Toxicology

<p>Applications N,N-Diethyl-3-methyl-d3-benzamide-2,4,5,6-d4 (CAS# 1219799-37-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Triticonazole is a small molecule pesticide compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Biscarfentrazone is herbicidal compounds.<br>References Trabold, K., et al.:PCT Int. Appl.,(2020);<br></p>

<p>Applications 3-Benzyloxybutyrylcarnitine O-Benzyl Chloride is an intermediate used in the synthesis of 3-Hydroxybutyrylcarnitine Chloride (H830900), which is a reagent used to study acylcarnitine profile in thyroid disease.<br>References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)<br></p>

<p>Applications Endosulfandiol is a metabolite of Endosulfan (E555505), an insecticide that poses health risks to humans and animals that acquire it through ingestion, inhalation, and percutaneous contact. Despite its potential risks, it is still being widely used all around the globe to protect cotton, sugarcane, and vegetable crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cerrillo, I., et al.: Environ. Res., 98, 233 (2005); Bhalerao, T. &amp; Puranik, P.: Int. Biodeter. Biodegr., 59, 315 (2007); Kalender, S., et al.: Toxicology, 202, 227 (2004); Naqvi, S. &amp; Vaishnavi, C.: Comp. Biochem. Phys. C, 105, 347 (1993)<br></p>

<p>Applications 1S-cis-Bifenthrin is a pyrethroid which was evaluated in vitro and the interactions with estrogen receptor were predicted to determine disruption of the hormonal network and the enantioselectivity of bifenthrin in trophoblast. 1S-cis-Bifenthrin was observed to have greater effects of consistent enantioselective interference o hormone signaling. Thus, 1S-cis-Bifenthrin are of significant concern to maternal-fetal health.Third generation synthetic pyrethroid. Insecticide, acaricide. Used in Pesticide detection<br>References Zhao, Meirong., Environmental Science &amp; Technology, 48, 8109-8116, (2014)Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Labelled 2-Chloropyridine (C380605). (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),<br></p>

<p>Applications PropamocarbHydrochloride (CAS# 25606-41-1) is a useful research chemical compound.<br></p>

<p>Applications Used as an anticholinergic<br>References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971)<br></p>

<p>Applications N-Boc-(Ethylamino)-1,1-dimethylethyl Ester Fluvoxamine is an intermediate used in the synthesis of N-(Ethylamino) Fluvoxamine (E898280), which is a Fluvoxamine impurity.<br></p>

<p>Applications N-(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)-N-methylurea is a photolysis product of herbicide Tribenuron-methyl (T767555) on glass, soil, and plant surfaces.<br>References Bhattacharjee, A., Dureja, P.: J. Environ. Sci. Health B, B37, 131 (2002); Marzouk, E., et al.: J. Appl. Sci. Res., 9, 4907 (2013);<br></p>

<p>Applications Dihydrotestosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.<br>References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)<br></p>

<p>Applications (R)-Dimethenamid is the R-enantiomer of Dimethenamid (D460580(P)), which is a preemergence herbicide for use in food crops.<br>References Couderchet, M., et al.: Pestic. Sci., 50, 221 (1997), Barriuso, E., et al.: Environ. Sci. Technol., 42, 1845 (2008), Matthies, M., et al.: Environ. Pollut., 156, 99 (2008),<br></p>

<p>Stability very hygroscopic<br>Applications Labelled Ivabradine (I940500). Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>

<p>Applications Karetazan is used in the preparation of Pyrazole derivatives as pesticides as well as as a chemical hybridisation agent for commercial hybrid seed production.<br>References Buysse, A., et al.: U.S. Pat. Appl. Publ., 118 (2016); Walsh, M., et al.: U.S. Pat. Appl. Publ. 77., (2015)<br></p>

<p>Applications Rotigotine β-D-Glucuronide is a metabolite of Rotigotine (R700700).<br>References Braun, M., et al.: Eur. J. Neurol., 12, 96 (2005), Cawello, W., et al.: Clin. Pharmacokinet., 46, 851 (2007), Poewe, W., et al.: Lancet Neurol., 6, 513 (2007),<br></p>

<p>Applications 3’-Dechloro-4’-chloro Bupropion is an impurity of Bupropion (B689625), a arylaminoketone based monoamine reuptake inhibitor.<br>References Soroko, F., et al.: J. Pharm. Pharmacol., 29, 769 (1977); Tucker, W.E., J. Clin. Psychiatry, 44, 60 (1983); Hsyu, P-H., et al.: J. Clin. Pharmacol., 37, 737 (1997); West, R., et al.: Expert Opin. Pharmacother., 4, 533 (2003);<br></p>

<p>Applications N-Methyl Ticlopidine-13C,D3 iodide is a labelled analogue of N-Methyl Ticlopidine iodide (M330270). N-Methyl Ticlopidine iodide is a derivative of Ticlopidine (T438325), a compound that antagonizes adenosine diphosphate-stimulated platelet aggregation.<br>References Kimchi, N., et al.: Digestion, 75, 36 (2007)<br></p>

<p>Applications O-Desethyl O-Isopropyl Dabigatran Etexilate-d13 is the labelled form of O-Desethyl O-Isopropyl Dabigatran Etexilate (D289378). O-Desethyl O-Isopropyl Dabigatran Etexilate is an impurity of Dabigatran Etexilate Mesylate (D100150). Dabigatran Etexilate Mesylate is a nonpeptide, direct thrombin inhibitor and an Antithrombotic agent.<br>References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>

<p>Applications Plumbagin-d3 is labelled Plumbagin (P627000) which induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klotz, L., et al.: Molecules, 19 14902 (2014); Gupta, S., et al.: Cancer Metastasis Rev., 29, 405 (2010); Schramm, A., et al.: Vascul. Pharmacol., 56, 216 (2012)<br></p>

<p>Applications A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.<br>References Francis, R.J., et al.: Eur. J. Clin. Pharmacol., 23, 529 (1982), Pringle, T.H., et al.: Br. J. Clin. Pharmacol., 22, 527 (1986),<br></p>

<p>Stability Hygroscopic<br>Applications Thiacloprid-d4 is the isotope labelled analog of Thiacloprid, which is a chloronicotinyl insecticide for use in fruits and vegetables.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nauen, R., et al.: Pestic. Sci., 53, 133 (1998), Jetter, R., et al.: Plant Physiol., 126, 1725 (2001), Weichert, H., et al.: J. Agric. Food Chem., 54, 6294 (2006), Hoffmann, E., et al.: J. Insect. Sci., 8 (2008),<br></p>

<p>Applications 4-Methylsulfonyl-2-nitrobenzoic acid is a metabolite of Mesotrione.<br>References Guengerich, F., et al.: Drug Metab. Rev., 34, 607 (2002), Kurian, J., et al.: Chem. Res. Toxicol., 19, 1366 (2006), Yang, C., et al.: Biotechnol. Lett., 29, 487 (2007), Beaudegnies, R., et al.: Bioorg. Med. Chem., 17, 4134 (2009),<br></p>

<p>Applications Thiamine Hydrogen Succinate is an intermediate in the synthesis of Vitamin B1 O-Succinic Acid-N-Hydroxy Succinimide which is a useful synthetic intermediate and a related compound of thiamine (T344185). Thiamine or vitamin B1 is an essential nutrient required for carbohydrate metabolism and it is also involved in nerve function.<br>References Kawaski, T., et al.: Methods Enzymol., 122, 15 (1986); Mascher, H., et al.: J. Pharm. Sci., 82, 56 (1993)<br></p>

<p>Applications Isotope labelled cis-5-Dodecenoyl Carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007);<br></p>

<p>Stability Volatile<br>Applications tert-Butylamine is common reagent in pharmaceuticals syntheses. Used in the preparation of aminoBODIPY compounds for chemical analyses. Also it aids in the synthesis of benzylurea-based insecticides containing amide and sulfonate groups. It has also been used in the synthesis of BPTES analogs, that act as glutaminase inhibitors, which can attenuate the growth of human lymphoma B cells. This is the labeled analog.<br> E0<br>References Osorio-Martinez, C. et al.: J. Org. Chem., 77, 5434 (2012); Sun, R. et al.: J. Agri. Food, Chem., 61, 517 (2013); Shukla, K. et al.: J. Med. Chem., 55, 10551 (2012);<br></p>

<p>Applications 3,4-Dichloroaniline-d2 (cas# 1219803-22-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Mycophenolic Acid β-D-Glucuronide Disodium Salt is A metabolite of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.<br>References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)<br></p>

<p>Applications Malathion-d7 (dimethyl-d6; 3-d1) (CAS# 352438-94-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone 17-Hexahydrobenzoate-d11 is the isotope analog of Testosterone 17-Hexahydrobenzoate. Testosterone 17-Hexahydrobenzoate is a metabolite of testosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications Α labelled metabolite of Tamoxifen (T006000).<br>References Sun, D., et al.: Breast Cancer Res., 8(4), (2006), Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007),<br></p>

<p>Applications 10β-Hydroxyl Dextrorphan 3-O-β-D-Glucuronide is a metabolite of Dextrorphan.<br>References Thurman, E. Michael., et al.: J. Chrom. A., 1259, 158-166 (2012)<br></p>

<p>Applications Synthetic thrombin inhibitor. Antithrombotic.<br>References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),<br></p>

<p>Applications Palmitoyl-L-carnitine-d3 Hydrochloride is labelled Palmitoyl-L-carnitine Hydrochloride (P155050), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications 3-trans-Hydroxy Norcotinine (cas# 1292911-83-1) is a compound useful in organic synthesis.<br></p>

<p>Applications An antitussive. Controlled substance (opium derivative).<br>References Kabayashi, S., et al.: Arzneim.-Forsch., 20, 43 (1970), Yanagita, T., et al.: Bull. Narc., 29, 33 (1977),<br></p>

<p>Applications 7-Methyltryptophol is a metabolite of Tryptophan (T947200), an essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Codeine (C634075). Analgesic (narcotic); antitussive.<br>References Frances, B., et al.: J. Pharm. Exp. Ther., 25, 262 (1992), Osborne, R., et al.: Br. J. Clin. Pharm., 34, 130, (1992),<br></p>