Biochemicals and Reagents

<p>IL6 antibody was raised in mouse using recombinant human IL6 as the immunogen.</p>

<p>H-CIQNTGDYYDLYGGEK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CIQNTGDYYDLYGGEK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CIQNTGDYYDLYGGEK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CIQNTGDYYDLYGGEK-OH at the technical inquiry form on this page</p>

<p>Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.</p>

<p>Pigment Red 38 is a red dye that is used in the production of magnetic particles, cross-linking agents, and fluorescent dyes. Pigment Red 38 has a hydroxyl group at the 4 position and a methyl ethyl group at the 2 position. It can be synthesized from diethyl 4,4'-(3,3'-dichlorobiphenyl)-4,4'-diylbisazolate. Pigment Red 38 is thermoreversible because it can be converted to its anhydrous form when heated or dissolved in water and then reconverted back to its original form when cooled or dried. The pigment was named for its ability to produce light emission when exposed to ultraviolet radiation. Pigment Red 38 has a diameter of 6 nm and reacts with coordination complexes to form particle clusters with diameters ranging from 10-200 nm.</p>

<p>Please enquire for more information about N-(3-Sulfo)succinimidyl-p-formylbenzoate sodium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lysozyme antibody was raised in rabbit using full length protein corresponding to amino acids 1-129 of Hen Egg White lysozyme as the immunogen.</p>

<p>BQ-123 is a cyclic peptide that blocks the endothelin-A receptor. It has been shown to be an effective treatment for pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. BQ-123 binds to the endothelin-A receptor, which is located on the surface of cells in many tissues throughout the body. When bound, it inhibits intracellular calcium concentrations by reducing voltage-gated calcium channels and prevents the release of neurotransmitters. BQ-123 also has a stabilizing effect on hydrogen bonds due to its charged side chains. This property may account for its ability to form stable complexes with other proteins, inhibiting their function.<br>BQ-123 has been shown to have an active binding site on cyclic AMP response element binding protein (CREB) that inhibits CREB activity, thereby reducing protein synthesis. It also blocks cyclic GMP (cGMP)-dependent protein kin</p>

<p>H-HTVGHIILSEHK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-HTVGHIILSEHK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-HTVGHIILSEHK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-HTVGHIILSEHK-OH at the technical inquiry form on this page</p>

<p>Ac-CHAPYRNISQRISVDPVT-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CHAPYRNISQRISVDPVT-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CHAPYRNISQRISVDPVT-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CHAPYRNISQRISVDPVT-NH2 at the technical inquiry form on this page</p>

<p>Inhibitor of PDE4 enzyme; anti-inflammatory</p>

<p>Influenza B antibody was raised in mouse using Influenza B as the immunogen.</p>

<p>H-PECRITSNFVIPSEYWVEEK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PECRITSNFVIPSEYWVEEK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PECRITSNFVIPSEYWVEEK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PECRITSNFVIPSEYWVEEK-OH at the technical inquiry form on this page</p>

<p>Peptide LCBiot-SGRGKGGKGLGKGGAKRHRKV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Plasminogen antibody was raised in sheep using purified mouse plasminogen as the immunogen.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-VLFGLGFAI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VLFGLGFAI-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VLFGLGFAI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VLFGLGFAI-OH at the technical inquiry form on this page</p>

<p>IgG Fc antibody was raised in mouse using immunoglobulin G Fc region as the immunogen.</p>

<p>Purified Recombinant HSV1 gG protein</p>

<p>β-Sheet Breaker Peptide iAß5 (Bulk) is a peptide that inhibits the formation of β-sheets in proteins. It has been shown to be an excellent inhibitor of protein interactions, with good selectivity for its target. This peptide also has high purity and can be used as a research tool for studying the function of ion channels and antibodies.</p>

<p>Peptide LCBiot-VTSAPDTRPAPGSTAPPAHG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-LATGLR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LATGLR-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LATGLR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LATGLR-OH at the technical inquiry form on this page</p>

<p>H-DGTFPLPIGESVTVTR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DGTFPLPIGESVTVTR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DGTFPLPIGESVTVTR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DGTFPLPIGESVTVTR-OH at the technical inquiry form on this page</p>

<p>Inhibitor of dihydroorotate dehydrogenase; broad spectrum antiviral</p>

<p>H-GVLLPQK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GVLLPQK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GVLLPQK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GVLLPQK-OH at the technical inquiry form on this page</p>

<p>H-Ser-Phe-Leu-Leu-Arg-Asn-OH is a biocompatible polymer that has been shown to have strong antioxidative properties. This polymer has been used in the development of a new class of drug for the treatment of inflammatory bowel disease, which may be due to its ability to inhibit toll-like receptor activity. H-Ser-Phe-Leu-Leu-Arg-Asn-OH also has potent immunosuppressive and antiinflammatory activities, and is stable at doses up to 200mg/kg. These properties make this polymer an attractive candidate for use as a therapeutic agent in treating bowel disease.</p>

<p>Please enquire for more information about rel-DHMEQ including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fmoc-D-Pro-OH is a building block for peptide synthesis. It is a protected form of proline with an amido group, which can be used to synthesize polypeptides. Fmoc-D-Pro-OH can be coupled with other amino acids using the aldol condensation or methodologies like the strategy of organocatalysts. This building block is also useful in the synthesis of macrocycles and cyclohexanones, which are aliphatic and cyclic compounds. The recoverable nature of Fmoc-D-Pro-OH allows it to be reused in multiple reactions, so it is an economical choice for Building Blocks.</p>

<p>As a chemotactic peptide, For-Met-Leu-Phe (FMLP) has chemotactic properties, which means it can attract cells. For example it is a chemoattractant for phagocytic leukocytes and neutrophils. Neutrophils which have seven transmembrane G-protein coupled receptors are activated during the acute inflammatory response by FMLP and other chemotactic factors which bind to its surface receptors. This results in the activate of NF- κB, MAPK and PI3K pathways. In particular FMLP is known to induce Interleukin-8 (IL-8) which is responsible for both tissue damage and the pathogenesis of inflammatory processes resulting from neutrophils. Chemotactic peptide have been used to study the function of polymorphonuclear leukocytes and other white blood cells in inflammation. Chemotactic peptides are often used as fluorescent probes to measure intracellular metabolic responses to chemoattractant stimulation.<br>This product is available as a 0.5mg vial.</p>

<p>Inhibitor of EGFR receptor</p>

<p>Peptide H-ISTLNSHNLPILR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Cyclo(Arg-Ala-Asp-D-Phe-Val) is an active, cyclic peptide that has been shown to have localized effects on the metaphase, meiosis, and gamete cells. Cyclo(Arg-Ala-Asp-D-Phe-Val) is a cilengitide, which are small molecules that bind to calcium ions and increase intracellular levels of calcium. This leads to the activation of biochemical pathways in cells. Cyclo(Arg-Ala-Asp-D-Phe-Val) has been shown to have a diacylglycerol antagonist effect in porcine oocytes and was used in clinical trials for the treatment of infertility. Cyclo(Arg-Ala-Asp-D-Phe Val) also has apoptotic activity in cancer cells.</p>

<p>EDDnp is a potent and selective inhibitor of the proteolytic enzyme dipeptidyl peptidase IV (DPP-IV). EDDnp binds to the active site of DPP-IV, which prevents it from cleaving peptides at the carboxy terminus. The inhibition of DPP-IV results in an increase of peptide hormones such as glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), which are involved in regulating blood glucose levels. In addition, there are high values of EDDnp in human serum and urine, which may be due to its function as a potential biomarker for diabetes. The physiological function of EDDnp is still being investigated.</p>

<p>Boc-Cys(4-CH3Bzl)-OH is a building block for the synthesis of peptides and other biologically active molecules. It is a protected amino acid that can be used in peptide synthesis, and it is commonly used as a building block for the synthesis of Boc-protected L-amino acids.</p>

<p>A potent antagonist of androgen receptor with IC50 value of 16 nM. Binds androgen receptors, thereby inhibiting nuclear translocation, DNA binding and transcriptional activation. Has therapeutic applications in non-metastatic, castration-resistant prostate cancer.</p>

<p>The SLC12 family consists of nine member proteins, SLCA1 through to SLC12A9. Solute Carrier Family 12 Member 2 (SLC12A2) encodes a protein used in mediating the cotransport and reabsorption of Na+, K+ and 2Cl- ions (NKCC), it is a membrane-bound symporter channel needed for both epithelial absorption and secretion of ions. SLC12A2 spans the membrane and is necessary in maintaining ionic balance, cell volume and overall homeostasis of a cell.SLC12A2 is shown to be involved in neurodevelopment, specifically in the cortex, and is associated with neurodevelopmental disorders, with SLC12A2 mutation rate being significantly higher in individuals with neurodevelopmental issues. Additionally, mutations in SLC12A2 have been shown to cause issues with sensorineural pathways, causing hearing loss and deafness. Research into SLC12A2 and the SLC12 family as a whole could be beneficial in finding treatments for these complex neuronal issues.</p>

<p>Lactoferrin antibody was raised in mouse using lactoferrin from human milk as the immunogen.</p>

<p>Colivelin is a peptide that can be found in the central nervous system. It has been shown to have a wide variety of biological activities, including being an inhibitor of neuronal death, enhancing axonal growth and proliferation, and decreasing the activity of signal pathways. Colivelin has also been shown to inhibit the proliferation of human osteosarcoma cells by binding to their cell surface receptors.</p>

<p>PTH-Pyridylethylcysteine is a peptide that is used as a research tool in cell biology. It inhibits the interactions between proteins and receptors, which may be due to its ability to bind to the receptor. PTH-Pyridylethylcysteine also interacts with ion channels, which may contribute to its inhibitory effects on protein interactions. This peptide has been shown to inhibit the phospholipase Cγ2 (PLCγ2) enzyme, which is involved in cellular signaling pathways. The CAS number for this peptide is 484-03-7.</p>

<p>Glycerol-3 phosphate dehydrogenase antibody was raised in goat using glycerol-3-phosphate dehydrogenase isolated from rabbit muscle as the immunogen.</p>

<p>CNTF receptor alpha antibody was raised in goat using CNTF soluble receptor alpha as the immunogen.</p>

<p>Fmoc-ß-Ala-OH is a synthetic amino acid that is used in the synthesis of cyclic peptides. It has been shown to have receptor activity, such as the ability to bind to an erythrocyte membrane protein. Fmoc-ß-Ala-OH is also able to stimulate macrophage-like cells and polypeptide synthesis. Fmoc-ß-Ala-OH has been synthesized by chemical ligation, followed by purification on an agarose gel. This synthetic amino acid is used as a building block for affinity ligands, which are compounds that bind to specific receptors or other molecules with high specificity and affinity.</p>

<p>Streptavidin Poly-HRP80 Conjugate (diluted to 50 µg/ml in stabilizer 85R-104).</p>

<p>Peptide Ac-ADE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Boc-Tyr(Br-Z)-OH is a research tool used in the study of protein interactions and receptor pharmacology. It is an ion channel activator that binds to the Ligand-gated Ion channel receptor. Boc-Tyr(Br-Z)-OH has been shown to increase the rate of potassium ion permeability through the channel, which is associated with pain perception. This ligand also decreases calcium ion permeability, which may be beneficial for some conditions such as epilepsy or cardiac arrhythmia.</p>

<p>inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex in HT4 cells.  Causes accumulation of ubiquitinylated proteins in neuronal cells.</p>

<p>Duloxetine is a serotonin and norepinephrine reuptake inhibitor drug that is used to treat anxiety, pain, osteoarthritis and stress incontinence. This drug inhibits the reuptake of the neurotransmitters serotonin and norepinephrine so that there are increased levels of them in the synaptic cleft.</p>

<p>The PAPPA protein is a key player in various biological processes. It is involved in the regulation of TGF-beta and fibronectin, making it crucial for tissue development and repair. Our monoclonal antibody specifically targets the PAPPA protein, allowing for precise detection and analysis. This specific antibody has been extensively validated in Life Sciences research and is widely used in studies involving EGF-like growth factors. Additionally, our neutralizing antibody has shown promising results in blocking the activity of PAPPA, making it a valuable tool for investigating its role in various diseases. Whether you are studying autoantibodies, chemokines, or other growth factors, our Native Proteins &amp; Antigens collection offers high-quality reagents to support your research needs.</p>

<p>H-Glu(Tyr-OH)-OH is an amino acid analogue that has been shown to have natriuretic effects. It also has anti-inflammatory and analgesic properties, which are likely due to its ability to inhibit the bacterial enzyme arginase. H-Glu(Tyr-OH)-OH is a part of a class of compounds called oximes, which are used in the treatment of poisoning by organophosphates, pyrethroid insecticides, and carbamates. The compound is synthesized by treating L-glutamic acid with hydrogen peroxide and tyrosine in acidic conditions. H-Glu(Tyr-OH)-OH has also been found to have a protective effect on alcohol induced damage in rats. This may be due to its ability to increase the synthesis of dopamine, which is involved in the regulation of blood pressure and water balance.</p>

<p>Fmoc-Acc-OH is a proteolytic amino acid with an apical profile. It is used as a building block for peptide synthesis and as a tool for the synthesis of peptides, proteins, and other biomolecules. Fmoc-Acc-OH has been shown to induce apoptosis in cancer cells and viruses. This amino acid also has biochemical properties that include reversine-treated apoptotic signaling and anti-inflammatory activities.</p>