Heterocycles with Nitrogen (N)

Applications 4-Aminopiperidine is a useful reactant in organic synthesis.
References Park, Sun Jun, et al.: Bioorg. & Med. Chem. Let., 27(18), 4399-4404 (2017);Le Manach, Claire, et al.: J. of Med. Chem., 59(21), 9890-9905 (2016)

Applications 5-[bis(2-chloroethyl)amino]pyrimidine-2,4-diol (cas# 66-75-1) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-phenyl-1,3,5-triazine-2,4-diamine (cas# 91-76-9) is a useful research chemical.

Applications 4-Amino-3-chloropyridine is a chlorinated heteroarylamine. 4-Amino-3-chloropyridine is used in the preparation of inhibitor of phosphodiesterase type 4 (PDE4) as antiasthmatic agents as well as other pyridine based pharmaceutical agents
References Ashton, M.J. et al.: J. Med. Chem., 37, 1696 (1994);

Applications 5-Bromo-2,4-diamino-6-hydroxypyrimidine (cas# 6312-72-7) is a compound useful in organic synthesis.

Applications 4-Oxo-6-(2-oxo-5-vinylpyrrolidin-1-yl)hexanoic Acid is derived from Ethyl Succinoyl Chloride (E818230), which is used in the synthesis of bivalent ligands for D2/D3 dopamine receptors. Also used in the preparation of antimicrobial pyrrolo-isoquinolinones. Vigabatrin Impurity 2
References Gogoi, S. et al.: ACS Med. Chem. Lett., 3, 991 (2012)

Applications Methyl 2-Oxo-1-pyrrolidineacetate is used a reagent in the synthesis of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents. It is also used as a a reagent in the synthesis of (acylamino)acridines as choline uptake enhancers.
References Zhao, S., et al.: Bioorg. Med. Chem., 7, 1637 (1999); Chaki, H., et al.: Bioorg. Med. Chem. Lett., 5, 1489 (1995)

Applications Ethyl (5-Ethyl-2-pyridinyl)acetate (cas# 99986-02-4) is a compound useful in organic synthesis.

Impurity Cefoperazone EP Impurity C
Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.
References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),

Applications Orotic Acid Monosodium Salt is used in the formation of a complex with lanthanium(III) which displats cytotoxic activity on different tumor cell lines.Also, it is the unlabeled form of Orotic Acid-15N2 Monosodium Salt (O691517), which is an intermediate used in the synthesis of Orotic Acid-15N2 Monohydrate (O691504), which is a labeled analogue of Orotic Acid Monohydrade (O691500), which is used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment.
References Kostova, I., et al.: Int. J. Curr. Chem., 1, 271-280 (2010)

Applications 1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic acid (cas# 1432680-68-6) is a useful research chemical.

Applications An intermediate in the preparation of 4-Amino-2,2,6,6-tetra-methyl Piperidine-1-oxyl.
References Li, W., et al.: J. Pharm. Pharmacol., 58, 941 (2006),

Applications N-Benzyl-4-carboethoxypiperidine (cas# 24228-40-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 5-phenyl-1,3-oxazolidin-2-one (cas# 7693-77-8) is a useful research chemical.

Applications 3-(Methoxycarbonyl)pyridine-5-boronic acid, pinacol ester

Applications 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is used in preparation and structure of alkaline earth iodide phosphine oxide and urea complexes as reactant or reagents.
References Fitts, Lacey S., et al.: New J. of Chem., (2016); Hall, Jessica E., et al.: Angew. Chem. Int. Ed., 55, 11153-11157 (2016)

Applications L-Alanyl-L-proline is a dipeptide that contains a sterically constrained proline, a well-known turn inducer in proteins.
References Moriuchi, T., et al.: J. Organomet. Chem., 589, 50 (1999)

Stability Volatile
Applications 2,4,6-Tris(trifluoromethyl)-1,3,5-triazine is used as a secondary battery electrolyte in power storage systems.
References Hiasa, T., et al.: Jpn. Kokai Tokkyo Koho, 77 (2018)

Applications 2,3,5-Trichloropyridin-4-amine (cas# 28443-69-8) is a useful research chemical.

Applications Pyrazine 1,4-Dioxide (cas# 2423-84-9) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Urazole (cas# 3232-84-6) is a useful research chemical.

Applications 2-Oxo-1-benzimidazolinebutyric Acid (cas# 3273-68-5) is a compound useful in organic synthesis.

Applications 2-(Ethylthio)-1H-benzimidazole is the active substance or the active ingredient in the synthesis of the drug Metaprot. Performs a transplacental function: daily administration of bemithyl (20 mg/kg) from 6 th to 16 th day of pregnancy in female rats led to the decrease in fetal death after the implantation and increased fetal body weight.
References Kibal'chich, D. A., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 74, 30 (2011); Bugaeva, L. I., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 70, 40 (2007).

Applications 2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.

Applications 1-(9-Fluorenylmethyl)piperidine is an intermediate when synthesizing 9-​Fluorenylmethoxycarbonyl group (FMOC), which is a new amino-protecting group.
References Carpino, L., et al.: J. Org. Chem., 37, 3404 (1972)

Applications 2-Phenyl-1H-benzimidazole is a reagent used in the synthesis of various aryl-substituted benzimidazole derivatives. Also used in the synthesis of benzimidazole and quinocaline derivatives
References Saleh, V. et al.: Org. Chem. Int., 1, (2015); Hasanpour, M. et al.: J. Chin. CHem. Soc., 62, 412 (2015);

Applications 4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.
References Northrup, A. et al.: J. Med. Chem., 56, 2294 (2013);

Applications 5-Hydroxy-N-methyl-2-pyrrolidinone is a metabolite of N-methylpyrrolidone (NMP).
References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),

Impurity Flecainide EP Impurity B
Applications 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.
References Reddy, G. et al.: Hetero. Chem., 23, 247 (2012); Fujita, M. et al.: Chem. Pharm. Bull., 46, 787 (1998);

Applications Isotope Labelled 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);

Applications s-Triazine-1,3,5-triethanol (cas# 4719-04-4) is a compound useful in organic synthesis.

Applications 2,4-Diaminopyrimidine-5-carbonitrile is used as an intermediate for the preparation of medicines and agrochemicals (1).
References (1) Otzen, T., et al.: J. Med. Chem., 47, 240 (2004)

Applications L-Dihydroorotic acid is used as a reactant in the preparation of long acting Gonadotrophin-releasing hormone (GnRH) antagonist containing p-ureido-phenylalanine.
References Jiang, G., et al.: J. Med. Chem., 44, 453 (2001);

Applications 3,5-Dimethyl-4-nitropyridine 1-Oxide is an intermediate used to prepare 2-[(2-pyridylmethyl)thio or -sulfinyl]benzimidazoles as antiulcer agents.
References Nohara, A., et al.: U.S., US 4689333 A 19870825. (1987)

Applications 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);

Applications 5-(4-Chlorobutyl)-1-cyclohexyltetrazole-d11 (cas# 1073608-19-1) is a compound useful in organic synthesis.

Applications A common additive for peptide coupling.
E0

Applications 5-Amino-2-chloro-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 30161-95-6) is a compound useful in organic synthesis.
References Nagahara, K., et al.: J. Med. Chem., 33, 407 (1990),

Stability Air Sensitive, Hygroscopic, Moisture Sensitive
Applications N-Bromosuccinimide is a brominated succinimide used as a chemical reagent in radical substitution and electrophilic addition reactions in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Alberola, A. et al.: Anal. Quim., 74, 761 (1968); Kobayashi, T. et al.: J. Chem. Soc. Perk. Trans., 12, 1372 (2001); Paulini, K. et al.: CHem. Ber., 127, 685 (1994);

Applications 1,2-DIMETHYLIMIDAZOLE (cas# 1739-84-0) is a useful research chemical.

Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.
References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)

Applications 3-Aminopiperidine DiHCl can be used as reactant/reagent for xanthine dipeptidyl peptidase inhibitors for treatment of type 2 diabetes.
References Eckhardt, M., et al.: J Med Chem, 50, 6450 (2007)

Applications (R)-4-(Hydroxymethyl)oxazolidin-2-one, is a building block used in various chemical synthesis.

Applications 1-Formylpiperazine (cas# 7755-92-2) is a useful research chemical.

Applications 2-Chloro-4,6-dimethoxy-1,3,5-triazine (cas# 3140-73-6) is a compound useful in organic synthesis.

Applications 1-(4-Nitrophenyl)-2-piperidinone is used in the synthesis of inhibitors of blood coagulation factor Xa.
References Pinto, D., et al.: J. Med. Chem., 50, 5339 (2007); Xing, J., et al.: Eur. J. Med. Chem., 95, 388 (2015)

Applications (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.
References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012); Sakashita, H., et al.: Bioorg. Med. Chem., 15, 641 (2007)