Heterocycles with Nitrogen (N)

Applications 4-Amino-3-chloropyridine is a chlorinated heteroarylamine. 4-Amino-3-chloropyridine is used in the preparation of inhibitor of phosphodiesterase type 4 (PDE4) as antiasthmatic agents as well as other pyridine based pharmaceutical agents
References Ashton, M.J. et al.: J. Med. Chem., 37, 1696 (1994);

Applications Pyridin-3-yl dimethylcarbamate (cas# 51581-32-9) is a useful research chemical.

Applications Intermediate in the production of Methotrexate
References Chiosis, G., et al.: Bioorg. Med. Chem., 10, 3555 (2002), Palanki, M., et al.: J. Med. Chem., 50, 4279 (2007), Zav'yalov, S., et al.: Pharm. Chem. J., 42, 51 (2008),

Applications 4,5,6,7-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridine (cas# 109904-25-8) is a compound useful in organic synthesis.

Applications L-Dihydroorotic acid is used as a reactant in the preparation of long acting Gonadotrophin-releasing hormone (GnRH) antagonist containing p-ureido-phenylalanine.
References Jiang, G., et al.: J. Med. Chem., 44, 453 (2001);

Applications (3-Chloropyrazin-2-yl)methanol (cas# 89283-32-9) is a useful reagent for the preparation of indazolylquinazolinones as inhibitors of human immunodeficiency virus replication.
References Gillis, E. P., et al.: PCT Int. Appl. (2020), WO 2020084492 A1

Applications Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates.
References Erkelenz, M. et al.: J. Am. Chem. Soc., 133, 16111 (2011);

Applications Used for preparation of thieno-tetrahydropyridines useful as class III antiarrhythmic agents.
References Bahekar, R., et al.: Bioorg. Med. Chem., 15, 5950 (2007), Hayakawa, M., et al.: Bioorg. Med. Chem. Lett., 17, 2438 (2007),

Applications 2-Ethylpyridine can be used to prepare Dimethindene Maleate (D460460). It is also used to study its effect on the proliferation and survival of human umbilical vein endothelial cells (HUVECs), HMVECs from lung, and NIH 3T3 cells.2-Ethylpyridine linked with silica is a popular stationary phase for chiral and achiral separations in supercritical fluid chromatography.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Richard, Y., et al.: Toxicol. Sci., 93, 82 (2006); Speybrouck, D., et a.: Curr. Topics in Med. Chem., 12, 1250(2012)

Applications 2,4-Di-tert-butyl-6-(5-chloro-2H-benzotriazol-2-yl)phenol is a UV absorber.
References Moisan, J.: Eur. Polymer J., 16, 979 (1980); Nakata, H., et al.: Environ. Sci. Technol.,43, 6920 (2009)

Applications (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.
References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012); Sakashita, H., et al.: Bioorg. Med. Chem., 15, 641 (2007)

Stability Light Sensitive
Applications 1-Vinyl-2-pyrrolidinone is used in the preparation of NMDA receptor antagonists. Also used in the synthesis of copolymers used to stabilize rhodium nanoclusters.
References Leeson, P. et al.: J. Med. Chem., 35, 1954 (1992); Mu, X. et al.: J. Am. Chem. Soc., 127, 9694 (2005);

Stability Hygroscopic
Applications 2,6-Dimethoxypyridine-3,5-diamine hydrochloride (cas# 56216-28-5) is useful component in hair dyes. Has cosmetic applications.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Krohn, R., et al.: PCT Int. Appl. (2020), WO 2020089365 A1

Applications 2-Amino-4-hydroxy-6-chloro-s-triazine is an aromatic intermediate compound useful for the preparation of substituted melamine, ammelides, and ammelines.
References Hapeman, C., et al.: J. Agric. Food Chem., 43, 1383 (1995), Garcia-Montano, J., et al.: Environ. Sci. Technol., 42, 6663 (2008),

Applications N-methyl-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine-2,4-diamine (cas# 101988-70-9) is a useful research chemical.

Applications Ethyl (5-Ethyl-2-pyridinyl)acetate (cas# 99986-02-4) is a compound useful in organic synthesis.

Applications 2-Nitrosopyridine is a useful reactant in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, Xing, et al.: J. of Org. Chem., 84(7), 4402-4412 (2019);Zhang, Jingchuan, et al.: Chem. - A Euro. J., 24(17), 4289-4293 (2018)

Stability Light Sensitive
Applications 1-Vinylimidazole (cas# 1072-63-5) is a useful research chemical.

Applications 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol (cas# 29529-99-5) is a useful research chemical.

Applications 1-Piperidineethanol (cas# 3040-44-6) is a compound useful in organic synthesis.

Applications 2-Phenyl-1H-benzimidazole is a reagent used in the synthesis of various aryl-substituted benzimidazole derivatives. Also used in the synthesis of benzimidazole and quinocaline derivatives
References Saleh, V. et al.: Org. Chem. Int., 1, (2015); Hasanpour, M. et al.: J. Chin. CHem. Soc., 62, 412 (2015);

Applications 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used in the preparation of blue pyrrole dyes. 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is also used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.
References Treibs, A. et al.: Lieb. Ann. Chem., 2, 289 (1978); Elsinghorst, P. et al.: J. Lab. Comp. Radiopharm., 52, 360 (2009);

Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.

Applications Used in oligonucleotide synthesis. Also a radiosensitizer of hypoxic cells in vitro.
References Nagao, Y., et al.: Chem. Pharm. Bull., 37, 1951 (1989), Takaoka, M., et al.: J. Vet. Med. Sci., 56, 341 (1994),

Applications 2,4-Diaminopyrimidine-5-carbonitrile is used as an intermediate for the preparation of medicines and agrochemicals (1).
References (1) Otzen, T., et al.: J. Med. Chem., 47, 240 (2004)

Applications s-Triazine-1,3,5-triethanol (cas# 4719-04-4) is a compound useful in organic synthesis.

Applications methyl 1-(2,4-difluorophenyl)-3-phenyl-1H-pyrazole-5-carboxylate (cas# 1202030-37-2) is a useful research chemical.

Applications 5,6-Dimethylbenzimidazole (cas# 582-60-5) is a useful research chemical.

Applications 2,2,6,6-Tetramethyl-1-hydroxypiperidine is a reactant used in various synthesis and investigations. It was used as a reactant in the study of predicting organic hydrogen atom transfer rate constants using the Marcus cross relation. 2,2,6,6-Tetramethyl-1-hydroxypiperidine was also used as a reactant in the preparation of ammonia from an iron nitrido complex.
References Scepaniak, J., et al.: Angew. Chem. Int. Ed., 48, 3158 (2009); Warren, J., Mayer, J.: Proc. Natl. Acad. Sci. U.S.A., 107, 5282 (2010);

Applications 3-(4-iodo-1H-pyrazol-1-yl)propanenitrile (cas# 88393-88-8) is a useful research chemical.

Applications 3-Amino-5-mercapto-1,2,4-triazole is used as a corrosion inhibitor. It can also be used as a reactant in the synthesis of triazole derivatives.
References Ergun, Umit, et al.: J. of Mat. Eng. and Perf., 23(1), 213-221 (2014); Elgemeie, Galal H., et al.: Nucleosides, Nucleotides & Nucleic Acids, 37(2), 112-123 (2018)

Applications 1,2,3,6-Tetrahydropyridine (cas# 694-05-3) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.

Applications 5-phenyl-1,3-oxazolidin-2-one (cas# 7693-77-8) is a useful research chemical.

Applications 4-(2-Hydroxyethyl)piperazin-2-one (cas# 23936-04-1) is a useful research chemical.

Applications 5-Hydroxy-2-methyl-1H-imidazole-1-ethanol is a degradation product of Metronidazole (M338880), an antibiotic.
References Perez, Tzayam, et al.: Electrochimica Acta, 165, 173-181 (2015)

Applications 4'-Bromo-2,2':6',2''-terpyridine (cas# 149817-62-9) is a useful research chemical.

Applications 4-(2-cyclopropyl-1,3-oxazol-5-yl)aniline (cas# 1031130-92-3) is a useful research chemical.

Applications 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.
References Hojati, S. F., et al.: Can. J. Chem., 88, 135 (2010);

Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (cas# 2387-48-6) is a compound useful in organic synthesis.

Applications 4-azidopyridine (cas# 39910-67-3) is a useful research chemical.

Applications An impurity arising in the synthesis of zoledronic acid (Z623500).

Applications 1H-1,2,3-Triazole-1-acetic acid (cas# 4314-22-1) is a useful research chemical.

Stability Hygroscopic
Applications 4-Aminopyridine N-Oxide (cas# 3535-75-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2,4-Diaminopyrimidine 3-N-Oxide is a useful organic synthetic reagent for the preparation of pyrimidines and in the making of hair loss and skin care compositions.
References von, A. S., et al.: Science of Synthesis, 16, 379 (2004); Mahe, Y., et al.: Skin Pharmacol., 9, 177 (1996); Hocquaux, M., et al.: From PCT Int. Appl. (1992), WO 9201437 A1 19920206

Stability Hygroscopic
Applications 1-Ethyl-5-hydroxy-2-pyrrolidinone is an important organic solvent used in varnishing. Industrial solvent.
References Koch, H. et al. Arch. Toxicol., 88, 893 (2014); Koslitz, S. et al.: Toxicol. Lett., 231, 142 (2014);

Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);

Applications 2-Pyridineethanol is a metabolite of the anti-vertigo drug Betahistine (B324000).
References Botta, L. et al.: Acta Oto-Laryngol., 120, 25 (2000); Fossati, A. et al.: Pharmacol. Res., 43, 389 (2001); Konzett, H. et al.: J. Pharmacol. Exp. Ther., 178, 122 (1977);

Applications 5-Amino-2-chloro-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 30161-95-6) is a compound useful in organic synthesis.
References Nagahara, K., et al.: J. Med. Chem., 33, 407 (1990),

Stability Light Sensitive
Applications 1-[4-bromo-2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (cas# 1179507-09-5) is a useful research chemical.

Stability Air Sensitive, Light Sensitive
Applications 3,4-DIETHYLPYRROLE (cas# 16200-52-5) is a useful research chemical.

Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.
References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)

Applications 4-(4-Chlorophenyl)-4-hydroxypiperidine (cas# 39512-49-7) is a compound useful in organic synthesis.

Applications Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.
References Stubbins, J. et al.: Eur. J. Med. Chem., 14, 219 (1979);

Applications 3,5-Dinitropyridine is used as an azabenzyne pyrolytic precursor. The anion radical of 3,5-dinitropyridine aundergoes reversible dimerization reactions.
References Winkler, M., et al.: J. Am. Chem. Soc., 126, 6135 (2004); Macias-Ruvalcaba, N., et al.: J. Electroanal. Chem., 600, 294 (2007)

Stability Hygroscopic
Applications 1H-Pyrrolo[3,2-b]pyridine-2,3-dione (cas# 153072-89-0) is a useful research chemical.

Applications An intermediate in the synthesis of rabeprazole (R070500).

Applications An intermediate in the synthesis of Prasugrel (P701150).

Applications 2,4-Dihydroxypyrrolo[2,3-d]pyrimidine (cas# 39929-79-8) is a compound useful in organic synthesis.

Applications 3-Amino-6-chloropyridazine (cas# 5469-69-2) is a compound useful in organic synthesis.

Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.
References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010

Applications 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol (cas# 172152-53-3) is a useful research chemical.

Applications 4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.
References Northrup, A. et al.: J. Med. Chem., 56, 2294 (2013);

Applications 2-Oxo-1-benzimidazolinebutyric Acid (cas# 3273-68-5) is a compound useful in organic synthesis.

Applications Pyridoxal 5-phosphate Hydrate (cas# 853645-22-4) is a useful research chemical.

Impurity Clavulanate Potassium EP Impurity C
Applications 3-Ethyl-2,5-pyrazinediethanol (Clavulanate Potassium EP Impurity C) is an impurity of Clavulanic acid (C563750). High concentrations of Clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus.
References Zupke, C., et al.: Biotechnol. Prog., 10, 489 (1994), Finlay, J., et al.: J .Antimicrob. Chemother., 52, 18 (2003), Alper, H., et al.: Science, 314, 1565 (2006), Brethauer, S., et al.: Biotechnol. Bioeng., 98, 356 (2007),

Applications Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.
References Schalk, M. et al.: Plant Physiol., 118, 209 (1998);

Impurity Clavulanate Potassium EP Impurity A
Applications 2,5-Pyrazinediethanol (Clavulanate Potassium EP Impurity A) is an impurity of Clavulanic acid (C563750). High concentrations of Clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus.
References Zupke, C., et al.: Biotechnol. Prog., 10, 489 (1994), Finlay, J., et al.: J .Antimicrob. Chemother., 52, 18 (2003), Alper, H., et al.: Science, 314, 1565 (2006), Brethauer, S., et al.: Biotechnol. Bioeng., 98, 356 (2007),

Applications Hydrocinnamic Acid N-Hydroxysuccinimide Ester (cas# 109318-10-7) is a compound useful in organic synthesis.

Applications 5-Hydroxy-N-methyl-2-pyrrolidinone is a metabolite of N-methylpyrrolidone (NMP).
References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),

Stability Hygroscopic, Moisture Sensitive
Applications Used in the synthesis of peptides. Contains up to 10% imidazole.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pierschbacher, M., et al.: Nature, 309, 30 (1984),

Applications 2-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]benzoic Acid is a research reagent with antispasmodic
References Bal-Tembe, S., et al.: Bioorg. Med. Chem., 5, 1381(1997);Punekar, N., et al.: Biotech. App. Biochem, 14, 378 (1991);

Applications 2-(Aminomethyl)pyrazine is a useful synthetic intermediate. It is used to synthesize pyrazolo[4,3-c]pyridinediones as orally bioavailable NADPH oxidase isoform 4 inhibitors for the treatment of idiopathic pulmonary fibrosis. It is also used to prepare pyrazolyl-indoles with the abilities to induce T-cell kinase inhibition.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Laleu, B., et al.: J. Med. Chem., 53, 7715 (2010); Velankar, A., et al.: Bioorg. Med. Chem., 18, 4547 (2010)

Applications 5-[1-(Methylthio)ethyl]-2-trifluoromethylpyridine is an intermediate in the synthesis of Sulfoxaflor (S755005), a novel pesticide of the sulfoximine group and the only sulfoximine class of pesticide that act on the central nervous system.
References Sparks, T.C., et al. Pestic. Biochem. Physiol., 107, 1 (2013);

Applications 1,4-Bis(3-chlorophenyl)-piperazine acts as a reagent in the preparation of diarylalkylene diamines and N, N’,N’’-triaryldialkylene triamines.
References Mohr, R., et al.: From Eur. Pat. Appl. (1981), EP 31089 A1 19810701

Applications 1-Piperidin-2-ylacetone Hydrochloride is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.

Stability Air Sensitive, Hygroscopic, Moisture Sensitive
Applications N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Alberola, A. et al.: Anal. Quim., 74, 761 (1968); Kobayashi, T. et al.: J. Chem. Soc. Perk. Trans., 12, 1372 (2001); Paulini, K. et al.: CHem. Ber., 127, 685 (1994);

Applications 2-Hydrazino-1,3-benzoxazole

Stability Hygroscopic
Applications 4-Diphenylmethoxypiperidine, HCl

Applications rac-trans-2,5-Dimethyl-3-(2-methylphenyl)-1-propylimidazolini-4-one Hydrochloride is the salt analogue of 2,5-Dimethyl-3-(2-methylphenyl)-1-propylimidazolini-4-one (D477055), an impurity of Prilocaine (Prilocaine Hydrochloride P725000). Prilocaine is a local anesthetic of the amino amide type and is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA) towards the treatment of conditions like paresthesia.
References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003)

Applications Pyridine-2-aldoxime (cas# 873-69-8) is a useful research chemical.

Applications METHYL PIPERIDINE-1-CARBOXYLATE (cas# 1796-27-6) is a useful research chemical.

Applications 2-Chloro-3-(trifluoromethyl)pyridine is a building block used to prepare various high affinity TRPV1 (VR1) vanilloid receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Swanson, D., et al.: J. Med. Chem., 48, 1857 (2005); Rami, H., et al.: Bioorg. Med. Chem. Lett., 16, 3287 (2006)

Applications 4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.
References Cheng, C., et al.: ACS Med. Chem. Lett., 1, 466 (2010); Yonetoku, Y., et al.: Bioorg. Med. Chem., 16, 9457 (2008)

Applications N-(5-Methyl-3-isoxazolyl)benzenesulfonamide is used in the preparation of isoxazolecarboxylic acid derivatives as agricultural fungicides.
References Gomes, J.R.B., et al.: Tetrahedron, 61, 2705 (2005),

Applications 3-Ethyl-2,4-dimethyl-1H-pyrrole is a important diagnostic compound for pyrrole disorder or pyroluria, an abnormality in biochemistry resulting in overproduction of pyrrole molecules and resulting in improper hemoglobin synthesis.
References Walsh, W.J., et al.: Physiol. Behav., 82, 835 (2004); Inrvine, D.G., et al.: Clin. Chem., 24, 2069 (1978);