Toxicology

<p>Applications Carcinogenic compound commonly found in hair dyes and henna ink, also a commonly used synthetic intermediate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mulyono; T., et al.: J. Biosci. Bioeng., 103, 147 (2007), Mosley-Foreman, C., et al.: Food Chem. Toxicol., 46, 3780 (2008), Patel, A.K., et al.: J. Agric. Food Chem., 56, 9236 (2008), Akyuz, M., et al.: J. Pharm. Biomed. Anal., 47, 68 (2008),<br></p>

<p>Applications A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor. It is a COVID19-related research product.<br>References Li, Q., et al.: J. Med. Chem., 39, 3070 (1996), Ptasznik, A., et al.: Nat. Med., 10, 1187 (2004), Tetsuo, A., et al.: Bioorg. Med. Chem. Lett., 16, 1421 (2006),<br></p>

<p>Applications Labelled N-Methylserotonin, the N-methylated derivative of serotonin with similar activity. Studies have identified N-Methylserotonin as a potential active constituent that contributes to the serotonergic activity of black cohosh.<br>References Powell, S.L. et al.: J. Agric. Food Chem., 56, 11718 (2008); Mais, D.E. et al.: J. Chrom. Biomed. Appl., 225, 27 (1981);<br></p>

<p>Applications N,N-Diethyl-3-methyl-d3-benzamide-2,4,5,6-d4 (CAS# 1219799-37-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone 21-Chlorocypionate, is a derivative of Testosterone Cypionate (T155100), which is an anabolic steroid with androgenic properties. Testosterone Cypionate is used for testosterone therapy in males with hypogonadism.<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010);<br></p>

<p>Applications Protected metabolite of Theobromine.<br>References Tarka, S.M., et al.: Clin. Pharmacol. Therap., 34, 546 (1983), Bonati, M., et al.: Toxicology, 30, 327 (1984)<br></p>

<p>Applications Biscarfentrazone is herbicidal compounds.<br>References Trabold, K., et al.:PCT Int. Appl.,(2020);<br></p>

<p>Stability Hygroscopic<br>Applications Mefenamic acid metabolite.<br>References Besunder, J., et al.: Clin. Pharmacokinet., 14, 261 (1988), Smith, P., et al.: Drug Metab. Dipos., 18, 639 (1990), Kraus, D., et al.: Clin. Pharmacol. Ther., 54, 351 (1993), Sato, J., et al.: Biol. Pharm. Bull., 16, 811 (1993),<br></p>

<p>Applications Clothianidin-d3 (N-methyl-d3) (CAS# 1262776-24-8) is a useful isotopically labeled research compound. This compound can be used to detect trace levels of neonicotinoid insecticides in honey bee royal jelly using ultra-sound assisted liquid-liquid extraction-UHPLC/MS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Giroud, B., et.al., Microchemical J., 151,104249,(2019);<br></p>

<p>Applications Labelled 2-Chloropyridine (C380605). (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),<br></p>

<p>Applications PropamocarbHydrochloride (CAS# 25606-41-1) is a useful research chemical compound.<br></p>

<p>Applications Used as an anticholinergic<br>References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971)<br></p>

<p>Applications N-Hydroxy Vortioxetine O-β-D-Glucuronide Sodium Salt, is a metabolite of Vortioxetine (V766000, HBr); a multimodal serotonergic agent which inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013); Uldam, H.K., et al.: Drug Metab. Dispos., 39, 2264 (2011)<br></p>

<p>Applications Dihydrotestosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.<br>References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)<br></p>

<p>Applications (R)-Dimethenamid is the R-enantiomer of Dimethenamid (D460580(P)), which is a preemergence herbicide for use in food crops.<br>References Couderchet, M., et al.: Pestic. Sci., 50, 221 (1997), Barriuso, E., et al.: Environ. Sci. Technol., 42, 1845 (2008), Matthies, M., et al.: Environ. Pollut., 156, 99 (2008),<br></p>

<p>Stability very hygroscopic<br>Applications Labelled Ivabradine (I940500). Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>

<p>Applications Karetazan is used in the preparation of Pyrazole derivatives as pesticides as well as as a chemical hybridisation agent for commercial hybrid seed production.<br>References Buysse, A., et al.: U.S. Pat. Appl. Publ., 118 (2016); Walsh, M., et al.: U.S. Pat. Appl. Publ. 77., (2015)<br></p>

<p>Applications N-Methyl Ticlopidine-13C,D3 iodide is a labelled analogue of N-Methyl Ticlopidine iodide (M330270). N-Methyl Ticlopidine iodide is a derivative of Ticlopidine (T438325), a compound that antagonizes adenosine diphosphate-stimulated platelet aggregation.<br>References Kimchi, N., et al.: Digestion, 75, 36 (2007)<br></p>

<p>Applications O-Desethyl O-Isopropyl Dabigatran Etexilate-d13 is the labelled form of O-Desethyl O-Isopropyl Dabigatran Etexilate (D289378). O-Desethyl O-Isopropyl Dabigatran Etexilate is an impurity of Dabigatran Etexilate Mesylate (D100150). Dabigatran Etexilate Mesylate is a nonpeptide, direct thrombin inhibitor and an Antithrombotic agent.<br>References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>

<p>Applications 17α-Testosterone-16,16,17-d3 Cypionate is the isotope labelled analog of 17α-Testosterone Cypionate (T155155); the 17α-isomer of Testosterone Cypionate (T155100) which is an anabolic steroid with androgenic properties. Also used for testosterone therapy in males with hypogonadism.<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications Thiacloprid-d4 is the isotope labelled analog of Thiacloprid, which is a chloronicotinyl insecticide for use in fruits and vegetables.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nauen, R., et al.: Pestic. Sci., 53, 133 (1998), Jetter, R., et al.: Plant Physiol., 126, 1725 (2001), Weichert, H., et al.: J. Agric. Food Chem., 54, 6294 (2006), Hoffmann, E., et al.: J. Insect. Sci., 8 (2008),<br></p>

<p>Applications 2-Chloro-4-nitrophenol is used as a sole source of carbon and nitrogen by Cupriavidus strain a3.<br>References Tiwari, J., et al.: Bioresour. Technol., 223, 184-191 (2017)<br></p>

<p>Applications Sorbic Acid-13C2 is an isotope labelled compound of Sorbic Acid (S676890). Sorbic Acid is a naturally occurring organic compound first isolated from unripe berries. Sorbic acid has been used as a food preservative and as an inhibitor of Clostridium Botulinum bacteria in meat products in order to reduce the amount of nitrites which produce carcinogenic nitroamines.<br>References Van, M.C., et al.: Int. J. Food. Microbiol., 160, 124 (2012); Li, J., et al.: J. Am. Soc. Mass. Spec., 23, 1625 (2012);<br></p>

<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>

<p>Applications Isotope labelled 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);<br></p>

<p>Applications Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.<br>References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Della Paschoa, O.E., et al.: Br. J. Pharmacol., 125, 1610 (1998), Grimes, C.A., et al.: J. Neirochem., 73, 1384 (1999), Loscher, W., Prog. Neurobiol., 58, 31 (1999),<br></p>

<p>Applications 3,5-Dichloroaniline-2,4,6-d3 (CAS# 1219795-03-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Metazachlor Oxalic Acid-d6 is deuterium labelled form of Metazachlor Oxalic Acid (M226230), which is a chloroacetanilide herbicide metabolite that has been detected in surface water and groundwater from urban surfaces runoff.<br>References Reemtsma, T., et al.: Water Res., 47, 5535 (2013);<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dong, Y., et al.: Bioorg. Med. Chem. Lett., 20, 4085 (2010), Vassiltsova, O., et al.: J. Nanosci. Nanotechnol., 10, 1635 (2010), Garcia-Lavandeira, J., et al.: Anal. Bioanal. Chem., 397, 751 (2010),<br></p>

<p>Applications Naftalofos<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications An anlogue of β-Carotene (C184250). Decapreno-β-carotene is used as an internal standard for the quantification of the hydrocarbon carotenoids by HPLC.<br>References Hemley, R., et al.: Biophysical J., 20, 377 (1977), Taylor, R.F, et al.: Methods Enzymol., 67, 233 (1980),<br></p>

<p>Applications 2,4-Dimethylphenol is used both as a pesticide to ward of insects or other common pests from crops from crops as well as in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. This is a labelled analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, B. et al.: J. Agri. Chem., 58, 2673 (2010); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); J. Agri. Chem., 46, 1276 (1999); Kim, S. et al.: J. Agri. Chem., 59, 4570 (2011);<br></p>

<p>Applications Acetophos is used as an insecticide.<br>References Saito, T., et al.: Bochu Kagaku. 31, 77 (1966)<br></p>

<p>Applications Isotope labelled (R,R,S,R)-Nebivolol Hydrochloride is a stereoisomer of rac Nebivolol (N387900) which is a β1-Adrenergic blocker. Nebivolol is used as an antihypertensive.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988); De Cree, J., et al.: Angiology, 41, 95 (1990)<br></p>

<p>Applications A piperidine based pesticide<br>References Iwakubo, M., et al.: Bioorg. Med. Chem., 15, 350 (2007), Jia, P., et al.: Eur. J. Med. Chem., 44, 772 (2009),<br></p>

<p>Applications 3,5,6-Trichloro-8-quinolinecarboxylic Acid is an impurity of Quinclorac (Q670300), which is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds, particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.<br>References Haden, E. et al.: Proc. Br. Corp. Prot. Conf. Weeds, 1, 77 (1985); Chism, W.J. et al.: Weed Sci., 39, 62 (1991); Grossmann, K. et al.: Weed Sci., 46, 707 (1998);<br></p>

<p>Applications 10β-Hydroxyl Dextrorphan 3-O-β-D-Glucuronide is a metabolite of Dextrorphan.<br>References Thurman, E. Michael., et al.: J. Chrom. A., 1259, 158-166 (2012)<br></p>

<p>Applications Propicillin, is a derivative of penicillin. Properties are similar to benzylpenicillin particularly used in streptococcal infections, not resistant to penicillinase.<br>References Fleming, A., et al.: Br. J. Exp. Pathol., 10, 226 (1929), Clutterbuck, P.W., et al.: Biochem. J., et al.: 26, 1907 (1932), Chain, E., et al.: Lancet, 2, 226 (1940),<br></p>

<p>Applications Fluoxetine (F597100) derivative. A stereoselective inhibitor of serotonin re-uptake and phosphodiesterase. Potential antidepressants<br>References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)<br></p>

<p>Applications Prazosin Hydrochloride Dihydrate (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.<br>References Jaillon, P., et al.: Clin. Pharmacokinet., 5, 365 (1980), Russell, I.J., et al.: J. Rheumatol., 12, 94 (1985), Kostek, L.J.: Anal. Profiles Drug Subs., 18, 351 (1989),<br></p>