Biochemicals and Reagents

<p>MOPS is a morpholinic buffer with an optimal pH range of 6.5-7.9 and a pKa of 7.14. It does not coordinate metal ions and can be used in cell culture and electrophoresis.</p>

<p>Please enquire for more information about Procalcitonin Positive Human Plasma (Li Heparin) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is used to treat major depression, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and premenstrual dysphoric disorder. This drug inhibits the reuptake of serotonin which results in an increased synaptic concentration of serotonin in the CNS.</p>

<p>Peptide H-SSATTFRLLWENGNLLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>EGF antibody was raised in Mouse using recombinant human EGF as the immunogen.</p>

<p>Transmitted by mosquito vectors, Chikungunya is a positive-stranded RNA, alpha virus infecting human musculoskeletal tissues. The two glycoproteins E1 and E2 of the Chikungunya virus, to which this Mab is complementary to E2, are responsible for viral entry into host cells and both contain a transmembrane domain. Furthermore E2 has the three globular domains A, B and C which are linked by a β-ribbon connector region. While E2 is essential for mediating viral attachment, E1’s β-sheet structure and class II viral glycoproteins: DI, DII and DIII domains enable the virus to fuse with the host’s membrane. This primarily occurs through the insertion of the DII domain’s fusion loop into the host’s cell membrane.<br>Together E1 and E2 form a viral spike protein which when binding with high affinity to host alphavirus receptors such as Mxra8, allow this receptor to be inserted into E1 and E2. This results in Mxra8 contact between E2’s A and B domains and E1’s fusion loop. Neutralizing antibodies can target these domains, in particular A and B domains within E2, hence preventing viral attachment to host cells.This antibody can be used in the development of diagnostic assays for detection of Chikungunya virus.See also our other Chikungunya virus diagnostic reagents</p>

<p>Inhibitor of 3β-hydroxysteroid dehydrogenase in steroid biosynthesis</p>

<p>H-RVGTEDIPS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RVGTEDIPS-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RVGTEDIPS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RVGTEDIPS-OH at the technical inquiry form on this page</p>

<p>Zoledronic acid is a drug that is used for the treatment of malignancy associated with hypercalcemia and bone metastasis from tumors. This drug induces apoptosis pf hematopoietic tumor cells by inhibiting farnesyl diphosphate. Zoledronic acid is a bisphosphate that inhibits osteoclast function and bone resorption.</p>

<p>PMX 53 TFA is a synthetic cyclic peptide, which is derived from the advanced study of complement system interactors. This product, sourced from specialized peptide synthesis methodologies, functions through the inhibition of the C5a receptor, a key player in the immune response. By blocking this receptor, PMX 53 TFA modulates inflammatory pathways, effectively reducing overactive immune responses associated with various pathological conditions.</p>

<p>Potent and selective MAP/ERK kinase 1/2 inhibitor. Reduces growth of tumor cells with B-Raf and Ras mutations. Tumor regression observed after chronic treatment in in vivo xenograft models. Enhances anti-tumor effect in combination with irinotecan or docetaxel.</p>

<p>Metformin is a widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. This is due to it decreasing blood glucose by decreasing hepatic glucose product by activation of the AMP-activated protein kinase AMPK. Studies have also demonstrated Metformin to have anti-cancer activity, attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation.</p>

<p>3-o-Methyldopa d3 is an isotopically labeled analog of 3-o-Methyldopa, which is a deuterated compound used primarily in biochemical and pharmacokinetic research. This compound is a synthetic derivative where three hydrogen atoms are replaced by deuterium, offering a stable and non-radioactive isotopic tracer. The source of 3-o-Methyldopa d3 is chemical synthesis, where precise isotopic labeling techniques are employed.</p>

<p>Peptide H-IVEIPFNSTNK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-WKNDMVDQMHEDVIS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-WKNDMVDQMHEDVIS-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-WKNDMVDQMHEDVIS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-WKNDMVDQMHEDVIS-OH at the technical inquiry form on this page</p>

<p>Troponin I antibody (cardiac) was raised in mouse using human cardiac troponin I as the immunogen.</p>

<p>Peptide H-GYSFVTTAER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Cardiac Troponin T (cTnT) Mouse Monoclonal Antibody, Recombinant</p>

<p>Bovine albumin antibody was raised in rabbit using bovine serum albumin as the immunogen.</p>

<p>Decitabine is a synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. It has demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Also, it has anti-growth effects on solid tumor cell lines.<br>Decitabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Ac-ARGESPTPSFGQRNEC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-ARGESPTPSFGQRNEC-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-ARGESPTPSFGQRNEC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-ARGESPTPSFGQRNEC-NH2 at the technical inquiry form on this page</p>

<p>ATP competitive JAK2 inhibitor</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Inhibitor of CDK4/6 serine/threonine kinases; antineoplastic</p>

<p>Ac-CELSKTQNSISR-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CELSKTQNSISR-NH2 is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CELSKTQNSISR-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CELSKTQNSISR-NH2 at the technical inquiry form on this page</p>

<p>Ac-CWPSQTAEPGPAQ-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CWPSQTAEPGPAQ-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CWPSQTAEPGPAQ-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CWPSQTAEPGPAQ-NH2 at the technical inquiry form on this page</p>

<p>Topoisomerase II inhibitor; chemotherapeutic drug</p>

<p>Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.</p>

<p>H-GTEDIPSKI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GTEDIPSKI-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GTEDIPSKI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GTEDIPSKI-OH at the technical inquiry form on this page</p>

<p>H-VLMGNIASGAEPYIK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VLMGNIASGAEPYIK-OH is provided at greater that Flashpure (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VLMGNIASGAEPYIK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VLMGNIASGAEPYIK-OH at the technical inquiry form on this page</p>

<p>H-KLNSSVYSL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KLNSSVYSL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KLNSSVYSL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KLNSSVYSL-OH at the technical inquiry form on this page</p>

<p>Region of IL31 protein corresponding to amino acids SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>H-TLSPGWSAV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TLSPGWSAV-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TLSPGWSAV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TLSPGWSAV-OH at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Ac-CDADLKDVNVIPATA-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CDADLKDVNVIPATA-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CDADLKDVNVIPATA-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CDADLKDVNVIPATA-OH at the technical inquiry form on this page</p>

<p>Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.</p>

<p>H-RIKEKIEEL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RIKEKIEEL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RIKEKIEEL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RIKEKIEEL-OH at the technical inquiry form on this page</p>

<p>H-YVLDDEYTSSVGSK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YVLDDEYTSSVGSK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YVLDDEYTSSVGSK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YVLDDEYTSSVGSK-OH at the technical inquiry form on this page</p>

<p>Calcipotriol is a vitamin D analogue that is used to treat psoriasis. It is classified as an aprotic solvent and is not soluble in water, but it dissolves in organic solvents. Calcipotriol binds to the receptor for nuclear factor kappa-B (NF-κB) and inhibits its activation, which suppresses the production of cytokines that are involved in inflammation and immune responses. The calcipotriol molecule has been shown to inhibit EGFR signaling, thereby suppressing tumor growth. This drug has also been shown to be effective in combination therapy with other drugs such as dithranol or anthralin for the treatment of psoriasis. Calcipotriol can be administered topically or by oral administration. It is usually applied twice daily and the dosage depends on the severity of the disease.</p>

<p>Serotonin 5-HT4 receptor agonist</p>

<p>H-TVYYGVPVWRDAETT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TVYYGVPVWRDAETT-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TVYYGVPVWRDAETT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TVYYGVPVWRDAETT-OH at the technical inquiry form on this page</p>

<p>Amenamevir is an antiviral medication, which is synthesized from a chemical source. Its mode of action involves the selective inhibition of the helicase-primase complex of the varicella-zoster virus (VZV), thereby disrupting the viral DNA replication process. By specifically targeting this enzyme complex, Amenamevir impairs the viral replication machinery, leading to a reduction in viral load and amelioration of symptoms associated with infection.</p>

<p>Peptide H-YSDYFKPFSTGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Prasugrel is a thienopyridine prodrug that inhibits the enzyme ADP-dependent P2Y purinergic receptor. Prasugrel inhibits platelet aggregation and the formation of blood clots by blocking the conversion of ADP to ATP on the surface of platelets, thus preventing the release of serotonin from platelets. The reaction products formed by prasugrel are similar to those formed by clopidogrel and include hydrogen sulfate ions and a thiol-containing metabolite. It has also been shown to have potent cytotoxic activity against melanoma cells and anti-inflammatory properties.</p>

<p>Leupeptin is a protein inhibitor that binds to the ubiquitin ligases and inhibits their activity. It has been shown to inhibit the transcriptional regulation of gene expression, which is important in cancer, chronic oral administration, and experimental models. Leupeptin also blocks the binding of proteins to DNA in cell culture and animal models. This leads to decreased production of fatty acids, which are needed for cellular growth and function. Leupeptin also has an anti-depressant effect by blocking the transcriptional regulation of gene expression for serotonin receptors.</p>

<p>PTP-β is a protein that belongs to the group of protein tyrosine phosphatases (PTPs). It has been shown to have clinical relevance as a marker for the M2 phenotype in human fibroblasts. PTP-β is also an integrin receptor, which means it can be used to detect the presence of glycan ligands. PTP-β has been shown to inhibit polymerase chain reaction amplification, and may play a role in axonal growth and neuronal differentiation. This protein has also been shown to have neurotrophic effects on carcinoma cells and it can stimulate axonal growth in vivo.</p>

<p>Peptide H-IIWDSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Cardiac Troponin I (cTnI) Porcine Monoclonal Antibody, Recombinant</p>

<p>Cardiac Troponin I (cTnI) Rabbit Monoclonal Antibody, Recombinant</p>