Toxicology

<p>Applications A β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder.<br>References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985), Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986),<br></p>

<p>Applications Cymoxanil-d3 (methoxy-d3) (CAS# 2140803-92-3) is a useful isotopically labeled research compound of Cymoxanil(C988995). Cymoxanil is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br>References Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012);<br></p>

<p>Applications Metribuzin DK is a selective triazine herbicide used in the control of broadleaf weeds. Used in the protection of vegetable and fruit crops. Pesticide.<br>References Xie, Y. et al.: Microchem. J., 133, 468 (2017);<br></p>

<p>Applications Diethanolamine similar to triethanolamine (T775580) is used as a surfactant. It also has the potential to be a corrosion inhibitor by means of chemisorption. This is the labelled analog.<br>References Bhajiwala, H.M et al.: Bull. Electrochem., 17, 441 (2001); Yu, J. et al.: Thin. Solid. Films., 379, 7 (2000);<br></p>

<p>Applications Chlorethoxyfos is an organophosphorous pesticide/insecticide.<br>References Li, S., et al.: Toxicology In Vitro, 56, 93 (2019); Yi, X., et al.: Sepu, 34, 1097 (2016); Can, A., et al.: Toxicol. Lett., 230, 434 (2014)<br></p>

<p>Applications Thiamine (T344185) derivative used in the treatment of neurogenic bladder dysfunction. It is absorbed from the intestine and rapidly metabolized into thiamine in the blood. Studies suggest that it has stimulant action on intestinal motility.<br>References Nihira, H. et al.: Hinyok. Kiyo, 12, 823 (1966); Shiobara, Y. et al.: Bitamin, 37, 306 (1968); Kuriaki, K. et al.: Bitamin, 41, 30 (1970);<br></p>

<p>Applications Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leather, G.R., et al.: Pestic. Biochem. Physiol., 7, 437 (1977),<br></p>

<p>Applications Pyrethrin is a pesticide most commonly used around homes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hudson, N.L., et. al.: Am. J. Ind. Med., 57, 15 (2014)<br></p>

<p>Applications 1H-1,2,4-triazole-3-sulfonamide (cas# 89517-96-4) is a useful research chemical.<br></p>

<p>Applications Ethyl Indole-3-acetate is a compound used in the synthesis of 9H-Pyrrolo[1,2-α]Indoles via Michael Addition-Condensation with α,β-Unsaturated Ketimines.<br>References Zhang, M., et al.: J. Heterocyclic Chem. (2016)<br></p>

<p>Stability Hygroscopic<br>Applications rac-Cotinine-d3 N-β-D-Glucuronide is a labelled racemic analogue of Cotinine N-β-D-Glucuronide (C725175), a major metabolite of Nicotine (N412420) in humans. Carcinogen.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),<br></p>

<p>Applications Alloxydim-sodium can be used to prepare methods and formulas for prevention of downward migration of agricultural materials, as well as, controlling of herbicide resistant or tolerant weeds.<br>References Essig, K., et.al., PCT Int. Appl., 84,(2020); Kraus, H., et.al., PCT Int. Appl., 75,(2019);<br></p>

<p>Applications Amiodarone is a non-selective ion channel blocker. Antiarrhythmic (class III).<br>References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984); Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991); Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)<br></p>

<p>Applications Thifensulfuron-methyl is a sulfonylurea herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhuang, Q-K., et al.: Huanjing Yu Jiankang Zazhi, 32, 621-623 (2015)<br></p>

<p>Applications Amfenac is an antibacterial agent for the treatment of otitis externa.<br>References Sofia, R.D., et al.: Pharmacol. Res. Communications, 11, 179 (1979),<br></p>

<p>Applications Flupyradifurone (F598615), the unlabelled version of Flupyradifurone-d5, can be used as an insecticide.<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications Propineb is used as a fungicide.<br>References Sharma, I.M., et. al.: J. Mycology Plant Pathology, 44, 92 (2014); Gupta, R.C., et. al.: Pestology, 37, 43 (2013)<br></p>

<p>Applications N-carbamoylformimidamide Tritosulfuron is a metabolite of Tritosulfuron (T886903) is a sulfonylurea herbicide found in in ground, surface and wastewater.<br>References Fenoll, J., et al.: Talanta, 101, 273 (2012); Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: Water Res., 47, 5535 (2013);<br></p>

<p>Applications Hydroxy Tyrosol 3-Sulphate is a metabolite of Hydroxy Tyrosol (H977000).<br>References Owen, R., et al.: Eur. J. Cancer., 36, 1235 (2000), Bakalbassis, E., et al.: Lipids, 36, 181 (2001), Nenadis, N., et al.: J. Agric. Food Chem., 51, 1874 (2003),<br></p>

<p>Stability Light Sensitive<br>Applications Disperse Polyester Dark Blue causes photocontact dermatitis in workers engaged in its manufacturing.<br>References Davies, Keith A., et al.: J. Appl. Chem. Biotechn., 25(3), 195-204 (1975)<br></p>

<p>Applications Brivaracetam-d7, is the labeled analogue of Brivaracetam (B677645), which is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications Semisynthetic aminoglycoside antibiotic, related to sisomicin. Antibacterial.<br>References Miller, G.H., et al.: Antimicrob. Agents Chemother., 10, 827 (1976), Raab, W., et al.: Adv. Clin. Pharmacol., 15, 91 (1978), Noone, P., et al.: Drugs, 27, 548 (1984),<br></p>

<p>Applications Xiaochongliulin is used in methods and formulations for preventing downward migration of agricultural materials.<br>References Essig, Kenneth J., et al.: PCT Int. Appl.,(2020);<br></p>

<p>Applications Topical anti-infective<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, S., et al.: Food Sci., Biotechnol., 17, 971 (2008), Mary, G., et al.: Chem. Pharm. Bull., 56, 888 (2008), Noda, Y., et al.: Int. J. Pharm., 372, 85 (2009),<br></p>

<p>Applications Aprepitant-d4 is a labeled analogue of Aprepitant (A729800), A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Aprepitant-d4 is a potential treatment for chemotherapy induced nausea and vomiting.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998); Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001); Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)<br></p>

<p>Applications Hydroxydiazinon is an organophosphorus pesticide.<br>References Xu, H.: Shijie Nongyao, 29, 42 (2007).<br></p>

<p>Applications Tetraoctyltin was coupled to C-H bonds of 2-aryl- and 2-benzyl-substituted 4,4-​dimethyl-​2-​oxazolines and pyridines to give the benzene ring-​alkylated products in good yields by using 5 mol % Pd(OAc)​2 as the catalyst.<br>References Chen, X., et al.: J. Am. Chem. Soc., 128, 78 (2006).<br></p>

<p>Applications 4-Chlorophenylamine is an organic chemical reagent and precursor in the synthesis of various drugs and dyestuffs. It is a building block and a degredation product of Chlorhexidine (C335045), an antiseptic as well as azo dyes and pigments in printing and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leucea, D. et al.: Ind. Text., 61, 304 (2010); Below, H. et al.: Microchim. Acta 146, 129 (2004);<br></p>

<p>Applications Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.<br>References Patick, A.K., et al.: Antimicrob. Agents Chemother., 40, 292 (1996), Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000)<br></p>

<p>Applications Hawkinsin is a urinary metabolite from the rare disorder of tyrosine metabolism, known as Hawkinsinuria; Also, it is derived from 4-Hydroxyphenylacetic Acid (H949060), which is a compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.<br>References Gomez-Ospina, N., et al.: J. Inherit. Metab. Dis., 39, 821-829 (2016); Shu, Y., et al.: Guangdong Huagong, 37, 108 (2010), Papadopoulos, G., et al.: J Am Oil Chem Soc, 68, 669 (1991),<br></p>

<p>Applications Anorexic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),<br></p>

<p>Applications Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.<br>References McDonald, M., et al.: Drugs Exp. Clin. Res., 10, 745 (1984), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 17, 221 (1988),<br></p>

<p>Applications Docetaxel is an antimitotic Taxol analog antibiotic.<br></p>

<p>Applications Labelled Ferulic acid (4-hydroxy-3-methoxycinnamic acid or, in IUPAC nomenclature, 3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid) which is a highly abundant phenolic phytochemical which is present in plant cell walls. It may have significant health benefits through its antioxidant and anti-cancer activity, and may also serve as a precursor in the manufacturing of useful aromatic compounds. Used as an antioxidant.<br>References Smart, M.G., et al.: Aust. J. Plant Physiol., 6, 485 (1979), Chen, C., et al.: J. Food Lipids, 2, 35,1995, Benzie, I., et al.: Anal. Biochem. 239, 70 (1996), Nardini, M., et al.: Food Chem., 79, 119 (2002), Lee, J., et al.: J. Agric. Food Chem., 52, 2647 (2004),<br></p>

<p>Applications Mevinphos is a pesticide used in the protection of crops. Insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rajski, L. et al.: Analyst, 138, 921 (2013); Lozano, A. et al.: J. Chrom. A., 1268, (2012);<br></p>

<p>Applications 3-Hydroxyglutaric Acid (cas# 638-18-6) is a compound useful in organic synthesis.<br></p>