Biochemicals and Reagents

<p>Dabcyl-γ-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Edans is an angiotensinogen peptide. It has been used as a substrate for Renin and assayed by fluorescence to study the binding affinity of protease inhibitors. Dabcyl is a fluorescent label that can be used in peptide and biochemicals assays, including fluorescence assay. Dabcyl is soluble in water and has little fluorescence quenching with other compounds, making it ideal for use in these applications.</p>

<p>[Trp3, Arg5]-Ghrelin (1-5) is a Growth-Hormone Secretagogue (GHS) receptor agonist which stimulates growth hormone release . The full lenth 28 amino acid peptide Ghrelin is a peptide hormone that regulates appetite, energy balance, meal initiation and nutrient sensing. Ghrelin is produced in the stomach, but is also found in the blood, brain, and other tissues.. It influences bodily functions through associating with growth hormone secretagogue receptors (GHS-R) through its unique N-octanoyl group which is linked to its serine 3 residue covalently. It wider functions are in the regulation of insulin resistance, diabetes and obesity. On top of this Ghrelin is also found to be involved with glucose homeostasis, energy homeostasis, cardio-protective effects, bone metabolism and is a potential target for cancer. Therefore it can be used to develop therapies for a whole spectrum of diseases. This molecule is used as a research tool for studying cell biology and pharmacology.</p>

<p>Calcitonin (salmon) acetate is a peptide hormone that is naturally produced by the parafollicular cells of salmon. It contains a disulphide bridge between two cysteine residues, which is crucial for its biological activity. This hormone plays an important role in regulating calcium levels in the body and is commonly used in life sciences research. Calcitonin (salmon) acetate has been shown to have potent effects on bone metabolism, making it a valuable tool for studying osteoporosis and other bone disorders. Its unique structure and function make it an essential component of biochemical studies and research in the field of endocrinology.</p>

<p>Moclobemide is a monoamine oxidase inhibitor that is used to treat major depressive disorder and dipolar disorder. This drug’s mechanism of action involves the reversible inhibition of the enzyme MAO-A. The inhibition of this enzyme results in a decreased metabolism and destruction of neurotransmitters thus relieving the symptoms of depression and bipolar disorder.</p>

<p>H-KRTNSSQLV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KRTNSSQLV-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KRTNSSQLV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KRTNSSQLV-OH at the technical inquiry form on this page</p>

<p>2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 is a synthetic peptide that binds to the 5HT3 receptor. It has been shown to have an effect on locomotor activity and growth factor secretion in wild type mice and cell culture, as well as binding to acetylcholine receptors in C57/BL6 mice. 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn was synthesized by the reaction of furoic acid with L -alanine, L -glycine, L -arginine and L -ornithine. The product is a white powder.</p>

<p>For-Met-Leu-pNA is a synthetic peptide that can be used as a research tool for studying protein interactions. It has been shown to inhibit ion channels and may be useful in the treatment of epilepsy, especially in cases of drug resistant seizures. For-Met-Leu-pNA is also an inhibitor and can be used as an anticonvulsant.</p>

<p>H-CQSTPLSPPPLTPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CQSTPLSPPPLTPK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CQSTPLSPPPLTPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CQSTPLSPPPLTPK-OH at the technical inquiry form on this page</p>

<p>Poly-L-Lysine Hydrobromide is a neurotrophic factor that is used to stimulate nerve growth in the peripheral nervous system. It has been shown to increase the production of nerve growth factor, which is important for neuronal development and regeneration. Poly-L-Lysine Hydrobromide also has biological properties against human erythrocytes, enabling it to bind to the erythrocyte membrane and subsequently cause hemolysis. This process is mediated by Toll-like receptors. The active form of this drug has been shown to have antiviral activity against HIV and other viruses in transfection experiments using cells from mice, as well as an ability to inhibit replication of herpes simplex virus type 1 (HSV-1) in a model system consisting of rat neurons grown on a polymer substrate. Poly-L-Lysine Hydrobromide can be cleaved into smaller pieces by enzymes such as DNase I or terminal transferases, forming polymers</p>

<p>Activates muscarinic GPCR DREADDs, which are unaffected by the endogenous ligand acetycholamine of the parent receptor. Clozapine is metabolized to clozapine N oxide in the liver, mainly by CYP3A4. Has anti-seizure effects, when induced by chemoconvulsants pilocarpine and picrotoxin.</p>

<p>Tumour vascular disrupting agent acting through targeting the STING pathway</p>

<p>H-ALRTSLAAL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ALRTSLAAL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ALRTSLAAL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ALRTSLAAL-OH at the technical inquiry form on this page</p>

<p>Inhibitor of PDE4 enzyme; anti-inflammatory</p>

<p>H-LDFEGPDAK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LDFEGPDAK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LDFEGPDAK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LDFEGPDAK-OH at the technical inquiry form on this page</p>

<p>Myelin PLP (139-151) acetate salt is a cyclic peptide that is derived from the sequence of human myelin basic protein and contains the sequence PLP (139-151). This peptide has shown to have antioxidative properties. It has been shown to have an inhibitory effect on the production of proinflammatory cytokines in experimental autoimmune encephalomyelitis (EAE), which is a model for multiple sclerosis. The peptide has also been shown to block signal pathways, such as toll-like receptor 4, and decrease Ca2+ overload. Clinical relevance remains unclear.</p>

<p>H-SFALPYWNFATGKNE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SFALPYWNFATGKNE-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SFALPYWNFATGKNE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SFALPYWNFATGKNE-OH at the technical inquiry form on this page</p>

<p>Ac-CDRKIIWPGGETEKPRG-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CDRKIIWPGGETEKPRG-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CDRKIIWPGGETEKPRG-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CDRKIIWPGGETEKPRG-NH2 at the technical inquiry form on this page</p>

<p>Biotinoylsarcosine is a synthetic compound that is used in biotechnology as a building block for the production of biotin-conjugated proteins and peptides. Biotinoylsarcosine has been shown to bind to human serum albumin with high affinity, which may be due to its carboxylate functionalities. This chemical can also be conjugated with other molecules through multistep reactions, simplifying the process of creating biotin-conjugated compounds. Biotinoylsarcosine is deactivated by biotinidase enzymes and used as a pretargeting agent in positron emission tomography imaging studies. Streptavidin, an avidin protein, can bind this compound with high affinity and has been used in biochemical studies as a tool for peptide synthesis.</p>

<p>Ac-DDKVAQSLC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-DDKVAQSLC-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-DDKVAQSLC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-DDKVAQSLC-NH2 at the technical inquiry form on this page</p>

<p>OxymaPure® is a hydrogen bond-based molecular probe that binds to the hydroxamic acid group of bacterial cell walls. It has been shown to have an antibacterial activity against Staphylococcus aureus and Escherichia coli. OxymaPure® is soluble in water, making it suitable for oral administration. The safety profile of OxymaPure® includes studies in rats, indicating that it does not cause any toxic effects at doses up to 2000 mg/kg body weight. OxymaPure® can be synthesized on a solid phase by using carbodiimides as reactive agents and linkers as additive materials. This process is relatively rapid and produces high yields of the desired product.</p>

<p>This is a synthetic peptide that mimics the endogenous human epidermal growth factor (EGF) and binds to the toll-like receptor. It has been shown to stimulate physiological function in experimental models of bowel disease and cardiac disease, as well as cancer tissues. The peptide also binds to the guanine nucleotide-binding protein, polymerase chain reaction, and inflammatory bowel disease genes. In vivo studies have confirmed that this peptide enhances the production of EGF in maternal blood and stimulates squamous carcinoma growth in an animal model.</p>

<p>Fmoc-D-His(Trt)-OH is a chiral building block that is used in peptide synthesis. It can be used to synthesize an enantiomer or homologue of the original amino acid. Fmoc-D-His(Trt)-OH has been postulated to exist as two stereoisomers, 1R,2S and 2R,1S. The 1R,2S enantiomer is the naturally occurring form of this compound and is produced with a shift of +6 ppm in the proton NMR spectrum. The 2R,1S enantiomer has also been observed in the solid state but not in solution and it exhibits a shift of -6 ppm in the proton NMR spectrum.<br>Fmoc-D-His(Trt)-OH is soluble in solvents such as DMSO and DMF. It has also been shown to be a potent inhibitor of organophosphate and re</p>

<p>Cyclo(Arg-Ala-Asp-D-Phe-Cys) is a peptide macrocycle with the amino acid sequence Arg-Ala-Asp-D-Phe-Cys. RGD peptides are biologically active peptides that have been shown to be useful in the treatment of various conditions, including angiogenesis and cancer. Cyclo(Arg-Ala-Asp-D-Phe-Cys) is a cyclic peptide composed of nine amino acids, where each amino acid has one chiral center. This results in two possible stereoisomers (mirror images) for the molecule. The biological activity of this compound has yet to be fully determined.</p>

<p>Boc-Val-Leu-Lys-AMC is a research tool that has been shown to activate ion channels and increase the permeability of cell membranes. This compound also binds to receptors on cells, which may be due to its ability to bind with antibodies. Boc-Val-Leu-Lys-AMC has been used as an inhibitor in protein interactions and pharmacology studies, as well as for the study of ion channels in cell biology.</p>

<p>H-TIFIISMYK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TIFIISMYK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TIFIISMYK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TIFIISMYK-OH at the technical inquiry form on this page</p>

<p>Ubenimex is a peptide-based inhibitor of aminopeptidase enzymes that act on the N-terminus of amino acid chains. It is also an inhibitor of Leucine aminopeptidase 3 (LAP3) and a potent irreversible inhibitor of Leukotriene A4 (LTA4) hydrolase. It is used in the treatment of non-alcoholic steatohepatitis. Ubenimex binds to the active site of aminopeptidases and inhibits their activity, thus preventing degradation of peptides. Ubenimex has been shown to inhibit aminopeptidase A and B, but not C or D. As a result, it prevents cleavage of the N-terminal amino acids from proteins, which may be involved in inflammatory processes. Furthermore Bestatin has been shown to exhibit antibacterial properties against P. gingivalis and F. nucleatum and is available in the salt form: Hydrochloride.</p>

<p>H-IYGYPKKGHGHSYTT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-IYGYPKKGHGHSYTT-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-IYGYPKKGHGHSYTT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-IYGYPKKGHGHSYTT-OH at the technical inquiry form on this page</p>

<p>Fmoc-Lys(Biotin)-OH is a biotin-reactive derivative of the lysine amino acid. It is used to study the interactions between bacterial pathogens and human cells. Fmoc-Lys(Biotin)-OH has been shown to inhibit the growth of P. aeruginosa in thp-1 cells, which are immortalized human lung epithelial cells. This drug also inhibits the synthesis of proteins in the cell nuclei, which prevents the development of bacterial colonies on solubilized cell nuclei in human serum. The effects of Fmoc-Lys(Biotin)-OH have been observed using an unlabeled drug and preincubation with unlabeled protein to observe cytosolic protein synthesis inhibition. A confocal microscope was used to show that Fmoc-Lys(Biotin)-OH inhibited recombinant proteins that bind to human pathogens, such as Staphylococcus a</p>

<p>Maprotiline is a tetracyclic antidepressant that is used for the treatment of major depressive disorder and anxiety that is associated with depression. This drug inhibits noradrenaline reuptake and has anticholinergic properties. Additionally, Maprotiline inhibits the amine transporter which allows for a delay in the reuptake of noradrenaline.</p>

<p>Non-prostanoid IP receptor agonist</p>

<p>H-NPSENSTSSL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-NPSENSTSSL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-NPSENSTSSL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-NPSENSTSSL-OH at the technical inquiry form on this page</p>

<p>Please enquire for more information about Goat anti Mouse IgG (H + L) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Glt-Gly-Arg-MCA is a research tool that is used to activate the GLT1 receptor. It binds to the GLT1 receptor and activates it by binding to the Ligand-binding site. Glt-Gly-Arg-MCA has been shown to be an inhibitor of ion channels, such as Na+ channels, K+ channels, Ca2+ channels and voltage-gated Ca2+ channels. This product also binds to antibody molecules and inhibits their ability to bind with antigens or receptors. Glt-Gly-Arg-MCA has been used in research for Cell Biology, Pharmacology, and Life Science.</p>

<p>Ala-AMC is a fluorescent peptide that binds to the receptor AMPA and activates it. This product is used in research as a tool for studying protein interactions, cellular biology and pharmacology.</p>

<p>MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg is a peptide that is used as an activator and inhibitor of ion channels. This peptide has been shown to be a potent inhibitor of the voltage dependent Na+ channel, which is responsible for the depolarization of nerve and muscle cells. MOCAc has also been shown to bind with high affinity to the NMDAR receptor in a competitive manner. The binding of this peptide to the NMDAR receptor prevents glutamate from binding, which leads to inhibition of downstream signaling pathways such as NMDA receptor activation and intracellular calcium release.</p>

<p>VIP Antagonist is a drug that inhibits the α7 nicotinic acetylcholine receptor and has been shown to have inhibitory properties against cancer tissues. The drug blocks the response element for VIP, inhibiting cyclase activity. This prevents the production of VIP and other neuropeptides, which are involved in nerve cell growth and survival. VIP Antagonist also inhibits toll-like receptor signaling pathways by blocking TLR2 and TLR4, which are receptors on immune cells that recognize bacterial products. In addition, this drug binds to human immunoglobulin G (IgG) and prevents it from binding to its Fc receptor on immune cells, thus preventing IgG-mediated complement activation or antibody-dependent cellular cytotoxicity.</p>

<p>SARS-CoV-2/Flu A/Flu B/RSV Negative Human Nasal Swab (UTM) is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about SARS-CoV-2/Flu A/Flu B/RSV Negative Human Nasal Swab (UTM) including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>This is a monoclonal antibody that binds to the alpha-integrin receptor. The alpha-integrin receptor is an integrin that is involved in cell adhesion and migration, as well as the activation of several signaling pathways. This antibody has been shown to inhibit the binding of alpha-integrins to phospholipid membranes, which may be due to inhibition of protein kinase C (PKC). This antibody also inhibits thrombin receptor activation and dextran sulfate-induced cytosolic calcium mobilization.</p>

<p>Cyclin D1 is a key regulator of cell proliferation and its expression and accumulation within cells is under tight control. Cyclin D1 is the regulatory subunit of cyclin-dependent kinases 4 and 6. These activated cyclin dependent kinases then phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression. Cyclin D1 promotes cell proliferation through interaction with transcription factors such as the oestrogen receptor and specificity protein 1 (Sp1). Cell proliferation is extremely sensitive to altered levels of cyclin D1, with even modest changes in its expression having noticeable effects on cell cycle progression. Cyclin D1 is a proto-oncogene and its overexpression is one of the most frequent alterations seen in multiple cancer types._x000D_<br>_x000D_<br>This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.</p>

<p>X-Neu5Ac is a peptide inhibitor of the protein interactions. It has been shown to activate the Ligand, which may be due to its ability to bind to the Receptor. This drug has been used as a research tool for studying ion channels and antibodies. X-Neu5Ac is a high purity product that can be used in life science research.</p>

<p>Enkephalins are a group of endogenous peptides that are the most potent natural analgesic and have been shown to relieve pain by inhibiting neurotransmitters. The (Met(O)5)-enkephalin analog is a structural analog of the enkephalin peptide with a sulfoxide linkage at position 5. This analog has been shown to inhibit acetylcholine release from intestinal ganglia, which may be related to its effects on postsynaptic potentials and glutamate release. This compound also absorbs in the small intestine, where it is taken into the blood stream and transported to the brain. The (Met(O)5)-enkephalin analog has been shown to reduce pain in Sprague-Dawley rats, as well as inhibit intestinal transit time and stimulate intestinal motility.</p>

<p>Consisting of the following disulfide Bonds: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, Cys14-Cys22, this product is a rat Hepcidin peptide hormone available as a Trifluoroacetate Salt. Hepcidin is a hormone that regulates iron homeostasis in mammals. It is synthesized by hepatocytes and released into the blood, where it binds to ferroportin, expressed on the surface of cells lining the small intestine. Through binding to ferroportin, Hepcidin inhibits ferroportin's function and prevents iron from being absorbed from the gut.</p>

<p>Cyclo(Arg-Ala-Asp-D-Phe-Val) is an active, cyclic peptide that has been shown to have localized effects on the metaphase, meiosis, and gamete cells. Cyclo(Arg-Ala-Asp-D-Phe-Val) is a cilengitide, which are small molecules that bind to calcium ions and increase intracellular levels of calcium. This leads to the activation of biochemical pathways in cells. Cyclo(Arg-Ala-Asp-D-Phe-Val) has been shown to have a diacylglycerol antagonist effect in porcine oocytes and was used in clinical trials for the treatment of infertility. Cyclo(Arg-Ala-Asp-D-Phe Val) also has apoptotic activity in cancer cells.</p>

<p>EDDnp is a potent and selective inhibitor of the proteolytic enzyme dipeptidyl peptidase IV (DPP-IV). EDDnp binds to the active site of DPP-IV, which prevents it from cleaving peptides at the carboxy terminus. The inhibition of DPP-IV results in an increase of peptide hormones such as glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), which are involved in regulating blood glucose levels. In addition, there are high values of EDDnp in human serum and urine, which may be due to its function as a potential biomarker for diabetes. The physiological function of EDDnp is still being investigated.</p>

<p>Boc-Cys(4-CH3Bzl)-OH is a building block for the synthesis of peptides and other biologically active molecules. It is a protected amino acid that can be used in peptide synthesis, and it is commonly used as a building block for the synthesis of Boc-protected L-amino acids.</p>

<p>Obestatin is a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.</p>

<p>The SLC12 family consists of nine member proteins, SLCA1 through to SLC12A9. Solute Carrier Family 12 Member 2 (SLC12A2) encodes a protein used in mediating the cotransport and reabsorption of Na+, K+ and 2Cl- ions (NKCC), it is a membrane-bound symporter channel needed for both epithelial absorption and secretion of ions. SLC12A2 spans the membrane and is necessary in maintaining ionic balance, cell volume and overall homeostasis of a cell.SLC12A2 is shown to be involved in neurodevelopment, specifically in the cortex, and is associated with neurodevelopmental disorders, with SLC12A2 mutation rate being significantly higher in individuals with neurodevelopmental issues. Additionally, mutations in SLC12A2 have been shown to cause issues with sensorineural pathways, causing hearing loss and deafness. Research into SLC12A2 and the SLC12 family as a whole could be beneficial in finding treatments for these complex neuronal issues.</p>

<p>Colivelin is a peptide that can be found in the central nervous system. It has been shown to have a wide variety of biological activities, including being an inhibitor of neuronal death, enhancing axonal growth and proliferation, and decreasing the activity of signal pathways. Colivelin has also been shown to inhibit the proliferation of human osteosarcoma cells by binding to their cell surface receptors.</p>

<p>Fmoc-ß-Ala-OH is a synthetic amino acid that is used in the synthesis of cyclic peptides. It has been shown to have receptor activity, such as the ability to bind to an erythrocyte membrane protein. Fmoc-ß-Ala-OH is also able to stimulate macrophage-like cells and polypeptide synthesis. Fmoc-ß-Ala-OH has been synthesized by chemical ligation, followed by purification on an agarose gel. This synthetic amino acid is used as a building block for affinity ligands, which are compounds that bind to specific receptors or other molecules with high specificity and affinity.</p>

<p>Boc-D-Lys(Cl-Z)-OH is a synthetic peptide that has been shown to bind to the activator region of the human epidermal growth factor receptor (EGFR). It has also been shown to inhibit ion channels and activate ligand-gated ion channels. This product is a research tool for use in cell biology, pharmacology, and other life science research. Boc-D-Lys(Cl-Z)-OH can be used as an antibody or ligand for a receptor, as well as an inhibitor for protein interactions.</p>