Heterocycles with Nitrogen (N)

<p>Applications 4-(3,5-Dimethylpyrazol-1-yl)phenylboronic acid, pinacol ester<br></p>

<p>Applications α-Butyl-α-(2,4-dichlorophenyl)-4H-1,2,4-triazole-4-ethanol is a useful synthetic intermediate.<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Acetoxysuccinimide (cas# 14464-29-0) is a useful research chemical.<br></p>

<p>Applications 1-Ethyl-3-piperidinamine is an intermediate of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495).<br>References Elslager, E.F., et al.: J. Med. Chem., 24, 127 (1981),<br></p>

<p>Applications 4-Hydroxythieno[2,3-d]pyrimidine (cas# 14080-50-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,​2-​Dihydro-​2-​thioxo-​6-​(trifluoromethyl)​-4-​pyrimidinecarboxylic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>

<p>Applications Methyl 6-aminopyridazine-3-carboxylate<br></p>

<p>Applications 3-Amino-1,4-dimethylpyrazole is used in the preparation of peptides as cysteine protease inhibitors.<br></p>

<p>Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethyl(pyridin-​4-​yl)​borane is a powerful reducing agent used in the synthesisof non-basic compounds as factor Xa inhibitors. Diethyl(pyridin-​4-​yl)​borane is used for the synthesis of 4-aryl- and 4-heteroarylpyridines by the palladium-catalyzed cross-coupling reaction.<br>References Komoriya, S. et al.: Bioorg. Med. Chem. 13, 3927 (2005); Ishikura, Minoru., et al.: Chem. Pharm. Bull., 33, 4755(1985)<br></p>

<p>Applications 2-(Ethylthio)-1H-benzimidazole is the active substance or the active ingredient in the synthesis of the drug Metaprot. Performs a transplacental function: daily administration of bemithyl (20 mg/kg) from 6 th to 16 th day of pregnancy in female rats led to the decrease in fetal death after the implantation and increased fetal body weight.<br>References Kibal'chich, D. A., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 74, 30 (2011); Bugaeva, L. I., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 70, 40 (2007).<br></p>

<p>Applications 2-Amino-5-bromopyrazine (cas# 59489-71-3) is a compound useful in organic synthesis.<br>References Shi, Z., et al.: J. Med. Chem., 51, 3684 (2008), Onda, K., et al.: Bioorg. Med. Chem., 16, 5452 (2008),<br></p>

<p>Applications 5-Benzyl-4H-1,2,4-triazol-3-amine can be used as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity.<br>References Huang, L., et.al.: Eur. J. Med. Chem., 185, 111824, (2020);<br></p>

<p>Impurity Flecainide EP Impurity B<br>Applications 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.<br>References Reddy, G. et al.: Hetero. Chem., 23, 247 (2012); Fujita, M. et al.: Chem. Pharm. Bull., 46, 787 (1998);<br></p>

<p>Applications Octahydro-1H-pyrrolo[3,4-b]pyridine-d2 Di-trifluoroacetate is an intermediate in the synthesis ofhybrid antibacterial agents that exhibits inhibitory activities towards DNA Polymerase-Topoisomerase.<br>References Zhi, C.X., et al.: J. Med. Chem., 49, 1455 (2006);<br></p>

<p>Applications N-(2-(2-Nitro-1H-imidazol-1-yl)ethyl)acrylamide is a useful synthesis intermediate.<br></p>

<p>Applications An intermediate in the production of Zolpidem metabolites<br>References Klupsch, F., et al.: Chem. Pharm. Bull., 54, 1318 (2006),<br></p>

<p>Applications 6-(2,3-Difluorophenyl)picolinic acid<br></p>

<p>Applications 3-Bromopicolinic Acid Sodium Salt (cas# 1189933-55-8) is a compound useful in organic synthesis.<br>References See mercaptopicolinic acid file<br></p>

<p>Applications 3-(1H-Tetrazol-5-yl)benzoic Acid is a useful reactant in organic synthesis.<br>References Ouellette, Wayne, et al.: Inorganica Chimica Acta, 391, 36-43 (2012);Ramachandran, Sreekanth A., et al.: Bioorg. &amp; Med. Chem. Let., 27(10), 2153-2160 (2017)<br></p>

<p>Applications 5-Amino-1-phenylpyrazole is a reagent that is used in the synthesis of sulfaphenazole(S689020) derivatives as inhibitors and tools for comparing active sites of human liver cytochromes P 450 2C subfamily.<br>References Vestergren, A.L.S. et al.: Mol. Biol. Rep., 39, 6867 (2012); Huang, C. et al.: Amer. J. Phys., 298, H570 (2010); Ha-Douong, N., et al.: J. Med. Chem., 44, 3622 (2001);<br></p>

<p>Applications Methyl 1-[(2-Fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carboximidate is a useful reactant to study metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002);<br></p>

<p>Applications Thieno[2,3-d]pyrimidine derivative.<br></p>

<p>Stability Hygroscopic<br>Applications 2-(2-Aminobenzoyl)pyridine, is an intermediate used for the synthesis of various Quinoline derivatives. It can also be used in the synthesis of the antitumoral agent batracylin and related isoindolo[1,2-b]quinazolin-12(10H)-ones.<br>References Chia-Chung, Ch., et al.: Organic Reactions, 28 (1982); Martinez-Viturro, C. M., et al.: Tetrahedron Letters, 48, 1023 (2007);<br></p>

<p>Applications 2-Chloromethyl-3,5-dimethylpyridin-4-ol (cas# 220771-03-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Oxyl-2,2,5,5-tetramethyl-∆3-(methanesulfonyloxymethyl)pyrroline is an intermediate in the synthesis of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N the isotope labelled analog of 3-Iodomethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (I709500); a thio-reactive spin label.<br>References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001);<br></p>

<p>Applications 2-Chloro-4(1H)-pyrimidinone Hydrochloride is a reactant in the preparation of aminobenzamide derivatives as glycogen synthase kinase 3β (GSK3β) inhibitors for preventing or treating GSK3β-mediated diseases (1).<br>References (1) Freyne, E.J.E., et al.: PCT Int. Appl., WO 2003037877 (2003<br></p>

<p>Applications 2-Chloro-4-(trifluoromethyl)pyrimidine (cas# 33034-67-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive, Unstable in DMSO Solution<br>Applications 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine also known as Comins’ Reagent is used as a triflyl compouind in the synthesis of vinyl triflates from metallo enolates.<br>References Comins, D., et al.: Tetrahedron Lett., 33, 6299 (1992);<br></p>

<p>Stability Light Sensitive, Moisture Sensitive<br>Applications (1-Oxyl-2,2,5,5-tetramethyl-4-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-3-yl)methyl Methanesulfonate is an intermediate in the synthesis of highly active spin labelling reagents.<br></p>

<p>Applications An intermediate for the synthesis of Alpidem.<br></p>

<p>Applications 3-phenyl-1H-pyrrole-2-carboxylic acid (cas# 802052-63-7) is a useful research chemical.<br></p>

<p>Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Applications 3,4-Dihydro-4-hydroxy-1(2H)-pyridinecarboxylic Acid Ethyl Ester is a synthetic intermediate/reactant in the synthesis of streptazolin.<br>References Kozikowski, A., Park, P.: J. Org. Chem., 55, 4668 (1990);<br></p>

<p>Applications 5-Hydroxy-N-methyl-2-pyrrolidinone-d3 is an isotopically labelled analogue of the metabolite of N-methylpyrrolidone (NMP, M326120).<br>References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),<br></p>

<p>Applications Used in the preparation of indoline derivatives as PERK inhibitors.<br></p>

<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Bromo-2-fluoropyridin-3-ol (cas# 850142-72-2) is a useful research chemical.<br></p>

<p>Applications 2-​Hydrazinyl-​4-​methylbenzoxazole is a useful research chemical.<br></p>

<p>Applications 5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid (cas# 543739-84-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Bromopyridine-15N (cas# 54267-53-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Succinimidyl Nervonate (cas# 191354-88-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloro-2,3-dimethoxypyridine (cas# 1087659-30-0) is a useful research chemical.<br></p>

<p>Applications 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic Acid is used to prepare a selective CB2 receptor agonist for the treatment of inflammatory pain.<br>References Giblin, G., et al.: J. Med. Chem., 50, 2597 (2007)<br></p>

<p>Applications 4,6-Dimethyl-2-(methylthio)pyrimidine is a useful reactant for the synthesis of substituted heterocycles via nickel-catalyzed cross-coupling reaction.<br>References Melzig, L., et al.: J. Org. Chem., 75, 2131-33 (2010);<br></p>

<p>Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.<br></p>