Heterocycles with Oxygen (O)

M02244 - Penitrem A, Penicillium paxilli

Applications 2-Ethylfuran is a substance used in the studies on variations of essentials oils from leaves of Jasminum nudiflorum Lindl for medicinal purposes
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jin, H., et al.: Anhui Nongye Kexue, 40, 10078 (2012)

Applications 2-(4-Hydroxybutoxy)tetrahydrofuran is an impurity of Poly(butylene terephthalate) and a by-product of 1,4-Butanediol.
References Rafler, G., et al.: Acta Polymerica, 39, 661 (1988);

Stability Unstable in Aqueous Solution
Applications (±)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone is a volatile organic compound used in the silylation of alcohols,
References D'Sa, B.A. et al.: J. Org. Chem., 62, 5057 (1997);

Applications methyl 5-(hydroxymethyl)furan-2-carboxylate (cas# 36802-01-4) is a useful research chemical.

Applications 2-Ethylbenzofuran is used in the synthesis of benzofurans as potential antianginal agents. They are also used in the preparation of 2-arylpyridines that are used in the synthesis of complexes with physical properties.
References Goldenberg, C. et al.: Eur. j. Med. Chem., 12, 81 (1977); Baloch, M. et al.: Eur. J. Med. Chem., 2012, 4454 (2012);

Applications 2,3-Dihydrofuran is a dehydration product of tetrahydrofuran (THF). 2,3-Dihydrofuran is also used in the preparation of niologically active compounds such as antitumor agents.
References Kohlweyer, U. et al.: FEMS Microbiol. Lett., 186, 301 (2000); Li, J. et al.: Lett. Drug Design Disc., 9, 379 (2012);

Applications 2-Propenylfuran (cas# 75135-41-0) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Hydroxytetrahydrofuran (cas# 5371-52-8) is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications 3A-METHYLHEXAHYDROISOBENZOFURAN-1,3-DIONE (cas# 25550-51-0) is a useful research chemical.

Applications Dibenzofuran is a reagent in Friedel-Crafts acylation.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Albrecht, W. L., et al.: J. Med. Chem., 20, 364 (1977);

Applications 6-Bromo-3H-isobenzofuran-1-one

Applications (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is an intermediate used in the synthesis of dronedarone hydrochloride (I), a class III antiarrhythmia drug for the prevention of cardiac arrhythmias such as atrial fibrillation.
References Mali, A. C., et al.: Org. Proc. Res. Dev., 17, 863 (2013)

Applications 1-(furan-2-yl)propan-1-one (cas# 3194-15-8) is a useful research chemical.

Stability Volatile
Applications 2-Pentylfuran is a volatile compound that is detected in meat smoke aerosol, rice aroma and tomato paste volatiles.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rogge, W., et al.; Environ. Sci. Technol., 25, 1112 (1991); Buttery, R., et al.: J. Agric. Food Chem., 36, 1006 (1988); Buttery, R., et al.: J. Agric. Food Chem., 38, 336 (1990);

Applications 1,3,5-Tri-O-benzoyl-2-deoxyribofuranose (cas# 145416-96-2) is a compound useful in organic synthesis.

Applications 2,3-Dihydro-2,2-dimethyl-7-benzofuranol (cas# 1563-38-8) is a useful research chemical.

Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.

Applications 2-Phenylfuran (cas# 17113-33-6) is a useful research chemical.

Applications (3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists.
References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999); Eur. J. Org. Chem., 2013, 4495 (2013); Yang, H. et al.: Chinese. Chem. Lett., 24, 553 (2013);

Stability Moisture Sensitive
Applications 2-Furanone is a heterocyclic organic compound that is used widely in the synthetic preparation of pharmaceutical goods.
References Kim, H.K., et al.: Plant. Pathol. J., 28, 259 (2012); Nam, S., et al.: J. Agr. Food. Chem., 60, 9097 (2012); Durchschein, K., et al.: Eur. J. Org. Chem., 2012, 4963 (2012);

M02724 - 3-Indolyl-b-D-glucuronide Cyclohexylammonium salt

Applications 2-(Dimethoxymethyl)-5-(methoxymethyl)furan is used in the study of reaction pathways of glucose during esterifications.
References Hu, X., et al.: Green. Chem., 13, 1676 (2011); Hu, X., et al.: Biores. Technol/, 102, 10104 (2011);

Applications Tetrahydro-2-furanpropanol is used in organic reactions the synthesis of oxocanes.
References Sakamoto, Y. et al.: Org. Lett., 4, 675 (2002); Paquette, L. et al.: J. Am. Chem. Soc., 94, 6760 (1972);

Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.

Stability Volatile
Applications 2-Propylfuran is a useful reagent in the catalytic production of renewable lubricant base oils.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, S., et al.: Green Chem., 21, 3606 (2019)

Stability Moisture Sensitive
Applications (s)-(-)-5-hydroxymethyl-2(5h)-furanone (cas# 78508-96-0) is a useful research chemical.

Applications 2-Acetylfuran is a widely used reagent in manufacturing pharmaceuticals and aroma compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bertero, M., et al.: Fuel, 95, 263 (2012); Dang, Q., et al.: J. Medn. Chem., 54, 153 (2011); Candu, N., et al.: Topics. Catalysis., 52, 571 (2009);

Applications Cholinesterase inhibitor. Use as systemic insecticide, acaricide, nematocide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dorough, W.H., et al.: J. Agric. Food Chem., 16, 319 (1968),

Stability Volatile
Applications It is an ideal marker for detecting cigarette smoke.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Spitzer, W., et al.: Clin. Invest. Med., 13, 17 (1990), Alonso, M., et al.: Anal. Bioanal. Chem., 396, 2989 (2010),

Diethyl 3,4-furandicarboxylate is a chemical compound that is used as an antiproliferative drug in cancer therapy. It is synthesized by the thermal isomerization of diethyl acetylenedicarboxylate. The product has been shown to inhibit the growth of human cancer cells and has antibacterial activity against Gram-positive bacteria. Diethyl 3,4-furandicarboxylate also inhibits the synthesis of DNA and RNA by binding to the enzyme ribonucleotide reductase. Its cytostatic effects are due to its ability to inhibit cellular proliferation by inhibiting protein synthesis.

Carbofuran is a broad-spectrum insecticide that belongs to the class of carbamates. It is used to control insects that damage crops and other plants. The mechanism of action for carbofuran involves inhibition of the sorbitol dehydrogenase enzyme, which blocks the conversion of glucose to sorbitol in insects, leading to their death. Carbofuran also has synergistic effects with nitrite ions. Carbofuran's chemical name is 3-methyl-2-(methylthio)propanal O-carbamate. It has been shown that carbofuron causes oxidative injury in mitochondria by inhibiting mitochondrial functions and energy metabolism, leading to its acute toxicities at high doses.

N-[(3S)-2,5-Dioxotetrahydro-3-furanyl]-2,2,2-trifluoroacetamide is a boronic acid that has been used to synthesize polymers. This compound is of interest for the synthesis of hydrophobic amino acids such as threonine and lysine. The high yield and functionalisation of this molecule make it deserving of further investigation.