<p>Applications Androsterone glucuronide (ADT-G) is one of the major circulating C19-steroid metabolites in humans. Exaggerated Androsterone (A637535) metabolism is observed in hyper-androgenic as well as in some normo-androgenic women with acne and androsterone glucuronide could be a marker in differentiating acne and hirsutism in hyperandrogenic women.<br>References Thompson, D.L. et al.: Clin. Endocrinol., 32, 283 (1990); Stener-Victorin, E. et al.: J. Clin. Endocrinol. Metab., 95, 810 (2010);<br></p>

<p>Applications Dicamba is a herbicide. Dicamba functions by increasing plant growth rate. At sufficient concentrations, the plant outgrows its nutrient supplies and dies. Dicamba has been approved by the EPA for use on genetically modified soybeans and cotton.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Oehler, D.D., et al.: J. Agric. Food Chem., 28, 685 (1980); Griffin, J., et al.: Weed Techno., 27, 696 (2013); Chem. and Eng. News, Nov. 14, 2016, p. 17<br></p>

<p>Applications Antitussive. Chain between 6 and 17 units of ethylene glycol with the major product containing 10 units.<br>References Scholtissek, C., et al.: Antiviral Res., 38, 213 (1998), McGovern, S., et al.: J. Med. Chem., 45, 1712 (2002), Regenthal, R., et al.: Hum. Exp. Toxicol., 21, 343 (2002),<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications A metabolite of Aniline. Arylamines are predominantly conjugated by constitutive enzyme forms in the liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Axelrod, J., et al.: J. Biol. Chem., 232 835 (1958), Lilienblum, W., et al.: Biochem. Pharmacol., 33, 2041 (1984),<br></p>

<p>Applications Combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainati, S.M., et al.: J. Clin. Pharmacol., 35, 713 (1995), Szewczak, M.R., et al.: J. Pharmacol. Exp. Ther., 274, 1404 (1995), Kongsamut, S., et al.: Eur. J. Pharmacol., 317, 417 (1996),<br></p>

<p>Applications KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro<br>References Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);<br></p>

<p>Applications Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Viste, K.L., et al.: Science, 167, 280 (1970), Yoshii, K., et al.: J. Agric. Food Chem., 48, 2502 (2000), Paya, P., et al.: Anal. Bioanal. Chem., 389, 1697 (2007),<br></p>

<p>Applications Labelled (S)-Amphetamine. CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake.Controlled substance (stimulant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 85, 119 (1945), Behrendt, W.A, et al.: Arzneim.-Forsch., 13, 711 (1963), Seiden, L.S., Annu. Rev. Pharmacol. Toxicol., 32, 639 (1993),<br></p>