Toxicology

<p>Applications 3-Ketocarbofuran is a metabolite of Carbofuran (C176590). A pesticide residue found in fruits and vegetables. 3-Ketocarbofuran causes cell migration in cell gel electrophoresis (SCGE) test.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abass, K., et al.: Chem-Biol. Interact., 18, 210 (2009); Ambrus, A., et al.: J. Environ. Sci. Heal. B., B40, 297 (2005); Usmani, K., et al.: Chem-Biol. Interact., 150, 221 (2004)<br></p>

<p>Stability Moisture Sensitive<br>Applications A cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pickering, W.R., et al.: Biochem. Pharmacol., 16, 1183 (1967)<br></p>

<p>Applications Cuprolinic Blue, has been shown to be able to form a particularly stable blue chromophore with single-stranded RNA in neuronal Nissl substance and nucleoli, and thus can be used for counterstaining of enteric neurons for peroxidase immunocytochemistry<br>References Holst, M., et al.: J. Neurosci., Meth., 62, 121 (1995);<br></p>

<p>Impurity Propofol EP Impurity E; Propofol USP Related Compound A<br>Applications Dipropofol (Propofol EP Impurity E) is a dimeric derivative of Propofol (P829750). Dipropofol is an antibacterial agent with strong activity againts Gram-positive bacteria. Dipropofol also displays antioxidant and radical scavenging activity. Propofol USP Related Compound A.<br>References Ogata, M. et al.: Chem. Pharm. Bull., 53, 344 (2005); Ogata, M. et al.: Biol. Pharmac. Bull., 30, 1565 (2007);<br></p>

<p>Applications Used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.<br>References Denny, W., et al.: J. Med. Chem., 33, 814 (1990), Maurya, M., et al.: J. Chem. Res., 446 (1998),<br></p>

<p>Applications Labelled Veratric Acid, a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.<br>References Alissandrakis, E. et al.: Eur. Food Res. Technol., 229, 365 (2009); Spaccini, R. et al.: Soil Biol. Biochem., 41, 1164 (2009); Narasimhan, B. et al.: Eur. J. Med. Chem., 44, 689 (2009); Pereira, L. et al.: J. Biotechnol., 139, 68 (2009);<br></p>

<p>Impurity Mometasone Furoate EP Impurity B<br>Stability Light Sensitive<br>Applications (11β,16α,17α)-9-Chloro-17-(2,2-dioxido-5H-1,2-oxathiol-4-yl)-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-androsta-1,4-dien-3-one (Mometasone EP Impurity B) is an impurity of Mometasone Furoate, a topical corticosteroid used as an anti-inflammatory.<br>References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)<br></p>

<p>Applications Spirotetramat Metabolite BYI08330-​cis-​enol is a metabolite and can be used as analyte in analytical and biological studies for multi-residue method for determination of pesticides and pesticide metabolites in honeybees by liquid and gas chromatography coupled with tandem mass spectrometry, used to investigate honeybee poisoning incidents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiljanek, T., et al.: J Chromatgr A, 1435, 100 (2016)<br></p>

<p>Applications Ethyl Deoxycholate is the ethyl ester of the common bile salt Deoxycholic Acid (D232645), a Cholic Acid (C432600) derivative used as a component in cell lysis buffers.<br>References Tuangtong, R. et al.: Dermatol. Surg., 36, 899 (2010); Araki, Y. et al.: Scand. J. Gast., 36, 533 (2001);<br></p>

<p>Applications 3’-Hydroxytyrosol 4’-Glucuronide Sodium Salt, is a glucuronide metabolite of Hydroxytyrosol (H977000) which is a metabolite of Tyrosol (T947800). Tyrosol is a phenolic antioxidant.<br>References Perez-Trujillo, M., et al.: J. Agric. Food Chem., 58, 9129 (2010), Gregus, P., et al.: J. Pharm. Biomed. Anal., 53, 674 (2010)<br></p>

<p>Applications A labelled metabolite of Nabumetone (N200500). A competitive, non-selective COX inhibitor.<br>References Turpeinen et. al.: Drug Metabolism and Dispositoin, 37: 1017 (2009); Daniels, F., et al.: J. Invest. Dermatol., 44, 259 (1965), Bosca, F., et al.: Photochem. Photobiol., 71, 173 (2000),<br></p>

<p>Applications Ciprofibrate is a hypolipemic agent, related structurally to Clofibrate (C586910). Ciprofibrate is used as an antilipemic.<br>References Davison, C., et al.: Drug. Metab. Dispos., 3, 520 (1975), Arnold, A., et al.: J. Pharm. Sci., et al.: 68, 1557 (1979), Tuchman-Duplessis, H., et al.: Toxicology, 12, 1 (1979),<br></p>

<p>Applications Isotope labelled Epoxiconazole is a fungicide used to inhibit the metabolism and growth of mycelia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gromadzka, K., et al.: Cereal. Res. Commun., 40, 518 (2012); Chen, Yu,, Plant. Disease., 96, 1495 (2012); Echeverria-Saenz, S., et al.: Sci. Total. Environ., 440, 106 (2012);<br></p>

<p>Applications Acetoacetyl-CoA is a derivative of CoA (C636400). In the mevalonate pathway, Acetoacetyl-CoA is a precursor of HMG-CoA (H456365), and a precursor of poly-beta-hydroxybutyrate.<br>References Okamura, E., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 11265 (2010)<br></p>

<p>Applications Labelled Talinolol. Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.<br>References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),<br></p>

<p>Applications Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors.<br>References Wentling, C.D., et al.: Anal. Profiles Drug Subs., 1, 65 (1972), Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999), Qian, H., et al.: J. Neurobiol., 40, 67 (1999), Qian, H., et al.: Mol. Pharmacol., 67, 470 (2005), Hadley, S., et al.: J. Physiol., 581, 1001 ( 2007),<br></p>

<p>Applications Iron Saccharate has been used to treat iron deficiency and iron deficiency anemia associated with different chronic diseases.<br>References Stein, J., et al.: Curr. Med. Res. Opinion, 28, 241 (2012),<br></p>

<p>Applications Paraquat is a quarternary nitrogen compound that is used as an herbicide to eliminate unwanted weeds and grasses by inducing superoxide production in the mitochondria, causing a great deal of oxidative damage. Paraquat is highly toxic to humans, causing acute poisoning, lung damage and death. Paraquat is also thought to cause Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cochemé, H., &amp; Murphy, M.: J. Biol. Chem., 283, 1786 (2008); Suntres, Z.: Toxicology, 180, 65 (2002); Yang, W., et al.: J. Toxicol. Env. Heal. Part A: 71, 289 (2008)<br></p>

<p>Impurity Azithromycin EP Impurity M<br>Applications Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Applications Sarolaner is used in the making of formulations for the control of ticks in cats, and flea infestations in dogs. A parasiiticide.<br>References Vatta, A. F., et al.: Veterinary Parasitol., 270, S19 (2019), Packianathan, R., et al.: Parasit. Vectors, 10, 387 (2017)<br></p>

<p>Applications Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.<br>References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001)<br></p>

<p>Applications Insect growth regulator. Insecticide.<br>References Hall, R.D., et al.: J. Econ. Entomol., 73, 564 (1980), Hart, R.J., et al.: Aust. Vet. J., 59, 104 (1982),<br></p>

<p>Applications Satisfar is a pesticide sprayed on plants and vegetables as insecticide to fend off pests.<br>References Cairns, T. et al.: J. Assoc. Off. Anal. Chem., 70, 858 (1987);<br></p>

<p>Stability Moisture Sensitive<br>Applications Fosthietan is used as a nematicide, to protect soils and crops from nematodes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Choudhari, K. &amp; Koli, S.: Pesticides, 12, 29 (1978); King, P., et al.: Anim. Prod. Sci., 22, 209 (1982); Murthy, M., et al.: Pesticides, 19, 40 (1985)<br></p>

<p>Applications R(-)-Methamphetamine is an intermediate in the synthesis of (R)-Benzphetamine Hydrochloride (B209870), the R-enantiomer of Benzphetamine (B209880). Controlled substance (stimulant). Anorexic.<br>References Stewart, J.T., et al.: J. Pharma. Sci., 60, 461 (1971),<br></p>

<p>Applications A labelled anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.<br>References Salako, L.A.: Arch. Int. Pharmacodyn, Ther., 184, 233 (1970); Vas, C.J. et al.: Neurol., 19, 234 (1969);<br></p>

<p>Stability Hygroscopic<br>Applications Used in the preparation of indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Stability Hygroscopic<br>Applications Piperacillin sodium is an antibiotic related to penicillin. Also, it possesses anti-microbial activity against enterobacteria.<br>References Zhang, Y., et al.: Linchuang Wuzhen Wuzhi, 27, 63-65 (2014)<br></p>

<p>Applications Fenoxycarb is a carbamate insect growth regulator by preventing immature insects from reaching maturity by mimicking juvenile hormone. Used as a standard for Pesticide detection. Fenoxycarb is also used in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El-Saeid, M.H., et al.: J. Chem., 10, (2013); Coors, A., et al.: Environ. Toxicol. Chem., 31, 1239 (2012);<br></p>

<p>Applications Prosulfuron is one of the 309 mostly pesticide active chemicals.<br>References Judson, R., et al.: Environ. Health Perspect., 118, 485 (2010).<br></p>

<p>Applications Labelled Mecoprop (M203052). Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Amisulpride (A633250). Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.<br>References Protais, P., et al.: Neuropharmacol., 24, 861 (1985), Perrault, G., et al.: J. Pharmacol. Exp. Ther., 280, 73 (1997),<br></p>

<p>Applications 2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates.<br>References Laha, J. K.; et al.: J. Org. Chem., 82, 7346 (2017).<br></p>

<p>Impurity Amlodipine EP Impurity H<br>Applications Amlodipine Besilate (A633500) impurity. Used in the process for preparing Amlodipine benzenesulfonate. Amlodipine EP Impurity H<br></p>

<p>Stability Light Sensitive<br>Applications Amidotrizoic Acid Dihydrate is used as a density gradient reagent for blood cell seperation. Diagnostic aid (radiopaque medium).<br>References Kalmer, J.R., et al., J. Immunol. Methods, 110, 275 (1988), Wang, Y., et al.: Br. J. Radiol., 170, 1229 (1997), Wong, V., et al.: Eur. J. Pharmacol., 433, 135 (2001).<br></p>

<p>Stability Very Very Hygroscopic<br>Applications Quetiapine is a dibenzothiazepine antipsychotic commonly used as monotherapy for patients with major depressive disorder and schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cutler, A., et al.: J. Clin. Psych., 70, 526 (2009); Kapur, S., et al.: Arch. Gen. Psych., 57, 553 (2000); Peuskens, J. &amp; Link, C.: Acta. Psych. Scand., 96, 265 (1997)<br></p>

<p>Applications A metabolite of Venlafaxine.<br></p>

<p>Applications β-(4-Chlorophenoxy)-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol is a agricultural fungicide that is systemically active against powdery mildews and rusts of grains.<br>References Echeverria-Saenz, S., et al.: Sci. Total. Environ., 440, 106 (2012); Hrouzkova, S., et al.: Int. J. Environ. Anal. Chem., 92, 1546 (2012); Loos, M., et al.: Environ. Sic. Technol., 46, 9830, (2012);<br></p>

<p>Applications SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.<br>References Bromidge, et al.: J. Med. Chem., 40, 3494 (1997), Kennet, et al.: Neuropharmacology, 36, 609 (1997), Dalton, et al.: Psychopharmacology, 185, 45 (2006),<br></p>

<p>Applications Tetrachloro-1,4-benzoquinone is a potential intermediate in the process of pentachlorophenol-induced carcinogenicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhu, B. et al.: Cham. Res. Toxicol., 22, 969 (2009);<br></p>

<p>Applications Telmisartan-d4 is deuterium labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998)<br></p>

<p>Applications Cyadox is an antibiotic drug and has the potential to be used as a feedstuff additive in promoting the growth of animals.<br>References Huang, C., et al.: J. Proteome, Res. 4, 537 (2013); Wu, H.X., et al.: J. Pharma. Biomed. Anal., 67, 175 (2012);<br></p>

<p>Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyloctan-1-ol Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Stability Unstable in Solution<br>Applications A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance.<br>References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);<br></p>