Toxicology

<p>Applications 2,2,4-Trimethyl-6(2H)-quinolinone 1-Oxide is a derivative of 2,6-Dihydro-2,2,4-trimethyl-6-quinolone (D449900) which is a metabolite of Ethoxyquin (E892800), an oxidation product of the antidegradant.<br>References Kahl, R., et al.: Toxicology, 28, 229 (1983), Burka, L., et al.: Xenobiotica, 26, 597 (1996), Bammler, T., et al.: Toxicol. Sci., 54, 30 (2000), Hayes, J., et al.: Cancer, 174, 103 (2001),<br></p>

<p>Applications Succinylacetone (SA) is a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It was developed a stable-isotope for the determination of SA in dried blood spots (DBS) and liquid urine using a 13C4-SA as internal standard. The method was applied retrospectively and prospectively for the diagnosis of hepatorenal tyrosinemia and for follow-up of patients under treatment.<br>References Kvittingen, E., et al.: Inher. Metab. Dis., 14, 554 (1991), Lindstedt, S., et al.: Lancet, 340, 813 (1992), Schulze, A., et al.: Clin. Chem., 47, 1424 (2001), Allard, P., et al.: Clin. Biochem., 37, 1010 (2004),<br></p>

<p>Applications Epitizide is a diuretic agent.<br>References Pilsbury, V., et al.: J. Pharm. Pharmacol., 18, 713 (1966), Tisdall, P., et al.: Clin. Chem., 26, 702 (1980),<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Rifabutin N-Oxide is a metabolite of Rifabutin (R505000) and like its parent compound it exhibits antibacterial activity.<br>References Medeiros, M., et al.: PCT Int. Appl., 44, (2004); Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988), Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),<br></p>

<p>Applications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.<br></p>

<p>Impurity Azithromycin EP Impurity M<br>Applications Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications Used in the preparation of indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Applications 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid is used in the synthesis of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Also used in the synthesis of 4-carboxamide derivatives acting as antifungal agents.<br>References Cheng, G. et al.: Bioorg. Med. Chem. Lett., 23, 2035 (2013); Wu, Z. et al.: Molecules, 17, 14205 (2012);<br></p>

<p>Applications Cefdaloxime is an orally administered cephalosporin that has activity against Haemophilus influenzae, a bacteria that causes meningitis in humans. Cefdaloxime is also the active metabolite of HR916K, a cephalosporin ester.<br>References Jones, R. &amp; Erwin, M.: Diag. Micro. Infect. Dis., 15, 693 (1992); Jones, R. &amp; Erwin, M.: J. Clin. Micro., 30, 1297 (1992); Käyhty, R., et al.: J. Infect. Dis., 147, 1100 (1983)<br></p>

<p>Applications 4-(4-(4-(4H-1,2,4-Triazol-4-yl)phenyl)piperazin-1-yl)phenyl Acetate is an intermediate in the synthesis of Deoxo Anhydro Itraconazole Bromide (D231675). Deoxo Anhydro Itraconazole Bromide is an impurity of Itraconazole (I937500), which is orally active antimycotic drug structurally related to Ketoconazole (K186000). Antifungal.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)<br></p>

<p>Applications The S,S-stereoisomer of Chloramphenicol (C325030). Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.<br>References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),<br></p>

<p>Applications 2-Hydroxyisoquinoline-1,3(2H,4H)-dione was recently discovered as a scaffold for the inhibition of HIV-1 integrase and the RNase H function of HIV-1 reverse transcriptase. Its interaction with Mg2+ and Mn2+ was investigated using different spectroscopic techniques and it was reported that 2-hydroxyisoquinoline-1,3(2H,4H)-dione forms a 1:1 complex with Mg2+ but a 1:2 complex with Mn2+. Antiviral agent.<br>References Greenwald, J., et al.: Biochemistry, 38, 8892 (1999), Tramontano, E., et al.: Antiviral Res., 65, 117 (2005), Schultz, S., et al.: Virus Res., 134, 86 (2008), Williams, P., et al.: Bioorg. Med. Chem. Lett., 22, 6754 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Desacetyl Rifampicin Quinone is an impurity of Rifampicin (R508000).<br>References Wilson, W.L. et al.: J. Chrom., 144, 270 (1977);<br></p>

<p>Applications Efavirenz Pen-3-ene-1-yne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications (3aR,4R,6S,6aS)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-(1-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]isoxazole-6-carboxylic Acid Methyl Ester is an intermediate used in the synthesis of peramivir (P285500), a neuraminidase inhibitor developed as an antiviral agent for the treatment of influenza.<br>References Hansen, T., et al.: Europ. J. Med. Chem., 58, 22 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Diquat-d8 Dibromide (dipyridine-d8) is a useful isotopically labeled compound of Diquat Dibromide Monohydrate (D492900(M)), which is a contact herbicide used also to produce desiccation and defoliation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brian, et al.: Nature, 181, 446 (1958), Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986),<br></p>

<p>Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),<br></p>

<p>Applications Isotope labelled Acephate (A130850) acts as a contact and systemic insecticide in agriculture through pesticide formulations. Through perinatal exposure studies, it has been linked to hyperglycemia, changes in lipid metabolism and type 2 diabetes (1). Acephate exposed Drosophila melanogaster potentially display an L-ascorbic acid mediated defense (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Ribeiro, T., et al.: Toxicology, 372, 12-21 (2016); Rajak, P., et al.: J. Hazard. Mater., 321, 690-702 (2017)<br></p>

<p>Applications Fenoxaprop-P is an agro-product, used in pesticide formulations.<br>References Han, Y. et al. et al.: J. Sep. Sci., 40, 878 (2017);<br></p>

<p>Applications Selective serotonin reuptake inhibitor (SSRI).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feret, B., et al.: Formulary, 40, 227 (2005),<br></p>

<p>Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5<br></p>

<p>Applications Acrivastine is an allergy medication that is histamine H2 antagonists.<br>References Manna, V.K., et al.: J. Int. Med. Res., 20, 106 (1992);<br></p>

<p>Applications The S-enantiomer of Clobenzorex (C583000), an anorexic.<br>References Thomasset, M., et al.: Experienta, 26, 692 (1970), Glasson, B., et al.: Arzneim.-Forsch., 21, 1985 (1971),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Loperamide, which is used as an antidiarrheal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973), Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990),<br></p>

<p>Applications Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor<br>References Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);<br></p>

<p>Applications 26-Deoxymonensin A Sodium Salt is a metabolite of Monensin (M515600, Na salt); a polyether antibiotic and coccidiostat.<br>References Pospisil, S., et al.: Appl. Environ. Microb., 60, 1561 (1994); Ashworth, D.M., et al.: J. Antibiot., 42, 1088 (1989);<br></p>

<p>Stability Air Sensitive<br>Applications Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.<br>References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),<br></p>

<p>Stability Light Sensitive<br>Applications Labelled Thiamethoxam (T344180). A neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens. Used in Cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications: Has been used as antiseptic, anthelmintic and counter-irritant in alopecia.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diggle, S., et al.: Chem. Biol., 13, 701 (2006), Tashiro, Y., et al.: J. Bacteriol.,190, 3969 (2008),<br></p>

<p>Applications Flunitrazepam is used as an hypnotic. This is a controlled substance (depressant).<br>References Sternbach, L.H., et al.: J. Med. Chem., 6, 261 (1963), Eidelberg, E., et al.: Neurology, 5, 223 (1965), Caplan, Y., et al.: J. Anal. Toxicol., 25, 396 (2001), Wood, M., et al.: Forensic Sci. Int., 150, 227 (2005),<br></p>

<p>Applications Cefprozil Monohydrate (cas# 121123-17-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.<br>References Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997); Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007); Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>

<p>Applications β'-Phenyl Fentanyl is a potent analgesic and a derivative compound of the controlled substance Fentanyl (F274990). Fentanyl Analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhu, Y., et al.: Yaoxue Xuebao, 16, 199 (1981); Zernig, G., et al.: Life Sci., 57, 2113 (1995); Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998);<br></p>

<p>Applications Dimethachlor Oxalic Acid is a pesticide metabolite that is a pollutant found in untreated wastewater, surface water, and groundwater.<br>References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013); Neale, P., et al.: Sci. Total Environ., 576, 785 (2017);<br></p>

<p>Stability Moisture Sensitive, Hygroscopic<br>Applications Leaf-systemic broad-spectrum fungicide for use in cereal and food crops; member of methoxy-imiodihydro-dioxazines. Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Milus, E., et al.: Plant Dis., 78, 697 (1994), D'Mello, J., et al.: Eur. J. Plant Pathol., 104, 745 (1998), Domijan, A., et al.: Food Addit. Contam., 22, 677 (2005),<br></p>

<p>Applications N,N'-(1,2-Propylene)thiourea is an intermediate used in various organic chemical reactions such as the preparation of aryl 2-Iminoimidazoline derivatives.<br>References O’Donovan, D.H., et al.: Tetrahedron. Lett., 53, 4532 (2012); Liu, K.C., et al.: J. Chin. Chem. Soc., 24, 65 (1977);<br></p>

<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>

<p>Applications Dexketoprofen Trometamol is an non-steroidal anti-inflammatory drug used for the treatment of mild to moderate pain.<br>References Gokce, B., et al.: J. Enzyme. Inhibit. Med. Chem., 27, 37 (2012); Sagiroglu, G., et al.: Eurosian. J. Med., 43, 23 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Methyl Isofenphos is an organophosphorus compound, that according to biological studies, can cause acute toxicity to animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, S.: Huanjing Wuran Yu Fangzhi, 20, 13 (1998); Yin, Y., et al.: Huanjing Yu Jiankang Zazhi, 28, 583 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>

<p>Applications Direct Blue 6 is a deep blue azo dye used in textiles however contributes to environmental pollution and potentially reproductive toxicity.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Wu, S. et al.: Chem. Res. Toxicol., 26, 1840 (2013); Wang, P. et al.: J. Alloys. Comp., 701, 759 (2017);<br></p>

<p>Applications A specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>

<p>Applications Controlled substance (stimulant). Anorexic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stewart, J.T., et al.: J. Pharma. Sci., 60, 461 (1971),<br></p>

<p>Applications Flupyrimin is used in the method for controlling pests of sugarcane, citrus, rapeseed, and potato plants.<br>References Huang, H., et al.: Eur. Pat. Appl. 48pp (2020)<br></p>

<p>Stability Hygroscopic, Unstable in Solution<br>Applications Hetacillin is a β-lactam antibiotic.<br>References Newall, C.E., Hallam, P.D.: Comp. Med. Chem., 2, 609 (1990)<br></p>

<p>Stability Very Hygroscopic<br>Applications 3-Methylglutarylcarnitine Chloride is the chloride salt of M226345, which is derived from DL-Carnitine Benzyl Ester Chloride (C184135), which is an intermediate in the synthesis of 3-Hydroxybutyrylcarnitine Hydrochloride (H830900), a reagent used to study acylcarnitine profile in thyroid disease.<br>References Hintze, U., et al.: Lipids., 10, 20 (1975)<br></p>

<p>Applications 2-[4-(2,4-Dichloro-5-hydroxyphenoxy)phenoxy]propanoic Acid Methyl Ester, is the metabolite of Diclofop-methyl, used as a herbicide.<br>References Tanaka, F. S., et al.: J. Agri. Food Chem., 38, 553 (1990);<br></p>

<p>Applications O,O-Dimethyl-d6 Dithiophosphate is the isotope labelled analog of O,O-Dimethyl Dithiophosphate (3, an dimethyl phosphorodithiolate derivatives used as insecticides.<br></p>

<p>Applications Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Knize, M.G., et al: Envir. Health Perspectives, 67, 17 (1986), Stavric, B., et al.: Fd. Chem. Toxic., 31, 981 (1993), Sugimura, T., et al.: Mutation Res., 290, 43 (1993), van Herwaarden, A.E, et al.: Cancer Res., 63, 6447 (2003),<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References IARC Monographs, 4, 97 (1974),<br></p>

<p>Applications 4,4'-Dichlorodiphenyltrichloroethane is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989);<br></p>

<p>Applications Bispyribac is used as a herbicide for the prevention and control of weeds.<br>References Alister, C., et al.: Crop Prot., 25, 202 (2006), Chandi, G., et al.: J. Food Eng., 79, 592 (2007), Wilkowska, A., et al.: Food Chem., 125, 803 (2011),<br></p>

<p>Applications Labelled Tiludronic Acid (T441250). A biphosphonate bone resorption inhibitor.<br>References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),<br></p>

<p>Applications A glucuronide metabolite of Chlorpyrifos (C425300).<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.<br>References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analog of aminomethanephosphonic acid (A617340), a degradation product of glyphosate (G765000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goupe, R.H., et al.: Pest. Manag. Sci., 68, 16 (2012); Saxton, M.A., et al.: J. Great. Lakes. Res., 37, 683 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.<br>References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Impurity Hydrocortisone Acetate EP Impurity E<br>Applications Anecortave (Hydrocortisone Acetate EP Impurity E) is an angiostatic steroid. Used in treatment of macular degeneration.<br>References Clark, A.F., et al.: Expert Opin. Invest. Drugs, 6, 1867 (1997), Slakter, J.S., et al.: Ophthalmology 110, 2372 (2003),<br></p>

<p>Applications Picolinafen-d4 is deuterium labelled Picolinafen (P436800), a pesticide. It is a molecule for selective post emergence weed control in wheat and barley.<br>References Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010); Sinclair, C., et al.: Environ. Sci. Technol., 40, 7283 (2006); Magnani, D., et al.: Atti, Giornate fitopatologiche, Perugia, 2, 405 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Tubercidin is used as a chemotherapeutic agent in the treatment of cancer. Also used in the treatment of cardiovascular disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murray, V. et al.: Exp. Parasitol., 132, 440 (2012); Szentmiklosi, A. et al.: Curr. Med. Chem., 18, 1164 (2011);<br></p>

<p>Applications A metabolite of 6β-Naltrexol (N285700). Narcotic antagonist.<br>References Portoghese, P. et al,: J. Med. Chem., 37, 579 (1994); Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1998);<br></p>

<p>Applications 4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.<br>References El-Moghazy, S.M. et al.: J. Chin. Chem. Soc., 56, 360 (2009); Gorski, L. et al.: Anal. Bional. Chem., 389, 533 (2007);<br></p>

<p>Applications Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect crops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several bacteriosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, M. et al.: Turang Tong., 41, 1365 (2010); Navneet; M. et al.: J. Ind. Botan. Soc., 74, 19 (1995); Lecigne, P. et al.: Phytoma, 531, 13 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications Empagliflozin is a novel, potent and selective SGLT-2 inhibitor. It improves glycaemic control syndrome in diabetic rats.<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>

<p>Applications Chloroxuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Daidzein-3',5',8-d3 is labelled Daidzein (D103500) which is an inactive analog of Genistein (Cat. #G350000). It blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity.<br>References Jones, P., et al.: J. Biol. Chem., 274, 32008 (1999), Hassan, M., et al.: Anticancer Res., 19, 5657 (1999), Salti, G., et al.: Eur. J . Cancer, 36, 796 (2000).<br></p>

<p>Stability Very Hygroscopic<br>Applications rac Tenofovir-d6 Diphosphate Triethylamine Salt is an isotopic analog of Tenofovir Diphosphate Triethylamine Salt (T018525), which is a metabolite of Tenofovir (T018500).<br>References Hazra, R., et al.: Antimicrob. Agents Chemother., 48, 124 (2004), Piketty, C., et al.: Antivir. Ther., 11, 213 (2006), Molto, J., et al.: Ther. Drug Monit., 29, 648 (2007),<br></p>

<p>Applications Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications cis-9-Hexadecenoylcarnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Minkler, P. et al.: J. Chrom. B., Anal. Tech. Biomed. Life Sci. 1061, 128 (2017);<br></p>

<p>Applications Saflufenacil is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010);<br></p>

<p>Applications Pyrisoxazole is a novel fungicide, inhibitor of Sterol 14α-demethylase.<br>References Chen, F., et al.: Plant Dis., 96, 416 (2012); Chen, F., et al.: Sci. Rep., 4, 6473 (2014);<br></p>

<p>Applications A vasodilator.<br>References Varga, J., et al.: Mol. Immunol., 28, 641 (1991), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005),<br></p>

<p>Applications Fosetyl Aluminum is a fungicide. It is highly inhibitory in vitro against several species of Phytophthora.<br>References Fenn, M., et al.: Phytopathology, 74, 606 (1984); Matheron, M., et al.: Plant Disease, 84, 454 (2000)<br></p>

<p>Applications Zinc Thiozole is a fungicide.<br>References Domagalina, E., et al.: Fresenius' Zeitschrift fuer Analytische Chemie, 207, 411-14 (1965);<br></p>