Heterocycles with Oxygen (O)

<p>M02244 - Penitrem A, Penicillium paxilli</p>

<p>Stability Volatile<br>Applications 2-Propylfuran is a useful reagent in the catalytic production of renewable lubricant base oils.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, S., et al.: Green Chem., 21, 3606 (2019)<br></p>

<p>Applications 6-Bromo-3H-isobenzofuran-1-one<br></p>

<p>Applications Dibenzofuran is a reagent in Friedel-Crafts acylation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Albrecht, W. L., et al.: J. Med. Chem., 20, 364 (1977);<br></p>

<p>Applications 2-(4-Hydroxybutoxy)tetrahydrofuran is an impurity of Poly(butylene terephthalate) and a by-product of 1,4-Butanediol.<br>References Rafler, G., et al.: Acta Polymerica, 39, 661 (1988);<br></p>

<p>Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.<br>References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)<br></p>

<p>M02724 - 3-Indolyl-b-D-glucuronide Cyclohexylammonium salt</p>

<p>Applications 2,3-Dihydro-2,2-dimethyl-7-benzofuranol (cas# 1563-38-8) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxytetrahydrofuran (cas# 5371-52-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Propenylfuran (cas# 75135-41-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Ethylfuran is a substance used in the studies on variations of essentials oils from leaves of Jasminum nudiflorum Lindl for medicinal purposes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jin, H., et al.: Anhui Nongye Kexue, 40, 10078 (2012)<br></p>

<p>Applications 2-(Dimethoxymethyl)-5-(methoxymethyl)furan is used in the study of reaction pathways of glucose during esterifications.<br>References Hu, X., et al.: Green. Chem., 13, 1676 (2011); Hu, X., et al.: Biores. Technol/, 102, 10104 (2011);<br></p>

<p>Applications 1,3,5-Tri-O-benzoyl-2-deoxyribofuranose (cas# 145416-96-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3,5-Trimethylfuran (cas# 10504-04-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications (s)-(-)-5-hydroxymethyl-2(5h)-furanone (cas# 78508-96-0) is a useful research chemical.<br></p>

<p>Applications Tetrahydro-2-furanpropanol is used in organic reactions the synthesis of oxocanes.<br>References Sakamoto, Y. et al.: Org. Lett., 4, 675 (2002); Paquette, L. et al.: J. Am. Chem. Soc., 94, 6760 (1972);<br></p>

<p>Applications 5-Formylfuran-2-carboxylic Acid is a compound useful in organic synthesis.<br>References Nocito, F., et al.: ACS Omega, 3, 18724 (2018); Chen, G., et al.: Ind. Eng. Chem. Res., 57, 16172 (2018)<br></p>

<p>Stability Volatile<br>Applications It is an ideal marker for detecting cigarette smoke.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spitzer, W., et al.: Clin. Invest. Med., 13, 17 (1990), Alonso, M., et al.: Anal. Bioanal. Chem., 396, 2989 (2010),<br></p>

<p>Applications (3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999); Eur. J. Org. Chem., 2013, 4495 (2013); Yang, H. et al.: Chinese. Chem. Lett., 24, 553 (2013);<br></p>

<p>Applications methyl 5-(hydroxymethyl)furan-2-carboxylate (cas# 36802-01-4) is a useful research chemical.<br></p>

<p>Applications 2,3-Dihydrofuran is a dehydration product of tetrahydrofuran (THF). 2,3-Dihydrofuran is also used in the preparation of niologically active compounds such as antitumor agents.<br>References Kohlweyer, U. et al.: FEMS Microbiol. Lett., 186, 301 (2000); Li, J. et al.: Lett. Drug Design Disc., 9, 379 (2012);<br></p>

<p>Applications 1-(furan-2-yl)propan-1-one (cas# 3194-15-8) is a useful research chemical.<br></p>

<p>Applications Cholinesterase inhibitor. Use as systemic insecticide, acaricide, nematocide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dorough, W.H., et al.: J. Agric. Food Chem., 16, 319 (1968),<br></p>

<p>Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.<br></p>

<p>Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.<br></p>

<p>Applications 2-Phenylfuran (cas# 17113-33-6) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications 2-Pentylfuran is a volatile compound that is detected in meat smoke aerosol, rice aroma and tomato paste volatiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogge, W., et al.; Environ. Sci. Technol., 25, 1112 (1991); Buttery, R., et al.: J. Agric. Food Chem., 36, 1006 (1988); Buttery, R., et al.: J. Agric. Food Chem., 38, 336 (1990);<br></p>

<p>Stability Moisture Sensitive<br>Applications 3A-METHYLHEXAHYDROISOBENZOFURAN-1,3-DIONE (cas# 25550-51-0) is a useful research chemical.<br></p>

<p>Applications 2-Ethylbenzofuran is used in the synthesis of benzofurans as potential antianginal agents. They are also used in the preparation of 2-arylpyridines that are used in the synthesis of complexes with physical properties.<br>References Goldenberg, C. et al.: Eur. j. Med. Chem., 12, 81 (1977); Baloch, M. et al.: Eur. J. Med. Chem., 2012, 4454 (2012);<br></p>

<p>Stability Volatile<br>Applications 3,4-Dimethylfuran (cas# 20843-07-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Furanone is a heterocyclic organic compound that is used widely in the synthetic preparation of pharmaceutical goods.<br>References Kim, H.K., et al.: Plant. Pathol. J., 28, 259 (2012); Nam, S., et al.: J. Agr. Food. Chem., 60, 9097 (2012); Durchschein, K., et al.: Eur. J. Org. Chem., 2012, 4963 (2012);<br></p>

<p>Please enquire for more information about (S)-Tetrahydrofuran-3-amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Furan-2-carboximidamide hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Furan-2-acrolein is a reaction product of furfuryl alcohol and acrolein. Furan-2-acrolein has been synthesized as an intermediate for the production of 2,5-furandione, which is used in the manufacture of dyes and pharmaceuticals. The optimal conditions for this reaction are a temperature range from 130 to 140°C and a pH range from 7 to 9. Furan-2-acrolein is bacteriostatic due to its steric interactions with bacterial enzymes and its ability to inhibit proton transfer reactions that are essential for bacterial growth. This compound also has functional groups that can be modified by chemical reactions, such as amination reactions. Furan-2-acrolein may also have potential applications in magnetic resonance spectroscopy.br&gt;br&gt;</p>

<p>2-Ethylbenzofuran is a benzofuran derivative that has been shown to be a potent inhibitor of acid transport. It is effective in the treatment of gastric and duodenal ulcers, as well as hyperchloremic acidosis. 2-Ethylbenzofuran inhibits the action of calcium carbonate by binding to the active site on rat liver microsomes. This binding prevents the formation of an enzyme-inhibitor complex with polyvinyl chloride, which is required for dibutyl acylation reaction and acidolysis. The drug also blocks acid transporter activity, which may be due to its ability to induce demethylation and inhibit calcium carbonate from forming an enzyme-inhibitor complex with polyvinyl chloride.</p>

<p>2,2,7-Trimethyl-2,3-dihydro-1-benzofuran-5-carbaldehyde is a fine chemical that is used as a building block in research and synthesis of other chemicals. It has been shown to be a versatile building block for the synthesis of complex compounds. 2,2,7-Trimethyl-2,3-dihydro-1-benzofuran-5-carbaldehyde is also a useful intermediate to make other chemicals as well as a reagent in the production of speciality chemicals. This compound can be used in reactions with amines and alcohols. It has been found to have high quality that makes it useful for use in reactions with DNA and RNA nucleotides and proteins.</p>

<p>3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone belongs to the class of polymerase chain inhibitors. It inhibits DNA synthesis by binding to the enzyme DNA polymerase and blocking the progression of DNA synthesis. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone has significant cytotoxicity in mammalian cells and is genotoxic, which may be due to its mutagenicity. The mechanism of its mutagenicity is not known, but it has been shown that this compound reacts with effector proteins such as thiols and sulfhydryls. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone can react with chlorine in water to form a chlorinated derivative that is more stable than the parent compound. This chemical stability has been used</p>

<p>Perfluoro(2-butyltetrahydrofuran) is a fluorinated, non-polar organic solvent with a high boiling point. It can be used for thermal expansion measurements of dextran sulfate solutions and in the preparation of cell culture samples prior to histological analysis. The phase transition temperature of perfluoro(2-butyltetrahydrofuran) is 4.6°C, which means that it is liquid at room temperature and can be used as a vehicle to deliver magnetic particles to lung tissue. Perfluoro(2-butyltetrahydrofuran) also has an experimental model for studying the effects of laser ablation on lung cells.</p>

<p>Furanoeudesma 1,3-diene is a chemical compound that has been shown to have potent antibacterial activity against bacteria such as Escherichia coli and Staphylococcus. Furanoeudesma 1,3-diene is a stereoselective inhibitor of the Gram-negative bacterial enzyme enoyl-ACP reductase (FabI). This inhibition prevents the production of fatty acids in bacteria, leading to cell death. Furanoeudesma 1,3-diene also has an inhibitory effect on chronic bronchitis. It can be found in skin care products or as an ingredient in lettuce leaves.</p>

<p>2,2,5,5-Tetramethyldihydrofuran-3(2H)-one is an organic compound that is classified as a heterocyclic compound. This substance has been shown to be a good mercurial reagent and can be used for the synthesis of polycyclic compounds. 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one has been shown to form a dimer with sulfuric acid in the presence of polyphosphoric acid. It also reacts with ethers to form sulfates and furans.</p>

<p>2,5-Bishydroxymethyl tetrahydrofuran is an organic compound that is synthesized from 2,5-dihydroxyacetophenone and hydrochloric acid. It has significant cytotoxicity against cells and inhibits the growth of cancer cells in culture. This compound can be used as a monoclonal antibody to help identify certain types of cells. 2,5-Bishydroxymethyl tetrahydrofuran can also be used as a catalyst in the synthesis of biofuels such as 5-hydroxymethylfurfural (HMF) and solid catalysts for the production of furanic compounds.</p>

<p>1-Methyl-2-nitro-3-(tetrahydrofuran-3-yl)methyl)guanidine (1MNTG) is a pesticide that is used to control pests. It has been shown to be highly resistant to degradation by cytochrome P450, which may cause chronic exposure and/or analytical problems. 1MNTG has also been shown to cause genetic damage in bacteria, as well as enzyme activities in the liver and kidneys of rats exposed for short periods of time. 1MNTG has been shown to be an agonist of toll-like receptor 4, which can lead to health effects such as inflammation and have been shown to affect biochemical processes in vitro.</p>

<p>Nilotinib is a small molecule that inhibits the tyrosine kinase activity of TK1, TK2, and TK3. It binds to the ATP-binding site of these kinases and prevents the phosphorylation of the cellular substrate. Nilotinib has been shown to inhibit the proliferation of leukemia cells in vitro, as well as to have antiproliferative effects in vivo. Nilotinib can be used for the treatment of chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). In addition, it has been shown to have synergistic effects with other drugs such as α1-acid glycoprotein inhibitors or methyltransferase inhibitors. Nilotinib can also be used for cases of hepatic steatosis.</p>

<p>4-Methyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione is a racemic benzofuran analogue</p>

<p>[(5,5-Dimethyltetrahydrofuran-3-yl)methyl]amine is a synthetic compound that regulates the expression of regulatory genes. It has been shown to be a potent inhibitor of neurospora sensitivity. The structure of [(5,5-dimethyltetrahydrofuran-3-yl)methyl]amine is similar to the structure of the acid analogues of this compound. [(5,5-Dimethyltetrahydrofuran-3-yl)methyl]amine also binds to and derepresses structural genes by inhibiting transcription and pathways for protein synthesis. This mechanism may be related to its inhibitory effects on neurospora sensitivity.</p>

<p>4-Methyl-2(5H)-furanone is an isomeric compound that can be isolated from various plant sources including isoprene, chalcones, and other plant extracts. It has been shown to inhibit the formation of dental plaque and the growth of oral bacteria in a functional group study. 4-Methyl-2(5H)-furanone is also known as a chalcone and has been shown to have antibacterial properties. This chemical reaction can be used as an alternative to chlorhexidine for the treatment of dental plaque.</p>

<p>cis-3,4-Dihydroxy-2,5-dimethoxytetrahydrofuran is a tetrahydrofuran derivative that has been shown to have neuroprotective effects. It has been shown to inhibit the formation of crosslinks in rat spinal cord neurons and to inhibit the release of reactive oxygen species (ROS) and nitric oxide (NO), which are known to be neurotoxic. In addition, cis-3,4-dihydroxy-2,5-dimethoxytetrahydrofuran has antibacterial activity against Staphylococcus aureus and Dasycarpus sp. This compound is also a precursor for limonoids and glyceraldehyde.</p>

<p>2(5H)-Furanone is a naturally occurring compound that has been found to have hypoglycemic effects. Studies have shown that 2(5H)-furanone inhibits the activity of cox-2, an enzyme involved in the synthesis of prostaglandins, which are inflammatory compounds. This chemical may be useful as an anti-inflammatory agent and for the treatment of bowel diseases. 2(5H)-Furanone also has antimicrobial properties and has been shown to inhibit the growth of animal cells that are resistant to anticancer drugs. It binds to cell nuclei and disrupts DNA synthesis by competing with basic proteins for binding sites on DNA strands. The chemical structure of 2(5H)-furanone is very similar to butenolide, a natural plant compound used in traditional Chinese medicine; both compounds have been shown to inhibit COX-2 activity.</p>

<p>6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide is a fine chemical which is used as a building block in the synthesis of complex compounds. It can be used as a reactant in various reactions, such as Friedel-Crafts reactions and cycloadditions. This compound has been shown to be a useful intermediate for the synthesis of various heterocyclic compounds and scaffolds for drug development. 6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide has CAS number 638217-08-0 and is readily available in high quality.</p>