Heterocycles with Nitrogen (N)

<p>Applications L, L'-Bisuccinimide is great oil antioxidant detergent compound.<br>References Wen, Y., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications Ethyl 1-(4-(aminosulfonyl)phenyl)-3-(trifluoromethyl)-5-p-tolyl-1h-pyrazole-4-carboxylate<br></p>

<p>Applications N-(3-(2-Methylpiperidin-1-yl)propyl)-2-(p-tolyl)benzo[d]imidazo[2,1-b]thiazole-7-carboxamide is a useful synthetic intermediate in organic synthesis and pharmaceuticals.<br></p>

<p>Applications 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium-d5 Chloride is an intermediate used in the synthesis of Girard’s Reagent P-d5 (G388502), which is a labeled girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H. et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R. et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications N-BOC-Piperidin-4-ylmethyleneboronic acid pinacol ester is a useful research chemical.<br></p>

<p>Applications 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid<br></p>

<p>Applications 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine is used in preparation of pyridine-2,4-diamine derivatives as FAK inhibitors for the treatment of arthritis, inflammatory and immune disorders.<br>References Lide, D., et al.: J. Chem. Phys., 29, 914 (1958), Giovannini, E., et al.: Helv. Chim. Acta, 42, 1142 (1959),<br></p>

<p>Applications 3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thiophenecarboxylic Acid (cas# 477888-48-5) is a useful research chemical.<br></p>

<p>Applications 6-(4-(hydroxymethyl)piperidin-1-yl)pyridazine-3-carboxylic acid (cas# 1178931-24-2) is a useful research chemical.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 3-Isopropenyl-2-oxo-1-benzimidazolinebutyric Acid Ethyl Ester (cas# 116199-87-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-{3H-Imidazo[4,5-c]pyridin-2-yl}aniline is derived from 3,4-Diaminopyridine (D415950), which is used as a reagent in the preparation of 9-deazaxanthine derivatives which had activity as dual antagonists/MAO-B inhibitors with potential as anti-Parkinson’s agent.<br>References Rivara, S., et al.: J. Med. Chem., 56, 1247 (2013)<br></p>

<p>Applications [4-[(4-Methylpiperazin-1-yl)methyl]phenyl]boronic Acid is used to prepare N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides as B-Raf kinase inhibitors.<br>References Berger, D., et al.: Bioorg. Med. Chem. Lett., 19, 6519 (2009)<br></p>

<p>Applications A new reagent that is a naphtalene analog of 4-(4'-N,N-Dimethylaminophenyl)urazole (D451750).<br>References Shams, E., et al.: Analitical Sci., 2002, 18, 993 ;<br></p>

<p>Applications B-[2-(Methylamino)-4-pyridinyl]boronic Acid Hydrochlroide, is used to prepare novel selective thiazoleacetic acids as CRTH2 antagonists.<br>References Grimstrup, M., et al.: Bioorg. Med. Chem. Lett., 20, 1181 (2010)<br></p>

<p>Applications 3-Bromo-1-(triisopropylsilyl)pyrrole<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications 5,6-DIHYDRO-4H-PYRROLO[3,4-D]THIAZOLE HYDROCHLORIDE (cas# 1434128-58-1) is a useful research chemical.<br></p>

<p>Applications 3-FLUOROPYRAZIN-2-AMINE (cas# 1206523-95-6) is a useful research chemical.<br></p>

<p>Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.<br>References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);<br></p>

<p>Applications Methyl 5-Hydroxy-2-benzimidazolecarbamate-d3, is a labeled analogue of Methyl 5-Hydroxy-2-benzimidazolecarbamate (M312585), which is a derivative of Carbendazim (C175900).<br>References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),<br></p>

<p>Applications 1-(4-Bromophenyl)piperidin-2-one<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N4 is an intermediate in the synthesis of 2’-Deoxyguanosine-5N5 which is a nucleoside.<br>References Krenitsky, T.A., et al.: Biochemistry, 20, 3615 (1981), Chapeau, M.-C., et al.: Chem. Res. Toxicol., 4, 636 (1991),<br></p>

<p>Applications 2-(4,5-dihydro-1H-imidazol-2-yl)pyridine (cas# 7471-05-8) is a useful research chemical.<br></p>

<p>Applications 2,3-Diaminopyridine is used as a reagent in the synthesis of novel imidazopyridine derivatives which can exhibit cytotoxic activity against MCF-7 human breast adenocarcinoma cell line. 2,3-Diaminopyridine is also used in the preparation of non-camptothecin topoisomerase I inhibitors which exhibit antitumor activity.<br>References Puskullu, M.O., et al.: Chem. Heterocyc. Compd., 51, 723 (2015); Zhang, C., et al.: Bioorg. Med. Chem. Lett., 25, 4693 (2015)<br></p>

<p>Applications methyl 2-amino-5-benzyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-3-carboxylate (cas# 1428234-04-1) is a useful research chemical.<br></p>

<p>Applications 2-(3,5-Dichlorophenyl)-imidazo[1,2-a]pyridine is derived from Ethyl Bromoacetate (E900140), which is used in the synthesis of metabolites of carcinogenic PAHs. Also it is used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antimicrobial and antioxidant coumarinyloxymethyl-thiadiazolone.<br>References Wu, A. et al.: Tetrahedron, 68, 7217 (2012); Clark, E. et al.: J. Med. Chem., 20, 1096 (1977); Al-Amiery, A. et al.: Chem. Nat. Comp., 48, 950 (2013);<br></p>

<p>Applications 5-Amino-1-phenylpyrazole is a reagent that is used in the synthesis of sulfaphenazole(S689020) derivatives as inhibitors and tools for comparing active sites of human liver cytochromes P 450 2C subfamily.<br>References Vestergren, A.L.S. et al.: Mol. Biol. Rep., 39, 6867 (2012); Huang, C. et al.: Amer. J. Phys., 298, H570 (2010); Ha-Douong, N., et al.: J. Med. Chem., 44, 3622 (2001);<br></p>

<p>Stability Moisture Sensitive, Hygroscopic<br>Applications 1,2-dimethyl-1H-imidazole-4-sulfonyl chloride (cas# 137049-02-6) is a useful research chemical.<br></p>

<p>Applications Diethyl Pyridine-2,3-dicarboxylate is a useful reagent in preparation of herbicides.<br>References Doehner, R.: Eur. Pat. Appl. (1988), EP 254951 A2 19880203.<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications Methyl 1-[(2-Fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carboximidate is a useful reactant to study metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002);<br></p>

<p>Applications 4-Hydroxythieno[2,3-d]pyrimidine (cas# 14080-50-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(Formamidomethyl)-1H-benzotriazole is a useful reagent for the synthesis 1-​isocyanomethyl azoles and related compounds.<br>References Saikachi, H., et al.: Chem. Pharm. Bull., 31, 723 (1983)<br></p>

<p>Applications 4-(3,5-Dimethylpyrazol-1-yl)phenylboronic acid, pinacol ester<br></p>

<p>Applications An intermediate in the preparation of serotonin 5-HT2a receptor antagonists<br>References Ullrich, T., et al.: Bioorg. Med. Chem., 8, 2427 (2000),<br></p>

<p>Applications Sulfosuccinimidyl Linoleate Sodium is an analog of Sulfosuccinimidyl Oleate Sodium (S689200).<br></p>

<p>Applications 3,5-Dimethylpyrazole-4-boronic acid, Hydrochloride is a useful research chemical for organic synthesis and other chemical processes.<br>References Jones, A., et al.: From PCT Int. Appl. (2016), WO 2016046530 A1 20160331<br></p>

<p>Stability Unstable in DMSO Solution<br>Applications 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine is used as a reactnat in the synthesis of carba-nucleosides as potent antagonists of ADP purinergic receptor P2Y12 on human platelets.<br>References Ye, H., et al.: ChemMedChem, 3, 732 (2008);<br></p>

<p>Applications 2,4-Dimethyl-N-(phenyl(pyridin-3-yl)methyl)pyrimidine-5-carboxamide is a useful research chemical.<br></p>

<p>Applications 1,1'-Ethylenedipiperazine Hydrochloride Salt is the salt form of 1,1'-Ethylenedipiperazine, which is used in the synthetic preparation of novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazoles as anticancer agents.<br>References Zhang, R.; et al.: Bioorganic Med. Chem., 19, 7023 (2011)<br></p>

<p>Applications 3-[3-(aminomethyl)phenyl]-1,3-oxazolidin-2-one (cas# 952391-73-0) is a useful research chemical.<br></p>

<p>Applications Heterocyclic compound used in cosmetic compositions.<br>References Windheuser, J., et al.: J. Pharm. Sci., 71, 121 (1982), Davis, E., et al.: J. Med. Entomol., 22, 237 (1985), Osimitz, T., et al.: J. Toxicol., 35, 435 (1997), Ross, E., et al.: Drug Metab. Dispos., 32, 783 (2004),<br></p>

<p>Applications 2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloro-2-methoxypyridine-3-boronic acid<br></p>

<p>Applications 5,6-Dichloro-1,3-benzoxazol-2-amine<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications 2-Fluoropyridine acts as a reagent in the synthesis of aminopyrimidines with antimicrobial and antifungal properties.<br>References Hedidi, M., et al.: Eur. J. Org. Chem., 39, 5903 (2017)<br></p>

<p>Applications 2,3-Dichloropyridine-5-boronic acid<br></p>

<p>Applications β-Chlorophenethylamine derivatives and their conversion into halogen-free compounds.<br>References Bretschneider, H., et al.: Monatshefte fuer Chemie, 78, 82 (1948),<br></p>

<p>Applications 2-(2-Thienyl)pyrrolidine is used in the preparation of imidazopyridine derivatives for treating viral infections.<br>References Serradeil-Le Gal, C., et al.: J. Pharmacol. Exp. Ther., 300, 1122 (2002), Hodgson, R., et al.: Pharmacol. Biochem. Behav., 3, 431 (2007),<br></p>

<p>Applications 3-(Trifluoromethyl)-1H-1,2,4-triazole, is a fluorinated building block used in various chemical synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-ethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid (cas# 80709-74-6) is a useful research chemical.<br></p>

<p>Applications 6-ACETYL-PICOLINIC ACID ETHYL ESTER (cas# 114578-70-0) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is used in the synthesis of morpholinothiazoles as alpha 7 position allosteric modulators.<br>References MacDonald, G., et al.: PCT Int. Appl. (2011), WO 2011064288 A1 20110603<br></p>

<p>Applications A boc-protected cyclic amine used in the preparation of heterocyclic boronic acid compounds.<br></p>

<p>Applications 5-Bromo-2-chloro-3-nitropyridine (cas# 67443-38-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Butyryl-4-(S)-phenylmethyl-2-oxazolidinone (cas# 112459-79-7) is a compound useful in organic synthesis.<br></p>

<p>Applications ethyl 4-(hydroxymethyl)piperidine-1-carboxylate (cas# 118156-56-2) is a useful research chemical.<br></p>

<p>Please enquire for more information about tert-Butyl 4-(4-iodophenyl)tetrahydro-1(2H)-pyrazinecarboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ethyl 6-methyl-2-thioxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 7-Bromo-1-methyl-1H-imidazo[4,5-c]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ethyl N-piperazinecartoxylate is an organic compound that has been shown to inhibit the growth of Mycobacterium tuberculosis, Mycobacterium avium complex, and other mycobacteria. It is a potent anti-tuberculosis agent with a tuberculostatic activity against M. tuberculosis inactivated by ethyl nitrite. Ethyl N-piperazinecartoxylate inhibits the synthesis of DNA, RNA, and proteins by inhibiting the bacterial enzyme RNA polymerase. The antimycobacterial activity of this drug is also due to its ability to inhibit protein synthesis at the ribosome level. This drug has been shown to have antihypertensive activity as it blocks adrenergic receptors in blood vessels and thereby reduces blood pressure.</p>

<p>1-Benzyl-3-piperidinol is a synthetic chemical that has been used as a long-acting calcium antagonist. It is synthesized by the reaction of 1,2-dibromoethane with piperidine and benzaldehyde in the presence of an acid catalyst. The reaction yield is high, and impurities are low. This drug substance is soluble in organic solvents, such as chloroform, ethyl acetate, and ether. The synthesis process uses chiral catalysts to produce the desired enantiomeric form of the drug substance. The use of immobilized catalysts improves the conversion rate, kinetic parameters, and reaction yield of this process.</p>