Toxicology

<p>Applications Octhilinone-d17 is a fungicide and an antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.<br>References Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991), Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1992), McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)<br></p>

<p>Applications Cefprozil Monohydrate (cas# 121123-17-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.<br>References Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997); Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007); Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>

<p>Applications β'-Phenyl Fentanyl is a potent analgesic and a derivative compound of the controlled substance Fentanyl (F274990). Fentanyl Analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhu, Y., et al.: Yaoxue Xuebao, 16, 199 (1981); Zernig, G., et al.: Life Sci., 57, 2113 (1995); Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998);<br></p>

<p>Applications Dimethachlor Oxalic Acid is a pesticide metabolite that is a pollutant found in untreated wastewater, surface water, and groundwater.<br>References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013); Neale, P., et al.: Sci. Total Environ., 576, 785 (2017);<br></p>

<p>Applications Isotope Labelled Triphenyltin Hydroxide (T809350), an organotin compound. Triphenyltin Hydroxide is used as a fungicide and antifeeding compound for insect control (1,2). Recent studies show that Triphenyltin Hydroxide may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Sarpa M. et al.: J Toxicol Environ Health A. 2010;73(13-14):965-712. Soderquist, J. et al.: J. Agric. Food. Chem. Jan:28(1);111-1173. 3. Golub, M. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2004 Jul-Aug;7(4):281-95<br></p>

<p>Applications Methyl-1-Testosterone is a derivative of dihydrotestosterone. Methyl-1-Testosterone is a designer anabolic steroid that is on the world anti-doping agency’s (WADA) prohibited list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parr, M.K. et al.: Endocrinology, 152, 4718 (2011); Liu, Y. et al.: Drug Test. Anal., 3, 54 (2011); Jeon, B.W. et al.: Anal. Bioanal. Chem., 401, 1353 (2011);<br></p>

<p>Applications A labelled metabolite of Diethylstilbestrol.<br>References Liehr, J.G., et al.: Steroids, 40, 713 (1982),<br></p>

<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>

<p>Applications An optical isomer of the local anesthetic Mepivacaine (M225060) that is slightly more active than its (+)-isomer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Luduena, F.P. et al.: Arch. Int. Pharmacodyn. Ther., 200, 359 (1972); Jeske, A.H. et al.: Meth. Find. Exp. Clin. Pharmacol., 3, 33 (1981);<br></p>

<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of the pesticide Glyphosphate (G765000).<br>References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);<br></p>

<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Atropine. Mydriatic; antispasmodic; used in preanesthetic medication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, R.V., et al.: Br. J. Pharmacol., 15, 170 (1960), Shutt, L.E., et al.: Anaesthesia, 34, 476 (1979), Hinderling, P.H., et al.: J. Pharm. Sci., 74, 703 (1985),<br></p>

<p>Stability Air Sensitive<br>Applications 4,5-Dichloro-2-octyl-3(2H)-isothiazolone (cas# 64359-81-5) is a useful research chemical.<br></p>

<p>Applications Spinetoram belongs to spinosyn family of insecticides and shows potential of natural products research.<br>References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)<br></p>

<p>Stability Moisture Sensitive, Hygroscopic<br>Applications Leaf-systemic broad-spectrum fungicide for use in cereal and food crops; member of methoxy-imiodihydro-dioxazines. Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Milus, E., et al.: Plant Dis., 78, 697 (1994), D'Mello, J., et al.: Eur. J. Plant Pathol., 104, 745 (1998), Domijan, A., et al.: Food Addit. Contam., 22, 677 (2005),<br></p>

<p>Applications N,N'-(1,2-Propylene)thiourea is an intermediate used in various organic chemical reactions such as the preparation of aryl 2-Iminoimidazoline derivatives.<br>References O’Donovan, D.H., et al.: Tetrahedron. Lett., 53, 4532 (2012); Liu, K.C., et al.: J. Chin. Chem. Soc., 24, 65 (1977);<br></p>

<p>Stability Air sensitive, Material darkens in storage with no loss in purity<br>Applications Aniline is used in the manufacture of dyes, medicinals, resins, varnishes, perfumes, as a vulcanizing rubber or even as a solvent (1,2). Hazardous and noxious substance which affects the early life stages of marine animals (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Barkov, A. et al.: Russ. Chem. Bull. 2012. Aug:61(8) pp1564-92. Zhang, X. et al.: Synthesis. 2013 45(10): 1357-13633. Cunha, I. et. al.: Environ. Sci. Pollut. Res. Int. 2017 Mar 10.<br></p>

<p>Applications An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.<br>References Chang, S.C., et al.: Science, 144, 57 (1964), Ames, M.M., et al.: Cancer Res., 39, 5016 (1979), D’Incalci, M., et al.: Br. J. Cancer, 41, 630 (1980),<br></p>

<p>Applications Isotope labelled Metolachlor (M338702), which is an acyanilide herbicide similar to selective pre-emergence herbicides (1). It is a contaminant in the groundwater and potential pollutant (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. McGahen, L. et al.: J. Agric. Food Chem. 1978 26 (2), pp 414–4192. Chesters, G. et al.: Rev. Environ Contam Toxicol. 1989;110:1-74.<br></p>

<p>Applications Analgesic (narcotic). Preparation by electrolytic reduction of Morphine.Controlled substance (opiate).<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Zernig, G., et al.: Life Sci., 57, 2113 (1995), Keith, D., et al.: J. Biol. Chem., 271, 19021 (1996), Pawar, M., et al.: Eur. J. Pharmacol., 563, 92(2007),<br></p>

<p>Applications Carbapenem is an antibiotic and antibacterial.<br>References Sunagawa, M., et al.: J. Antibiot., 43, 519 (1990), Hurst, M., et al.: Drugs, 59, 653 (2000),<br></p>

<p>Applications Methylparaoxon is used in esterase detoxication of acetylcholinesterase inhibitor pesticides using human liver samples in vitro.<br>References Moser, V. C., et al.: Toxicology, 353, 11 (2016)<br></p>

<p>Applications Oxamyl is a carbamate pesticide used to control nematode in protected crops and potato cultivation (1). Oxamyl metabolites are useful compounds to characterize omxamyl-degrading microbes and to investigate metabolic pathway of Oxamyl. Oximino Oxamyl is a metabolite of Oxamyl (O845140) in apple, orange, and tomato (2,3).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Rousidou, K., et al.: Front Microbiol. 29, 7 (2016)(2) Salama, A. K.: J Environ Sci Health B 33, 569 (1998)(3) Baines, R. C., and Small, R. H.: J Nematol. 8, 122 (1976)<br></p>

<p>Applications Iprovalicarb-d8 is the deuterated form of Iprovalicarb (I747500), which is a systematic fungicide. Iprovalicarb is used for the control of pathogenic fungi from the oomycetes class in grapes, potatoes, tomatoes and other crops.<br>References Stubler, D., et al.: Pflanzensch.-Nach. Bay., 52, 33 (1999); Stenzel, K., et al.: Bright. Crop Prot. Conf. Pests Dis., 2, 367 (1998);<br></p>

<p>Applications Sulfobromophthalein (BSP) is an organic dye used a for liver diagnostics in vitro. Reagent for the quantitative determination of proteins.<br>References 1. McGuire, J., et al. 1977. Anal. Biochem. 83: 75-81. PMID: 920954<br></p>

<p>Applications A novel antiplatelet agent; it is a third-generation thienopyridine. Antiplatelet agent Prasugrel showed greater platelet inhibition and decreased incidence of ischemic events than Clopidogrel but may induce increased incidence of bleeding in patient with acute coronary syndrome<br>References Von Beckerath, N., et al.: Circulation, 112, 2946 (2005), Jernberg, T., et al.: Eur. Heart J., 27, 1166 (2006), Farid, N., et al.: Drug Metab. Dispos., 35, 1096 (2007), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007), Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 49, 167 (2007), Wiviott, S., et al.: N. Engl. J. Med., 357, 2001 (2007),<br></p>

<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>

<p>Applications Dexketoprofen Trometamol is an non-steroidal anti-inflammatory drug used for the treatment of mild to moderate pain.<br>References Gokce, B., et al.: J. Enzyme. Inhibit. Med. Chem., 27, 37 (2012); Sagiroglu, G., et al.: Eurosian. J. Med., 43, 23 (2011);<br></p>

<p>Applications Diamidafos is a useful building block and a pesticide whose residues are sometimes found in fruits and vegetables.<br>References Kaewsuya, P.; et al.: J. Agric. Food. Chem., 61, 2299 (2013).<br></p>

<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Metabolite of Flurbiprofen (F598700).<br>References Van Breemen, R., et al.: Drug Metab. Disposition, 14, 197 (1986), Spraul, M., et al.: J. Pharm. Biomed. Anal., 11, 1009 (1993),<br></p>

<p>Applications An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.<br>References Park, J.M., et al.: J. Urol., 162, 1110 (1999), Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)<br></p>

<p>Applications N-Decarboxymethylated Indoxacarb is used in HPLC determination of DCJW in rat plasma and also has its application to pharmacokinetics studies<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang. H., et al.: Chromatographia, 66, 493 (2007);<br></p>

<p>Applications Propafenone-d5 Hydrochloride is labelled Propafenone which is a sodium channel blocker.<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983), Bryson, H. M., et al.:Drugs, 45, 85 (1993), Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998),<br></p>

<p>Stability Hygroscopic<br>Applications Methyl Isofenphos is an organophosphorus compound, that according to biological studies, can cause acute toxicity to animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, S.: Huanjing Wuran Yu Fangzhi, 20, 13 (1998); Yin, Y., et al.: Huanjing Yu Jiankang Zazhi, 28, 583 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>